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Bibliography on: Calcium Metabolism and Urinary Stones

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RJR: Recommended Bibliography 04 Sep 2026 at 01:42 Created: 

Calcium Metabolism and Urinary Stones

Wikipedia: Calcium Metabolism — everybody knows that osteoporosis is a huge threat and that the best way to reduce the risk of osteoporosis is to take lots of dietary calcium supplements and vitamin D pills.

OK, exercise is good, too, but that can involve actually breaking a sweat — something that not everyone wants to do.

But, did you also know that hypercalciuria (too much secreted calcium in the urine) is associated with a significant increase in the risk for kidney stones? And, you can easily get hypercalciuria if you pop too many calcium-supplement pills. Hmmmm. Nice choice, break a hip or pass kidney stones... What to do? As with most things biological, reality lies somewhere in the trade-off zone. A quick look at the literature dealing with calciuria and kidney stones is one way to start.

Created with PubMed® Query: (calciuria OR "calcium metabolism") AND (urolith OR "kidney stone" OR "kidney stones" OR "bladder stones" OR stones) NOT pmcbook NOT ispreviousversion

Citations The Papers (from PubMed®)

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RevDate: 2019-09-11
CmpDate: 1977-04-30

Hesse A, Berg W, Schneider HJ, et al (1976)

A contribution to the formation mechanism of calcium oxalate urinary calculi. II. In vitro experiments concerning the theory of the formation of Whewellite and Weddellite urinary calculi.

Urological research, 4(4):157-160.

In vitro investigations of the formation of Whewellite or Weddellite are described. By means of different precipitation models the influence of cationic minerals on the formation of Weddellite could be observed. The possible conversion of Weddellite into Whewellite in vivo is demonstrated by in vitro experiments. A theory of the formation of Weddellite or Whewellite urinary calculi is developed on the basis of the results obtained.

RevDate: 2019-09-11
CmpDate: 1977-04-30

Berg W, Hesse A, HJ Schneider (1976)

A contribution to the formation mechanism of calcium oxalate urinary calculi. III. On the role of magnesium in the formation of oxalate calculi.

Urological research, 4(4):161-167.

The influence of magnesium in vitro on the precipitation of calcium oxalate was investigated. Even at maximum physiological magnesium concentrations a litholytic effect could not be observed, but the retardation of the calcium oxalate crystallization caused by magnesium might be decisive for a reduction in calculi formation. The enlargement of the calcium oxalate crystals and aggregates caused by the retardation of crystallization, however, should be regarded as a contraindicating factor for Mg therapy in oxalate calculous disease. It is safe to say that high magnesium concentrations prevent the conversion into Whewellite of the calcium oxalate calculi substance primarily formed as Weddellite.

RevDate: 2013-11-21
CmpDate: 1979-09-27

Bleich HL, Moore MJ, Lemann J, et al (1979)

Urinary calcium excretion in human beings.

The New England journal of medicine, 301(10):535-541.

RevDate: 2019-09-02
CmpDate: 1978-09-30

Sidaway DA (1978)

A microbiological study of dental calculus. II. The in vitro calcification of microorganisms from dental calculus.

Journal of periodontal research, 13(4):360-366.

RevDate: 2013-11-21
CmpDate: 1975-06-13

Pak CY, Kaplan R, Bone H, et al (1975)

A simple test for the diagnosis of absorptive, resorptive and renal hypercalciurias.

The New England journal of medicine, 292(10):497-500.

A test was developed to diagnose various forms of hypercalciuria. A two-hour urine sample after an overnight fast and a four-hour urine sample after 1 g of calcium by mouth were tested for calcium, cyclic AMP and creatinine. The 24 patients with absorptive hypercalciuria had normocalcemia and normal fasting urinary calcium (less than 0.11 mg per milligram of urinary creatnine). Urinary calcium was high (greater than or equal to 0.2 mg per milligram of creatinine) after a calcium load. Of the 28 patients with primary hyperparathyroidism (resorptive hypercalciuria), 25 had hypercalcemia and 21 had high fasting urinary calcium. Urinary cyclic AMP, elevated in 30 per cent of fasting patients, was high (greater than 4.60 mu moles per gram of creatinine) in 82 per cent of cases after calcium load. Six patients with renal hypercalciuria had normocalcemia, high fasting urinary calcium, and high (greater than 6.86 mu moles per gram of creatinine) or high-normal fasting urinary cyclic AMP was normal. This simple test should facilitate the differentiation of various causes of hypercalciuria.

RevDate: 2013-11-21
CmpDate: 1975-08-18

Schwartz MK (1975)

Recent advances in calcium and phosphorus metabolism.

Annals of clinical and laboratory science, 5(3):176-184.

This review considers the most recent developments concerning the metabolism and homeostasis of calcium and phosphorus. The kinetics of the distribution of calcium, theories of calculus formation, hypercalcemia and hypocalcemia are discussed, as well as the role of parathyroid hormone, thyrocalcitonin and 1,25 dihydroxy Vitamin D(3) in maintaining calcium levels and skeletal integrity. In addition, the role of calcium in enzyme activation and inhibition, muscle and nerve function, and intracellular metabolism are considered.

RevDate: 2019-05-16
CmpDate: 1975-09-18

Russell RG, H Fleisch (1975)

Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.

Clinical orthopaedics and related research.

Pyrophosphate and diphosphonates produce striking results on calcium metabolism in experimental animals and man. Compounds containing P-O-P- bonds (e.g. inorganic pyrophosphate [PP-ii1 or P-C-P bonds (diphosponates) inhibit both the formation and dissolution of calcium phosphate crystals in vitro. PP-i may have a physiological function in regulating calcification and bone turnover, and obnormalities in its metabolism may occur in some human diseases notably hypophosphatasia and pseudogout. Diphosphonates inhibit ectopic calcification, and slow down resorption and bone turnover in several experimental systems in vivo. They have helped in studies of various aspects of the regulation of calcium metabolism. The diphosphonate, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) has been shown in clinical studies to be effective against ectopic calcification particularly in myositis ossificans progressiva and in disorders of increased bone resorption such as Paget's diseases and some types of osteoporosis. -99mTechnetium complexes of EHDP, PP-i and other polyphosphates have also recently been used successfully as bone scanning agents.

RevDate: 2018-11-13
CmpDate: 1977-06-11

Kaplan RA, Haussler MR, Deftos LJ, et al (1977)

The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria.

The Journal of clinical investigation, 59(5):756-760.

The cuase for the intestinal hyperabsorptionof calcium (Ca) in various forms of hypercalciurias was explored by a careful measurement of plasma 1 alpha, 25-dihydroxycholecalciferol [1 alpha, 25-(OH)I D] and by an assessment of intestinal Ca absorption and of parathyroid function. In 18 cases of primary hyperparathyroidism (PHPT), the mean plasma concentration of 1 alpha, 25-(OH)2D was significantly increased (4.9 +/- 2.2 SD ng/dl vs. 3.4 +/- 0.9 ng/dl for the control group), and was significantly correlated with fractional Ca absorption (alpha) (r = 0.80, P less than 0.001). Plasma 1 alpha, 25-(OH)2D was also correlated with urinary Ca (P less than 0.05), but not with serum Ca or phosphorus (P), P clearance, urinary cyclic AMP, or serum immunoreactive parathyroid hormone. In 21 cases of absorptive hypercalciuria (AH), plasma 1 alpha, 25-(OH)2D was elevated in one-third of cases, and the mean value of 4.5 +/- 1.1 ng/dl was significantly higher than that of the control group (P less than 0.01). Since relative hypoparathyroidism may be present, the normal absolute value of plasma 1 alpha, 25-(OH)2D, found in two-thirds of cases of AH, may be considered to be inappropriately high. Moreover, in the majority of cases of AH, the data points relating plasma 1 alpha, 25-(OH)2D and alpha fell within 95% confidence limits of values found in non-AH groups (including PHPT). The results suggest that the intestinal hyperabsorption of Ca in PHPT aw AH may be vitamin D dependent. However, the disturbance in vitamin D metabolism may not be the sole cause for the high Ca absorption in AH, since in some patients with AH, the intestinal Ca absorption appears to be inapp

RevDate: 2019-06-22
CmpDate: 1977-10-14

Fleisch H, Fast D, Rizzoli R, et al (1977)

Diphosphonates. Mode of action and clinical applications.

Advances in experimental medicine and biology, 81:279-289.

RevDate: 2013-11-21
CmpDate: 1977-11-25

Baumann JM (1977)

[Effect of orthophosphate, pyrophosphate and diphosphonate in urinary-calculi metaphylaxis].

Zeitschrift fur Urologie und Nephrologie, 70(6):449-452.

RevDate: 2013-11-21
CmpDate: 1978-04-17

Vattimo GC, Galli M, Nuti R, et al (1977)

Cyclic AMP urinary excretion and radiocalcium intestinal absorption in hypercalciurias.

Bollettino della Societa italiana di biologia sperimentale, 53(14):1178-1182.

RevDate: 2015-05-23
CmpDate: 1978-07-24

Backman U, Danielson BG, Johansson G, et al (1978)

[Etiology of hypercalciuria in recurrent kidney calculi].

Lakartidningen, 75(19):1910-1911.

RevDate: 2013-11-21
CmpDate: 1978-12-02

Tschöpe W, Schmidt-Gayk H, E Ritz (1978)

[Therapeutic measures in recurrent calcium oxalate nephrolithiasis].

Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 67(38):1385-1388.

RevDate: 2013-11-21
CmpDate: 1979-09-01

Bertolissi F, Maschio M, A Benedetti (1979)

[Kidney and parathyroid hormone].

Minerva medica, 70(27):1951-1955.

RevDate: 2013-11-21
CmpDate: 1981-09-15

Graziani G, Mioni G, Aroldi A, et al (1979)

[Hyperparathyroidism and recurrent calcic nephrolithiasis].

Minerva nefrologica, 26(3):305-308.

RevDate: 2013-11-21
CmpDate: 1981-09-15

Ciccarelli C, Pizzarelli F, Parlongo S, et al (1979)

[Incidence and genesis of idiopathic hypercalciuria in calcic urolithiasis in a southern area].

Minerva nefrologica, 26(3):321-323.

RevDate: 2017-02-14
CmpDate: 1977-04-30

Ennever J, Vocel JJ, Riggan LJ, et al (1977)

Proteolipid and calculus matrix calcification in vitro.

Journal of dental research, 56(2):140-142.

The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid.

RevDate: 2018-02-16
CmpDate: 1977-05-12

Luoma H, T Nuuja (1977)

Caries reduction in rats by phosphate, magnesium and fluoride additions to diet with modifications of dental calculus and calcium of the kidneys and aorta.

Caries research, 11(2):100-108.

RevDate: 2013-11-21
CmpDate: 1978-02-18

Pfister AK (1977)

Renal calcium and its implications.

The West Virginia medical journal, 73(12):319-321.

RevDate: 2004-11-17
CmpDate: 1978-12-27

Clergeau-Guerithault S (1977)

[Diphosphonates and calcified tissues].

L' Information dentaire, 59(41):21-31.

RevDate: 2019-12-10
CmpDate: 1977-10-31

Rugendorff EW, Schneider HJ, Gundlach G, et al (1977)

[Results of clinical trials with the cation exchange preparation campanyl in the therapy and metaphylaxis of calcium-containing urinary calculi (author's transl)].

Der Urologe. Ausg. A, 16(4):197-203.

The efficacy of the cation exchange preparation Campanyl (T1286) was tested in the treatment and metaphylaxis of calcium-containing urinary calculi. For this purpose, in vitro experiments, animal exeriments, orienting clinical studies in 79 patients, and a long term clinical trial in 42 patients over 12 months were undertaken; 22 of the latter patients are also still being treated with the cation exchange preparation, the observation period for 15 patients being 3 1/2 years and 2 1/2 years for 7 patients. As a result of these studies a lowering of the medium calcium excretion and a reduction of calculus discharge by more than half was achieved in the patients being treated with the cation exchanger, without restriction of calcium in the diet. There was not yet seen litholysis. Serious side effects or an influence on the serum electrolytes was not recorded with Campanyl (T1286).

RevDate: 2013-11-21
CmpDate: 1977-11-25

Modliński L (1977)

[Experiences with nephrolith in the treatment of patients with kidney calculi].

Zeitschrift fur Urologie und Nephrologie, 70(6):429-435.

In patients with urolithiasis "Nephrolith" has a favourable influence on many parameters which are responsible for the development of renal calculi. I could never observe a complete dissolution of the urinary calculi.

RevDate: 2013-11-21
CmpDate: 1978-02-18

Smith LH, Van Den Berg CJ, DM Wilson (1978)

Nutrition and urolithiasis.

The New England journal of medicine, 298(2):87-89.

RevDate: 2019-08-13
CmpDate: 1978-04-26

Nordin BE (1978)

Diagnostic procedures in disorders of calcium metabolism.

Clinical endocrinology, 8(1):55-67.

The investigation of a patient with a suspected disorder of calcium metabolism is most rapidly and efficiently performed by observing a standard procedure, the initial stages of which are simple and mandatory, the later stages more complex and determined by the initial results and the depth of investigation required. Needless to say, the investigations are preceded by history taking and routine physical examination. The following account is a summary of available procedures, most of which have been described elsewhere in greater detail (Nordin et al., 1976a).

RevDate: 2013-11-21
CmpDate: 1979-06-11

Bablumian IuA (1978)

[Antirelapse action of the flowers of the blue cornflower in urolithiasis].

Zhurnal eksperimental'noi i klinicheskoi meditsiny, 18(6):110-114.

RevDate: 2019-09-11
CmpDate: 1980-01-24

Schwille PO (1979)

A survey of calcium urolithiasis in normocalcemic hypercalciuria: possible role of nutrients and diet-mediated factors.

Urological research, 7(3):149-155.

Three types of hypercalciuria are described; their existence and frequent association with calcium urolithiasis in humans are accepted. Various dietary factors such as minerals, electrolytes, fluids, vitamin D, carbohydrates, proteins are discussed with regard to their ability to alter the nature and the degree of calcium excretion following their ingestion. It is emphasised that at present we have only limited knowledge on the chain of events linking calorie intake and the response of the kidney.

RevDate: 2013-11-21
CmpDate: 1980-09-28

Tschöpe W, E Ritz (1979)

[What has been achieved in the therapy of calcium nephrolithiasis?].

Der Internist, 20(12):599-606.

RevDate: 2019-06-19
CmpDate: 1979-07-16

Weber DV, Coe FL, Parks JH, et al (1979)

Urinary saturation measurements in calcium nephrolithiasis.

Annals of internal medicine, 90(2):180-184.

Urinary saturation with respect to calcium oxalate monohydrate was measured in 111 consecutive patients with calcium nephrolithiasis. Each patient also was evaluated by a detailed conventional metabolic protocol. Patients with idiopathic hypercalciuria produced abnormally oversaturated urine more frequently than normal subjects and normocalciuric patients, but normocalciuric patients had unexpectedly high levels of urine saturation. Measuring levels of calcium concentration, oxalate concentration, or the chemical concentration product of calcium and oxalate in urine did not predict oversaturation. During thiazide treatment, saturation level tended to fall if it was initially elevated, whether the patient was hypercalciuric or not. Patients whose urine was not remarkably oversaturated showed no tendency to elaborate even less saturated urine during thiazide treatment; instead, the average calcium oxalate saturation level remained constant. Direct urine saturation measurements can detect a small but significant number of normocalciuric patients who have marked oversaturation with respect to calcium oxalate and appear to benefit from treatment.

RevDate: 2016-11-23
CmpDate: 1979-08-29

Van Den Berg CJ (1979)

Clinical evaluation of renal lithiasis.

Geriatrics, 34(7):35-42.

Determining metabolic activity in urolithiasis may avoid excessive laboratory tests and unnecessary treatment. A simple regimen such as increased oral fluids is often effective therapy in metabolically inactive disease. Most cases of renal lithiasis are idiopathic, but a complete examination and laboratory work-up will usually establish an accurate etiologic diagnosis.

RevDate: 2013-11-21
CmpDate: 1979-09-27

Thind SK, Nath R, Aggarwal SK, et al (1979)

Calcium-45 uptake in blood and urine in experimental urolithiasis and idiopathic stoneformers.

The Indian journal of medical research, 69:639-644.

RevDate: 2013-11-21
CmpDate: 1979-10-24

Schwille PO, Paulus M, Scholz D, et al (1979)

[Urinary oxalate in recurrent calcium urolithiasis with and without hyperfunctioning parathyroid glands and in healthy controls. influence of age and season (author's transl)].

Der Urologe. Ausg. A, 18(4):215-224.

RevDate: 2018-03-30
CmpDate: 1979-11-28

Wilz DR, Gray RW, Dominguez JH, et al (1979)

Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans.

The American journal of clinical nutrition, 32(10):2052-2060.

We evaluated the relationship between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels, Net intestinal Ca absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary Ca absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-3, pmole/liter, r = + 0.58; P less than 0.001. By contrast, there was no significant correlation between PO4 or Mg absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. We conclude that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary Ca intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.

RevDate: 2013-11-21
CmpDate: 1979-12-27

Harrison HE, HC Harrison (1979)

Disorders of calcium and phosphate metabolism in childhood and adolescence.

Major problems in clinical pediatrics, 20:1-314.

RevDate: 2016-11-23
CmpDate: 1980-01-19

Meier W, Blumberg A, Imahorn W, et al (1979)

Idiopathic hypercalciuria with bilateral macular colobomata: a new variant of oculo-renal syndrome.

Helvetica paediatrica acta, 34(3):257-269.

Two siblings from a consanguineous family, suffering from nephrocalcinosis and nephrolithiasis caused by idiopathic hypercalciuria are described. The condition is associated with bilateral macular colobomata and tapeto-retinal degeneration. It is known that the latter can occur together with different nephropathies; however, until now it has never been described in combination with idiopathic hypercalciuria. Blood calcium levels were found to be normal, calcium excretion rates were, with one exception, more than 6 mg/kg/24 h corrected for 100 ml GFR. Hypomagnesemia of 1.5 and 1.2 mg/dl and hyermagnesuria of 1.9 and 2.5 mg/kg/24 h corrected for 100 ml GFR were found in both patients. Tubular phosphate reabsorption reached 87% and 84% at serum parathormone levels of 0.34 microgram/l and 0.31 microgram/l in the two patients, respectively. Under calcium and magnesium loading the clearance rates of calcium and magnesium were raised whilst there was only a small insignificant increase in the blood levels of these cations. Acid-base titrations showed normal excretion rates of acid and base in one patient and a mild proximal tubular acidosis in the other. Quantitative investigation of the renal concentrating and diluting capacity established a decrease in the formation of the medullary concentrating gradient in both patients.

RevDate: 2019-09-11
CmpDate: 1980-03-24

Hagmaier V, Flückiger B, Scholer A, et al (1979)

Influence of an orally administered calcium-binding cation exchanger on calcium metabolism in the rat.

Urological research, 7(4):277-279.

RevDate: 2016-11-23
CmpDate: 1980-03-24

Perales Juan JL, Ferrutxe Frau J, B Llopis Mínguez (1979)

[Parathyroid adenoma and renal lithiasis. Report of a case].

Archivos espanoles de urologia, 32(6):569-580.

A case is presented of nephrolithiasis in a patient with no other symptoms than the urological ones and in which considerable hypercalcemia led to a study being carried out on his phospho-calcium metabolism and the diagnosis reached was primary hyperparathyroidism caused by a parathyroid adenoma. Surgical treatment was performed on the lithiasis and the adenoma as a result of which the symptoms completely disappeared and the biochemical readings returned to normal.

RevDate: 2017-11-17
CmpDate: 1980-05-30

Macleod MA, NJ Blacklock (1979)

The influence of glucose and crude fibre (wheat bran) on the rate of intestinal 47Ca absorption. The influence of glucose and wheat bran on calcium absorption.

Journal of the Royal Naval Medical Service, 65(3):143-146.

RevDate: 2013-11-21
CmpDate: 1980-06-16

Shabtai M, Malamud A, Berenheim J, et al (1979)

[Increased incidence of nephrolithiasis among lifeguards in Israel].

Harefuah, 97(3-4):57-59.

RevDate: 2013-11-21
CmpDate: 1980-06-25

Surian M, Graziani G, Colussi G, et al (1979)

Urinary zinc excretion in recurrent calcareous nephrolithiasis (RCN) patients.

Minerva nefrologica, 26(4):537-542.

RevDate: 2013-11-21
CmpDate: 1978-02-18

Schneider HJ (1977)

[Etiology and pathogenesis of urolithiasis].

Zeitschrift fur arztliche Fortbildung, 71(18):856-861.

RevDate: 2013-11-21
CmpDate: 1978-02-18

Schneider HJ (1977)

[Significance of oxalic acid in urinary calculi].

Zeitschrift fur Urologie und Nephrologie, 70(10):757-761.

RevDate: 2013-11-21
CmpDate: 1978-05-17

Lewis LD, Chow FH, Taton GF, et al (1978)

Effect of virus dietary mineral concentrations on the occurrence of feline urolithiasis.

Journal of the American Veterinary Medical Association, 172(5):559-563.

RevDate: 2022-03-18
CmpDate: 1978-06-28

Yendt ER, M Cohanim (1978)

Thiazides and calcium urolithiasis.

Canadian Medical Association journal, 118(7):755-758.

RevDate: 2013-11-21
CmpDate: 1978-07-15

Jordan WR, Finlayson B, M Luxenberg (1978)

Kinetics of early time calcium oxalate nephrolithiasis.

Investigative urology, 15(6):465-468.

This paper examines the kinetics of calcium deposition in rat kidneys after an intraperitoneal sodium oxalate injection. From the results we conclude that only a limited portion of tubular surface is available for adsorption of calcium oxalate crystals, that adsorpption of calcium oxalate crystals onto tubular epithelium is a process of greater than first order with regard to the dose, and that the washout of retained particles from the tubules is a first-order process as related to time. Also, we conclude that in these animals, which were subjected to a large oxalate challenge, the deposition of calcium oxalate crystals is virtually all intratubular.

RevDate: 2013-11-21
CmpDate: 1978-07-24

Fritjofsson A (1978)

[Kidney calculi--current viewpoints on diagnosis and therapy].

Lakartidningen, 75(19):1909-1910.

RevDate: 2013-11-21
CmpDate: 1978-07-24

Berlin T, Collste L, B von Garrelts (1978)

[Calcium metabolism disorders in kidney calculi patients].

Lakartidningen, 75(19):1911-1912.

RevDate: 2019-05-09
CmpDate: 1978-07-15

Tao LC (1978)

Microliths in sputum specimens and their relationship to pulmonary alveolar microlithiasis.

American journal of clinical pathology, 69(5):482-485.

The sputa of 26 of 100 patients with chronic obstructive pulmonary disease contained microliths. The numbers of microliths per smear of sputum per patient ranged from one to 20. In seven of the sputum specimens containing microliths, deposition of calcium was present on the loops of Curshmann's spirals to different extents, from a single layer to the laminated appearance seen in a free microlith. Partial and complete separation of the calcified laminated masses from the spirals were also demonstrated. Based on these observations, the morphogenesis of microliths and the pathogenesis of pulmonary alveolar microlithiasis are discussed.

RevDate: 2013-11-21
CmpDate: 1978-09-25

Iguchi M, Nagai N, Matsuura T, et al (1978)

[Investigation of the causes of urolithiasts. I. Calcium metabolism, with special reference to serum ionized calcium (author's transl)].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 69(5):578-584.

RevDate: 2013-11-21
CmpDate: 1978-11-18

Kanis JA (1978)

Renal disease and disorders of calcium metabolism.

Comprehensive therapy, 4(8):44-50.

RevDate: 2013-11-21
CmpDate: 1978-11-29

Musialik D, Głuszek J, B Raszeja-Wanic (1978)

[Effect of hydrochlorothiazide on calcium-magnesium parameters in patients with recurrent nephrolithiasis].

Polski tygodnik lekarski (Warsaw, Poland : 1960), 33(30):1173-1175.

RevDate: 2013-11-21
CmpDate: 1978-11-18

Anke M, Schneider HJ, Partschefeld M, et al (1978)

[Effect of a calcium-deficient, phosphate- or ammonia-rich diet on the development and mineral metabolism of growing miniature pigs].

Zeitschrift fur Urologie und Nephrologie, 71(7):463-472.

The metaphylaxis of renal calculi in form of partial withdrawal of Ca and the nutrition rich in phosphate or NH4C1 in children was disputed and not ascertained by animal experiments. For this purpose growing female dwarf pigs got a semisynthetic ration with 1 g Ca and 23 g P, respectively, or 15 g NH4C1 per kg dry feeding mass during 168 days. The dwarf pigs fed poor in Ca had a reduced increase of body-weight of 30%, the pigs fed rich in P and NH4C1 a reduced increase of body-weight of 11 and 16%, respectively, compared with the control dwarf pigs. The feeding regime chosen has no significant influence on the Ca-, P-, Cu-, and Mn-state of the dwarf pigs (alpha greater than 0.05). Only the animals with deficiency of a Ca statistically ascertained stored more Zn in the liver than the control animals. The applied NH4C1 as well as the medicament Ammonchlor SSW contained traces of Cd. Concerning the lacking significant changes of metabolism on account of the retardation of growth conditioned by therapy it cannot be concluded that there is possible a metaphylaxis of the lithiasis in children by partial withdrawal of Ca or additions of P and NH4C1, respectively.

RevDate: 2013-11-21
CmpDate: 1978-12-20

Lian JB, Hauschka PV, PM Gallop (1978)

Properties and biosynthesis of a vitamin K-dependent calcium binding protein in bone.

Federation proceedings, 37(12):2615-2620.

Bone, whether of endochondral or intramembranous origin, contains the vitamin K-dependent calcium binding amino acid residue gamma-carboxyglutamic acid (Gla) in a small, anionic protein we have named osteocalcin. This protein, which constitutes 0.5 to 1.0% of the total bone proteins and about 20% of the noncollagenous protein, is extractable by EDTA, and contains at least 90% of bone Gla. Analysis of purified osteocalcin from chicken bone and independent sequence studies of an analogous bovine bone protein show no apparent homology to the Gla-containing region of prothrombin. Chicken osteocalcin specifically binds 2 moles of calcium ions per 6,500 g protein. Employing coumarin drugs and vitamin K-deficient diets, vitamin K-dependent osteocalcin biosynthesis has been demonstrated in the chick before and after hatching. Organ cultures of embryonic chick bone show de novo synthesis of osteocalcin, and microsomal preparations of embryonic bone also exhibit vitamin K-dependent carboxylase activity. In addition to the presence of osteocalcin in bone, a Gla-protein of unknown function is present in normal nonmineralized kidney cortex. Furthermore, in various pathological calcifications such as hard atheromatous plaque, renal calculi, and subcutaneous ectopic calcifications other Gla-proteins are found, thus implicating such proteins and vitamin K in many facets of calcium metabolism.

RevDate: 2013-11-21
CmpDate: 1979-02-23

Netelenbos JC, Haagsma-Schouten WA, E Lopes Cardozo (1978)

[Hypercalciuria and kidney calculi].

Nederlands tijdschrift voor geneeskunde, 122(51):2020-2025.

RevDate: 2013-11-21
CmpDate: 1979-04-25

Castrillo García J, Rodríguez-Miñón Cifuentes J, J Salinas Casado (1978)

[Sponge kidney (review of 34 cases of a lithiasic population)].

Revista clinica espanola, 151(5):389-393.

RevDate: 2019-10-21
CmpDate: 1979-07-16

Pak CY (1978)

Calcium urolithiasis: is it analogous to bone formation?.

Calcified tissue research, 26(3):195-197.

RevDate: 2019-08-23
CmpDate: 1979-07-16

Jovanović V (1978)

Determination of intestinal radiocalcium absorption by double tracer method with 85Sr i.v.

European journal of nuclear medicine, 3(2):115-120.

RevDate: 2013-11-21
CmpDate: 1979-07-25

Thind SK, R Nath (1978)

Experimental urolithiasis: Part III-metabolic alterations of calcium, phosphorus & oxalate using 45Ca, 32P & oxalate (U)-14C.

Indian journal of experimental biology, 16(11):1161-1163.

RevDate: 2013-11-21
CmpDate: 1976-08-23

Berthoux FC (1976)

[Letter; Treatment of urinary calcic lithiasis with allopurinol].

La Nouvelle presse medicale, 5(21):1363.

RevDate: 2016-11-23
CmpDate: 1988-03-21

Biggi E, Rosso F, Oliveri M, et al (1976)

[Echographic and urographic findings in a case of liquid renal calculosis].

La Radiologia medica, 62(3):196-201.

RevDate: 2015-11-19
CmpDate: 1976-09-02

Rapado A, de la Calle H, Castrillo JM, et al (1976)

[Nephrolithiasis in hypercalciuria and hyperparathyroidism].

MMW, Munchener medizinische Wochenschrift, 118(25):799-810.

In the group of 1635 patients with nephorolithiasis the authors found 16% with idiopathic hypercalciuria. They administered thiazide diuretics for 8 days as a test for the detection of masked hyperparathyroidism in idiopathic hypercalciuria. In 6 cases which were diagnosed in this manner, the existence of a parathyroidadenoma could be demonstrated by surgical operation. The hypercalciuria persisted after exstirpation of the tumor, in some cases the nephrolithiasis also remained active. the various pathogenetic mechanisms connected with these common diseases are discussed in relation to these results.

RevDate: 2013-11-21
CmpDate: 1977-02-16

Keminger K (1976)

[Parathyroid adenoma from the surgical view point. Report of 65 cases].

MMW, Munchener medizinische Wochenschrift, 118(48):1549-1554.

Experience in the surgical management of a series of 65 cases with hyperparathyroidism is described (primary HPT: 55, secondary HPT: 3, tertiary HPT: 2, malignant HPT: 5) The consecutive forms of primary HPT, i.e. quarternary or quinternary HPT, and of secondary HPT, i.e. tertiary HPT, are discussed in more detail. Dystopic location was observed in 12.3%. In 4.6% no adenoma was found during the operation. A modern method for the localisation is the measurement of parathyroid hormone levels by radioimmunoassay. In nearly all publications we observe an increase in the renal forms. Intensive search for primary HPT is essential in all cases with recurrent renal calculi.

RevDate: 2018-11-13
CmpDate: 1977-03-31

Marquez-Julio A, Rapoport A, Wilansky DL, et al (1977)

Purpura associated with hypergammaglobulinemia, renal tubular acidosis and osteomalacia.

Canadian Medical Association journal, 116(1):53-58.

Two patients with hyperglobulinemia associated with purpura were studied. One had features of Sjögren's syndrome, while the other appeared to have a primary condition -- "chronic benign purpura". Both patients also had renal tubular acidosis, osteomalacia and renal calculi, with disturbed calcium metabolism and acid-base balance. Autoantibodies were detected in the serum of both patients, and mononuclear cell infiltrates were noted in skin and kidney biopsies from both.

RevDate: 2013-11-21
CmpDate: 1977-03-15

Hartung R (1977)

[The role of uric acid in calcium-oxalate nephrolithiasis].

Fortschritte der Medizin, 95(2):67.

RevDate: 2013-11-21
CmpDate: 1977-04-30

Kokot F (1977)

[Metabolic causes of nephrolithiasis].

Polski przeglad chirurgiczny, 49(2A):219-226.

RevDate: 2013-11-21
CmpDate: 1977-05-20

Elomaa I (1977)

[Idiopathic hypercalciuria and urolithiasis].

Duodecim; laaketieteellinen aikakauskirja, 93(3):195-197.

RevDate: 2016-11-23
CmpDate: 1977-06-11

Mundy GR, Canalis EM, LG Raisz (1977)

Calcium and the kidney: renal osteodystrophy and renal calculi.

Connecticut medicine, 41(4):205-209.

RevDate: 2013-11-21
CmpDate: 1977-08-12

Bick C, Schubert G, Brien G, et al (1977)

[Topographic phase analysis of urinary concrements using crystal-optic methods].

Zeitschrift fur Urologie und Nephrologie, 70(2):99-105.

In the present paper was reported on the results of the topographic crystal-optic analysis of urinary calculi of 560 concrements. 59% of all urinary calculi had a different phase content in the nucleus and in the calyx. All frequent minerals of the urinary calculi could be proved in the nucleus of the calculus. It could be shown that nucleus and calyx may have a monomineral as well as a polymineral structure. It is referred to the importance of the topographic analysis of the urinary calculi for the metaphylaxis of the urolithiasis.

RevDate: 2019-08-27
CmpDate: 1977-10-14

Ritz E, SG Massry (1977)

The kidney in disorders of calcium metabolism.

Contributions to nephrology, 7:114-127.

RevDate: 2018-02-15
CmpDate: 1977-10-14

Maschio G, D'Angelo A, Bonucci E, et al (1977)

Aspects of calcium metabolism in obstructive nephropathy: a metabolic and bone biopsy investigation.

Nephron, 19(1):32-43.

RevDate: 2013-11-21
CmpDate: 1977-10-14

Swoboda G (1977)

[Treatment of calcium oxalate calculi using Reducto-Special].

Wiener medizinische Wochenschrift (1946), 127(13):431-432.

RevDate: 2015-11-19
CmpDate: 1977-11-25

Schneider HJ, Hesse A, Berg W, et al (1977)

[Animal-experiment studies on the effect of magnesium and vitamin B 6 on calcium-oxalate nephrolithiasis].

Zeitschrift fur Urologie und Nephrologie, 70(6):419-427.

By chronic intoxication with ethylene glycol or acute intoxication by Na-glyoxalate in the animal experiment a Ca-oxalatenephrolithiasis could be produced. At this model the influence of magnesium, pyridoxine and phosphate was studied. The combination therapy of magnesium and vitamin B6 can completely prevent the formation of Ca-oxalate-microliths in the kidney. The production of a preparation with 200 mg MgO and 10 mg pyridoxine per tablet for the metaphylaxis of oxalate calculi is recommended.

RevDate: 2013-11-21
CmpDate: 1977-11-25

Merceron RE, Cavailloles F, Delorme ML, et al (1977)

[Etiopathogenic study of idiopathic hypercalciuria].

Annales de medecine interne, 128(5):421-430.

RevDate: 2013-11-21
CmpDate: 1978-01-27

Shen FH, Baylink DJ, Nielsen RL, et al (1977)

Increased serum 1,25-dihydroxyvitamin D in idiopathic hypercalciuria.

The Journal of laboratory and clinical medicine, 90(6):955-962.

RevDate: 2013-11-21
CmpDate: 1978-01-27

Jorgensen H, Quist Paulsen A, Berstad A, et al (1977)

[Active and recurrent kidney calculi. Metabolic findings and therapeutic consequences].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 97(30):1551-1555.

RevDate: 2013-11-21
CmpDate: 1976-10-02

Zechner O (1976)

[Metabolic disorders in patients with urolithiasis].

Zeitschrift fur Urologie und Nephrologie, 69(4):295-299.

RevDate: 2019-10-21
CmpDate: 1976-11-01

Luoma H, Nuuja T, Collan Y, et al (1976)

The effect of magnesium and fluoride on nephrocalcinosis and aortic calcification in rats given high sucrose diets with added phospnates.

Calcified tissue research, 20(3):291-302.

The study was conducted to observe in rats the possible modification of ectopic calcification by magnesium-orthophosphate-fluoride combinations, used as additives of diet for reduction of the cariogenicity of the sucrose. In rats, fed low magnesium diets, extra dietary orthophosphate (2%) considerably elevated the calcification of kidneys. Further additions of magnesium and fluoride partially reduced this adverse effect of phosphate. While the calcium content of the aorta in rats, fed low magnesium-high phosphate diet, was considerably elevated, the further addition of magnesium (40 ppm) partially reduced the calcifying effect of phosphate in aorta. Fluoride (15 ppm) together with magnesium (40 ppm) completely reduced it. The appearance of renal calculi caused by a low magnesium diet or by extra phosphate were similar according to light and electron microscopy except for the larger size in the latter case and occasional extratubular calculi found in groups with high phosphate-low magnesium and high phosphate with added magnesium diets.

RevDate: 2013-11-21
CmpDate: 1976-11-01

Schwille PO (1976)

[Urolithiasis and mineral metabolism].

Hippokrates, 47(1):53-65.

RevDate: 2013-11-21
CmpDate: 1976-12-03

Schmiedt E (1976)

[Report on a symposium on the treatment of Ca-containing urinary calculi using ion exchangers, Munich, May 8, 1976].

Der Urologe. Ausg. A, 15(5):262.

RevDate: 2006-11-15
CmpDate: 1977-01-29

Rapado A, de la Calle H, Castrillo JM, et al (1976)

[Hypercalciuric and hyperparathyroid renal lithiasis].

Minerva medica, 67(55):3573-3581.

Idiopathic hypercalciuria was noted in 10% of a series of 1635 subjects with renal lithiasis. Eight-day administration of thiazide diuretics as a test for the discovery of latent hyperparathyroidism in idiopathic hypercalciuria is described. In 6 cases diagnosed in this way, surgery disclosed the presence of a parathyroid adenoma. Resection was followed by persistent hypercalciuria and, in some instances, renal lithiasis activity. The pathogenesis of associations of these frequently observed diseases is examined.

RevDate: 2017-11-16
CmpDate: 1975-08-26

Pope AL (1975)

Mineral interrelationships in ovine nutrition.

Journal of the American Veterinary Medical Association, 166(3):264-268.

RevDate: 2019-12-10
CmpDate: 1975-08-29

Hartmann F, H Lehmann (1975)

[A case of sarcoidosis with simultaneous primary hyperparathyroidism, coincedence or consequnce?].

Medizinische Klinik, 70(20):904-908.

We have reported of a case of generalised sarcoidosis with primary hyperparathyroidism. A pathogenetic relation between sarcoidosis associated with hypercalcemia and the development of parathyroid adenoma will be discussed and a causal connection will be proposed. According to our hypothesis every primary hyperparathyroidism could have developed from regulatory hyperfunction. This is illustrated by sarcoidosis with hypercalcemia and hypercalcuria. In this case a disturbance in vitamin D dependent calcium metabolism induces hyperplasia of the parathyroid which later leads to the development of a parathyroid adenoma. In addition a review of literature describing similar cases is given.

RevDate: 2013-11-21
CmpDate: 1976-02-21

Deftos LJ, Roos BA, JG Parthemore (1975)

Calcium and skeletal metabolism.

The Western journal of medicine, 123(6):447-458.

RevDate: 2019-07-06
CmpDate: 1975-06-21

Silk DB, Perrett D, Clark ML, et al (1975)

A study of the renal handling and intestinal absorption of dibasic amino acids in a patient with genotype +/11 heterozygous cystinuria and idiopathic hypercalcuria.

Clinica chimica acta; international journal of clinical chemistry, 59(2):195-201.

A case is reported of a patient with idiopathic hypercalcuria who was referred for investigation of renal calculi. Studies of urinary amino acid excretion in the patient and all living members of his family, as well as studies of endogenous renal clearances of dibasic amino acids and cystine in the patient and his daughter, indicated that the patient had genotype +/11 heterozygous cystinuria. Intestinal perfusion studies showed however that the patient was able to absorb L-lysine, L-arginine normally from the jejunum and ileum. This suggests that a difference exists between renal and intestinal handling of lysine and arginine in cystinuria.

RevDate: 2013-11-21
CmpDate: 1975-09-05

Hlavácek V, D Ulrichová (1975)

[Analysis of the submandibular gland calculi with regard to the presence of side elements by means of an electronic microanalyzer].

Ceskoslovenska otolaryngologie, 24(3):176-179.

RevDate: 2013-11-21
CmpDate: 1975-10-30

Claus-Walker J, Spencer WA, Carter RE, et al (1975)

Bone metabolism in quadriplegia: dissociation between calciuria and hydroxyprolinuria.

Archives of physical medicine and rehabilitation, 56(8):327-332.

Relationships between duration of paralysis, recumbency, muscular activity, and urinary loss of calcium (Cau), phosphorus (Pu), and hydroxyproline (OHPu) were studied daily in 32 traumatic quadriplegic patients during comprehensive rehabilitation and randomly in those readmitted for treatment. Within days after onset, quadriplegic patients had increases in Pu, then OHPu, and finally, Cau. Patients actively engaged in rehabilitation exercises showed a steady fall in OHPu, whereas CAU remained high for up to 18 months. Patients paralyzed for over 18 months (late) had low Cau, Pu and OHPu; but if the patients were kept in bed, OHPu increased rapidly. Patients with early quadriplegia have an increased bone remodeling, suggesting that the excess OHPu and Cau are derived from resorbed bone. Patients with late quadriplegia have little bone remodeling, therefore the excess OHPu occurring during recumbency may be derived from the resorption of new collagen produced during the removal of weight bearing without further change in muscular activity. Resorbed new collagen is excreted in part as large, OHP-containing polypeptides; these were found in the urine of quadriplegic patients, and therefore were present in blood and may play a role in initiating ectopic bone and renal calculi. The presence of OHP in 11 bladder calculi from quadriplegic patients tends to support this hypothesis. These studies indicate that muscular activity and weight bearing influence the bone metabolism of quadriplegic patients and suggest that the presence in body fluids of increased catabolic products from bone may have a role in bone-related complications.

RevDate: 2016-11-23
CmpDate: 1975-11-22

Piazza G, Macchi C, Cosciani S, et al (1975)

[Liquid renal calculosis].

Minerva urologica, 27(4):158-163.

RevDate: 2013-11-21
CmpDate: 1975-11-22

Cassan P, A Baglin (1975)

[A special cause of urinary lithiasis: dysfunction of the terminal ileum].

La Nouvelle presse medicale.

RevDate: 2013-11-21
CmpDate: 1976-04-02

Eisenkraft C, Gaist L, Rubinstein J, et al (1975)

Proceedings: Acid and alkaline urinary inorganic pyrophosphatase in the formation of calcium-containing urinary calculi.

Israel journal of medical sciences, 11(11):1226-1227.

RevDate: 2006-11-15
CmpDate: 1976-03-15

Maschio G, D'Angelo A, Ossi E, et al (1975)

[Aspects of phosphorus-calcium metabolism in obstructive nephropathy].

Minerva nefrologica, 22(1):38-44.

RevDate: 2013-11-21
CmpDate: 1976-05-25

Bernheim J, Pozet N, Zech P, et al (1975)

[Evaluation of hyperparathyroidism and recurrent renal lithiasis].

Journal d'urologie et de nephrologie, 81(10-11):824-830.

RevDate: 2016-11-23
CmpDate: 1976-07-06

Deplante JP, Daumont A, Bouvier M, et al (1975)

[Primary hyperparathyroidism. 50 personal cases].

Revue du rhumatisme et des maladies osteo-articulaires, 42(12):747-758.

On the basis of a study of a series of 50 personal cases, the results of which are reported, and of a series of 2800 cases from the literature, the authors describe certain radiological and clinical aspects of primary hyperparathyroidism and the conditions under which this disease may appear. They emphasize the value of the different laboratory investigations for determining disturbances in phosphorus-calcium metabolism and of the study of bone histology, particularly the quantitative study of iliac bone biopsies. They discuss the various aspects of their methods of surgical treatment (pre-operative location of the tumour, surgical problems, early and later sequelae) and finally describe the indications for surgery.

RevDate: 2013-11-21
CmpDate: 1976-08-02

Berg W, Schneider HJ, E Vogel (1975)

[The excretion of oxalates in urine following oral administration of oxalic acid and magnesium].

Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 35(5):241-245.

RevDate: 2013-11-21
CmpDate: 1976-10-02

Shimonko IT (1975)

[Disorders of electrolyte and acid-base metabolism in children after nephrectomy for nephrolithiasis].

Urologiia i nefrologiia.

RevDate: 2013-11-21
CmpDate: 1976-08-02

Kwias Z, W Twardosz (1976)

[Calcium, phosphorus and magnesium metabolism in patients with recurrent nephrolithiasis].

Polski przeglad chirurgiczny, 48(5):605-610.

RevDate: 2013-11-21
CmpDate: 1976-08-02

Bissada NK, JF Redman (1976)

Medical management of urolithiasis.

American family physician, 13(5):89-94.

Knowledge of the crystalline structure of the calculus provides the basis of the therapeutic plan. Laboratory evaluation depends heavily upon routine urinalysis. Assessment of renal function, serum calcium, phosphorus, uric acid and, in some cases electrolytes is usually indicated, as is urography. General principles of management include maintenance of an ample urine volume, eradication of infection and correction of any obstructing lesions or metabolic abnormalities. Specific antistone regimens are indicated for patients with recurrent urolithiasis.

RevDate: 2013-11-21
CmpDate: 1992-11-05

Kocián J (1992)

[Hypercalciuria].

Vnitrni lekarstvi, 38(7):672-677.

Hypercalciuria is the cause of almost 20% of all secondary osteoporoses and in 23% these cases are associated with calcium urolithiasis. It is therefore necessary to search for these patients actively because their treatment with hydrochlorothiazide and amiloride is easy and highly effective. We must not be satisfied with the finding of hypercalciuria as the only cause of demineralization of bone, as several causes may combine in a single patient. Comprehensive treatment of osteopenia associated with hypercalciuria is relatively shorter and more successful than in other forms of secondary osteopenias.

RevDate: 2013-11-21
CmpDate: 1993-02-02

Castrillo JM (1992)

[Influence of parathyroidectomy on the clinical course of primary hyperparathyroidism].

Revista clinica espanola, 191(7):385-392.

RevDate: 2017-11-16
CmpDate: 1993-02-12

Grases F, Masárová L, Costa-Bauzá A, et al (1992)

Effect of "Rosa Canina" infusion and magnesium on the urinary risk factors of calcium oxalate urolithiasis.

Planta medica, 58(6):509-512.

The effects on the calcium oxalate urolithiasis urinary risk factors of "Rosa Canina", in herb infusion form, and magnesium chloride have been studied using female Wistar rats under balanced dietary conditions. No significant effects on the volume of liquids drunk or on creatinine, phosphate, and oxalate urinary concentrations and excretions were observed. The herb infusion did not cause any diuretic effect. Calciuria decreased and citraturia increased when taking the herb infusion, and vice versa when taking magnesium chloride. Magnesium chloride decreased the urinary pH value, but this effect was not observed when magnesium chloride was administered with herb infusion. In conclusion, the same beneficial effects of the studied infusion herb on calcium oxalate urolithiasis urinary risk factors can be clearly detected. An interesting fact is that it seems that some possible effects depend on dietary components, thus, i.e., an increase in the urinary pH was only detected when the intake of the herb infusion was studied in a magnesium chloride-supplemented diet.

RevDate: 2022-03-21
CmpDate: 1992-09-10

Piry A, Vin F, FA Allaert (1992)

[Inflammation and subcutaneous calcification of venous origins].

Phlebologie, 45(1):41-7; discussion 48-9.

There have been few descriptions up to now of calcifications in chronic venous insufficiency, other than in cases where venous insufficiency is complicated be severe trophic disorders and in particular ulcers. It was therefore felt to be of interest to assess the presence of calcifications in venous insufficiency without trophic disorders. This study was based upon 40 cases recruited in the phlebology out-patient clinic of the Notre Dame de Bon Secours Hospital. Calcifications of the lower limbs were found in 7 patients, either by palpation, routine X-rays or ultrasonography. The etiopathogenic mechanisms of this occurrence not having been elucidated, a number of hypotheses are put forward on the basis of acquired data concerning: the process of formation of ectopic calcifications, changes in subcutaneous tissue, the ultimate consequences of venous stasis and of raised venous pressure, due essentially to anoxia and inflammation. One hypothesis can thus be put forward: that of inflammation. The release of cells and mediators of inflammation, the production of free radicals, causing damage to the cells of connective tissue and to the organic framework (collagen fibres) and changes in the chemical environment could combine to result in the formation of calcifications in subcutaneous tissue. However, inflammation has not been proven to be the primary etiological factor.

RevDate: 2013-11-21
CmpDate: 1992-06-11

Daragon A, Dhib M, Morin JP, et al (1992)

[Idiopathic hypercalciuria and bone density].

Revue du rhumatisme et des maladies osteo-articulaires, 59(1):35-38.

A decrease in bone density of the spine has been reported in individuals with hypercalciuria and the finding of the latter in osteoporosis patients is not uncommon. We studied 21 men and 8 women (mean age 47 +/- 13) with idiopathic hypercalciuria (IHCU) defined by an urinary calcium of more than 7.5 mmol/24 h in men and 6.25 mmol/24 h in women. The duration of IHCU was 10 (+/-) 8 years. Among the 29 patients, 24 had one or more renal calculi. Twenty one had been treated, by low calcium diet only (and diuresis), combined with a thiazide diuretic, or sodium phytate, or phosphorus. Bone mineral content (BMC) was measured in the lumbar spine and the upper end of the femur using an ORIS ODC 200 densitometer and compared with 29 control subjects paired for age and sex. No difference was found between the two groups concerning BMC values in either the spine or the 3 femoral sites (neck, Ward, trochanter). BMC was not correlated with urinary calcium. Thus individuals with IHCU showed no decrease in their bone mass, among this group seen in a department of nephrology. The influence of the treatment of IHCU remains to be defined.

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Robbins holds BS, MS, and PhD degrees in the life sciences. He served as a tenured faculty member in the Zoology and Biological Science departments at Michigan State University. He is currently exploring the intersection between genomics, microbial ecology, and biodiversity — an area that promises to transform our understanding of the biosphere.

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Robbins has extensive experience in college-level education: At MSU he taught introductory biology, genetics, and population genetics. At JHU, he was an instructor for a special course on biological database design. At FHCRC, he team-taught a graduate-level course on the history of genetics. At Bellevue College he taught medical informatics.

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OK, this book I have not actually read. But it seems super relevant, it is from a reputable publisher, and the table of contents looks genuinely interesting. Given that I have personally had big kidney stones removed twice (once via percutaneous nephrolithotomy, the next time via shockwave lithotripsy) and that (a) I still have some stones in one kidney and (b) I have just been shown to have hypercalciuria, I guess it is time for me to put a book like this on my must-read list. And maybe it is also time to ditch the daily dose of calcium pills... R. Robbins

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