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RJR: Recommended Bibliography 29 Aug 2026 at 01:54 Created:
Corvids (crows, jays, etc)
Wikipedia: Corvidae (crows, jays, etc) is a cosmopolitan family of oscine passerine birds that contains the crows, ravens, rooks, jackdaws, jays, magpies, treepies, choughs, and nutcrackers. In common English, they are known as the crow family, or, more technically, corvids. Over 120 species are described. The genus Corvus, including the jackdaws, crows, rooks, and ravens, makes up over a third of the entire family. Corvids display remarkable intelligence for animals of their size and are among the most intelligent birds thus far studied. Specifically, members of the family have demonstrated self-awareness in mirror tests (European magpies) and tool-making ability (crows, rooks), skills which until recently were thought to be possessed only by humans and a few other higher mammals. Their total brain-to-body mass ratio is equal to that of great apes and cetaceans, and only slightly lower than in humans. They are medium to large in size, with strong feet and bills, rictal bristles, and a single moult each year (most passerines moult twice). Corvids are found worldwide except for the tip of South America and the polar ice caps. The majority of the species are found in tropical South and Central America, southern Asia and Eurasia, with fewer than 10 species each in Africa and Australasia. The genus Corvus has re-entered Australia in relatively recent geological prehistory, with five species and one subspecies there. Several species of raven have reached oceanic islands, and some of these species are now highly threatened with extinction or have already gone extinct.
Created with PubMed® Query: (corvus[TIAB] OR corvid[TIAB] OR OR corvids[TIAB] OR corvidae[TIAB] OR crow[TIAB] OR crows[TIAB] OR raven[TIAB] OR ravens[TIAB] OR jay[TIAB] OR jays[TIAB] OR magpie[TIAB] OR magpies[TIAB] OR jackdaw[TIAB] OR jackdaws[TIAB]) NOT pmcbook NOT ispreviousversion
Citations The Papers (from PubMed®)
RevDate: 2026-08-27
The cognitive architecture of degraded speech intelligibility.
Cognition, 277:106692 pii:S0010-0277(26)00261-1 [Epub ahead of print].
Accurate speech understanding is crucial in everyday life. Yet, speech is often degraded by a variety of talker and environmental factors, which listeners must overcome. In this online experiment, we assess how degraded speech intelligibility is supported by "elemental" cognitive processes. Eighty-nine healthy adults listened to spoken sentences degraded in five ways and reported the words that they heard. In addition, they completed the Reading Span and N-back tasks to assess working memory capacity (WM), as well as a short version of Raven's Advanced Progressive Matrices to assess fluid reasoning ability. In bivariate correlational analyses, all cognitive test scores predicted degraded speech intelligibility. However, multivariate and dominance analyses revealed that the test of fluid reasoning was the most important predictor of intelligibility. These results may undermine the assumption that WM, as measured by the Reading Span and other tasks, is the primary cognitive construct supporting degraded speech intelligibility.
Additional Links: PMID-42659749
Publisher:
PubMed:
Citation:
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@article {pmid42659749,
year = {2026},
author = {Rovetti, JE and Johnsrude, IS and Van Hedger, SC},
title = {The cognitive architecture of degraded speech intelligibility.},
journal = {Cognition},
volume = {277},
number = {},
pages = {106692},
doi = {10.1016/j.cognition.2026.106692},
pmid = {42659749},
issn = {1873-7838},
abstract = {Accurate speech understanding is crucial in everyday life. Yet, speech is often degraded by a variety of talker and environmental factors, which listeners must overcome. In this online experiment, we assess how degraded speech intelligibility is supported by "elemental" cognitive processes. Eighty-nine healthy adults listened to spoken sentences degraded in five ways and reported the words that they heard. In addition, they completed the Reading Span and N-back tasks to assess working memory capacity (WM), as well as a short version of Raven's Advanced Progressive Matrices to assess fluid reasoning ability. In bivariate correlational analyses, all cognitive test scores predicted degraded speech intelligibility. However, multivariate and dominance analyses revealed that the test of fluid reasoning was the most important predictor of intelligibility. These results may undermine the assumption that WM, as measured by the Reading Span and other tasks, is the primary cognitive construct supporting degraded speech intelligibility.},
}
RevDate: 2026-08-28
CmpDate: 2026-08-28
Human food sources shape routine movements across elevational gradients in an alpine bird.
Movement ecology, 14(1):.
BACKGROUND: Human activities are reshaping animal movement patterns worldwide, with human food sources emerging as a significant driver. While such subsidies are known to reduce space use and alter migration behaviour, their role in shaping routine movement patterns-such as sequential visits to specific sites-remains poorly understood.
METHODS: Here, we investigated the impact of human food sources on the movement patterns of Alpine choughs (Pyrrhocorax graculus), a high-elevation corvid that readily exploits human food. In winter, these birds engage in altitudinal movements, descending from alpine areas to lower elevations in search of food. Thereby, they encounter diverse human food sources ranging from mountain restaurants at high altitudes to urban garbage dumps and bird feeders in the valleys. We analysed the movements of 40 GPS-tagged individuals and combined tracking data with behavioural observations to (1) quantify the occurrence and spatiotemporal patterns of altitudinal movements (2), assess the extent to which human food sources shape space use, and (3) identify potential recursive movement patterns.
RESULTS: Alpine choughs performed daily altitudinal movements during winter, spanning up to 3000 m in elevation per round trip. Birds typically descended in the early morning and returned upslope around midday. Their movements consistently overlapped with human-modified environments providing human food sources, including towns, villages, and mountain restaurants. Notably, individuals repeatedly visited four main foraging locations associated with human food, showing strong route fidelity by returning to the same food-provisioning sites in a consistent sequence and at predictable times of day.
CONCLUSIONS: Our findings highlight how human food sources can shape population-level movement patterns and foraging routines, with potential ecological consequences for species increasingly reliant on human-modified habitats. Such dependence may limit behavioural flexibility and create ecological traps, where individuals repeatedly exploit risky or suboptimal resources. By moving daily between alpine and urban areas, Alpine choughs may also transport seeds, nutrients, and pathogens across ecosystems, generating cascading effects in both mountain and lowland habitats.
Additional Links: PMID-42661233
PubMed:
Citation:
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@article {pmid42661233,
year = {2026},
author = {Beck, KB and Loretto, MC and Müller, T},
title = {Human food sources shape routine movements across elevational gradients in an alpine bird.},
journal = {Movement ecology},
volume = {14},
number = {1},
pages = {},
pmid = {42661233},
issn = {2051-3933},
abstract = {BACKGROUND: Human activities are reshaping animal movement patterns worldwide, with human food sources emerging as a significant driver. While such subsidies are known to reduce space use and alter migration behaviour, their role in shaping routine movement patterns-such as sequential visits to specific sites-remains poorly understood.
METHODS: Here, we investigated the impact of human food sources on the movement patterns of Alpine choughs (Pyrrhocorax graculus), a high-elevation corvid that readily exploits human food. In winter, these birds engage in altitudinal movements, descending from alpine areas to lower elevations in search of food. Thereby, they encounter diverse human food sources ranging from mountain restaurants at high altitudes to urban garbage dumps and bird feeders in the valleys. We analysed the movements of 40 GPS-tagged individuals and combined tracking data with behavioural observations to (1) quantify the occurrence and spatiotemporal patterns of altitudinal movements (2), assess the extent to which human food sources shape space use, and (3) identify potential recursive movement patterns.
RESULTS: Alpine choughs performed daily altitudinal movements during winter, spanning up to 3000 m in elevation per round trip. Birds typically descended in the early morning and returned upslope around midday. Their movements consistently overlapped with human-modified environments providing human food sources, including towns, villages, and mountain restaurants. Notably, individuals repeatedly visited four main foraging locations associated with human food, showing strong route fidelity by returning to the same food-provisioning sites in a consistent sequence and at predictable times of day.
CONCLUSIONS: Our findings highlight how human food sources can shape population-level movement patterns and foraging routines, with potential ecological consequences for species increasingly reliant on human-modified habitats. Such dependence may limit behavioural flexibility and create ecological traps, where individuals repeatedly exploit risky or suboptimal resources. By moving daily between alpine and urban areas, Alpine choughs may also transport seeds, nutrients, and pathogens across ecosystems, generating cascading effects in both mountain and lowland habitats.},
}
RevDate: 2026-08-28
CmpDate: 2026-08-28
Economic gradients of health insurance coverage in India.
Frontiers in public health, 14:1872163.
INTRODUCTION: Universal Health Coverage (UHC) aims to ensure accessible, affordable, and quality healthcare for all. In India, achieving UHC is challenging due to very low public health expenditure and a highly privatized healthcare system. This places a significant financial burden on households, often pushing them into poverty and catastrophic health spending. Health insurance is a key tool for reducing financial risk and improving access to healthcare. The study attempts to examine the economic determinants of health insurance coverage in India. It also assesses the temporal-economic gradients of health insurance coverage.
METHODS: The National Family Health Survey (NFHS) rounds conducted during 2005-06, 2015-16, and 2019-21 were used. Overall health insurance coverage and different types of health insurance coverage were estimated by the two main economic variables namely wealth quintile and Below Poverty Line (BPL) status. The logistic regression models were applied to estimate the adjusted odds ratio of health insurance coverage by the socioeconomic variables.
RESULTS AND DISCUSSION: There has been notable progress in enhancing insurance coverage, particularly among poor, primarily through Government-sponsored health insurance (GSHI) schemes. However, a considerable proportion of impoverished households (64 percent of poorest and 58 percent of poorer households) remains without any insurance coverage, largely stemming from a lack of awareness and issues of identification of target groups. Conversely, a notable portion of the middle (71 percent) and affluent classes (70 percent) are accessing the benefits of the GSHI scheme compared to 54 percent among poorest households, mainly due to leakage issues. Consequently, there is a need to recalibrate the exclusion of the middle and affluent classes and the inclusion of the poorest within existing GSHI schemes like PM-JAY. There is need to implement appropriate strategies such as linking SECC data with Aadhaar, conducting regular enrolment audits, developing state-level targeting metrics, and using community-based enrolment to reduce identification errors and leakage. These should be paired with broader reforms, including integrating state and central schemes, expanding outpatient coverage and awareness, regulating private providers, and strengthening primary healthcare alongside insurance expansion.
Additional Links: PMID-42661750
PubMed:
Citation:
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@article {pmid42661750,
year = {2026},
author = {Pal, P and Rana, MJ},
title = {Economic gradients of health insurance coverage in India.},
journal = {Frontiers in public health},
volume = {14},
number = {},
pages = {1872163},
pmid = {42661750},
issn = {2296-2565},
mesh = {India ; Humans ; *Insurance, Health/statistics & numerical data/economics ; *Universal Health Insurance/economics/statistics & numerical data ; *Insurance Coverage/statistics & numerical data/economics ; Poverty/statistics & numerical data ; Socioeconomic Factors ; Health Surveys ; Socioeconomic Disparities in Health ; },
abstract = {INTRODUCTION: Universal Health Coverage (UHC) aims to ensure accessible, affordable, and quality healthcare for all. In India, achieving UHC is challenging due to very low public health expenditure and a highly privatized healthcare system. This places a significant financial burden on households, often pushing them into poverty and catastrophic health spending. Health insurance is a key tool for reducing financial risk and improving access to healthcare. The study attempts to examine the economic determinants of health insurance coverage in India. It also assesses the temporal-economic gradients of health insurance coverage.
METHODS: The National Family Health Survey (NFHS) rounds conducted during 2005-06, 2015-16, and 2019-21 were used. Overall health insurance coverage and different types of health insurance coverage were estimated by the two main economic variables namely wealth quintile and Below Poverty Line (BPL) status. The logistic regression models were applied to estimate the adjusted odds ratio of health insurance coverage by the socioeconomic variables.
RESULTS AND DISCUSSION: There has been notable progress in enhancing insurance coverage, particularly among poor, primarily through Government-sponsored health insurance (GSHI) schemes. However, a considerable proportion of impoverished households (64 percent of poorest and 58 percent of poorer households) remains without any insurance coverage, largely stemming from a lack of awareness and issues of identification of target groups. Conversely, a notable portion of the middle (71 percent) and affluent classes (70 percent) are accessing the benefits of the GSHI scheme compared to 54 percent among poorest households, mainly due to leakage issues. Consequently, there is a need to recalibrate the exclusion of the middle and affluent classes and the inclusion of the poorest within existing GSHI schemes like PM-JAY. There is need to implement appropriate strategies such as linking SECC data with Aadhaar, conducting regular enrolment audits, developing state-level targeting metrics, and using community-based enrolment to reduce identification errors and leakage. These should be paired with broader reforms, including integrating state and central schemes, expanding outpatient coverage and awareness, regulating private providers, and strengthening primary healthcare alongside insurance expansion.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
India
Humans
*Insurance, Health/statistics & numerical data/economics
*Universal Health Insurance/economics/statistics & numerical data
*Insurance Coverage/statistics & numerical data/economics
Poverty/statistics & numerical data
Socioeconomic Factors
Health Surveys
Socioeconomic Disparities in Health
RevDate: 2026-08-27
CmpDate: 2026-08-27
Perioperative Cognitive Decline in Verbal Associative Memory Following Carotid Revascularization and Subsequent Risk of Adverse Events: Clinical Significance of the Standard Verbal Paired Associate Learning Test (S-PA).
Brain sciences, 16(8): pii:brainsci16080877.
BACKGROUND/OBJECTIVES: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing specifically on the Standard Verbal Paired Associate Learning Test (S-PA).
METHODS: This prospective, single-center study enrolled 69 patients who underwent CEA or CAS between June 2018 and June 2024. Neuropsychological assessments (Raven's Colored Progressive Matrices (RCPM), Kohs Block Design Test for IQ (Kohs-IQ), the Trail Making Test (TMT)-A/B, and the Standard Verbal Paired Associate Learning Test (S-PA)) were conducted preoperatively and within seven days postoperatively. Patient characteristics and diagnostic imaging results, including magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and single-photon emission computed tomography (SPECT), were evaluated. Multivariate Cox proportional hazards models and Kaplan-Meier survival analyses were used to identify predictors of adverse outcomes, defined as recurrent stroke, restenosis, or mortality, during outpatient follow-up.
RESULTS: Fifteen patients experienced adverse outcomes during follow-up. Perioperative neuropsychological assessment showed that 36 patients experienced S-PA decline, indicating a tendency towards lower mean cerebral blood flow. Receiver operating characteristic (ROC) curve for perioperative ΔS-PA decline associated with adverse outcomes. The area under the curve (AUC) was 0.728. The optimal cutoff determined by the Youden index was a decline of 2 points (ΔS-PA ≤ -2), yielding a sensitivity of 73.3% and specificity of 68.5%. In a time-to-event analysis, S-PA decline was associated with adverse outcomes in an unadjusted analysis. A similar trend was observed in limited multivariable models; however, effect estimates were imprecise (HR = 4.01, 95% CI: 1.01-15.91, p = 0.048).
CONCLUSIONS: This study indicates that perioperative decline in S-PA may reflect underlying cerebrovascular vulnerability and may be associated with subsequent adverse outcomes. However, given the limited number of events and potential for residual confounding, these findings should be interpreted with caution. Larger multicenter studies are required to validate these findings.
Additional Links: PMID-42651185
Publisher:
PubMed:
Citation:
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@article {pmid42651185,
year = {2026},
author = {Nakai, Y and Kurosu, S and Akimoto, T and Ikeda, G and Chujo, T and Kusakabe, M and Hara, T and Uemura, K and Yamamoto, T},
title = {Perioperative Cognitive Decline in Verbal Associative Memory Following Carotid Revascularization and Subsequent Risk of Adverse Events: Clinical Significance of the Standard Verbal Paired Associate Learning Test (S-PA).},
journal = {Brain sciences},
volume = {16},
number = {8},
pages = {},
doi = {10.3390/brainsci16080877},
pmid = {42651185},
issn = {2076-3425},
abstract = {BACKGROUND/OBJECTIVES: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing specifically on the Standard Verbal Paired Associate Learning Test (S-PA).
METHODS: This prospective, single-center study enrolled 69 patients who underwent CEA or CAS between June 2018 and June 2024. Neuropsychological assessments (Raven's Colored Progressive Matrices (RCPM), Kohs Block Design Test for IQ (Kohs-IQ), the Trail Making Test (TMT)-A/B, and the Standard Verbal Paired Associate Learning Test (S-PA)) were conducted preoperatively and within seven days postoperatively. Patient characteristics and diagnostic imaging results, including magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and single-photon emission computed tomography (SPECT), were evaluated. Multivariate Cox proportional hazards models and Kaplan-Meier survival analyses were used to identify predictors of adverse outcomes, defined as recurrent stroke, restenosis, or mortality, during outpatient follow-up.
RESULTS: Fifteen patients experienced adverse outcomes during follow-up. Perioperative neuropsychological assessment showed that 36 patients experienced S-PA decline, indicating a tendency towards lower mean cerebral blood flow. Receiver operating characteristic (ROC) curve for perioperative ΔS-PA decline associated with adverse outcomes. The area under the curve (AUC) was 0.728. The optimal cutoff determined by the Youden index was a decline of 2 points (ΔS-PA ≤ -2), yielding a sensitivity of 73.3% and specificity of 68.5%. In a time-to-event analysis, S-PA decline was associated with adverse outcomes in an unadjusted analysis. A similar trend was observed in limited multivariable models; however, effect estimates were imprecise (HR = 4.01, 95% CI: 1.01-15.91, p = 0.048).
CONCLUSIONS: This study indicates that perioperative decline in S-PA may reflect underlying cerebrovascular vulnerability and may be associated with subsequent adverse outcomes. However, given the limited number of events and potential for residual confounding, these findings should be interpreted with caution. Larger multicenter studies are required to validate these findings.},
}
RevDate: 2026-08-27
CmpDate: 2026-08-27
Sarcocystis spp. Investigations in Iberian Wild Caprinae Reveal a Remarkable Degree of Interconnection with Parasites' Domestic Epidemiological Life Cycles.
Pathogens (Basel, Switzerland), 15(8): pii:pathogens15080816.
Many uncertainties exist on the epidemiology of the Sarcocystis species infecting wild ruminants. In this study, tongue and/or diaphragm tissues of free-ranging wild Caprinae species (54 Pyrenean chamois, 52 mouflons, 146 Iberian ibexes, and 19 Balearean wild goats) residing in the mountain areas of Spain were selected for Sarcocystis spp. detection and species identification. By light microscopy, Sarcocystis sarcocyst frequency rates were considerably high (85.7% in chamois, 82.7% in mouflon, 52.7% in Iberian ibexes), except for the Balearean wild goat (5.3%), which was investigated for the very first time. One excised sarcocyst of Iberian ibex was subjected to transmission electron microscopy, revealing a sibling S. capracanis ultrastructure. Genomic DNA isolated from 57 sarcocysts excised from the hosts' tissues was investigated through PCR amplicon sequencing of the 18S rRNA and cox1 genes. As a result, sequences of S. capracanis, S. cornagliai, S. rossii and S. tenella were detected, sharing high identity with conspecific sequences. Phylogenetic analyses confirmed a remarkable clustering of all Sarcocystis species in clades encompassing species transmitted via canids, except S. cornagliai, which is allocated in a clade with species using corvid birds as their definitive hosts. Therefore, a significant degree of interconnection between sylvatic and domestic Sarcocystis epidemiological cycles can be drawn in the study area.
Additional Links: PMID-42654753
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PubMed:
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@article {pmid42654753,
year = {2026},
author = {Delgado-De Las Cuevas, GE and Rudaitytė-Lukošienė, E and Prakas, P and Estruch, J and Velarde, R and Plasencia-Gutiérrez, AI and García-Gil, ML and Habela, MÁ and Calero-Bernal, R},
title = {Sarcocystis spp. Investigations in Iberian Wild Caprinae Reveal a Remarkable Degree of Interconnection with Parasites' Domestic Epidemiological Life Cycles.},
journal = {Pathogens (Basel, Switzerland)},
volume = {15},
number = {8},
pages = {},
doi = {10.3390/pathogens15080816},
pmid = {42654753},
issn = {2076-0817},
mesh = {Animals ; *Sarcocystis/genetics/classification/isolation & purification ; *Sarcocystosis/veterinary/epidemiology/parasitology ; Phylogeny ; RNA, Ribosomal, 18S/genetics ; Spain/epidemiology ; Animals, Wild/parasitology ; DNA, Protozoan/genetics ; Goats/parasitology ; Sequence Analysis, DNA ; Microscopy, Electron, Transmission ; },
abstract = {Many uncertainties exist on the epidemiology of the Sarcocystis species infecting wild ruminants. In this study, tongue and/or diaphragm tissues of free-ranging wild Caprinae species (54 Pyrenean chamois, 52 mouflons, 146 Iberian ibexes, and 19 Balearean wild goats) residing in the mountain areas of Spain were selected for Sarcocystis spp. detection and species identification. By light microscopy, Sarcocystis sarcocyst frequency rates were considerably high (85.7% in chamois, 82.7% in mouflon, 52.7% in Iberian ibexes), except for the Balearean wild goat (5.3%), which was investigated for the very first time. One excised sarcocyst of Iberian ibex was subjected to transmission electron microscopy, revealing a sibling S. capracanis ultrastructure. Genomic DNA isolated from 57 sarcocysts excised from the hosts' tissues was investigated through PCR amplicon sequencing of the 18S rRNA and cox1 genes. As a result, sequences of S. capracanis, S. cornagliai, S. rossii and S. tenella were detected, sharing high identity with conspecific sequences. Phylogenetic analyses confirmed a remarkable clustering of all Sarcocystis species in clades encompassing species transmitted via canids, except S. cornagliai, which is allocated in a clade with species using corvid birds as their definitive hosts. Therefore, a significant degree of interconnection between sylvatic and domestic Sarcocystis epidemiological cycles can be drawn in the study area.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
*Sarcocystis/genetics/classification/isolation & purification
*Sarcocystosis/veterinary/epidemiology/parasitology
Phylogeny
RNA, Ribosomal, 18S/genetics
Spain/epidemiology
Animals, Wild/parasitology
DNA, Protozoan/genetics
Goats/parasitology
Sequence Analysis, DNA
Microscopy, Electron, Transmission
RevDate: 2026-08-27
Working memory, updating and vocabulary development in Albanian-speaking children aged 8 and 10: the primacy of socioeconomic status.
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence [Epub ahead of print].
This study examined the relationship between receptive vocabulary, working memory processes, non-verbal intelligence, and socioeconomic status (SES) in Albanian-speaking children during middle childhood. The research was motivated by the linguistic characteristics of Albanian, a morphologically rich and orthographically transparent language that provides an informative context for examining how cognitive resources and environmental factors contribute to vocabulary acquisition. A sample of 168 children aged 8-10 years completed measures of receptive vocabulary (British Picture Vocabulary Scale), verbal working memory (Listening Recall), updating ability (N-back task), and non-verbal intelligence (Raven's Progressive Matrices). Descriptive statistics, correlational analyses, multiple regression, and moderation analyses were conducted to examine the associations among these variables. Results indicated that receptive vocabulary was positively correlated with age, SES, intelligence, and verbal working memory. Multiple regression analysis revealed that parental SES was the only significant predictor of receptive vocabulary performance, accounting for the largest unique proportion of variance. Working memory showed a modest association with receptive vocabulary, whereas updating ability was not a significant predictor. Moderation analyses further demonstrated that SES significantly moderated the relationship between working memory and receptive vocabulary, such that the association was stronger among children from higher SES backgrounds.
Additional Links: PMID-42655971
Publisher:
PubMed:
Citation:
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@article {pmid42655971,
year = {2026},
author = {Qehaja, F and Berisha, E},
title = {Working memory, updating and vocabulary development in Albanian-speaking children aged 8 and 10: the primacy of socioeconomic status.},
journal = {Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence},
volume = {},
number = {},
pages = {1-24},
doi = {10.1080/09297049.2026.2720194},
pmid = {42655971},
issn = {1744-4136},
abstract = {This study examined the relationship between receptive vocabulary, working memory processes, non-verbal intelligence, and socioeconomic status (SES) in Albanian-speaking children during middle childhood. The research was motivated by the linguistic characteristics of Albanian, a morphologically rich and orthographically transparent language that provides an informative context for examining how cognitive resources and environmental factors contribute to vocabulary acquisition. A sample of 168 children aged 8-10 years completed measures of receptive vocabulary (British Picture Vocabulary Scale), verbal working memory (Listening Recall), updating ability (N-back task), and non-verbal intelligence (Raven's Progressive Matrices). Descriptive statistics, correlational analyses, multiple regression, and moderation analyses were conducted to examine the associations among these variables. Results indicated that receptive vocabulary was positively correlated with age, SES, intelligence, and verbal working memory. Multiple regression analysis revealed that parental SES was the only significant predictor of receptive vocabulary performance, accounting for the largest unique proportion of variance. Working memory showed a modest association with receptive vocabulary, whereas updating ability was not a significant predictor. Moderation analyses further demonstrated that SES significantly moderated the relationship between working memory and receptive vocabulary, such that the association was stronger among children from higher SES backgrounds.},
}
RevDate: 2026-08-26
CmpDate: 2026-08-26
Media Multitasking and Cognitive Abilities: A Multi-Domain Assessment of Attention, Working Memory, Convergent Associative Thinking, and Fluid Reasoning.
Journal of Intelligence, 14(8): pii:jintelligence14080175.
The present study addressed a timely and important issue in cognitive and media psychology about the relationship between media multitasking and cognition. This study examined attention control, working memory, convergent associative thinking, and fluid reasoning, examining multiple functions within the same analytical framework and moving beyond the narrow focus on single cognitive domains that characterizes much prior research. The main aim was to deepen the understanding of the associations of media multitasking with these core domains of human cognition. A total of 214 healthy young adults (18-30 years) completed the Short Media Multitasking Questionnaire, Raven's Progressive Matrices, the Digit Span Test, the Trail-Making Test, and the Remote Associates Task. Multivariate general linear models and subsequent regression analyses were performed while controlling for age and gender. The results did not reveal a significant overall association between media multitasking and the combined cognitive outcomes. At the univariate level, higher media multitasking scores were associated with lower performance on the Remote Associates Task, although the observed effect size was small. Given the cross-sectional design and reliance on self-reported media multitasking, longitudinal studies employing objective measures of media multitasking use are needed to clarify the robustness and directionality of these associations.
Additional Links: PMID-42646021
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PubMed:
Citation:
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@article {pmid42646021,
year = {2026},
author = {Caprì, T},
title = {Media Multitasking and Cognitive Abilities: A Multi-Domain Assessment of Attention, Working Memory, Convergent Associative Thinking, and Fluid Reasoning.},
journal = {Journal of Intelligence},
volume = {14},
number = {8},
pages = {},
doi = {10.3390/jintelligence14080175},
pmid = {42646021},
issn = {2079-3200},
abstract = {The present study addressed a timely and important issue in cognitive and media psychology about the relationship between media multitasking and cognition. This study examined attention control, working memory, convergent associative thinking, and fluid reasoning, examining multiple functions within the same analytical framework and moving beyond the narrow focus on single cognitive domains that characterizes much prior research. The main aim was to deepen the understanding of the associations of media multitasking with these core domains of human cognition. A total of 214 healthy young adults (18-30 years) completed the Short Media Multitasking Questionnaire, Raven's Progressive Matrices, the Digit Span Test, the Trail-Making Test, and the Remote Associates Task. Multivariate general linear models and subsequent regression analyses were performed while controlling for age and gender. The results did not reveal a significant overall association between media multitasking and the combined cognitive outcomes. At the univariate level, higher media multitasking scores were associated with lower performance on the Remote Associates Task, although the observed effect size was small. Given the cross-sectional design and reliance on self-reported media multitasking, longitudinal studies employing objective measures of media multitasking use are needed to clarify the robustness and directionality of these associations.},
}
RevDate: 2026-08-26
CmpDate: 2026-08-26
Single-Point Periorbital Botulinum Neurotoxin Injection and Its Potential Role in Hematoma Risk Reduction: A Technical Report.
Toxins, 18(8):.
Botulinum neurotoxin type A (BoNT-A) injection for lateral canthal rhytids is among the most frequently performed nonsurgical aesthetic procedures; however, procedure-related hematoma and ecchymosis remain frequent local adverse events associated with the multiple puncture sites required in the conventional three-point technique. This prospective single-center preliminary clinical observation evaluated a single-point intramuscular injection technique designed to reduce percutaneous vascular-layer penetrations while preserving treatment territory, dose, and intramuscular target localization. A total of 152 consecutive patients (104 female and 48 male) underwent bilateral treatment between May 2025 and May 2026 using a single skin entry point per side, positioned 10-15 mm caudal to and 10 mm temporal to the lateral canthus, followed by 18-20 mm intramuscular advancement within the lateral orbicularis oculi and continuous retrograde infusion of 12 U of onabotulinumtoxinA per side. Post-procedural assessment after injection demonstrated small unilateral ecchymosis in 2 of 304 treated sides (0.66%; Clopper-Pearson 95% Confidence Interval (CI), 0.08-2.36%). After the 10-day follow-up, no persistent bruising or other adverse events were reported, and all patients confirmed satisfaction with the treatment. At the structured one-year follow-up, the satisfactory reduction in dynamic lateral canthal rhytids and continued patient satisfaction with the treatment were confirmed, while a subset elected to return for a subsequent treatment session during the observation period. By reducing bilateral percutaneous venous-layer penetrations from six to two while maintaining dose and treatment-territory equivalence, the single-point intramuscular technique may represent a structurally coherent refinement of established BoNT-A treatment concepts for lateral canthal rhytids. Because this was an uncontrolled preliminary clinical observation, the observed rate should be interpreted as descriptive only; any potential reduction in hematoma risk remains hypothetical.
Additional Links: PMID-42646756
PubMed:
Citation:
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@article {pmid42646756,
year = {2026},
author = {Gardetto, A and Thaler-Wolf, L},
title = {Single-Point Periorbital Botulinum Neurotoxin Injection and Its Potential Role in Hematoma Risk Reduction: A Technical Report.},
journal = {Toxins},
volume = {18},
number = {8},
pages = {},
pmid = {42646756},
issn = {2072-6651},
mesh = {Humans ; Female ; *Botulinum Toxins, Type A/administration & dosage/adverse effects ; Male ; *Hematoma/prevention & control/chemically induced ; Middle Aged ; Prospective Studies ; Injections, Intramuscular ; Adult ; Skin Aging/drug effects ; Aged ; Ecchymosis/prevention & control ; *Neuromuscular Agents/administration & dosage/adverse effects ; *Cosmetic Techniques/adverse effects ; },
abstract = {Botulinum neurotoxin type A (BoNT-A) injection for lateral canthal rhytids is among the most frequently performed nonsurgical aesthetic procedures; however, procedure-related hematoma and ecchymosis remain frequent local adverse events associated with the multiple puncture sites required in the conventional three-point technique. This prospective single-center preliminary clinical observation evaluated a single-point intramuscular injection technique designed to reduce percutaneous vascular-layer penetrations while preserving treatment territory, dose, and intramuscular target localization. A total of 152 consecutive patients (104 female and 48 male) underwent bilateral treatment between May 2025 and May 2026 using a single skin entry point per side, positioned 10-15 mm caudal to and 10 mm temporal to the lateral canthus, followed by 18-20 mm intramuscular advancement within the lateral orbicularis oculi and continuous retrograde infusion of 12 U of onabotulinumtoxinA per side. Post-procedural assessment after injection demonstrated small unilateral ecchymosis in 2 of 304 treated sides (0.66%; Clopper-Pearson 95% Confidence Interval (CI), 0.08-2.36%). After the 10-day follow-up, no persistent bruising or other adverse events were reported, and all patients confirmed satisfaction with the treatment. At the structured one-year follow-up, the satisfactory reduction in dynamic lateral canthal rhytids and continued patient satisfaction with the treatment were confirmed, while a subset elected to return for a subsequent treatment session during the observation period. By reducing bilateral percutaneous venous-layer penetrations from six to two while maintaining dose and treatment-territory equivalence, the single-point intramuscular technique may represent a structurally coherent refinement of established BoNT-A treatment concepts for lateral canthal rhytids. Because this was an uncontrolled preliminary clinical observation, the observed rate should be interpreted as descriptive only; any potential reduction in hematoma risk remains hypothetical.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Female
*Botulinum Toxins, Type A/administration & dosage/adverse effects
Male
*Hematoma/prevention & control/chemically induced
Middle Aged
Prospective Studies
Injections, Intramuscular
Adult
Skin Aging/drug effects
Aged
Ecchymosis/prevention & control
*Neuromuscular Agents/administration & dosage/adverse effects
*Cosmetic Techniques/adverse effects
RevDate: 2026-08-25
CmpDate: 2026-08-25
A Geospatial Study of Pradhan Mantri Jan Arogya Yojana (PM-JAY) Empaneled Healthcare Facilities across South Indian States.
Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine, 51(Suppl 3):S555-S562.
CONTEXT: To advance universal health coverage (UHC) in India, several healthcare reforms were introduced, including the Pradhan Mantri Jan Arogya Yojana (PM-JAY). The scheme provides secondary and tertiary inpatient care to eligible below-poverty-line and vulnerable populations through empaneled public and private hospitals.
AIMS: To examine the spatial distribution of PM-JAY empaneled hospitals and assess its alignment with equitable healthcare access.
METHODS: Open-access data on PM-JAY empaneled hospitals in South Indian states were retrieved from National Health Authority's (NHA) Hospital Empanelment Module (HEM) in January 2022. Data were cleaned and analyzed using SPSS, R, and ArcGIS. Distance correlation and Spearman's correlational analyses were performed between hospital-density variables and development indicators (Human Development Index [HDI], literacy rates) at 95% confidence interval.
RESULTS: A total of 8,946 hospitals were empaneled across South India. Public hospitals constituted 52.9% and private facilities 47.1%, with inter-state variations. Private facilities dominated in Kerala, while Karnataka had the highest public share. Distance correlation (dCor) and Spearman's correlation analyses showed significant associations (P < 0.05) between private hospitals' availability and development indices. Associations with literacy rates were significantly stronger for private hospitals per million population (dCor = 0.451) and per sq. km (dCor = 0.430). Geospatial analysis revealed a scattered distribution of public hospitals, while private facilities were clustered, specifically in urban pockets.
CONCLUSION: The observed distribution patterns suggest state-specific policies for healthcare advancements. Critical gaps identified in private hospitals' distribution need attention to mitigate challenges in underserved areas. Overall, a balanced and well-regulated mix of both sectors may be most effective in ensuring equitable and comprehensive healthcare access.
Additional Links: PMID-42639314
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Citation:
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@article {pmid42639314,
year = {2026},
author = {Amarthaluri, C and Balasubramani, K and Bhat, LD and Selvaraj, M and Philip, NE},
title = {A Geospatial Study of Pradhan Mantri Jan Arogya Yojana (PM-JAY) Empaneled Healthcare Facilities across South Indian States.},
journal = {Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine},
volume = {51},
number = {Suppl 3},
pages = {S555-S562},
pmid = {42639314},
issn = {0970-0218},
abstract = {CONTEXT: To advance universal health coverage (UHC) in India, several healthcare reforms were introduced, including the Pradhan Mantri Jan Arogya Yojana (PM-JAY). The scheme provides secondary and tertiary inpatient care to eligible below-poverty-line and vulnerable populations through empaneled public and private hospitals.
AIMS: To examine the spatial distribution of PM-JAY empaneled hospitals and assess its alignment with equitable healthcare access.
METHODS: Open-access data on PM-JAY empaneled hospitals in South Indian states were retrieved from National Health Authority's (NHA) Hospital Empanelment Module (HEM) in January 2022. Data were cleaned and analyzed using SPSS, R, and ArcGIS. Distance correlation and Spearman's correlational analyses were performed between hospital-density variables and development indicators (Human Development Index [HDI], literacy rates) at 95% confidence interval.
RESULTS: A total of 8,946 hospitals were empaneled across South India. Public hospitals constituted 52.9% and private facilities 47.1%, with inter-state variations. Private facilities dominated in Kerala, while Karnataka had the highest public share. Distance correlation (dCor) and Spearman's correlation analyses showed significant associations (P < 0.05) between private hospitals' availability and development indices. Associations with literacy rates were significantly stronger for private hospitals per million population (dCor = 0.451) and per sq. km (dCor = 0.430). Geospatial analysis revealed a scattered distribution of public hospitals, while private facilities were clustered, specifically in urban pockets.
CONCLUSION: The observed distribution patterns suggest state-specific policies for healthcare advancements. Critical gaps identified in private hospitals' distribution need attention to mitigate challenges in underserved areas. Overall, a balanced and well-regulated mix of both sectors may be most effective in ensuring equitable and comprehensive healthcare access.},
}
RevDate: 2026-08-24
Evolutionary spandrels in collective animal behaviour.
Trends in ecology & evolution pii:S0169-5347(26)00209-0 [Epub ahead of print].
Collective behaviour is widespread in the animal kingdom and can enhance individual fitness. Yet not all collective behaviours are adaptations. Instead, some may be nonadaptive or 'evolutionary spandrels'-traits that originated as by-products in the sense proposed by Stephen Jay Gould and Richard Lewontin. Here, we argue that self-organising processes provide a route through which evolutionary spandrels in collective animal behaviour can occur, and we provide three examples: spatial organisation in primate groups, division of labour in ants, and insect chorusing. We then consider how such outcomes may be co-opted into adaptive roles through exaptation and conclude by outlining the challenges associated with testing adaptive and nonadaptive hypotheses in collective behaviour research using individual-based studies, phylogenetic comparative analyses, and agent-based models.
Additional Links: PMID-42637655
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PubMed:
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@article {pmid42637655,
year = {2026},
author = {King, AJ and Henry, EG and Garnier, S and Allen, WL and Heathcote, RJP and Fele, M and Papadopoulou, M and Sankey, DWE and Fürtbauer, I},
title = {Evolutionary spandrels in collective animal behaviour.},
journal = {Trends in ecology & evolution},
volume = {},
number = {},
pages = {},
doi = {10.1016/j.tree.2026.07.011},
pmid = {42637655},
issn = {1872-8383},
abstract = {Collective behaviour is widespread in the animal kingdom and can enhance individual fitness. Yet not all collective behaviours are adaptations. Instead, some may be nonadaptive or 'evolutionary spandrels'-traits that originated as by-products in the sense proposed by Stephen Jay Gould and Richard Lewontin. Here, we argue that self-organising processes provide a route through which evolutionary spandrels in collective animal behaviour can occur, and we provide three examples: spatial organisation in primate groups, division of labour in ants, and insect chorusing. We then consider how such outcomes may be co-opted into adaptive roles through exaptation and conclude by outlining the challenges associated with testing adaptive and nonadaptive hypotheses in collective behaviour research using individual-based studies, phylogenetic comparative analyses, and agent-based models.},
}
RevDate: 2026-08-20
Stomata: an introduction to a Virtual Issue.
The New phytologist, 251(6):3061-3065.
This Editorial introduces the Virtual Issue ‘Stomata’ that includes the following papers: Apigo et al. (2026), Bernardo et al. (2026), Brench et al. (2026), Busby et al. (2026), Caine et al. (2019, 2026), Chen et al. (2026), Ding et al. (2026), Drake et al. (2019), Erberich et al. (2026), Fan et al. (2025), Grenzi et al. (2026), Gustavsson et al. (2026), Hõrak (2026), Huang et al. (2026), Kou et al. (2026), Li et al. (2026), Liu et al. (2025), Nguyen et al. (2026), Raven (2002), Roelfsema & Hedrich (2002), Samantara et al. (2025), Sicangco et al. (2026), Silva‐Alvim et al. (2026), Sinha et al. (2022), Song et al. (2014), Sun et al. (2025, 2026), Tan et al. (2026), Wilson et al. (2025), Woning et al. (2026), Yan et al. (2026), Yang et al. (2026), Zavala‐Paez et al. (2026), Zhang et al. (2025). Access the Virtual Issue at www.newphytologist.com/virtualissues.
Additional Links: PMID-42619622
PubMed:
Citation:
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@article {pmid42619622,
year = {2026},
author = {Assmann, SM and Dong, J and Gray, JE and Hõrak, H and Liang, YK and Song, CP and Yang, S and Hetherington, AM},
title = {Stomata: an introduction to a Virtual Issue.},
journal = {The New phytologist},
volume = {251},
number = {6},
pages = {3061-3065},
pmid = {42619622},
issn = {1469-8137},
abstract = {This Editorial introduces the Virtual Issue ‘Stomata’ that includes the following papers: Apigo et al. (2026), Bernardo et al. (2026), Brench et al. (2026), Busby et al. (2026), Caine et al. (2019, 2026), Chen et al. (2026), Ding et al. (2026), Drake et al. (2019), Erberich et al. (2026), Fan et al. (2025), Grenzi et al. (2026), Gustavsson et al. (2026), Hõrak (2026), Huang et al. (2026), Kou et al. (2026), Li et al. (2026), Liu et al. (2025), Nguyen et al. (2026), Raven (2002), Roelfsema & Hedrich (2002), Samantara et al. (2025), Sicangco et al. (2026), Silva‐Alvim et al. (2026), Sinha et al. (2022), Song et al. (2014), Sun et al. (2025, 2026), Tan et al. (2026), Wilson et al. (2025), Woning et al. (2026), Yan et al. (2026), Yang et al. (2026), Zavala‐Paez et al. (2026), Zhang et al. (2025). Access the Virtual Issue at www.newphytologist.com/virtualissues.},
}
RevDate: 2026-08-21
CmpDate: 2026-08-21
MiDAS: A Multimodal Data Acquisition System and Dataset for Robot-Assisted Minimally Invasive Surgery.
The international journal of medical robotics + computer assisted surgery : MRCAS, 22(4):e70220.
BACKGROUND: Robot-Assisted Minimally Invasive Surgery (RAMIS) research increasingly relies on multimodal data, yet access to proprietary robot telemetry remains a barrier. We introduce the Multimodal Data Acquisition System (MiDAS), an open-source, platform-agnostic system enabling time-synchronized, non-invasive multimodal data acquisition across surgical robotic platforms.
METHODS: MiDAS integrates electromagnetic and depth camera-based hand tracking, foot pedal sensing and surgical video capture without requiring proprietary robot interfaces. We validated MiDAS on the open-source Raven-II and the clinical da Vinci Xi by collecting multimodal datasets of Peg Transfer and Hernia Repair Suturing tasks performed by surgical residents. Correlation analysis and gesture recognition experiments were conducted.
RESULTS: External hand and foot sensing closely approximated internal robot kinematics and non-invasive motion signals achieved gesture recognition performance comparable to proprietary telemetry.
CONCLUSIONS: MiDAS enables reproducible multimodal RAMIS data collection and is released with annotated datasets, including the first multimodal dataset of hernia repair suturing on simulation models.
Additional Links: PMID-42626778
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Citation:
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@article {pmid42626778,
year = {2026},
author = {Weerasinghe, K and Roodabeh, SHR and Hawkins, A and Zhang, Z and Schrader, Z and Alemzadeh, H},
title = {MiDAS: A Multimodal Data Acquisition System and Dataset for Robot-Assisted Minimally Invasive Surgery.},
journal = {The international journal of medical robotics + computer assisted surgery : MRCAS},
volume = {22},
number = {4},
pages = {e70220},
doi = {10.1002/rcs.70220},
pmid = {42626778},
issn = {1478-596X},
support = {CNS-2146295//National Science Foundation/ ; AWD-006601//Commonwealth Cyber Initiative/ ; },
mesh = {*Robotic Surgical Procedures/methods/instrumentation ; *Minimally Invasive Surgical Procedures/methods/instrumentation ; Humans ; Motion Capture ; Gestures ; Biomechanical Phenomena ; Herniorrhaphy/methods ; Hand ; Foot ; Telemetry ; Computer Simulation ; Video Recording ; },
abstract = {BACKGROUND: Robot-Assisted Minimally Invasive Surgery (RAMIS) research increasingly relies on multimodal data, yet access to proprietary robot telemetry remains a barrier. We introduce the Multimodal Data Acquisition System (MiDAS), an open-source, platform-agnostic system enabling time-synchronized, non-invasive multimodal data acquisition across surgical robotic platforms.
METHODS: MiDAS integrates electromagnetic and depth camera-based hand tracking, foot pedal sensing and surgical video capture without requiring proprietary robot interfaces. We validated MiDAS on the open-source Raven-II and the clinical da Vinci Xi by collecting multimodal datasets of Peg Transfer and Hernia Repair Suturing tasks performed by surgical residents. Correlation analysis and gesture recognition experiments were conducted.
RESULTS: External hand and foot sensing closely approximated internal robot kinematics and non-invasive motion signals achieved gesture recognition performance comparable to proprietary telemetry.
CONCLUSIONS: MiDAS enables reproducible multimodal RAMIS data collection and is released with annotated datasets, including the first multimodal dataset of hernia repair suturing on simulation models.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
*Robotic Surgical Procedures/methods/instrumentation
*Minimally Invasive Surgical Procedures/methods/instrumentation
Humans
Motion Capture
Gestures
Biomechanical Phenomena
Herniorrhaphy/methods
Hand
Foot
Telemetry
Computer Simulation
Video Recording
RevDate: 2026-08-21
Stephen Jay Gould: the comic book history of an historian of science -or-ontogeny does not recapitulate phylogeny, but does the mismeasure of man recapitulate uncle $crooge?.
Endeavour, 50(3):101067 pii:S0160-9327(26)00026-8 [Epub ahead of print].
In the early 1980s, Marvel Comics worked on a series of textbooks in comic book form, including one volume that was to be authored by Stephen Jay Gould. This essay uses new archival documents to prove Gould explored a potential collaboration with Marvel, but this project never came to fruition. It then delves further into the Gould archives to reveal selections from Gould's comic book reading in his youth. For example, two Uncle $crooge comics contain stories of Indigenous Peoples defeating Scrooge's twentieth-century capitalism, mirroring the themes of Gould's well-known work, The Mismeasure of Man. This is further supported by the junior high school projects saved in his archives that include a report on political caricatures, also presaging his arguments in The Mismeasure of Man. The influence of comic books on Gould's science is also apparent in the several references he makes to Walt Disney comics throughout his life. For example, one of his motivational stories for a life in science began with Fantasia, and a later essay looked at the ontogenetic progress of Mickey Mouse. Therefore, this article reveals one of the few documentable occasions where a scientist's archives can be used to identify the influence of comic books on their later scientific work.
Additional Links: PMID-42628154
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PubMed:
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@article {pmid42628154,
year = {2026},
author = {Furmaniuk, Z},
title = {Stephen Jay Gould: the comic book history of an historian of science -or-ontogeny does not recapitulate phylogeny, but does the mismeasure of man recapitulate uncle $crooge?.},
journal = {Endeavour},
volume = {50},
number = {3},
pages = {101067},
doi = {10.1016/j.endeavour.2026.101067},
pmid = {42628154},
issn = {1873-1929},
abstract = {In the early 1980s, Marvel Comics worked on a series of textbooks in comic book form, including one volume that was to be authored by Stephen Jay Gould. This essay uses new archival documents to prove Gould explored a potential collaboration with Marvel, but this project never came to fruition. It then delves further into the Gould archives to reveal selections from Gould's comic book reading in his youth. For example, two Uncle $crooge comics contain stories of Indigenous Peoples defeating Scrooge's twentieth-century capitalism, mirroring the themes of Gould's well-known work, The Mismeasure of Man. This is further supported by the junior high school projects saved in his archives that include a report on political caricatures, also presaging his arguments in The Mismeasure of Man. The influence of comic books on Gould's science is also apparent in the several references he makes to Walt Disney comics throughout his life. For example, one of his motivational stories for a life in science began with Fantasia, and a later essay looked at the ontogenetic progress of Mickey Mouse. Therefore, this article reveals one of the few documentable occasions where a scientist's archives can be used to identify the influence of comic books on their later scientific work.},
}
RevDate: 2026-08-20
CmpDate: 2026-08-20
The screening tool of behavioral self-regulation "Head-Toes-Knees-Shoulders" task: a preliminary adaptation to Greek older adults.
Frontiers in psychology, 17:1891008.
The aim of the present study was to examine the psychometric properties of the Head-Toes-Knees-Shoulders (HTKS) behavioral self-regulation (executive function) measure in a sample of Greek older population. Specifically, 88 cognitively healthy Greek older adults over the age of 65 participated in the study. The Greek version of HTKS was administered along with the Greek versions of the Mini-Mental State Examination (MMSE), the Raven's Educational CPM, the Number Series (NS) test, the Positive and Negative Affect Scale (PANAS), the Barratt Impulsiveness Scale (BIS-11) and the Impulsive Behavior Scale (UPPS-P). Exploratory factor analysis supported the unidimensional structure of the HTKS. The internal consistency reliability was evaluated with Cronbach's alpha coefficient and found to be acceptable (α = 0.79). Furthermore, significant positive correlations of the HTKS with measures of cognitive ability (CPM, NS, and MMSE) supported its convergent validity. No significant bivariate correlations of the HTKS were found with older adults' emotional state or impulsivity. The path analysis indicated that nonverbal cognitive ability (CPM) and general cognitive ability (NS) positively influenced the performance on HTKS. In turn, behavioral self-regulation (HTKS) was found to influence positively both positive and negative affect as measured by the PANAS. Additionally, nonverbal cognitive ability (CPM) was found to negatively predict negative affect.
Additional Links: PMID-42620585
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Citation:
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@article {pmid42620585,
year = {2026},
author = {Rachanioti, E and Magkavila, D and Fragkomichelaki, O and Dinou, M and Katsadima, E and Foti, T and Tzalla, A and Dougali, A and Bourmpou, C and Staikopoulou, M and Papantoniou, A and Varlami, F and Dinaki, I and Tsiountala, M and Staikopoulos, K and Mavropalias, T and Efthymiou, E and Tomprou, D and Georgiadi, M and Katsarou, D and Kougioumtzis, G and Katsouri, IG and Zaragas, H and Moraitou, D and Sofologi, M and Papantoniou, G},
title = {The screening tool of behavioral self-regulation "Head-Toes-Knees-Shoulders" task: a preliminary adaptation to Greek older adults.},
journal = {Frontiers in psychology},
volume = {17},
number = {},
pages = {1891008},
pmid = {42620585},
issn = {1664-1078},
abstract = {The aim of the present study was to examine the psychometric properties of the Head-Toes-Knees-Shoulders (HTKS) behavioral self-regulation (executive function) measure in a sample of Greek older population. Specifically, 88 cognitively healthy Greek older adults over the age of 65 participated in the study. The Greek version of HTKS was administered along with the Greek versions of the Mini-Mental State Examination (MMSE), the Raven's Educational CPM, the Number Series (NS) test, the Positive and Negative Affect Scale (PANAS), the Barratt Impulsiveness Scale (BIS-11) and the Impulsive Behavior Scale (UPPS-P). Exploratory factor analysis supported the unidimensional structure of the HTKS. The internal consistency reliability was evaluated with Cronbach's alpha coefficient and found to be acceptable (α = 0.79). Furthermore, significant positive correlations of the HTKS with measures of cognitive ability (CPM, NS, and MMSE) supported its convergent validity. No significant bivariate correlations of the HTKS were found with older adults' emotional state or impulsivity. The path analysis indicated that nonverbal cognitive ability (CPM) and general cognitive ability (NS) positively influenced the performance on HTKS. In turn, behavioral self-regulation (HTKS) was found to influence positively both positive and negative affect as measured by the PANAS. Additionally, nonverbal cognitive ability (CPM) was found to negatively predict negative affect.},
}
RevDate: 2026-08-19
Whispering-gallery-modes in narrowband emission from B/N-PAH-doped geometrically arranged polymer photonic cavities, waveguides and splitters.
Physical chemistry chemical physics : PCCP [Epub ahead of print].
Polymer microcavity-based coupled-resonator optical waveguides (CROWs) with narrowband emission offer a promising approach for developing next-generation miniaturized photonic components. In a unique approach, a narrowband-emitting compound 9,9'-(4,4'-(tert-butyl)diphenylamino)dibenzo[b,d]borin-2-ylidene)dibenzonitrile (BCz-BN), with a full width at half maximum (FWHM) of 28.9 nm, was doped into polystyrene microspheres and assembled on a glass substrate. Using an atomic force microscope cantilever tip-based micromanipulation technique, we successfully created CROWs with distinct architectures for narrowband light transmission. Detailed micro-spectroscopy studies revealed CROWs capability to support optical whispering-gallery modes (WGMs) while retaining the narrowband emission of the doped fluorophore. Dimeric to pentameric, triangular, square, and Y-shaped BCz-BN-doped CROWs were realized, demonstrating efficient light-guiding, distribution and splitting. These fabricated waveguides provide a scalable platform for advanced photonic applications, including on-chip optical communication, biosensing and quantum optics, paving the way for advanced microscale optoelectronic devices.
Additional Links: PMID-42614085
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@article {pmid42614085,
year = {2026},
author = {Yadav, K and Gaddam, S and Hazarika, J and Khapre, A and Chandrasekar, R},
title = {Whispering-gallery-modes in narrowband emission from B/N-PAH-doped geometrically arranged polymer photonic cavities, waveguides and splitters.},
journal = {Physical chemistry chemical physics : PCCP},
volume = {},
number = {},
pages = {},
doi = {10.1039/d6cp01943a},
pmid = {42614085},
issn = {1463-9084},
abstract = {Polymer microcavity-based coupled-resonator optical waveguides (CROWs) with narrowband emission offer a promising approach for developing next-generation miniaturized photonic components. In a unique approach, a narrowband-emitting compound 9,9'-(4,4'-(tert-butyl)diphenylamino)dibenzo[b,d]borin-2-ylidene)dibenzonitrile (BCz-BN), with a full width at half maximum (FWHM) of 28.9 nm, was doped into polystyrene microspheres and assembled on a glass substrate. Using an atomic force microscope cantilever tip-based micromanipulation technique, we successfully created CROWs with distinct architectures for narrowband light transmission. Detailed micro-spectroscopy studies revealed CROWs capability to support optical whispering-gallery modes (WGMs) while retaining the narrowband emission of the doped fluorophore. Dimeric to pentameric, triangular, square, and Y-shaped BCz-BN-doped CROWs were realized, demonstrating efficient light-guiding, distribution and splitting. These fabricated waveguides provide a scalable platform for advanced photonic applications, including on-chip optical communication, biosensing and quantum optics, paving the way for advanced microscale optoelectronic devices.},
}
RevDate: 2026-08-19
CmpDate: 2026-08-19
Differential contributions of working memory and inhibitory control to prospective memory detection and retrieval.
Frontiers in psychology, 17:1871302.
BACKGROUND: Prospective memory (PM)-remembering to carry out intended actions at the right moment - depends on executive control, but the specific contributions of working memory and inhibitory control to PM cue detection versus intention retrieval remain debated.
METHODS: Eighty-four adults (44 action video game players, 40 non-players) aged 18-45 completed a within-subjects PM paradigm with separate detection and retrieval conditions, along with measures of working memory (digit span forward/backward, Corsi block), inhibitory control (Stroop interference), and nonverbal reasoning (Raven's Colored Progressive Matrices). Multiple regression and a stacked long-format model with cluster-robust standard errors tested predictor-outcome associations and their interaction with PM component.
RESULTS: Backward digit span (executive working memory) was a significant positive predictor of PM detection (β = 0.32, p = 0.009) but not PM retrieval; follow-up analyses confirmed the effect was carried by executive manipulation rather than verbal storage. Stroop interference was the only significant predictor of PM retrieval (β = -0.25, p = 0.042). The PM-component × working-memory interaction was significant (β = -0.34, p = 0.009), indicating that working memory was more strongly associated with detection than with retrieval, whereas the corresponding interaction for Stroop interference was not (β = -0.06, p = 0.649). Action video game experience was not associated with performance on any measure.
CONCLUSION: Working memory was selectively associated with the detection phase of PM, providing partial support for multiprocess accounts in which different executive mechanisms are differentially recruited across PM phases. The role of inhibitory control was less phase-specific. Modest action video game experience does not confer measurable PM advantages.
Additional Links: PMID-42614380
PubMed:
Citation:
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@article {pmid42614380,
year = {2026},
author = {Alnajashi, SA},
title = {Differential contributions of working memory and inhibitory control to prospective memory detection and retrieval.},
journal = {Frontiers in psychology},
volume = {17},
number = {},
pages = {1871302},
pmid = {42614380},
issn = {1664-1078},
abstract = {BACKGROUND: Prospective memory (PM)-remembering to carry out intended actions at the right moment - depends on executive control, but the specific contributions of working memory and inhibitory control to PM cue detection versus intention retrieval remain debated.
METHODS: Eighty-four adults (44 action video game players, 40 non-players) aged 18-45 completed a within-subjects PM paradigm with separate detection and retrieval conditions, along with measures of working memory (digit span forward/backward, Corsi block), inhibitory control (Stroop interference), and nonverbal reasoning (Raven's Colored Progressive Matrices). Multiple regression and a stacked long-format model with cluster-robust standard errors tested predictor-outcome associations and their interaction with PM component.
RESULTS: Backward digit span (executive working memory) was a significant positive predictor of PM detection (β = 0.32, p = 0.009) but not PM retrieval; follow-up analyses confirmed the effect was carried by executive manipulation rather than verbal storage. Stroop interference was the only significant predictor of PM retrieval (β = -0.25, p = 0.042). The PM-component × working-memory interaction was significant (β = -0.34, p = 0.009), indicating that working memory was more strongly associated with detection than with retrieval, whereas the corresponding interaction for Stroop interference was not (β = -0.06, p = 0.649). Action video game experience was not associated with performance on any measure.
CONCLUSION: Working memory was selectively associated with the detection phase of PM, providing partial support for multiprocess accounts in which different executive mechanisms are differentially recruited across PM phases. The role of inhibitory control was less phase-specific. Modest action video game experience does not confer measurable PM advantages.},
}
RevDate: 2026-08-19
CmpDate: 2026-08-19
Surveillance of West Nile virus infections in humans and animals in Europe, monthly report - data submitted up to 5 August 2026.
EFSA journal. European Food Safety Authority, 24(8):e10304 pii:EFS210304.
In 2026, and as at 5 August, seven countries in Europe have reported 245 locally acquired[1] human cases of West Nile Virus (WNV) infection. The earliest and latest date of onset were on 12 May 2026 and 1 August 2026, respectively. Locally acquired cases have been reported by Italy (139 cases), Greece (65, of which four with unknown place of infection), Spain (17 cases), North Macedonia (13 cases), Romania (six cases), France (four cases) and Germany (one case). In Europe, 12 deaths have been reported by Greece (six deaths), Italy (five deaths) and Romania (one death).The number of human cases reported so far (245 cases) is below the average for the corresponding period over the past decade (403 cases). However, reporting delays may result in an under-estimation of the current burden, as the 2026 data remain provisional, whereas the ten-year average is based on consolidated data from previous years. In addition, this ten-year average is influenced by several particularly intense WNV transmission seasons, notably in 2018 (1065 cases reported up to the corresponding week), 2022 (781 cases) and 2024 (654 cases). To date, most cases have been reported in Italy (139 cases) and Greece (65 cases). Although the number of cases reported in Italy is lower than during the same period in 2025 (168 cases), it remains the most affected country in Europe in 2026. Greece has reported more cases in 2026 than during the same period in 2025 (65 cases compared with 26 cases). WNV circulation is currently most intense in the Attica NUTS 2 region (48 cases), with Anatoliki Attiki (East Attica, 34 cases) and Voreios Tomeas Athinon (North Athens, seven cases) most affected.As at 5 August 2026, locally acquired human cases of WNV infection had been reported in 58 NUTS 3 regions across seven countries. This is higher than at the same point in 2025, when cases were reported in 40 NUTS 3 regions across six countries. However, the geographical spread observed so far in 2026 remains well below the final extent recorded in recent seasons: by the end of 2025, affected regions numbered 160 and in 2024 there were 218. The 2024 season remains the largest WNV season on record in terms of geographical spread.This year, six regions reported locally acquired human cases of WNV infection for the first time ever: France in Pyrénées-Orientales (FRJ15); Germany in Rhein-Pfalz-Kreis (DEB3I); Italy in Campobasso (ITF22) and Viterbo (ITI41); North Macedonia in Pelagoniski (MK005) and Vardarski (MK001). Similar to previous years, most cases were reported among males aged 65 years and above. Most cases were hospitalised (72%) and presented with neurological symptoms (58%). The proportion hospitalised was lower than the average reported during the previous decade (87%), while the proportion with neurological symptoms was also slightly lower than the historical 10-year average (64%). The case fatality rate was approximately 5%, lower than the average reported during the previous decade (11%). However, this estimate should be interpreted with caution, as clinical outcomes may not yet be known for all reported cases and additional deaths may be recorded as the season progresses and data are consolidated.Owing to delays in diagnosis and reporting, and because most WNV infections are asymptomatic or subclinical, the reported case numbers probably underestimate the true number of infections. Seasonal surveillance in humans primarily captures laboratory-confirmed cases, which may further contribute to reporting delays.
From the veterinary perspective, 17 WNV outbreaks among equids and 74 outbreaks among birds have been reported in Europe in 2026. The earliest start date of an outbreak among equids and birds was on 30 March 2026 in France and 31 March 2026 in Italy, while the latest onset of an outbreak among equids and birds was, respectively, on 31 July 2026 in Netherlands and 28 July 2026 in Italy. Outbreaks among equids were reported by France (five outbreaks), Greece (five outbreaks), Italy (five outbreaks), the Netherlands (one outbreak) and Spain (one outbreak). Outbreaks among birds were reported by Italy (64 outbreaks), France (five outbreaks), Spain (three outbreaks), Austria (one outbreak) and Belgium (one outbreak).No information was available on the equid species involved in the outbreaks reported in the Animal Disease Information System (ADIS). The bird species most frequently associated with the reported outbreaks were the common magpie (23) and the hooded crow (20), followed by the carrion crow (5), the common kestrel (5), the Eurasian blackbird (5), the yellow-legged gull (3), Adalbert's eagle (2), the common wood-pigeon (2), and the little owl (2). Single outbreaks were associated with the common loon, the common raven, the European turtle-dove, the golden eagle, the grey heron, the house sparrow and the northern goshawk.The monthly number of WNV outbreaks in equids reported during the first part of 2026 was comparable to the corresponding 10-year monthly average (2016-2025). However, the number of equid outbreaks in July 2026 remained below the levels observed in July 2018, 2024 and 2025, years characterised by particularly high WNV intensity. In contrast, the number of WNV outbreaks in birds slightly exceeded the corresponding four-year monthly average (2022-2025) in April and May, and was substantially higher in June. This trend reversed in July 2026, when the number of reported outbreaks in birds fell below the four-year average, although it remained higher than in July 2025. However, it should be noted that reporting delays may affect the July numbers, as some outbreaks occurring during that month may be notified in August.As at 5 August 2026, outbreaks in birds and/or equids have been reported in 43 NUTS 3 regions across seven countries. This compares with 55 regions (10 countries) during the same period in 2025 and 42 regions (eight countries) in 2024. All seven countries reported WNV outbreaks in birds and/or equids in 2025 and in prior years, reflecting endemic WNV activity in these territories. However, as at 5 August, outbreaks in birds and/or equids were reported to ADIS for the first time in the following six regions: by France in Hauts-de-Seine (FR105) and Seine-et-Marne (FR102); by Belgium in Arr. Namur (BE352), by Greece in Drama (EL514), by Italy in Genova (ITC33) and by the Netherlands in Delf en Westland (NL362).
Four countries - France, Greece, Italy, and Spain - reported both human WNV infections and outbreaks in equids and/or birds. As at 5 August, Italy accounted for most of the reported human cases (56.7%) and animal outbreaks (75.8%). Greece reported the second-largest share of human cases (26.5%) but only five equid outbreaks and no bird outbreaks, representing 5.5% of all reported animal outbreaks.Differences in the patterns observed across European countries may reflect a combination of ecological, climatic and surveillance-related factors. Favourable climatic conditions and the presence of ecological hotspots, such as wetlands and agricultural areas, may support mosquito vector populations and influence the distribution and behaviour of animal hosts, thereby facilitating WNV circulation. At the same time, differences in WNV surveillance systems across Europe may affect detection and reporting rates.The first indication of WNV activity may arise from either human or animal surveillance, depending on local epidemiology, detection capacity and surveillance system sensitivity. Therefore, the absence of reports from one sector should not be interpreted as evidence that WNV is not circulating. In France (Pyrénées-Orientales, FRJ15), Greece (Drama, EL514), and Italy (Genova, ITC33), human cases were reported before, or in the absence of, notified outbreaks in birds or equids. Conversely, in Belgium (Arr. Namur, BE352), France (Hauts-de-Seine, FR105 and Seine-et-Marne, FR102) and the Netherlands (Delft en Westland, NL362), animal detections preceded human cases. Belgium is a relevant example, as WNV was first reported in the country in 2025 through avian surveillance, with no previous detections in humans and animals. In 2026, it has again been identified in birds in a previously unaffected region, highlighting the role of avian surveillance in detecting local virus circulation and geographical spread.Active mosquito surveillance is also important for the early detection of WNV circulation. However, results on WNV detection in mosquitoes are not included in this report because they are not legally required to be reported at European level, and the available information is therefore scattered and often project-based.
SEASONAL OUTLOOK: Given the favourable weather conditions for WNV transmission in Europe, ECDC and EFSA expect further human cases and outbreaks in equids and birds to be reported in the coming weeks. In previous years, transmission has typically peaked in August and September.ECDC and EFSA continue to closely monitor the situation in Europe.
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@article {pmid42614799,
year = {2026},
author = {, and , },
title = {Surveillance of West Nile virus infections in humans and animals in Europe, monthly report - data submitted up to 5 August 2026.},
journal = {EFSA journal. European Food Safety Authority},
volume = {24},
number = {8},
pages = {e10304},
doi = {10.2903/j.efsa.2026.10304},
pmid = {42614799},
issn = {1831-4732},
abstract = {In 2026, and as at 5 August, seven countries in Europe have reported 245 locally acquired[1] human cases of West Nile Virus (WNV) infection. The earliest and latest date of onset were on 12 May 2026 and 1 August 2026, respectively. Locally acquired cases have been reported by Italy (139 cases), Greece (65, of which four with unknown place of infection), Spain (17 cases), North Macedonia (13 cases), Romania (six cases), France (four cases) and Germany (one case). In Europe, 12 deaths have been reported by Greece (six deaths), Italy (five deaths) and Romania (one death).The number of human cases reported so far (245 cases) is below the average for the corresponding period over the past decade (403 cases). However, reporting delays may result in an under-estimation of the current burden, as the 2026 data remain provisional, whereas the ten-year average is based on consolidated data from previous years. In addition, this ten-year average is influenced by several particularly intense WNV transmission seasons, notably in 2018 (1065 cases reported up to the corresponding week), 2022 (781 cases) and 2024 (654 cases). To date, most cases have been reported in Italy (139 cases) and Greece (65 cases). Although the number of cases reported in Italy is lower than during the same period in 2025 (168 cases), it remains the most affected country in Europe in 2026. Greece has reported more cases in 2026 than during the same period in 2025 (65 cases compared with 26 cases). WNV circulation is currently most intense in the Attica NUTS 2 region (48 cases), with Anatoliki Attiki (East Attica, 34 cases) and Voreios Tomeas Athinon (North Athens, seven cases) most affected.As at 5 August 2026, locally acquired human cases of WNV infection had been reported in 58 NUTS 3 regions across seven countries. This is higher than at the same point in 2025, when cases were reported in 40 NUTS 3 regions across six countries. However, the geographical spread observed so far in 2026 remains well below the final extent recorded in recent seasons: by the end of 2025, affected regions numbered 160 and in 2024 there were 218. The 2024 season remains the largest WNV season on record in terms of geographical spread.This year, six regions reported locally acquired human cases of WNV infection for the first time ever: France in Pyrénées-Orientales (FRJ15); Germany in Rhein-Pfalz-Kreis (DEB3I); Italy in Campobasso (ITF22) and Viterbo (ITI41); North Macedonia in Pelagoniski (MK005) and Vardarski (MK001). Similar to previous years, most cases were reported among males aged 65 years and above. Most cases were hospitalised (72%) and presented with neurological symptoms (58%). The proportion hospitalised was lower than the average reported during the previous decade (87%), while the proportion with neurological symptoms was also slightly lower than the historical 10-year average (64%). The case fatality rate was approximately 5%, lower than the average reported during the previous decade (11%). However, this estimate should be interpreted with caution, as clinical outcomes may not yet be known for all reported cases and additional deaths may be recorded as the season progresses and data are consolidated.Owing to delays in diagnosis and reporting, and because most WNV infections are asymptomatic or subclinical, the reported case numbers probably underestimate the true number of infections. Seasonal surveillance in humans primarily captures laboratory-confirmed cases, which may further contribute to reporting delays.
From the veterinary perspective, 17 WNV outbreaks among equids and 74 outbreaks among birds have been reported in Europe in 2026. The earliest start date of an outbreak among equids and birds was on 30 March 2026 in France and 31 March 2026 in Italy, while the latest onset of an outbreak among equids and birds was, respectively, on 31 July 2026 in Netherlands and 28 July 2026 in Italy. Outbreaks among equids were reported by France (five outbreaks), Greece (five outbreaks), Italy (five outbreaks), the Netherlands (one outbreak) and Spain (one outbreak). Outbreaks among birds were reported by Italy (64 outbreaks), France (five outbreaks), Spain (three outbreaks), Austria (one outbreak) and Belgium (one outbreak).No information was available on the equid species involved in the outbreaks reported in the Animal Disease Information System (ADIS). The bird species most frequently associated with the reported outbreaks were the common magpie (23) and the hooded crow (20), followed by the carrion crow (5), the common kestrel (5), the Eurasian blackbird (5), the yellow-legged gull (3), Adalbert's eagle (2), the common wood-pigeon (2), and the little owl (2). Single outbreaks were associated with the common loon, the common raven, the European turtle-dove, the golden eagle, the grey heron, the house sparrow and the northern goshawk.The monthly number of WNV outbreaks in equids reported during the first part of 2026 was comparable to the corresponding 10-year monthly average (2016-2025). However, the number of equid outbreaks in July 2026 remained below the levels observed in July 2018, 2024 and 2025, years characterised by particularly high WNV intensity. In contrast, the number of WNV outbreaks in birds slightly exceeded the corresponding four-year monthly average (2022-2025) in April and May, and was substantially higher in June. This trend reversed in July 2026, when the number of reported outbreaks in birds fell below the four-year average, although it remained higher than in July 2025. However, it should be noted that reporting delays may affect the July numbers, as some outbreaks occurring during that month may be notified in August.As at 5 August 2026, outbreaks in birds and/or equids have been reported in 43 NUTS 3 regions across seven countries. This compares with 55 regions (10 countries) during the same period in 2025 and 42 regions (eight countries) in 2024. All seven countries reported WNV outbreaks in birds and/or equids in 2025 and in prior years, reflecting endemic WNV activity in these territories. However, as at 5 August, outbreaks in birds and/or equids were reported to ADIS for the first time in the following six regions: by France in Hauts-de-Seine (FR105) and Seine-et-Marne (FR102); by Belgium in Arr. Namur (BE352), by Greece in Drama (EL514), by Italy in Genova (ITC33) and by the Netherlands in Delf en Westland (NL362).
Four countries - France, Greece, Italy, and Spain - reported both human WNV infections and outbreaks in equids and/or birds. As at 5 August, Italy accounted for most of the reported human cases (56.7%) and animal outbreaks (75.8%). Greece reported the second-largest share of human cases (26.5%) but only five equid outbreaks and no bird outbreaks, representing 5.5% of all reported animal outbreaks.Differences in the patterns observed across European countries may reflect a combination of ecological, climatic and surveillance-related factors. Favourable climatic conditions and the presence of ecological hotspots, such as wetlands and agricultural areas, may support mosquito vector populations and influence the distribution and behaviour of animal hosts, thereby facilitating WNV circulation. At the same time, differences in WNV surveillance systems across Europe may affect detection and reporting rates.The first indication of WNV activity may arise from either human or animal surveillance, depending on local epidemiology, detection capacity and surveillance system sensitivity. Therefore, the absence of reports from one sector should not be interpreted as evidence that WNV is not circulating. In France (Pyrénées-Orientales, FRJ15), Greece (Drama, EL514), and Italy (Genova, ITC33), human cases were reported before, or in the absence of, notified outbreaks in birds or equids. Conversely, in Belgium (Arr. Namur, BE352), France (Hauts-de-Seine, FR105 and Seine-et-Marne, FR102) and the Netherlands (Delft en Westland, NL362), animal detections preceded human cases. Belgium is a relevant example, as WNV was first reported in the country in 2025 through avian surveillance, with no previous detections in humans and animals. In 2026, it has again been identified in birds in a previously unaffected region, highlighting the role of avian surveillance in detecting local virus circulation and geographical spread.Active mosquito surveillance is also important for the early detection of WNV circulation. However, results on WNV detection in mosquitoes are not included in this report because they are not legally required to be reported at European level, and the available information is therefore scattered and often project-based.
SEASONAL OUTLOOK: Given the favourable weather conditions for WNV transmission in Europe, ECDC and EFSA expect further human cases and outbreaks in equids and birds to be reported in the coming weeks. In previous years, transmission has typically peaked in August and September.ECDC and EFSA continue to closely monitor the situation in Europe.},
}
RevDate: 2026-08-19
Correction: Detection of circovirus and herpesvirus co-infection in suddenly dead common ravens (Corvus corax).
Veterinary research communications, 50(6): pii:10.1007/s11259-026-11466-z.
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@article {pmid42616210,
year = {2026},
author = {Ledwoń, A and Sapierzyński, R and Dolka, B and Witkowska, D and Gbylik-Sikorska, M and Sell, B},
title = {Correction: Detection of circovirus and herpesvirus co-infection in suddenly dead common ravens (Corvus corax).},
journal = {Veterinary research communications},
volume = {50},
number = {6},
pages = {},
doi = {10.1007/s11259-026-11466-z},
pmid = {42616210},
issn = {1573-7446},
}
RevDate: 2026-08-19
CmpDate: 2026-08-19
Peter H. Raven: Botanist, evolutionary biologist, and biodiversity champion.
Proceedings of the National Academy of Sciences of the United States of America, 123(34):e2624553123.
Peter H. Raven was a transformative leader whose influence extended far beyond his own research. From a precocious childhood passion for natural history to landmark contributions to coevolution, ecological speciation, biogeography, and botanical systematics, his career reshaped modern plant science. He was also an extraordinary mentor, collaborator, and institution builder spending most of his career as Director of the Missouri Botanical Garden and professor at Washington University in Saint Louis, while taking leadership roles at the National Academy of Sciences, the National Geographic Society, and many other organizations. Raven advanced global biodiversity conservation and scientific infrastructure and worked tirelessly to provide opportunities for emerging scholars worldwide. His legacy lies not only in the breadth of his scholarship and public service but also in his enduring commitment to connecting people, fostering collaboration, and helping others realize their potential.
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@article {pmid42616793,
year = {2026},
author = {Losos, JB and Johnson, GB and Schaal, BA},
title = {Peter H. Raven: Botanist, evolutionary biologist, and biodiversity champion.},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {123},
number = {34},
pages = {e2624553123},
doi = {10.1073/pnas.2624553123},
pmid = {42616793},
issn = {1091-6490},
mesh = {*Biodiversity ; History, 20th Century ; *Biological Evolution ; History, 21st Century ; *Botany/history ; },
abstract = {Peter H. Raven was a transformative leader whose influence extended far beyond his own research. From a precocious childhood passion for natural history to landmark contributions to coevolution, ecological speciation, biogeography, and botanical systematics, his career reshaped modern plant science. He was also an extraordinary mentor, collaborator, and institution builder spending most of his career as Director of the Missouri Botanical Garden and professor at Washington University in Saint Louis, while taking leadership roles at the National Academy of Sciences, the National Geographic Society, and many other organizations. Raven advanced global biodiversity conservation and scientific infrastructure and worked tirelessly to provide opportunities for emerging scholars worldwide. His legacy lies not only in the breadth of his scholarship and public service but also in his enduring commitment to connecting people, fostering collaboration, and helping others realize their potential.},
}
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*Biodiversity
History, 20th Century
*Biological Evolution
History, 21st Century
*Botany/history
RevDate: 2026-08-19
Green monkeys' repertoires maintain consistency on Caribbean islands despite centuries of geographic isolation.
Folia primatologica; international journal of primatology [Epub ahead of print].
Green monkeys (Chlorocebus sabaeus) were introduced to the Caribbean in the 17th century. Since then, they have established isolated populations on the islands of Barbados, St. Kitts and St. Martin. This geographic distribution provides a unique opportunity to assess communication differences that may have arisen in these populations over this period of geographic isolation from the native West African population. Using an established vocal repertoire from monkeys living in Barbados, we investigated how call types may have diverged across these three islands. We collected vocal data from St. Kitts and St. Martin monkey populations and used Raven Pro to isolate vocalizations and collect acoustic measurements. We then statistically compared each call type to the same call type made in the other populations to identify areas of change. We found that the majority of call types did not drastically differ in acoustic parameters across islands, suggesting that vocal repertoires are largely conserved within species despite long periods of separation. However, some call types did exhibit differences in both acoustic parameters and degree of usage. For example, populations that experienced higher levels of human food provisioning made call types unique to these events. Further, the rates of call type usage varied across islands, illustrating an underlying dynamic of change in which monkey populations are shifting their vocal repertoires in response to variation within their environments. These findings emphasize the need for further investigation into how repertoires are impacted by other environmental, social, and anthropogenic factors.
Additional Links: PMID-42618045
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@article {pmid42618045,
year = {2026},
author = {Amrhein, RM and Eason, PK and Bastien, ISS and Huffman, HMA},
title = {Green monkeys' repertoires maintain consistency on Caribbean islands despite centuries of geographic isolation.},
journal = {Folia primatologica; international journal of primatology},
volume = {},
number = {},
pages = {1-15},
doi = {10.1163/14219980-bja10095},
pmid = {42618045},
issn = {1421-9980},
abstract = {Green monkeys (Chlorocebus sabaeus) were introduced to the Caribbean in the 17th century. Since then, they have established isolated populations on the islands of Barbados, St. Kitts and St. Martin. This geographic distribution provides a unique opportunity to assess communication differences that may have arisen in these populations over this period of geographic isolation from the native West African population. Using an established vocal repertoire from monkeys living in Barbados, we investigated how call types may have diverged across these three islands. We collected vocal data from St. Kitts and St. Martin monkey populations and used Raven Pro to isolate vocalizations and collect acoustic measurements. We then statistically compared each call type to the same call type made in the other populations to identify areas of change. We found that the majority of call types did not drastically differ in acoustic parameters across islands, suggesting that vocal repertoires are largely conserved within species despite long periods of separation. However, some call types did exhibit differences in both acoustic parameters and degree of usage. For example, populations that experienced higher levels of human food provisioning made call types unique to these events. Further, the rates of call type usage varied across islands, illustrating an underlying dynamic of change in which monkey populations are shifting their vocal repertoires in response to variation within their environments. These findings emphasize the need for further investigation into how repertoires are impacted by other environmental, social, and anthropogenic factors.},
}
RevDate: 2026-08-18
CmpDate: 2026-08-18
Aging Like Milk or Fine Wine: Content Analysis of Reactions to One's Future Self on TikTok.
JMIR aging, 9:e70794 pii:v9i1e70794.
BACKGROUND: The "aged" filter has gone viral on TikTok. This filter leverages AI to superimpose signs of aging, such as wrinkles, crow's feet, and sagging skin, onto a user's face. Notably, several dermatologists have attested to the accuracy of this filter in simulating the effects of aging. Reactions among the TikTok community have been mixed, with some utterly dismayed but others wholeheartedly embracing the sight of their aged visages.
OBJECTIVE: This study takes a deep dive into the ways in which TikTok users react to their aged selves through a content analysis of videos featuring the aged filter. Understanding how they respond to the filter can shed light on the types of meanings commonly attributed to old age as a social construct. The following research questions form the premise of our content analysis of videos on TikTok: (1) How do individuals react to the way their possible future selves look? (2) What types of attitudes toward old age are being conveyed in these videos? (3) What do these responses say about prevailing cultural beliefs, values, and attitudes toward old age?
METHODS: To build a comprehensive dataset, we compiled all publicly available videos (N=2682) using the following hashtags as search queries: "#AgedFilter," "#OldFilter," and "#AgeFilter." Collectively, these hashtags amassed >2,068,100,000 views at the time of writing this manuscript. After applying our exclusion criteria, the dataset comprised 681 videos, which received a total of 34,382,236 likes, 1,204,741 favorites, and 211,006 comments. Both deductive and inductive approaches informed our content analysis.
RESULTS: A total of 7 themes emerged from our content analysis. Half of the videos (n=342, 50%) fell under theme 1, "anxiety about aging." The second-largest theme (n=95, 14%) focused on the "pursuit of youthfulness" (theme 2). Theme 3 was about "aging with confidence" (n=84, 12%) and theme 4 was about the "beauty of aging" (n=54, 8%). Theme 5 examined the "privilege of aging" (n=48, 7%) and theme 6 examined "generational connections" (n=43, 6%). Theme 7 covered the "inevitability of aging" (n=15, 2%).
CONCLUSIONS: This study marks one of the first attempts to analyze videos using the aged filter on TikTok. Our findings suggest that ageist beliefs may be prevalent among some users. Going forward, there is value in adopting a definition of beauty that transcends age. By doing so, aging can be reframed as a natural part of life to be embraced rather than as a grim reality to be dreaded.
Additional Links: PMID-42612208
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@article {pmid42612208,
year = {2026},
author = {Ng, R and Indran, N},
title = {Aging Like Milk or Fine Wine: Content Analysis of Reactions to One's Future Self on TikTok.},
journal = {JMIR aging},
volume = {9},
number = {},
pages = {e70794},
doi = {10.2196/70794},
pmid = {42612208},
issn = {2561-7605},
mesh = {Humans ; *Aging/psychology/physiology ; *Skin Aging ; },
abstract = {BACKGROUND: The "aged" filter has gone viral on TikTok. This filter leverages AI to superimpose signs of aging, such as wrinkles, crow's feet, and sagging skin, onto a user's face. Notably, several dermatologists have attested to the accuracy of this filter in simulating the effects of aging. Reactions among the TikTok community have been mixed, with some utterly dismayed but others wholeheartedly embracing the sight of their aged visages.
OBJECTIVE: This study takes a deep dive into the ways in which TikTok users react to their aged selves through a content analysis of videos featuring the aged filter. Understanding how they respond to the filter can shed light on the types of meanings commonly attributed to old age as a social construct. The following research questions form the premise of our content analysis of videos on TikTok: (1) How do individuals react to the way their possible future selves look? (2) What types of attitudes toward old age are being conveyed in these videos? (3) What do these responses say about prevailing cultural beliefs, values, and attitudes toward old age?
METHODS: To build a comprehensive dataset, we compiled all publicly available videos (N=2682) using the following hashtags as search queries: "#AgedFilter," "#OldFilter," and "#AgeFilter." Collectively, these hashtags amassed >2,068,100,000 views at the time of writing this manuscript. After applying our exclusion criteria, the dataset comprised 681 videos, which received a total of 34,382,236 likes, 1,204,741 favorites, and 211,006 comments. Both deductive and inductive approaches informed our content analysis.
RESULTS: A total of 7 themes emerged from our content analysis. Half of the videos (n=342, 50%) fell under theme 1, "anxiety about aging." The second-largest theme (n=95, 14%) focused on the "pursuit of youthfulness" (theme 2). Theme 3 was about "aging with confidence" (n=84, 12%) and theme 4 was about the "beauty of aging" (n=54, 8%). Theme 5 examined the "privilege of aging" (n=48, 7%) and theme 6 examined "generational connections" (n=43, 6%). Theme 7 covered the "inevitability of aging" (n=15, 2%).
CONCLUSIONS: This study marks one of the first attempts to analyze videos using the aged filter on TikTok. Our findings suggest that ageist beliefs may be prevalent among some users. Going forward, there is value in adopting a definition of beauty that transcends age. By doing so, aging can be reframed as a natural part of life to be embraced rather than as a grim reality to be dreaded.},
}
MeSH Terms:
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Humans
*Aging/psychology/physiology
*Skin Aging
RevDate: 2026-08-17
Celebrating Jay Siegel's and Kim Baldridge's 65th birthdays.
Additional Links: PMID-42605560
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@article {pmid42605560,
year = {2026},
author = {Jessen, HJ and Stuparu, MC and Zysman-Colman, E},
title = {Celebrating Jay Siegel's and Kim Baldridge's 65th birthdays.},
journal = {Organic & biomolecular chemistry},
volume = {},
number = {},
pages = {},
doi = {10.1039/d6ob90095j},
pmid = {42605560},
issn = {1477-0539},
}
RevDate: 2026-08-17
Using Digital 3D Models for Faculty Calibration and Measurement of Calibration Effectiveness: A Feasibility Study.
Journal of dental education [Epub ahead of print].
PURPOSE: Faculty calibration is necessary for consistent assessment of dental students, yet many calibration activities rely on attendance, discussions, or static images rather than objective evidence of evaluator agreement. This study evaluated the feasibility of using digital three-dimensional (3D) tooth preparation models to support faculty calibration and measure calibration effectiveness.
METHODS: This feasibility study was conducted using anonymized standard tessellation language files exported from student full-coverage crown preparations in a preclinical fixed prosthodontics course. Ten representative cases were selected from approximately 200 preparations by two experienced faculty members to reflect a range of performance levels and common preparation errors. Fifteen faculty members participated in a 1-h calibration session that included rubric review, instruction on evaluation criteria, and orientation to the 3D viewing software. Faculty then independently evaluated each case across eight preparation criteria. Inter-rater reliability was analyzed using the intraclass correlation coefficient (ICC).
RESULTS: The mean completion time was 51.3 min. The average-measures ICC was 0.841, indicating good inter-rater agreement among faculty evaluators. Faculty feedback and implementation observations suggested that the digital 3D model environment, which allowed rotation, magnification, sectioning, and measurement, supported the visualization of preparation features that could be difficult to evaluate using two-dimensional images alone.
CONCLUSION: Digital 3D models provided a feasible method for faculty calibration and enabled objective measurement of calibration effectiveness. This approach may help dental schools move beyond attendance-based calibration toward evidence-based evaluation of faculty agreement, although additional studies are needed across institutions, procedures, and larger faculty samples.
Additional Links: PMID-42605798
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@article {pmid42605798,
year = {2026},
author = {Badr, Z and Tajik, M and Hamdan, M and Hodgson, BD},
title = {Using Digital 3D Models for Faculty Calibration and Measurement of Calibration Effectiveness: A Feasibility Study.},
journal = {Journal of dental education},
volume = {},
number = {},
pages = {},
doi = {10.1002/jdd.70347},
pmid = {42605798},
issn = {1930-7837},
abstract = {PURPOSE: Faculty calibration is necessary for consistent assessment of dental students, yet many calibration activities rely on attendance, discussions, or static images rather than objective evidence of evaluator agreement. This study evaluated the feasibility of using digital three-dimensional (3D) tooth preparation models to support faculty calibration and measure calibration effectiveness.
METHODS: This feasibility study was conducted using anonymized standard tessellation language files exported from student full-coverage crown preparations in a preclinical fixed prosthodontics course. Ten representative cases were selected from approximately 200 preparations by two experienced faculty members to reflect a range of performance levels and common preparation errors. Fifteen faculty members participated in a 1-h calibration session that included rubric review, instruction on evaluation criteria, and orientation to the 3D viewing software. Faculty then independently evaluated each case across eight preparation criteria. Inter-rater reliability was analyzed using the intraclass correlation coefficient (ICC).
RESULTS: The mean completion time was 51.3 min. The average-measures ICC was 0.841, indicating good inter-rater agreement among faculty evaluators. Faculty feedback and implementation observations suggested that the digital 3D model environment, which allowed rotation, magnification, sectioning, and measurement, supported the visualization of preparation features that could be difficult to evaluate using two-dimensional images alone.
CONCLUSION: Digital 3D models provided a feasible method for faculty calibration and enabled objective measurement of calibration effectiveness. This approach may help dental schools move beyond attendance-based calibration toward evidence-based evaluation of faculty agreement, although additional studies are needed across institutions, procedures, and larger faculty samples.},
}
RevDate: 2026-08-15
Ravens (Corvus corax) use conspecifics and heterospecifics to navigate risky foraging scenarios.
Behavioral ecology : official journal of the International Society for Behavioral Ecology, 37(5):arag093.
Foraging animals need to balance the trade-off between the benefits of exploiting new resources and the unknown risks they entail. Changing environments are especially challenging, as this balance between risk and reward needs to be constantly reevaluated. One strategy animals, and in particular scavengers employ, is using conspecifics and heterospecifics as sources of information to access food. In this study, we focused on free-ranging ravens that habitually forage in a wildlife park together with heterospecifics (boars) and tested their responses to unfamiliar and unpredictable foraging situations. In the 2-sites experiment (E1), we presented them with a choice between an unfamiliar (new) and a familiar (old) foraging site; in the object experiment (E2), we presented them with an object, otherwise not seen in the wildlife park, positioned randomly next to 1 of the sites. In both experiments, we found that ravens delayed their initial approach until the boars reached the food. In E1, ravens took longer to approach the food; stole more food from conspecifics but visited in larger numbers at the new site compared with the old. In conclusion: they flexibly used others, including heterospecifics, as sources of knowledge and means to access food. In E2, the object had a stronger aversive effect at the old site than at the new site, suggesting that the effect of unpredictability is stronger in familiar environments, where it might cause an expectancy violation. Our findings highlight that the behavior toward conspecifics and heterospecifics should be considered when studying scavengers' adaptability to changing environments.
Additional Links: PMID-42602813
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@article {pmid42602813,
year = {2026},
author = {Damini, S and Lindeman, A and Bapat, A and Sumasgutner, P and Bugnyar, T},
title = {Ravens (Corvus corax) use conspecifics and heterospecifics to navigate risky foraging scenarios.},
journal = {Behavioral ecology : official journal of the International Society for Behavioral Ecology},
volume = {37},
number = {5},
pages = {arag093},
pmid = {42602813},
issn = {1045-2249},
abstract = {Foraging animals need to balance the trade-off between the benefits of exploiting new resources and the unknown risks they entail. Changing environments are especially challenging, as this balance between risk and reward needs to be constantly reevaluated. One strategy animals, and in particular scavengers employ, is using conspecifics and heterospecifics as sources of information to access food. In this study, we focused on free-ranging ravens that habitually forage in a wildlife park together with heterospecifics (boars) and tested their responses to unfamiliar and unpredictable foraging situations. In the 2-sites experiment (E1), we presented them with a choice between an unfamiliar (new) and a familiar (old) foraging site; in the object experiment (E2), we presented them with an object, otherwise not seen in the wildlife park, positioned randomly next to 1 of the sites. In both experiments, we found that ravens delayed their initial approach until the boars reached the food. In E1, ravens took longer to approach the food; stole more food from conspecifics but visited in larger numbers at the new site compared with the old. In conclusion: they flexibly used others, including heterospecifics, as sources of knowledge and means to access food. In E2, the object had a stronger aversive effect at the old site than at the new site, suggesting that the effect of unpredictability is stronger in familiar environments, where it might cause an expectancy violation. Our findings highlight that the behavior toward conspecifics and heterospecifics should be considered when studying scavengers' adaptability to changing environments.},
}
RevDate: 2026-08-14
CmpDate: 2026-08-14
Helmintological Examination of Pica pica (Linnaeus, 1758) (Passeriformes: Corvidae) Specimens Collected from Bursa and Its Surroundings in Türkiye.
Iranian journal of parasitology, 21(2):205-226.
BACKGROUND: The Eurasian magpie, Pica pica (Linnaeus, 1758), is a widely distributed bird species inhabiting both rural and urban environments in Türkiye. Despite its ecological importance, information on its helminth fauna remains limited. We aimed to investigate the helminth fauna of P. pica specimens collected in Bursa Province and to contribute to the knowledge of parasite biodiversity in Türkiye.
METHODS: A total of 53 P. pica specimens, brought dead between June 2015 and August 2025 from Bursa Zoo and the Celal Acar Wildlife Rescue and Rehabilitation Center (Karacabey Ova Korusu, Bursa, Türkiye), were examined for helminths using standard parasitological techniques. Recovered helminths were identified morphologically.
RESULTS: Ten helminth species were identified: Brachylaima fuscata (Rudolphi, 1819) Joyeux, Baer & Timon-David, 1932, B. lobatum (Railliet, 1900), Lyperosomum longicauda (Rudolphi, 1809) (Digenea); Raillietina echinobothrida (Megnin, 1881), Passerilepis stylosa (Rudolphi, 1809), Choanotaenia macracantha (Krabbe, 1869) (Cestoda); Dispharynx nasuta (Rudolphi, 1819), Baruscapillaria obsignata (Madsen, 1945) Moravec, 1982, B. resecta (Dujardin, 1845) (Nematoda); and Sphaerirostris picae (Rudolphi, 1819) (Acanthocephala). R. echinobothrida, C. macracantha, B. obsignata, and B. resecta were recorded from P. pica for the first time worldwide. In addition, B. fuscata, B. lobatum, L. longicauda, C. macracantha, P. stylosa, and B. resecta represent new records for the helminth fauna of Türkiye.
CONCLUSION: This study expands current knowledge of the helminth fauna of P. pica and provides several novel host and geographical records. The findings highlight the importance of continued parasitological investigations of wild birds in Türkiye to improve our understanding of parasite diversity and host-parasite associations.
Additional Links: PMID-42598544
PubMed:
Citation:
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@article {pmid42598544,
year = {2026},
author = {Warsame Dirshe, M and Yıldırımhan, HS and Civil, Y and Redhwan, AM and Yıldırım, S and Hassan, AA},
title = {Helmintological Examination of Pica pica (Linnaeus, 1758) (Passeriformes: Corvidae) Specimens Collected from Bursa and Its Surroundings in Türkiye.},
journal = {Iranian journal of parasitology},
volume = {21},
number = {2},
pages = {205-226},
pmid = {42598544},
issn = {1735-7020},
abstract = {BACKGROUND: The Eurasian magpie, Pica pica (Linnaeus, 1758), is a widely distributed bird species inhabiting both rural and urban environments in Türkiye. Despite its ecological importance, information on its helminth fauna remains limited. We aimed to investigate the helminth fauna of P. pica specimens collected in Bursa Province and to contribute to the knowledge of parasite biodiversity in Türkiye.
METHODS: A total of 53 P. pica specimens, brought dead between June 2015 and August 2025 from Bursa Zoo and the Celal Acar Wildlife Rescue and Rehabilitation Center (Karacabey Ova Korusu, Bursa, Türkiye), were examined for helminths using standard parasitological techniques. Recovered helminths were identified morphologically.
RESULTS: Ten helminth species were identified: Brachylaima fuscata (Rudolphi, 1819) Joyeux, Baer & Timon-David, 1932, B. lobatum (Railliet, 1900), Lyperosomum longicauda (Rudolphi, 1809) (Digenea); Raillietina echinobothrida (Megnin, 1881), Passerilepis stylosa (Rudolphi, 1809), Choanotaenia macracantha (Krabbe, 1869) (Cestoda); Dispharynx nasuta (Rudolphi, 1819), Baruscapillaria obsignata (Madsen, 1945) Moravec, 1982, B. resecta (Dujardin, 1845) (Nematoda); and Sphaerirostris picae (Rudolphi, 1819) (Acanthocephala). R. echinobothrida, C. macracantha, B. obsignata, and B. resecta were recorded from P. pica for the first time worldwide. In addition, B. fuscata, B. lobatum, L. longicauda, C. macracantha, P. stylosa, and B. resecta represent new records for the helminth fauna of Türkiye.
CONCLUSION: This study expands current knowledge of the helminth fauna of P. pica and provides several novel host and geographical records. The findings highlight the importance of continued parasitological investigations of wild birds in Türkiye to improve our understanding of parasite diversity and host-parasite associations.},
}
RevDate: 2026-08-14
CmpDate: 2026-08-14
Trace element accumulation in hooded crow nestlings: tissue- and age-specific patterns and implications for avian biomonitoring in riverine wetlands.
Environmental monitoring and assessment, 198(9):.
Floodplain wetlands are dynamic ecosystems that may receive pollutants transported from upstream areas, but local exposure of wildlife to trace elements can vary depending on hydrology, bioavailability, habitat structure, and diet. In this study, we assessed the concentrations of potentially toxic non-essential elements (Cd, Pb, As) and essential elements (Cu, Se, Zn) in the blood and feathers of hooded crow (Corvus cornix) nestlings from a riverine wetland in Warta Mouth National Park, western Poland. Samples were collected at two developmental stages and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Concentrations of Cd, Pb, and As were consistently low in both tissues, suggesting limited exposure and/or low bioavailability of these elements in the local food web used by this omnivorous wetland-associated species. Element concentrations varied with nestling age. Older nestlings had higher blood Cu and Se concentrations. In feathers, Cd and Cu concentrations were also higher in older nestlings, whereas Zn concentrations were lower than at the earlier growth stage. These age-related differences may reflect a combination of physiological regulation, growth requirements, tissue-specific deposition, feather development, and element-specific toxicokinetics. No significant relationships were found between blood and feather concentrations, indicating that these matrices provide complementary information on exposure during nestling development. Feather Zn concentration was positively associated with nestling body condition, whereas no such relationship was detected for potentially toxic non-essential elements. Our findings highlight the importance of considering tissue type, feather ontogeny, and nestling growth stage when interpreting trace element concentrations in avian biomonitoring.
Additional Links: PMID-42599537
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@article {pmid42599537,
year = {2026},
author = {Zduniak, P and Kosicki, JZ and Komorowicz, I},
title = {Trace element accumulation in hooded crow nestlings: tissue- and age-specific patterns and implications for avian biomonitoring in riverine wetlands.},
journal = {Environmental monitoring and assessment},
volume = {198},
number = {9},
pages = {},
pmid = {42599537},
issn = {1573-2959},
mesh = {Animals ; *Wetlands ; *Trace Elements/metabolism/analysis ; *Environmental Monitoring/methods ; *Crows/metabolism ; Feathers/chemistry/metabolism ; *Environmental Pollutants/metabolism ; Poland ; },
abstract = {Floodplain wetlands are dynamic ecosystems that may receive pollutants transported from upstream areas, but local exposure of wildlife to trace elements can vary depending on hydrology, bioavailability, habitat structure, and diet. In this study, we assessed the concentrations of potentially toxic non-essential elements (Cd, Pb, As) and essential elements (Cu, Se, Zn) in the blood and feathers of hooded crow (Corvus cornix) nestlings from a riverine wetland in Warta Mouth National Park, western Poland. Samples were collected at two developmental stages and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Concentrations of Cd, Pb, and As were consistently low in both tissues, suggesting limited exposure and/or low bioavailability of these elements in the local food web used by this omnivorous wetland-associated species. Element concentrations varied with nestling age. Older nestlings had higher blood Cu and Se concentrations. In feathers, Cd and Cu concentrations were also higher in older nestlings, whereas Zn concentrations were lower than at the earlier growth stage. These age-related differences may reflect a combination of physiological regulation, growth requirements, tissue-specific deposition, feather development, and element-specific toxicokinetics. No significant relationships were found between blood and feather concentrations, indicating that these matrices provide complementary information on exposure during nestling development. Feather Zn concentration was positively associated with nestling body condition, whereas no such relationship was detected for potentially toxic non-essential elements. Our findings highlight the importance of considering tissue type, feather ontogeny, and nestling growth stage when interpreting trace element concentrations in avian biomonitoring.},
}
MeSH Terms:
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Animals
*Wetlands
*Trace Elements/metabolism/analysis
*Environmental Monitoring/methods
*Crows/metabolism
Feathers/chemistry/metabolism
*Environmental Pollutants/metabolism
Poland
RevDate: 2026-08-13
CmpDate: 2026-08-13
Household mental distress and child cognitive development in Ghana.
Frontiers in psychology, 17:1840678.
INTRODUCTION: Household mental wellbeing plays an important role in children's cognitive development, yet evidence from developing countries remains limited. This study examines the relationship between household mental distress and children's cognitive development in Ghana.
METHODS: We use nationally representative longitudinal data from the Ghana Socioeconomic Panel Survey (2009-2010, 2013-2014, and 2018), comprising 8,755 children aged 5-17 years. Children's cognitive ability is measured using a composite index derived from the Digit Span Forward, Digit Span Backward, and Raven's Progressive Matrices assessments. Household mental distress is measured using the average Kessler Psychological Distress Scale (K10) score of adults in the household. To address potential endogeneity, we employ a leave-one-out community mental distress instrumental variable and supplement the analysis with alternative instrumental-variable specifications, treatment matching, and placebo tests.
RESULTS: Across all estimation approaches, children living in mentally distressed households exhibit significantly lower cognitive performance than children in non-distressed households. Estimated effects range from 0.43 to 0.49 standard deviations and are observed among both pre-teens (5-12 years) and adolescents (13-17 years). Analyses using a continuous measure of household mental distress produce similar findings consistent with a dose-response relationship.
DISCUSSION: Household mental distress is strongly associated with children's cognitive development in Ghana. Policies aimed at improving children's developmental outcomes may therefore benefit from greater attention to adult mental health within households.
Additional Links: PMID-42591129
PubMed:
Citation:
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@article {pmid42591129,
year = {2026},
author = {Asiedu, E and Adjoh-Baliki, A and Opoku, A},
title = {Household mental distress and child cognitive development in Ghana.},
journal = {Frontiers in psychology},
volume = {17},
number = {},
pages = {1840678},
pmid = {42591129},
issn = {1664-1078},
abstract = {INTRODUCTION: Household mental wellbeing plays an important role in children's cognitive development, yet evidence from developing countries remains limited. This study examines the relationship between household mental distress and children's cognitive development in Ghana.
METHODS: We use nationally representative longitudinal data from the Ghana Socioeconomic Panel Survey (2009-2010, 2013-2014, and 2018), comprising 8,755 children aged 5-17 years. Children's cognitive ability is measured using a composite index derived from the Digit Span Forward, Digit Span Backward, and Raven's Progressive Matrices assessments. Household mental distress is measured using the average Kessler Psychological Distress Scale (K10) score of adults in the household. To address potential endogeneity, we employ a leave-one-out community mental distress instrumental variable and supplement the analysis with alternative instrumental-variable specifications, treatment matching, and placebo tests.
RESULTS: Across all estimation approaches, children living in mentally distressed households exhibit significantly lower cognitive performance than children in non-distressed households. Estimated effects range from 0.43 to 0.49 standard deviations and are observed among both pre-teens (5-12 years) and adolescents (13-17 years). Analyses using a continuous measure of household mental distress produce similar findings consistent with a dose-response relationship.
DISCUSSION: Household mental distress is strongly associated with children's cognitive development in Ghana. Policies aimed at improving children's developmental outcomes may therefore benefit from greater attention to adult mental health within households.},
}
RevDate: 2026-08-12
CmpDate: 2026-08-12
Assessing the Intelligence Quotient of 5-10-year-old Children in Salem District, India with Varying Fluoride Levels: A Cross-sectional Study.
International journal of clinical pediatric dentistry, 19(7):851-856.
AIM AND BACKGROUND: Prolonged exposure to excessive fluoride can cause fluorosis and affect the developing brain by crossing the placental and blood-brain barriers. Salem district, with an average groundwater fluoride concentration of 3.7 ppm, which exceeds the recommended levels, provides a setting to explore its impact on children's intelligence quotient (IQ). The aim of the study was to assess and correlate the IQ levels of children in the age group of 5-10 with fluoride levels in water using Raven's Colored Progressive Matrices (RCPM).
MATERIALS AND METHODS: This study employed a cross-sectional design to study a cohort of 5-10-year-old children in Salem. Participants were selected based on groundwater fluoride levels (<1.0 ppm, 1.0 ppm, and ≥1.0 ppm). The study included children born and raised in Salem, whose mothers resided there during pregnancy. Children with a history of brain diseases were excluded. Parents completed a validated modified questionnaire by Makharia et al., and socioeconomic status was rated using the Updated Modified Kuppuswamy Scale (2021). Children's intellectual ability was assessed with the RCPM under a trained psychologist's supervision, and IQ scores were classified per the Current Wechsler classification. Data were analyzed using chi-square tests, regression analysis, and Spearman's correlation.
RESULTS: Among the five areas assessed, Ayothiyapattinam had the highest fluoride levels, and Attayampatti the lowest. Children in low-fluoride areas had a higher proportion in the superior IQ group (5.6%) than those in high-fluoride areas (1.5%).
CONCLUSION: Elevated fluoride levels were linked to lower IQ scores, with no significant association between socioeconomic status and IQ.
CLINICAL SIGNIFICANCE: This study underscores the relatively underexplored effects of fluoride on neurodevelopment, demonstrating its potential to adversely impact children's IQ when exposure exceeds recommended limits. Maintaining optimal fluoride levels is essential to achieving a balance between its protective benefits for dental health and its implications for cognitive development.
Additional Links: PMID-42582294
PubMed:
Citation:
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@article {pmid42582294,
year = {2026},
author = {Rajan, RE and Arali, V and Gunasekaran, S and Duraisamy, V and Gainneos, PD and Latkar, Y and John, JB},
title = {Assessing the Intelligence Quotient of 5-10-year-old Children in Salem District, India with Varying Fluoride Levels: A Cross-sectional Study.},
journal = {International journal of clinical pediatric dentistry},
volume = {19},
number = {7},
pages = {851-856},
pmid = {42582294},
issn = {0974-7052},
abstract = {AIM AND BACKGROUND: Prolonged exposure to excessive fluoride can cause fluorosis and affect the developing brain by crossing the placental and blood-brain barriers. Salem district, with an average groundwater fluoride concentration of 3.7 ppm, which exceeds the recommended levels, provides a setting to explore its impact on children's intelligence quotient (IQ). The aim of the study was to assess and correlate the IQ levels of children in the age group of 5-10 with fluoride levels in water using Raven's Colored Progressive Matrices (RCPM).
MATERIALS AND METHODS: This study employed a cross-sectional design to study a cohort of 5-10-year-old children in Salem. Participants were selected based on groundwater fluoride levels (<1.0 ppm, 1.0 ppm, and ≥1.0 ppm). The study included children born and raised in Salem, whose mothers resided there during pregnancy. Children with a history of brain diseases were excluded. Parents completed a validated modified questionnaire by Makharia et al., and socioeconomic status was rated using the Updated Modified Kuppuswamy Scale (2021). Children's intellectual ability was assessed with the RCPM under a trained psychologist's supervision, and IQ scores were classified per the Current Wechsler classification. Data were analyzed using chi-square tests, regression analysis, and Spearman's correlation.
RESULTS: Among the five areas assessed, Ayothiyapattinam had the highest fluoride levels, and Attayampatti the lowest. Children in low-fluoride areas had a higher proportion in the superior IQ group (5.6%) than those in high-fluoride areas (1.5%).
CONCLUSION: Elevated fluoride levels were linked to lower IQ scores, with no significant association between socioeconomic status and IQ.
CLINICAL SIGNIFICANCE: This study underscores the relatively underexplored effects of fluoride on neurodevelopment, demonstrating its potential to adversely impact children's IQ when exposure exceeds recommended limits. Maintaining optimal fluoride levels is essential to achieving a balance between its protective benefits for dental health and its implications for cognitive development.},
}
RevDate: 2026-08-12
CmpDate: 2026-08-12
Evaluating the Correlation between IQ and Behavior of 5-10-year-old Children in Dental Operatory: A Cross-sectional Study.
International journal of clinical pediatric dentistry, 19(7):807-813.
BACKGROUND: Children with higher intelligence quotients (IQs) tend to manage dental stress better, follow instructions, and cooperate calmly. Lower IQs may correlate with increased anxiety and reduced compliance. Recognizing these behavioral patterns enables clinicians to tailor supportive approaches, enhancing treatment experiences and outcomes.
AIM: This study aimed to evaluate and compare the relation between children's IQ and their behavior in the dental operatory.
MATERIALS AND METHODS: This study evaluated how the IQ of children aged 5-10 years influenced their cooperation during dental treatments. A total of 180 children with no previous dental history, requiring pulpectomy or extraction in primary teeth, were selected for the study. All participants received local anesthesia before the procedure. The children's IQs were measured using the Raven's Progressive Matrices test, and the treatments were subsequently performed. Cooperation levels were assessed using the Modified Frankl's behavior rating scale, ranging from 1 (definitely negative) to 5 (definitely positive). The study analyzed the relationship between IQ scores and the type of cooperative behavior during dental procedures.
RESULTS: This study establishes a statistically significant link between higher IQ and better behavioral cooperation in children during pediatric dental procedures. Integrating cognitive assessment can enhance behavior management strategies and optimize clinical outcomes.
CONCLUSION: High IQ enhances children's adaptability in dental settings, enabling tailored behavior modification strategies for more effective treatment outcomes.
CLINICAL SIGNIFICANCE: Understanding a child's IQ helps dentists choose better behavior techniques, improving cooperation and treatment success.
Additional Links: PMID-42582761
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Citation:
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@article {pmid42582761,
year = {2026},
author = {Chauhan, S and Sheoran, N and Saraf, BG and Gupta, C and Vashist, S and Garg, P},
title = {Evaluating the Correlation between IQ and Behavior of 5-10-year-old Children in Dental Operatory: A Cross-sectional Study.},
journal = {International journal of clinical pediatric dentistry},
volume = {19},
number = {7},
pages = {807-813},
pmid = {42582761},
issn = {0974-7052},
abstract = {BACKGROUND: Children with higher intelligence quotients (IQs) tend to manage dental stress better, follow instructions, and cooperate calmly. Lower IQs may correlate with increased anxiety and reduced compliance. Recognizing these behavioral patterns enables clinicians to tailor supportive approaches, enhancing treatment experiences and outcomes.
AIM: This study aimed to evaluate and compare the relation between children's IQ and their behavior in the dental operatory.
MATERIALS AND METHODS: This study evaluated how the IQ of children aged 5-10 years influenced their cooperation during dental treatments. A total of 180 children with no previous dental history, requiring pulpectomy or extraction in primary teeth, were selected for the study. All participants received local anesthesia before the procedure. The children's IQs were measured using the Raven's Progressive Matrices test, and the treatments were subsequently performed. Cooperation levels were assessed using the Modified Frankl's behavior rating scale, ranging from 1 (definitely negative) to 5 (definitely positive). The study analyzed the relationship between IQ scores and the type of cooperative behavior during dental procedures.
RESULTS: This study establishes a statistically significant link between higher IQ and better behavioral cooperation in children during pediatric dental procedures. Integrating cognitive assessment can enhance behavior management strategies and optimize clinical outcomes.
CONCLUSION: High IQ enhances children's adaptability in dental settings, enabling tailored behavior modification strategies for more effective treatment outcomes.
CLINICAL SIGNIFICANCE: Understanding a child's IQ helps dentists choose better behavior techniques, improving cooperation and treatment success.},
}
RevDate: 2026-08-10
Carriage of ESBL-Producing Enterobacterales in Urban and Rural Hooded Crows in Hungary.
Journal of global antimicrobial resistance pii:S2213-7165(26)00138-4 [Epub ahead of print].
BACKGROUND: Considering the increasing reports of antimicrobial resistance (AMR) in wildlife, highlighting its complexity, importance, and spread. We investigated the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in the hooded crow.
METHODS: Faecal samples were collected from 52 rural and 212 urban wild crows in Hungary, caught using ladder traps, and tested for ESBL presence. Bacterial species were identified using MALDI-TOF. Antibiotic susceptibility was tested using the disc diffusion method, and ESBL producers were detected based on double-disc synergy. ESBL-encoding genes were identified using PCR, and WGS was performed on isolated ESBL-producing E. coli (197/221 isolated ESBLs).
RESULTS: Four of the sampled rural hooded crows and 130 urban ones (7.7% vs. 61%, chi-square p < 0.0001) yielded ESBL producers with the overwhelming dominance of E. coli. The blaCTX-M-1 group was predominant in both groups. In addition to CTX-M genes, genes encoding resistance to other antibiotic classes, such as APHs, sul genes, tet genes, etc, various virulence factors, and several incompatible plasmids were also detected. Most isolates belonged to the B1 and A phylogenetic groups. Overall, 22 sequence types (STs) and 33 distinct cgSTs were defined. The most prevalent ST was ST58, followed by ST10, S38, ST155, ST442, and more.
CONCLUSIONS: The much higher carrier frequency among urban crows points to the role of anthropogenic sources in the emergence of ESBL producers. Hooded crows, due to their increasing presence in cities and proximity to humans, likely facilitate the dissemination of ESBL producers between the environment and humans.
Additional Links: PMID-42575312
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PubMed:
Citation:
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@article {pmid42575312,
year = {2026},
author = {Benmazouz, I and Kövér, L and Laczkó, L and Gyure, P and Kardos, G},
title = {Carriage of ESBL-Producing Enterobacterales in Urban and Rural Hooded Crows in Hungary.},
journal = {Journal of global antimicrobial resistance},
volume = {},
number = {},
pages = {},
doi = {10.1016/j.jgar.2026.08.004},
pmid = {42575312},
issn = {2213-7173},
abstract = {BACKGROUND: Considering the increasing reports of antimicrobial resistance (AMR) in wildlife, highlighting its complexity, importance, and spread. We investigated the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in the hooded crow.
METHODS: Faecal samples were collected from 52 rural and 212 urban wild crows in Hungary, caught using ladder traps, and tested for ESBL presence. Bacterial species were identified using MALDI-TOF. Antibiotic susceptibility was tested using the disc diffusion method, and ESBL producers were detected based on double-disc synergy. ESBL-encoding genes were identified using PCR, and WGS was performed on isolated ESBL-producing E. coli (197/221 isolated ESBLs).
RESULTS: Four of the sampled rural hooded crows and 130 urban ones (7.7% vs. 61%, chi-square p < 0.0001) yielded ESBL producers with the overwhelming dominance of E. coli. The blaCTX-M-1 group was predominant in both groups. In addition to CTX-M genes, genes encoding resistance to other antibiotic classes, such as APHs, sul genes, tet genes, etc, various virulence factors, and several incompatible plasmids were also detected. Most isolates belonged to the B1 and A phylogenetic groups. Overall, 22 sequence types (STs) and 33 distinct cgSTs were defined. The most prevalent ST was ST58, followed by ST10, S38, ST155, ST442, and more.
CONCLUSIONS: The much higher carrier frequency among urban crows points to the role of anthropogenic sources in the emergence of ESBL producers. Hooded crows, due to their increasing presence in cities and proximity to humans, likely facilitate the dissemination of ESBL producers between the environment and humans.},
}
RevDate: 2026-08-08
CmpDate: 2026-08-08
Detection of circovirus and herpesvirus co-infection in suddenly dead.
Veterinary research communications, 50(5):.
This article investigates the causes of the sudden death of six common ravens (Corvus corax). All six birds were found on the same day in central Poland. The ravens were necropsied, and samples were collected for bacteriological, histopathological, and toxicological examinations. The presence of genetic material from common viral and some bacterial pathogens was examined using molecular methods. The ravens were found to be in good nutritional condition. Two birds had enlarged spleens with petechiae on their surface. Histopathological examination revealed multifocal hemorrhages and inflammatory infiltrates composed of mononuclear cells in the liver, and intranuclear inclusion bodies in hepatocytes. In the kidneys, inflammation, hemorrhages, parenchymal degeneration, and necrosis of the renal tubular epithelium were detected. Mild lymphocytic-plasmacytic inflammation was found in the intestines. Molecular tests were performed for circoviruses, herpesviruses, flaviviruses, adenoviruses, polyomavirus, avian bornavirus, avian paramyxovirus-1, rotavirus, avian reovirus, avian influenza viruses, Chlamydia spp., Salmonella spp., Clostridium spp., botulin toxins (A-E). Only PCR tests for circoviruses and herpesviruses yielded positive results. Toxicological tests were performed for the presence of organophosphate pesticides, rodenticides, coccidiostats, mycotoxins, and fungicides. Low and trace concentrations of brodifacoum (an anticoagulant rodenticide) and pentobarbital (a barbiturate) were detected. The remaining results were negative. There is a strong suspicion that the primary cause of death in the studied birds was raven herpesvirus, described in this case for the first time, with possible involvement of circovirus. However, other factors, including poisoning or other unknown viruses, cannot be ruled out. Although the toxicology profile was broad, it did not include all possible toxins.
Additional Links: PMID-42570032
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@article {pmid42570032,
year = {2026},
author = {Ledwoń, A and Sapierzyński, R and Dolka, B and Witkowska, D and Gbylik-Sikorska, M and Sell, B},
title = {Detection of circovirus and herpesvirus co-infection in suddenly dead.},
journal = {Veterinary research communications},
volume = {50},
number = {5},
pages = {},
pmid = {42570032},
issn = {1573-7446},
mesh = {Animals ; *Circovirus/isolation & purification ; *Coinfection/veterinary/virology ; *Bird Diseases/virology/pathology/mortality ; *Herpesviridae Infections/veterinary/virology/pathology ; *Circoviridae Infections/veterinary/virology/pathology ; *Death, Sudden/veterinary/etiology ; *Herpesviridae/isolation & purification ; Poland ; Male ; },
abstract = {This article investigates the causes of the sudden death of six common ravens (Corvus corax). All six birds were found on the same day in central Poland. The ravens were necropsied, and samples were collected for bacteriological, histopathological, and toxicological examinations. The presence of genetic material from common viral and some bacterial pathogens was examined using molecular methods. The ravens were found to be in good nutritional condition. Two birds had enlarged spleens with petechiae on their surface. Histopathological examination revealed multifocal hemorrhages and inflammatory infiltrates composed of mononuclear cells in the liver, and intranuclear inclusion bodies in hepatocytes. In the kidneys, inflammation, hemorrhages, parenchymal degeneration, and necrosis of the renal tubular epithelium were detected. Mild lymphocytic-plasmacytic inflammation was found in the intestines. Molecular tests were performed for circoviruses, herpesviruses, flaviviruses, adenoviruses, polyomavirus, avian bornavirus, avian paramyxovirus-1, rotavirus, avian reovirus, avian influenza viruses, Chlamydia spp., Salmonella spp., Clostridium spp., botulin toxins (A-E). Only PCR tests for circoviruses and herpesviruses yielded positive results. Toxicological tests were performed for the presence of organophosphate pesticides, rodenticides, coccidiostats, mycotoxins, and fungicides. Low and trace concentrations of brodifacoum (an anticoagulant rodenticide) and pentobarbital (a barbiturate) were detected. The remaining results were negative. There is a strong suspicion that the primary cause of death in the studied birds was raven herpesvirus, described in this case for the first time, with possible involvement of circovirus. However, other factors, including poisoning or other unknown viruses, cannot be ruled out. Although the toxicology profile was broad, it did not include all possible toxins.},
}
MeSH Terms:
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Animals
*Circovirus/isolation & purification
*Coinfection/veterinary/virology
*Bird Diseases/virology/pathology/mortality
*Herpesviridae Infections/veterinary/virology/pathology
*Circoviridae Infections/veterinary/virology/pathology
*Death, Sudden/veterinary/etiology
*Herpesviridae/isolation & purification
Poland
Male
RevDate: 2026-08-05
Hop, hop and away: On the take-off of Archaeopteryx using a multiple leaping mechanism.
Developmental biology pii:S0012-1606(26)00164-8 [Epub ahead of print].
Archaeopteryx, the iconic 150-million-year-old basal bird, lies at the heart of the debate on the origin of avian flight. While its asymmetric wing feathers indicate some flight capability, its limited shoulder mobility and reduced feather asymmetry suggest it lacked the capacity for the single, powerful leap used by modern birds for rapid take-off. Observations of extant birds reveal that many species, including corvids, employ multiple bipedal leaps with minimal wing assistance to gradually accelerate during take-off, particularly in low-stress contexts. Given Archaeopteryx's robust hindlimbs, we hypothesized that it could have used a similar multi-leap strategy to become airborne. We therefore tested the hypothesis that Archaeopteryx could generate sufficient take-off velocity via multiple hops or leaps. To test this, we developed a biomechanical model based on experimental take-off data from living birds, adapted to Archaeopteryx's anatomy. By analysing joint moments at the hip, knee, and ankle, alongside muscle capacity, we estimated its take-off velocity. Our results demonstrate that Archaeopteryx could have achieved its minimum sustainable flight speed in as few as two to three leaps, without requiring the energetically demanding single leap of modern birds. This study provides the first quantitative support for a ground-up, multi-leap take-off mechanism in early birds, distinct from the single-leap strategy usually observed today. We propose that the modern avian take-off may have evolved from this primitive multi-leap behaviour, offering new insights into the biomechanical transition from terrestrial locomotion to powered flight.
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@article {pmid42556771,
year = {2026},
author = {Meilak, EA and Gostling, NJ and Palmer, C and Provini, P and Heller, MO},
title = {Hop, hop and away: On the take-off of Archaeopteryx using a multiple leaping mechanism.},
journal = {Developmental biology},
volume = {},
number = {},
pages = {},
doi = {10.1016/j.ydbio.2026.07.018},
pmid = {42556771},
issn = {1095-564X},
abstract = {Archaeopteryx, the iconic 150-million-year-old basal bird, lies at the heart of the debate on the origin of avian flight. While its asymmetric wing feathers indicate some flight capability, its limited shoulder mobility and reduced feather asymmetry suggest it lacked the capacity for the single, powerful leap used by modern birds for rapid take-off. Observations of extant birds reveal that many species, including corvids, employ multiple bipedal leaps with minimal wing assistance to gradually accelerate during take-off, particularly in low-stress contexts. Given Archaeopteryx's robust hindlimbs, we hypothesized that it could have used a similar multi-leap strategy to become airborne. We therefore tested the hypothesis that Archaeopteryx could generate sufficient take-off velocity via multiple hops or leaps. To test this, we developed a biomechanical model based on experimental take-off data from living birds, adapted to Archaeopteryx's anatomy. By analysing joint moments at the hip, knee, and ankle, alongside muscle capacity, we estimated its take-off velocity. Our results demonstrate that Archaeopteryx could have achieved its minimum sustainable flight speed in as few as two to three leaps, without requiring the energetically demanding single leap of modern birds. This study provides the first quantitative support for a ground-up, multi-leap take-off mechanism in early birds, distinct from the single-leap strategy usually observed today. We propose that the modern avian take-off may have evolved from this primitive multi-leap behaviour, offering new insights into the biomechanical transition from terrestrial locomotion to powered flight.},
}
RevDate: 2026-08-06
CmpDate: 2026-08-06
RAVEN: Robust, generalizable, multi-resolution structural MRI upsampling using autoencoders.
Imaging neuroscience (Cambridge, Mass.), 4:.
Due to their high inter-tissue contrast, Magnetic resonance images (MRIs) can reflect neuroanatomical changes related to healthy aging and pathological processes. However, standard brain MRI acquisition resolutions hinder the ability to measure the more subtle changes that occur in early disease stages. Increasing the resolution during acquisition poses multiple challenges, including increased noise, higher acquisition times and cost, and discomfort of the scanned individual. In this work, we propose a robust, generalizable single-image super-resolution network for brain MRIs named Resolution Augmentation with Variational auto-Encoder Networks (RAVEN) with generative adversarial networks (GANs). We show RAVEN is capable of upsampling in-vivo and ex-vivo MRIs of diverse modalities (e.g. T1-weighted, T2-weighted, and T2*) and varying field strengths (3T to 7T) to target voxel sizes as small as 0.5 mm isotropic using arbitrary upsampling factors. RAVEN achieved state-of-the-art performance against deep learning and non-deep learning methods, best preserving true anatomical information. We have also made RAVEN open access, with the source code as well as training and evaluation scripts available and ready to use at: https://github.com/waadgo/raven.
Additional Links: PMID-42559373
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@article {pmid42559373,
year = {2026},
author = {Adame-Gonzalez, W and Moqadam, R and Zeighami, Y and Dadar, M},
title = {RAVEN: Robust, generalizable, multi-resolution structural MRI upsampling using autoencoders.},
journal = {Imaging neuroscience (Cambridge, Mass.)},
volume = {4},
number = {},
pages = {},
pmid = {42559373},
issn = {2837-6056},
abstract = {Due to their high inter-tissue contrast, Magnetic resonance images (MRIs) can reflect neuroanatomical changes related to healthy aging and pathological processes. However, standard brain MRI acquisition resolutions hinder the ability to measure the more subtle changes that occur in early disease stages. Increasing the resolution during acquisition poses multiple challenges, including increased noise, higher acquisition times and cost, and discomfort of the scanned individual. In this work, we propose a robust, generalizable single-image super-resolution network for brain MRIs named Resolution Augmentation with Variational auto-Encoder Networks (RAVEN) with generative adversarial networks (GANs). We show RAVEN is capable of upsampling in-vivo and ex-vivo MRIs of diverse modalities (e.g. T1-weighted, T2-weighted, and T2*) and varying field strengths (3T to 7T) to target voxel sizes as small as 0.5 mm isotropic using arbitrary upsampling factors. RAVEN achieved state-of-the-art performance against deep learning and non-deep learning methods, best preserving true anatomical information. We have also made RAVEN open access, with the source code as well as training and evaluation scripts available and ready to use at: https://github.com/waadgo/raven.},
}
RevDate: 2026-08-05
Intelligence quotient in children with dental fluorosis in rural areas of Paraíba.
Caries research pii:000553756 [Epub ahead of print].
INTRODUCTION: Concerns about possible neurotoxicity related to fluoride exposure remain controversial, and evidence is heterogeneous across exposure ranges and study settings. This study evaluated the association between dental fluorosis and intelligence quotient (IQ) among children living in rural areas of Paraíba, Brazil.
METHODS: A nested case-control study was conducted within a cross-sectional survey. Participants were matched 1:1 by age and sex. IQ was assessed using Raven's Colored Progressive Matrices and dichotomized as Lower IQ (Levels IV-V) versus Higher IQ (Levels I-III). Dental caries (DMFT/dmft) and fluorosis (TF index) were assessed after cleaning and drying. Fluoride concentration in drinking water was determined using a fluoride ion-specific electrode. Associations with Lower IQ were tested using conditional logistic regression in the matched sample (n=136) and a sensitivity analysis using logistic regression with cluster-robust standard errors.
RESULTS: In crude matched analyses (68 pairs; n = 136), low family income was associated with Lower IQ (OR = 3.50, 95% CI: 1.15-10.63; p = 0.027), while dental caries showed a borderline association (OR = 1.85, 95% CI: 0.94-3.63; p = 0.075). In the adjusted conditional logistic regression model, associations were not statistically significant (income: adjusted OR = 2.93, 95% CI: 0.89-9.58; p = 0.076; caries: adjusted OR = 1.32, 95% CI: 0.57-3.05; p = 0.514), and dental fluorosis (TF>0) was not associated with Lower IQ (adjusted OR = 1.02, 95% CI: 0.45-2.33; p = 0.965). In the sensitivity analysis using the full analytic sample (n = 175) with cluster-robust standard errors clustered at the school level, low income (adjusted OR = 2.64, 95% CI: 1.04-6.71; p = 0.0416) and dental caries (adjusted OR = 2.13, 95% CI: 1.20-3.78; p = 0.0096) were associated with Lower IQ, whereas dental fluorosis was not (adjusted OR = 0.89, 95% CI: 0.55-1.45; p = 0.6471).
CONCLUSION: Socioeconomic disadvantage and dental caries showed the most consistent associations with Lower IQ, whereas dental fluorosis, used as an indirect marker of earlier fluoride exposure during tooth development, was not independently associated with IQ status after adjustment when comparing Lower IQ versus Higher IQ.
Additional Links: PMID-42555539
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@article {pmid42555539,
year = {2026},
author = {Oliveira, MAC and Drumond, CL and Almeida Júnior, A and Lima, CBV and Sousa, RV and Knorst, JK and Coêlho, HFC and Sampaio, FC},
title = {Intelligence quotient in children with dental fluorosis in rural areas of Paraíba.},
journal = {Caries research},
volume = {},
number = {},
pages = {1},
doi = {10.1159/cre/abuag002},
pmid = {42555539},
issn = {1421-976X},
abstract = {INTRODUCTION: Concerns about possible neurotoxicity related to fluoride exposure remain controversial, and evidence is heterogeneous across exposure ranges and study settings. This study evaluated the association between dental fluorosis and intelligence quotient (IQ) among children living in rural areas of Paraíba, Brazil.
METHODS: A nested case-control study was conducted within a cross-sectional survey. Participants were matched 1:1 by age and sex. IQ was assessed using Raven's Colored Progressive Matrices and dichotomized as Lower IQ (Levels IV-V) versus Higher IQ (Levels I-III). Dental caries (DMFT/dmft) and fluorosis (TF index) were assessed after cleaning and drying. Fluoride concentration in drinking water was determined using a fluoride ion-specific electrode. Associations with Lower IQ were tested using conditional logistic regression in the matched sample (n=136) and a sensitivity analysis using logistic regression with cluster-robust standard errors.
RESULTS: In crude matched analyses (68 pairs; n = 136), low family income was associated with Lower IQ (OR = 3.50, 95% CI: 1.15-10.63; p = 0.027), while dental caries showed a borderline association (OR = 1.85, 95% CI: 0.94-3.63; p = 0.075). In the adjusted conditional logistic regression model, associations were not statistically significant (income: adjusted OR = 2.93, 95% CI: 0.89-9.58; p = 0.076; caries: adjusted OR = 1.32, 95% CI: 0.57-3.05; p = 0.514), and dental fluorosis (TF>0) was not associated with Lower IQ (adjusted OR = 1.02, 95% CI: 0.45-2.33; p = 0.965). In the sensitivity analysis using the full analytic sample (n = 175) with cluster-robust standard errors clustered at the school level, low income (adjusted OR = 2.64, 95% CI: 1.04-6.71; p = 0.0416) and dental caries (adjusted OR = 2.13, 95% CI: 1.20-3.78; p = 0.0096) were associated with Lower IQ, whereas dental fluorosis was not (adjusted OR = 0.89, 95% CI: 0.55-1.45; p = 0.6471).
CONCLUSION: Socioeconomic disadvantage and dental caries showed the most consistent associations with Lower IQ, whereas dental fluorosis, used as an indirect marker of earlier fluoride exposure during tooth development, was not independently associated with IQ status after adjustment when comparing Lower IQ versus Higher IQ.},
}
RevDate: 2026-08-04
CmpDate: 2026-08-04
Apicomplexan parasites in urban corvids: Presence of Toxoplasma gondii DNA and first detection of Lankesterella and Isospora DNA in the brain of Eurasian magpies, Pica pica.
Current research in parasitology & vector-borne diseases, 10:100417.
Corvids, including crows, magpies, ravens and jays, are among the most abundant and adaptable bird species in urban and peri-urban environments, where their proximity to humans and domestic animals may facilitate the circulation of parasites. This study aimed at analyzing the presence of DNA of Toxoplasma gondii, Neospora caninum and other coccidia with neurotropism in corvids. A total of 279 brain samples collected at two peri-urban locations in Hungary were examined using molecular methods. The majority of sampled individuals were Eurasian magpies (Pica pica; n = 273). In addition, Eurasian jays (Garrulus glandarius; n = 4) and hooded crows (Corvus cornix; n = 2) were included. Apicomplexan DNA was only detected in the brain of P. pica. In this species, T. gondii was identified with a prevalence of 3.7%, for the first time in P. pica in Hungary and Central Europe. Furthermore, DNA of a Lankesterella sp. was detected in 4% of the specimens of P. pica examined, representing the first molecular evidence of its presence in any corvid species. Because the 18S rRNA sequence of this Lankesterella sp. showed at least 1.3% sequence difference from already reported isolates/species but was 100% identical among all 11 infected P. pica at two locations, this isolate may represent a host-associated genotype. DNA of both T. gondii and Lankesterella sp. was detected in three birds. In the brain of one P. pica, an Isospora species was detected, showing the closest sequence identity to Isospora phylidonyrisae and Isospora coronoideae, which have so far been reported from avian hosts in Australia. These findings broaden our knowledge on the diversity of apicomplexan parasites harbored by P. pica and provide a basis for future studies assessing the potential One Health significance of corvids in urban environments.
Additional Links: PMID-42548994
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@article {pmid42548994,
year = {2026},
author = {Tuska-Szalay, B and Gaál, K and Horváth, M and Takács, N and Keve, G and Szabó, L and Gergely, I and Hornok, S},
title = {Apicomplexan parasites in urban corvids: Presence of Toxoplasma gondii DNA and first detection of Lankesterella and Isospora DNA in the brain of Eurasian magpies, Pica pica.},
journal = {Current research in parasitology & vector-borne diseases},
volume = {10},
number = {},
pages = {100417},
pmid = {42548994},
issn = {2667-114X},
abstract = {Corvids, including crows, magpies, ravens and jays, are among the most abundant and adaptable bird species in urban and peri-urban environments, where their proximity to humans and domestic animals may facilitate the circulation of parasites. This study aimed at analyzing the presence of DNA of Toxoplasma gondii, Neospora caninum and other coccidia with neurotropism in corvids. A total of 279 brain samples collected at two peri-urban locations in Hungary were examined using molecular methods. The majority of sampled individuals were Eurasian magpies (Pica pica; n = 273). In addition, Eurasian jays (Garrulus glandarius; n = 4) and hooded crows (Corvus cornix; n = 2) were included. Apicomplexan DNA was only detected in the brain of P. pica. In this species, T. gondii was identified with a prevalence of 3.7%, for the first time in P. pica in Hungary and Central Europe. Furthermore, DNA of a Lankesterella sp. was detected in 4% of the specimens of P. pica examined, representing the first molecular evidence of its presence in any corvid species. Because the 18S rRNA sequence of this Lankesterella sp. showed at least 1.3% sequence difference from already reported isolates/species but was 100% identical among all 11 infected P. pica at two locations, this isolate may represent a host-associated genotype. DNA of both T. gondii and Lankesterella sp. was detected in three birds. In the brain of one P. pica, an Isospora species was detected, showing the closest sequence identity to Isospora phylidonyrisae and Isospora coronoideae, which have so far been reported from avian hosts in Australia. These findings broaden our knowledge on the diversity of apicomplexan parasites harbored by P. pica and provide a basis for future studies assessing the potential One Health significance of corvids in urban environments.},
}
RevDate: 2023-11-01
CmpDate: 2023-11-01
Analysis of skin aging patterns using a facial imaging system in patients with atopic dermatitis.
European journal of dermatology : EJD, 33(4):383-393.
BACKGROUND: There are few studies on skin aging in patients with atopic dermatitis (AD).
OBJECTIVES: To clarify the characteristics of facial skin aging in AD patients.
MATERIALS & METHODS: Using facial images obtained by a digital imaging system (VISIA evolution), we compared the severity scores for 10 aging signs in 53 women in the AD group and 29 women in the healthy control group, all 35-49 years old.
RESULTS: The severity scores for fine lines on the forehead, periorbital wrinkles, nasolabial folds, and texture of the mouth contour were significantly higher in the AD group than in the controls. However, in order to exclude a direct effect of dermatitis at the time of measurement, cases with signs of AD at the evaluation site were excluded from the AD group (defined as the AD [non-lesion] group), revealing no statistical significance between the AD (non-lesion) group and the healthy control group for any of the 10 facial signs. Age subset analysis showed that for individuals in their late 40s, the AD (non-lesion) group exhibited significantly higher scores for crow's feet wrinkle and nasolabial fold compared to the healthy control group. Furthermore, these two scores correlated with one other, suggesting that they may be induced by the same factors.
CONCLUSION: The results of this study show that skin aging associated with AD is prominent in areas prone to transient wrinkling by frequent blinking and speaking or facial expressions. Understanding of the need for appropriate AD treatment from a cosmetic perspective may increase patient adherence.
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@article {pmid37823489,
year = {2023},
author = {Toyoshima, M and Nakaoji, K and Hamada, K and Yamanaka, A and Inaba, Y and Muraoka, K and Tohsuji, E and Sakakibara, K and Saji, N and Jinnin, M},
title = {Analysis of skin aging patterns using a facial imaging system in patients with atopic dermatitis.},
journal = {European journal of dermatology : EJD},
volume = {33},
number = {4},
pages = {383-393},
doi = {10.1684/ejd.2023.4528},
pmid = {37823489},
issn = {1952-4013},
mesh = {Humans ; Female ; Adult ; Middle Aged ; *Skin Aging ; *Dermatitis, Atopic/diagnostic imaging ; Face/diagnostic imaging ; Aging ; Skin ; },
abstract = {BACKGROUND: There are few studies on skin aging in patients with atopic dermatitis (AD).
OBJECTIVES: To clarify the characteristics of facial skin aging in AD patients.
MATERIALS & METHODS: Using facial images obtained by a digital imaging system (VISIA evolution), we compared the severity scores for 10 aging signs in 53 women in the AD group and 29 women in the healthy control group, all 35-49 years old.
RESULTS: The severity scores for fine lines on the forehead, periorbital wrinkles, nasolabial folds, and texture of the mouth contour were significantly higher in the AD group than in the controls. However, in order to exclude a direct effect of dermatitis at the time of measurement, cases with signs of AD at the evaluation site were excluded from the AD group (defined as the AD [non-lesion] group), revealing no statistical significance between the AD (non-lesion) group and the healthy control group for any of the 10 facial signs. Age subset analysis showed that for individuals in their late 40s, the AD (non-lesion) group exhibited significantly higher scores for crow's feet wrinkle and nasolabial fold compared to the healthy control group. Furthermore, these two scores correlated with one other, suggesting that they may be induced by the same factors.
CONCLUSION: The results of this study show that skin aging associated with AD is prominent in areas prone to transient wrinkling by frequent blinking and speaking or facial expressions. Understanding of the need for appropriate AD treatment from a cosmetic perspective may increase patient adherence.},
}
MeSH Terms:
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Humans
Female
Adult
Middle Aged
*Skin Aging
*Dermatitis, Atopic/diagnostic imaging
Face/diagnostic imaging
Aging
Skin
RevDate: 2023-10-31
Brain optimization with additional study time: potential brain differences between high- and low-performance college students.
Frontiers in psychology, 14:1209881.
This study investigates potential differences in brain function among high-, average-, and low-performance college students using electroencephalography (EEG). We hypothesize that the increased academic engagement of high-performance students will lead to discernible EEG variations due to the brain's structural plasticity. 61 third-year college students from identical majors were divided into high-performance (n = 20), average-performance (n = 21), and low-performance (n = 20) groups based on their academic achievements. We conducted three EEG experiments: resting state, Sternberg working memory task, and Raven progressive matrix task. Comprehensive analyses of the EEG data from the three experiments focused on power spectral density (PSD) and functional connectivity, with coherence (COH) employed as our primary metric for the latter. The results showed that in all experiments, there were no differences in working memory ability and IQ scores among the groups, and there were no significant differences in the power spectral densities of the delta, theta, alpha1, alpha2, beta, and gamma bands among the groups. Notably, on the Raven test, compared to their high-performing peers, low-performing students showed enhanced functional connectivity in the alpha 1 (8-9 Hz) band that connects the frontal and occipital lobes. We explored three potential explanations for this phenomenon: fatigue, anxiety, and greater cognitive effort required for problem-solving due to inefficient self-regulation and increased susceptibility to distraction. In essence, these insights not only deepen our understanding of the neural basis that anchors academic ability, but also hold promise in guiding interventions that address students' diverse academic needs.
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@article {pmid37829066,
year = {2023},
author = {Xu, Z and Zhang, P and Tu, M and Zhang, M and Lai, Y},
title = {Brain optimization with additional study time: potential brain differences between high- and low-performance college students.},
journal = {Frontiers in psychology},
volume = {14},
number = {},
pages = {1209881},
pmid = {37829066},
issn = {1664-1078},
abstract = {This study investigates potential differences in brain function among high-, average-, and low-performance college students using electroencephalography (EEG). We hypothesize that the increased academic engagement of high-performance students will lead to discernible EEG variations due to the brain's structural plasticity. 61 third-year college students from identical majors were divided into high-performance (n = 20), average-performance (n = 21), and low-performance (n = 20) groups based on their academic achievements. We conducted three EEG experiments: resting state, Sternberg working memory task, and Raven progressive matrix task. Comprehensive analyses of the EEG data from the three experiments focused on power spectral density (PSD) and functional connectivity, with coherence (COH) employed as our primary metric for the latter. The results showed that in all experiments, there were no differences in working memory ability and IQ scores among the groups, and there were no significant differences in the power spectral densities of the delta, theta, alpha1, alpha2, beta, and gamma bands among the groups. Notably, on the Raven test, compared to their high-performing peers, low-performing students showed enhanced functional connectivity in the alpha 1 (8-9 Hz) band that connects the frontal and occipital lobes. We explored three potential explanations for this phenomenon: fatigue, anxiety, and greater cognitive effort required for problem-solving due to inefficient self-regulation and increased susceptibility to distraction. In essence, these insights not only deepen our understanding of the neural basis that anchors academic ability, but also hold promise in guiding interventions that address students' diverse academic needs.},
}
RevDate: 2023-10-31
Efficacy, Safety, and Subject Satisfaction of PrabotulinumtoxinA for Moderate-to-Severe Crow's Feet: A Phase IV, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.
Journal of clinical medicine, 12(19):.
PrabotulinumtoxinA has been identified as an effective agent against crow's feet. Our study, which included Korean patients with moderate to severe crow's feet, was undertaken to compare the efficacy and safety of PrabotulinumtoxinA and placebo treatments. Of the 90 study participants, 60 received prabotulinumtoxinA (24 U), whereas 30 received a placebo. The primary outcome assessment included facial wrinkle grading by investigators. At week 4, 69.64% of patients in the prabotulinumtoxinA group exhibited minimal crow's feet severity; in contrast, a 0% improvement was observed in the placebo group (p < 0.0001). At week 12, the improvement rates were 30.36% for prabotulinumtoxinA and 6.90% for the placebo, demonstrating a significant difference (p = 0.0152). Based on the independent review panel's assessment at week 4, the improvement rate was 39.29% in the prabotulinumtoxinA group and 3.45% in the placebo group during maximum smiling. Additionally, patient satisfaction was notably higher in the prabotulinumtoxinA group (32.14%) than in the placebo group (10.34%) at week 4 (p = 0.0289). Both treatments displayed comparable safety profiles, with only mild local reactions reported as ADRs for one patient from the prabotulinumtoxinA group. Thus, prabotulinumtoxinA demonstrates significant potential as a potent and safe remedy for crow's feet.
Additional Links: PMID-37834970
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@article {pmid37834970,
year = {2023},
author = {Lee, SK and Kim, MS and Kwon, SH and Chung, BY and Han, SH and Kim, HJ},
title = {Efficacy, Safety, and Subject Satisfaction of PrabotulinumtoxinA for Moderate-to-Severe Crow's Feet: A Phase IV, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.},
journal = {Journal of clinical medicine},
volume = {12},
number = {19},
pages = {},
pmid = {37834970},
issn = {2077-0383},
support = {there is no grant number.//Daewoong Pharmaceutical (South Korea)/ ; },
abstract = {PrabotulinumtoxinA has been identified as an effective agent against crow's feet. Our study, which included Korean patients with moderate to severe crow's feet, was undertaken to compare the efficacy and safety of PrabotulinumtoxinA and placebo treatments. Of the 90 study participants, 60 received prabotulinumtoxinA (24 U), whereas 30 received a placebo. The primary outcome assessment included facial wrinkle grading by investigators. At week 4, 69.64% of patients in the prabotulinumtoxinA group exhibited minimal crow's feet severity; in contrast, a 0% improvement was observed in the placebo group (p < 0.0001). At week 12, the improvement rates were 30.36% for prabotulinumtoxinA and 6.90% for the placebo, demonstrating a significant difference (p = 0.0152). Based on the independent review panel's assessment at week 4, the improvement rate was 39.29% in the prabotulinumtoxinA group and 3.45% in the placebo group during maximum smiling. Additionally, patient satisfaction was notably higher in the prabotulinumtoxinA group (32.14%) than in the placebo group (10.34%) at week 4 (p = 0.0289). Both treatments displayed comparable safety profiles, with only mild local reactions reported as ADRs for one patient from the prabotulinumtoxinA group. Thus, prabotulinumtoxinA demonstrates significant potential as a potent and safe remedy for crow's feet.},
}
RevDate: 2024-09-26
Digestion-Related Enzyme Inhibition Potential of Selected Mexican Medicinal Plants (Ludwigia octovalvis (Jacq.) P.H.Raven, Cnidoscolus aconitifolius and Crotalaria longirostrata).
Foods (Basel, Switzerland), 12(19):.
Medicinal plants offer a valuable source of natural compounds with specific and selective bioactivity. These compounds have been isolated since the mid-nineteenth century and are now commonly used in modern medications. L. octovalvis (Jacq.) P.H.Raven, C. aconitifolius, and C. longirostrata are Mexican medicinal plants consumed regularly, and research has shown that they contain bioactive compounds capable of promoting the inhibition of digestive enzymes. This is noteworthy since enzyme inhibitors are bioactive substances that interact with enzymes, diminishing their activity and thereby contributing to the management of diseases and metabolic disturbances. To investigate the activity of these plants, individual analyses were conducted, assessing their proximal composition, bioactive compounds, and inhibition of α-Amylase, α-Glucosidase, lipase, and pepsin. The results revealed that all three plants exhibited enzymatic inhibition. When comparing the plants, it was determined that C. aconitifolius had the lowest concentration required for a 50% inhibition in α-Amylase, α-Glucosidase, and lipase, as indicated by the IC50 values. For pepsin, C. longirostrata demonstrated the lowest IC50 value. By understanding the bioactive compounds present in these plants, we can establish the relationship they have with enzymatic inhibition, which can be utilized for future investigations.
Additional Links: PMID-37835184
PubMed:
Citation:
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@article {pmid37835184,
year = {2023},
author = {Calonico, K and De La Rosa-Millan, J},
title = {Digestion-Related Enzyme Inhibition Potential of Selected Mexican Medicinal Plants (Ludwigia octovalvis (Jacq.) P.H.Raven, Cnidoscolus aconitifolius and Crotalaria longirostrata).},
journal = {Foods (Basel, Switzerland)},
volume = {12},
number = {19},
pages = {},
pmid = {37835184},
issn = {2304-8158},
abstract = {Medicinal plants offer a valuable source of natural compounds with specific and selective bioactivity. These compounds have been isolated since the mid-nineteenth century and are now commonly used in modern medications. L. octovalvis (Jacq.) P.H.Raven, C. aconitifolius, and C. longirostrata are Mexican medicinal plants consumed regularly, and research has shown that they contain bioactive compounds capable of promoting the inhibition of digestive enzymes. This is noteworthy since enzyme inhibitors are bioactive substances that interact with enzymes, diminishing their activity and thereby contributing to the management of diseases and metabolic disturbances. To investigate the activity of these plants, individual analyses were conducted, assessing their proximal composition, bioactive compounds, and inhibition of α-Amylase, α-Glucosidase, lipase, and pepsin. The results revealed that all three plants exhibited enzymatic inhibition. When comparing the plants, it was determined that C. aconitifolius had the lowest concentration required for a 50% inhibition in α-Amylase, α-Glucosidase, and lipase, as indicated by the IC50 values. For pepsin, C. longirostrata demonstrated the lowest IC50 value. By understanding the bioactive compounds present in these plants, we can establish the relationship they have with enzymatic inhibition, which can be utilized for future investigations.},
}
RevDate: 2025-06-11
CmpDate: 2024-02-05
Reduction of genetic diversity in 'Alalā (Hawaiian crow; Corvus hawaiiensis) between the late 1800s and the late 1900s.
The Journal of heredity, 115(1):32-44.
Genetic and genomic data are increasingly used to aid conservation management of endangered species by providing insights into evolutionary histories, factors associated with extinction risks, and potential for future adaptation. For the 'Alalā, or Hawaiian crow (Corvus hawaiiensis), genetic concerns include negative correlations between inbreeding and hatching success. However, it is unclear if low genetic diversity and inbreeding depression are consequences of a historical population bottleneck, or if 'Alalā had historically low genetic diversity that predated human influence, perhaps as a result of earlier declines or founding events. In this study, we applied a hybridization-based sequence capture to generate a genome-wide single nucleotide polymorphism (SNP) dataset for comparing historical specimens collected in the 1890s, when 'Alalā were more numerous, to samples taken between 1973 and 1998, when 'Alalā population densities were near the lowest documented levels in the wild, prior to all individuals being collected for captive rearing. We found low genome-wide diversity in both sample groups, however, the modern sample group (1973 to 1998 cohort) exhibited relatively fewer polymorphic alleles, a lower proportion of polymorphic loci, and lower observed heterozygosity, consistent with a population decline and potential bottleneck effects. These results combined with a current low population size highlight the importance of continued efforts by conservation managers to mitigate inbreeding and maintain founder representation to preserve what genetic diversity remains.
Additional Links: PMID-37846510
Publisher:
PubMed:
Citation:
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@article {pmid37846510,
year = {2024},
author = {Blanchet, G and Bellinger, MR and Kearns, AM and Cortes-Rodriguez, N and Masuda, B and Campana, MG and Rutz, C and Fleischer, RC and Sutton, JT},
title = {Reduction of genetic diversity in 'Alalā (Hawaiian crow; Corvus hawaiiensis) between the late 1800s and the late 1900s.},
journal = {The Journal of heredity},
volume = {115},
number = {1},
pages = {32-44},
doi = {10.1093/jhered/esad063},
pmid = {37846510},
issn = {1465-7333},
support = {BB/G023913/2/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom ; },
mesh = {Humans ; Animals ; *Crows/genetics ; Genetic Variation ; Hawaii ; Inbreeding ; Genome ; Endangered Species ; },
abstract = {Genetic and genomic data are increasingly used to aid conservation management of endangered species by providing insights into evolutionary histories, factors associated with extinction risks, and potential for future adaptation. For the 'Alalā, or Hawaiian crow (Corvus hawaiiensis), genetic concerns include negative correlations between inbreeding and hatching success. However, it is unclear if low genetic diversity and inbreeding depression are consequences of a historical population bottleneck, or if 'Alalā had historically low genetic diversity that predated human influence, perhaps as a result of earlier declines or founding events. In this study, we applied a hybridization-based sequence capture to generate a genome-wide single nucleotide polymorphism (SNP) dataset for comparing historical specimens collected in the 1890s, when 'Alalā were more numerous, to samples taken between 1973 and 1998, when 'Alalā population densities were near the lowest documented levels in the wild, prior to all individuals being collected for captive rearing. We found low genome-wide diversity in both sample groups, however, the modern sample group (1973 to 1998 cohort) exhibited relatively fewer polymorphic alleles, a lower proportion of polymorphic loci, and lower observed heterozygosity, consistent with a population decline and potential bottleneck effects. These results combined with a current low population size highlight the importance of continued efforts by conservation managers to mitigate inbreeding and maintain founder representation to preserve what genetic diversity remains.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Animals
*Crows/genetics
Genetic Variation
Hawaii
Inbreeding
Genome
Endangered Species
RevDate: 2026-04-19
CmpDate: 2023-11-15
Cognition mediates response to anthropogenic noise in wild Western Australian magpies (Gmynorhina tibicen dorsalis).
Global change biology, 29(24):6912-6930.
Anthropogenic noise is a pollutant of growing concern, with wide-ranging effects on taxa across ecosystems. Until recently, studies investigating the effects of anthropogenic noise on animals focused primarily on population-level consequences, rather than individual-level impacts. Individual variation in response to anthropogenic noise may result from extrinsic or intrinsic factors. One such intrinsic factor, cognitive performance, varies between individuals and is hypothesised to aid behavioural response to novel stressors. Here, we combine cognitive testing, behavioural focals and playback experiments to investigate how anthropogenic noise affects the behaviour and anti-predator response of Western Australian magpies (Gymnorhina tibicen dorsalis), and to determine whether this response is linked to cognitive performance. We found a significant population-level effect of anthropogenic noise on the foraging effort, foraging efficiency, vigilance, vocalisation rate and anti-predator response of magpies, with birds decreasing their foraging, vocalisation behaviours and anti-predator response, and increasing vigilance when loud anthropogenic noise was present. We also found that individuals varied in their response to playbacks depending on their cognitive performance, with individuals that performed better in an associative learning task maintaining their anti-predator response when an alarm call was played in anthropogenic noise. Our results add to the growing body of literature documenting the adverse effects of anthropogenic noise on wildlife and provide the first evidence for an association between individual cognitive performance and behavioural responses to anthropogenic noise.
Additional Links: PMID-37846601
Publisher:
PubMed:
Citation:
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@article {pmid37846601,
year = {2023},
author = {Blackburn, G and Ashton, BJ and Thornton, A and Woodiss-Field, S and Ridley, AR},
title = {Cognition mediates response to anthropogenic noise in wild Western Australian magpies (Gmynorhina tibicen dorsalis).},
journal = {Global change biology},
volume = {29},
number = {24},
pages = {6912-6930},
doi = {10.1111/gcb.16975},
pmid = {37846601},
issn = {1365-2486},
support = {//Ada Jackson Irwin Street Commemoration Award/ ; //Australian Government Research Training Program/ ; //Holsworth Wildlife Research Endowment/ ; },
mesh = {Humans ; Animals ; *Ecosystem ; Australia ; Noise/adverse effects ; Animals, Wild ; Cognition ; *Passeriformes ; },
abstract = {Anthropogenic noise is a pollutant of growing concern, with wide-ranging effects on taxa across ecosystems. Until recently, studies investigating the effects of anthropogenic noise on animals focused primarily on population-level consequences, rather than individual-level impacts. Individual variation in response to anthropogenic noise may result from extrinsic or intrinsic factors. One such intrinsic factor, cognitive performance, varies between individuals and is hypothesised to aid behavioural response to novel stressors. Here, we combine cognitive testing, behavioural focals and playback experiments to investigate how anthropogenic noise affects the behaviour and anti-predator response of Western Australian magpies (Gymnorhina tibicen dorsalis), and to determine whether this response is linked to cognitive performance. We found a significant population-level effect of anthropogenic noise on the foraging effort, foraging efficiency, vigilance, vocalisation rate and anti-predator response of magpies, with birds decreasing their foraging, vocalisation behaviours and anti-predator response, and increasing vigilance when loud anthropogenic noise was present. We also found that individuals varied in their response to playbacks depending on their cognitive performance, with individuals that performed better in an associative learning task maintaining their anti-predator response when an alarm call was played in anthropogenic noise. Our results add to the growing body of literature documenting the adverse effects of anthropogenic noise on wildlife and provide the first evidence for an association between individual cognitive performance and behavioural responses to anthropogenic noise.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Animals
*Ecosystem
Australia
Noise/adverse effects
Animals, Wild
Cognition
*Passeriformes
RevDate: 2024-12-07
CmpDate: 2023-10-23
Refining the provider payment system of India's government-funded health insurance programme: an econometric analysis.
BMJ open, 13(10):e076155.
OBJECTIVES: Reimbursement rates in national health insurance schemes are frequently weighted to account for differences in the costs of service provision. To determine weights for a differential case-based payment system under India's publicly financed national health insurance scheme, the Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (PM-JAY), by exploring and quantifying the influence of supply-side factors on the costs of inpatient admissions and surgical procedures.
DESIGN: Exploratory analysis using regression-based cost function on data from a multisite health facility costing study-the Cost of Health Services in India (CHSI) Study.
SETTING: The CHSI Study sample included 11 public sector tertiary care hospitals, 27 public sector district hospitals providing secondary care and 16 private hospitals, from 11 Indian states.
PARTICIPANTS: 521 sites from 57 healthcare facilities in 11 states of India.
INTERVENTIONS: Medical and surgical packages of PM-JAY.
The cost per bed-day and cost per surgical procedure were regressed against a range of factors to be considered as weights including hospital location, presence of a teaching function and ownership. In addition, capacity utilisation, number of beds, specialist mix, state gross domestic product, State Health Index ranking and volume of patients across the sample were included as variables in the models. Given the skewed data, cost variables were log-transformed for some models.
RESULTS: The estimated mean costs per inpatient bed-day and per procedure were 2307 and 10 686 Indian rupees, respectively. Teaching status, annual hospitalisation, bed size, location of hospital and average length of hospitalisation significantly determine the inpatient bed-day cost, while location of hospital and teaching status determine the procedure costs. Cost per bed-day of teaching hospitals was 38-143.4% higher than in non-teaching hospitals. Similarly, cost per bed-day was 1.3-89.7% higher in tier 1 cities, and 19.5-77.3% higher in tier 2 cities relative to tier 3 cities, respectively. Finally, cost per surgical procedure was higher by 10.6-144.6% in teaching hospitals than non-teaching hospitals; 12.9-171.7% higher in tier 1 cities; and 33.4-140.9% higher in tier 2 cities compared with tier 3 cities, respectively.
CONCLUSION: Our study findings support and validate the recently introduced differential provider payment system under the PM-JAY. While our results are indicative of heterogeneity in hospital costs, other considerations of how these weights will affect coverage, quality, cost containment, as well as create incentives and disincentives for provider and consumer behaviour, and integrate with existing price mark-ups for other factors, should be considered to determine the future revisions in the differential pricing scheme.
Additional Links: PMID-37857541
PubMed:
Citation:
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@article {pmid37857541,
year = {2023},
author = {Prinja, S and Bahuguna, P and Singh, MP and Guinness, L and Goyal, A and Aggarwal, V},
title = {Refining the provider payment system of India's government-funded health insurance programme: an econometric analysis.},
journal = {BMJ open},
volume = {13},
number = {10},
pages = {e076155},
pmid = {37857541},
issn = {2044-6055},
mesh = {Humans ; *Insurance, Health ; *Health Care Costs ; Hospital Costs ; Hospitals, Teaching ; Government ; India ; },
abstract = {OBJECTIVES: Reimbursement rates in national health insurance schemes are frequently weighted to account for differences in the costs of service provision. To determine weights for a differential case-based payment system under India's publicly financed national health insurance scheme, the Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (PM-JAY), by exploring and quantifying the influence of supply-side factors on the costs of inpatient admissions and surgical procedures.
DESIGN: Exploratory analysis using regression-based cost function on data from a multisite health facility costing study-the Cost of Health Services in India (CHSI) Study.
SETTING: The CHSI Study sample included 11 public sector tertiary care hospitals, 27 public sector district hospitals providing secondary care and 16 private hospitals, from 11 Indian states.
PARTICIPANTS: 521 sites from 57 healthcare facilities in 11 states of India.
INTERVENTIONS: Medical and surgical packages of PM-JAY.
The cost per bed-day and cost per surgical procedure were regressed against a range of factors to be considered as weights including hospital location, presence of a teaching function and ownership. In addition, capacity utilisation, number of beds, specialist mix, state gross domestic product, State Health Index ranking and volume of patients across the sample were included as variables in the models. Given the skewed data, cost variables were log-transformed for some models.
RESULTS: The estimated mean costs per inpatient bed-day and per procedure were 2307 and 10 686 Indian rupees, respectively. Teaching status, annual hospitalisation, bed size, location of hospital and average length of hospitalisation significantly determine the inpatient bed-day cost, while location of hospital and teaching status determine the procedure costs. Cost per bed-day of teaching hospitals was 38-143.4% higher than in non-teaching hospitals. Similarly, cost per bed-day was 1.3-89.7% higher in tier 1 cities, and 19.5-77.3% higher in tier 2 cities relative to tier 3 cities, respectively. Finally, cost per surgical procedure was higher by 10.6-144.6% in teaching hospitals than non-teaching hospitals; 12.9-171.7% higher in tier 1 cities; and 33.4-140.9% higher in tier 2 cities compared with tier 3 cities, respectively.
CONCLUSION: Our study findings support and validate the recently introduced differential provider payment system under the PM-JAY. While our results are indicative of heterogeneity in hospital costs, other considerations of how these weights will affect coverage, quality, cost containment, as well as create incentives and disincentives for provider and consumer behaviour, and integrate with existing price mark-ups for other factors, should be considered to determine the future revisions in the differential pricing scheme.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
*Insurance, Health
*Health Care Costs
Hospital Costs
Hospitals, Teaching
Government
India
RevDate: 2023-11-29
CmpDate: 2023-11-14
The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation.
eLife, 12:.
Plants produce new organs post-embryonically throughout their entire life cycle. This is due to stem cells present in the shoot and root apical meristems, the SAM and RAM, respectively. In the SAM, stem cells are located in the central zone where they divide slowly. Stem cell daughters are displaced laterally and enter the peripheral zone, where their mitotic activity increases and lateral organ primordia are formed. How the spatial arrangement of these different domains is initiated and controlled during SAM growth and development, and how sites of lateral organ primordia are determined in the peripheral zone is not yet completely understood. We found that the SHORTROOT (SHR) transcription factor together with its target transcription factors SCARECROW (SCR), SCARECROW-LIKE23 (SCL23) and JACKDAW (JKD), promotes formation of lateral organs and controls shoot meristem size. SHR, SCR, SCL23, and JKD are expressed in distinct, but partially overlapping patterns in the SAM. They can physically interact and activate expression of key cell cycle regulators such as CYCLIND6;1 (CYCD6;1) to promote the formation of new cell layers. In the peripheral zone, auxin accumulates at sites of lateral organ primordia initiation and activates SHR expression via the auxin response factor MONOPTEROS (MP) and auxin response elements in the SHR promoter. In the central zone, the SHR-target SCL23 physically interacts with the key stem cell regulator WUSCHEL (WUS) to promote stem cell fate. Both SCL23 and WUS expression are subject to negative feedback regulation from stem cells through the CLAVATA signaling pathway. Together, our findings illustrate how SHR-dependent transcription factor complexes act in different domains of the shoot meristem to mediate cell division and auxin dependent organ initiation in the peripheral zone, and coordinate this activity with stem cell maintenance in the central zone of the SAM.
Additional Links: PMID-37862096
PubMed:
Citation:
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@article {pmid37862096,
year = {2023},
author = {Bahafid, E and Bradtmöller, I and Thies, AM and Nguyen, TTON and Gutierrez, C and Desvoyes, B and Stahl, Y and Blilou, I and Simon, RGW},
title = {The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation.},
journal = {eLife},
volume = {12},
number = {},
pages = {},
pmid = {37862096},
issn = {2050-084X},
mesh = {*Arabidopsis/metabolism ; Meristem ; *Arabidopsis Proteins/genetics/metabolism ; Indoleacetic Acids/metabolism ; Transcription Factors/genetics/metabolism ; Gene Expression Regulation, Plant ; Homeodomain Proteins/genetics/metabolism ; Cyclins/metabolism ; },
abstract = {Plants produce new organs post-embryonically throughout their entire life cycle. This is due to stem cells present in the shoot and root apical meristems, the SAM and RAM, respectively. In the SAM, stem cells are located in the central zone where they divide slowly. Stem cell daughters are displaced laterally and enter the peripheral zone, where their mitotic activity increases and lateral organ primordia are formed. How the spatial arrangement of these different domains is initiated and controlled during SAM growth and development, and how sites of lateral organ primordia are determined in the peripheral zone is not yet completely understood. We found that the SHORTROOT (SHR) transcription factor together with its target transcription factors SCARECROW (SCR), SCARECROW-LIKE23 (SCL23) and JACKDAW (JKD), promotes formation of lateral organs and controls shoot meristem size. SHR, SCR, SCL23, and JKD are expressed in distinct, but partially overlapping patterns in the SAM. They can physically interact and activate expression of key cell cycle regulators such as CYCLIND6;1 (CYCD6;1) to promote the formation of new cell layers. In the peripheral zone, auxin accumulates at sites of lateral organ primordia initiation and activates SHR expression via the auxin response factor MONOPTEROS (MP) and auxin response elements in the SHR promoter. In the central zone, the SHR-target SCL23 physically interacts with the key stem cell regulator WUSCHEL (WUS) to promote stem cell fate. Both SCL23 and WUS expression are subject to negative feedback regulation from stem cells through the CLAVATA signaling pathway. Together, our findings illustrate how SHR-dependent transcription factor complexes act in different domains of the shoot meristem to mediate cell division and auxin dependent organ initiation in the peripheral zone, and coordinate this activity with stem cell maintenance in the central zone of the SAM.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
*Arabidopsis/metabolism
Meristem
*Arabidopsis Proteins/genetics/metabolism
Indoleacetic Acids/metabolism
Transcription Factors/genetics/metabolism
Gene Expression Regulation, Plant
Homeodomain Proteins/genetics/metabolism
Cyclins/metabolism
RevDate: 2024-02-10
CmpDate: 2023-11-01
American crows that excel at tool use activate neural circuits distinct from less talented individuals.
Nature communications, 14(1):6539.
Tools enable animals to exploit and command new resources. However, the neural circuits underpinning tool use and how neural activity varies with an animal's tool proficiency, are only known for humans and some other primates. We use 18F-fluorodeoxyglucose positron emission tomography to image the brain activity of naïve vs trained American crows (Corvus brachyrhynchos) when presented with a task requiring the use of stone tools. As in humans, talent affects the neural circuits activated by crows as they prepare to execute the task. Naïve and less proficient crows use neural circuits associated with sensory- and higher-order processing centers (the mesopallium and nidopallium), while highly proficient individuals increase activity in circuits associated with motor learning and tactile control (hippocampus, tegmentum, nucleus basorostralis, and cerebellum). Greater proficiency is found primarily in adult female crows and may reflect their need to use more cognitively complex strategies, like tool use, to obtain food.
Additional Links: PMID-37863938
PubMed:
Citation:
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@article {pmid37863938,
year = {2023},
author = {Pendergraft, LT and Marzluff, JM and Cross, DJ and Shimizu, T and Templeton, CN},
title = {American crows that excel at tool use activate neural circuits distinct from less talented individuals.},
journal = {Nature communications},
volume = {14},
number = {1},
pages = {6539},
pmid = {37863938},
issn = {2041-1723},
support = {S10 OD017980/OD/NIH HHS/United States ; },
mesh = {Humans ; Animals ; Adult ; Female ; *Crows ; *Tool Use Behavior ; Hippocampus ; },
abstract = {Tools enable animals to exploit and command new resources. However, the neural circuits underpinning tool use and how neural activity varies with an animal's tool proficiency, are only known for humans and some other primates. We use 18F-fluorodeoxyglucose positron emission tomography to image the brain activity of naïve vs trained American crows (Corvus brachyrhynchos) when presented with a task requiring the use of stone tools. As in humans, talent affects the neural circuits activated by crows as they prepare to execute the task. Naïve and less proficient crows use neural circuits associated with sensory- and higher-order processing centers (the mesopallium and nidopallium), while highly proficient individuals increase activity in circuits associated with motor learning and tactile control (hippocampus, tegmentum, nucleus basorostralis, and cerebellum). Greater proficiency is found primarily in adult female crows and may reflect their need to use more cognitively complex strategies, like tool use, to obtain food.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Animals
Adult
Female
*Crows
*Tool Use Behavior
Hippocampus
RevDate: 2024-08-24
CmpDate: 2023-12-07
Ectoparasite presence and brood size manipulation interact to accelerate telomere shortening in nestling jackdaws.
Molecular ecology, 32(24):6913-6923.
Early-life conditions impact fitness, but whether the combined effect of extrinsic stressors is additive or synergistic is not well known. This is a major knowledge gap because exposure to multiple stressors is frequent. Telomere dynamics may be instrumental when testing how stressors interact because many factors affect telomere shortening, and telomere shortening predicts survival. We evaluated the effect of manipulated brood size and natural infestation by the carnid fly Carnus hemapterus on nestling growth and telomere shortening of wild jackdaws (Corvus monedula). Telomere length, measured in blood using TRF, shortened on average by 264 bp, and on average, Carnus infection induced more telomere shortening. Further analyses showed that in enlarged broods, nestlings' telomeres shortened more when parasitized, while in reduced broods there was no effect of infection on telomere shortening. We conclude that there is a synergistic effect of number of siblings and Carnus infection on telomere shortening rate: blood-sucking parasites may negatively impact telomeres by increasing cell proliferation and/or physiological stress, and coping with infection may be less successful in enlarged broods with increased sibling competition. Larger nestlings had shorter telomeres independent of age, brood manipulation or infection. Growth was independent of infestation but in enlarged broods, nestlings were lighter at fledging. Our findings indicate that (i) evaluating consequences of early-life environmental conditions in isolation may not yield a full picture due to synergistic effects, and (ii) effects of environmental conditions may be cryptic, for example, on telomeres, with fitness consequences expressed beyond the temporal framework of the study.
Additional Links: PMID-37864481
Publisher:
PubMed:
Citation:
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@article {pmid37864481,
year = {2023},
author = {Badás, EP and Bauch, C and Boonekamp, JJ and Mulder, E and Verhulst, S},
title = {Ectoparasite presence and brood size manipulation interact to accelerate telomere shortening in nestling jackdaws.},
journal = {Molecular ecology},
volume = {32},
number = {24},
pages = {6913-6923},
doi = {10.1111/mec.17177},
pmid = {37864481},
issn = {1365-294X},
support = {8444403//European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie/ ; BA 5422/1-1//DFG fellowship/ ; 823.01.009//NWO/ ; 823.01.006//NWO/ ; },
mesh = {Animals ; *Crows ; Telomere Shortening/genetics ; Stress, Physiological ; Telomere/genetics ; },
abstract = {Early-life conditions impact fitness, but whether the combined effect of extrinsic stressors is additive or synergistic is not well known. This is a major knowledge gap because exposure to multiple stressors is frequent. Telomere dynamics may be instrumental when testing how stressors interact because many factors affect telomere shortening, and telomere shortening predicts survival. We evaluated the effect of manipulated brood size and natural infestation by the carnid fly Carnus hemapterus on nestling growth and telomere shortening of wild jackdaws (Corvus monedula). Telomere length, measured in blood using TRF, shortened on average by 264 bp, and on average, Carnus infection induced more telomere shortening. Further analyses showed that in enlarged broods, nestlings' telomeres shortened more when parasitized, while in reduced broods there was no effect of infection on telomere shortening. We conclude that there is a synergistic effect of number of siblings and Carnus infection on telomere shortening rate: blood-sucking parasites may negatively impact telomeres by increasing cell proliferation and/or physiological stress, and coping with infection may be less successful in enlarged broods with increased sibling competition. Larger nestlings had shorter telomeres independent of age, brood manipulation or infection. Growth was independent of infestation but in enlarged broods, nestlings were lighter at fledging. Our findings indicate that (i) evaluating consequences of early-life environmental conditions in isolation may not yield a full picture due to synergistic effects, and (ii) effects of environmental conditions may be cryptic, for example, on telomeres, with fitness consequences expressed beyond the temporal framework of the study.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
*Crows
Telomere Shortening/genetics
Stress, Physiological
Telomere/genetics
RevDate: 2024-07-15
CmpDate: 2024-04-17
Black Appalachia's Oldest Old: Untold Stories of Experienced Racism and Coping With Religious Practices/Beliefs.
The Gerontologist, 64(5):.
BACKGROUND AND OBJECTIVES: Racism and religion are recognized as prevailing Social Determinants of Health (SDoH). To explore ways in which racism and religion looms in the daily lives of African Americans, we analyzed the experiences of African Americans born during the Jim Crow years and living in the Southern Appalachian Region of the United States.
RESEARCH DESIGN AND METHODS: Twenty-seven African Americans participated in this qualitative descriptive study that utilized criterion sampling, open-ended semistructured interviews, and content analysis to identify a typology of categories related to experienced racism and ways in which religion was used in response to those experiences.
RESULTS: Participants were an average age of 82.22 years (SD = 5.07); primarily women (n = 19, 70.4%); married (n = 11, 40.7%); junior high school (n = 6, 22.2%), high school or general educational diploma (n = 7, 25.9%), completed college or professional school (n = 6, 22.2%); were retired (n = 27, 100.0%); and affiliated with Baptist churches (n = 18, 66.7%). Experiences with racism included inequities in healthcare and education, and racially motivated physical violence. Religious practices/beliefs included forgiveness, humility, and humanity.
DISCUSSION AND IMPLICATIONS: Racism experienced by African American participants was likely countered by religious practices/beliefs inspired through intergenerational teachings with affiliations to the Black Church. These experiences of the oldest old) African Americans living in communities of the Southern Appalachia, United States, illustrate the pervasive nature of racism. The religious beliefs that are frequently transmitted intergenerationally through the Black Church are relevant to understand present-day encounters with racism among African Americans and possibly other communities of color.
Additional Links: PMID-37875131
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PubMed:
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@article {pmid37875131,
year = {2024},
author = {Hamilton, JB and Abiri, A and Nicolas, CA and Grant, EJ and Best, NC},
title = {Black Appalachia's Oldest Old: Untold Stories of Experienced Racism and Coping With Religious Practices/Beliefs.},
journal = {The Gerontologist},
volume = {64},
number = {5},
pages = {},
doi = {10.1093/geront/gnad143},
pmid = {37875131},
issn = {1758-5341},
mesh = {Aged, 80 and over ; Female ; Humans ; Adaptation, Psychological ; Black or African American ; *Racism ; *Religion ; United States ; Male ; Aged ; },
abstract = {BACKGROUND AND OBJECTIVES: Racism and religion are recognized as prevailing Social Determinants of Health (SDoH). To explore ways in which racism and religion looms in the daily lives of African Americans, we analyzed the experiences of African Americans born during the Jim Crow years and living in the Southern Appalachian Region of the United States.
RESEARCH DESIGN AND METHODS: Twenty-seven African Americans participated in this qualitative descriptive study that utilized criterion sampling, open-ended semistructured interviews, and content analysis to identify a typology of categories related to experienced racism and ways in which religion was used in response to those experiences.
RESULTS: Participants were an average age of 82.22 years (SD = 5.07); primarily women (n = 19, 70.4%); married (n = 11, 40.7%); junior high school (n = 6, 22.2%), high school or general educational diploma (n = 7, 25.9%), completed college or professional school (n = 6, 22.2%); were retired (n = 27, 100.0%); and affiliated with Baptist churches (n = 18, 66.7%). Experiences with racism included inequities in healthcare and education, and racially motivated physical violence. Religious practices/beliefs included forgiveness, humility, and humanity.
DISCUSSION AND IMPLICATIONS: Racism experienced by African American participants was likely countered by religious practices/beliefs inspired through intergenerational teachings with affiliations to the Black Church. These experiences of the oldest old) African Americans living in communities of the Southern Appalachia, United States, illustrate the pervasive nature of racism. The religious beliefs that are frequently transmitted intergenerationally through the Black Church are relevant to understand present-day encounters with racism among African Americans and possibly other communities of color.},
}
MeSH Terms:
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Aged, 80 and over
Female
Humans
Adaptation, Psychological
Black or African American
*Racism
*Religion
United States
Male
Aged
RevDate: 2026-01-07
CmpDate: 2023-12-19
Numerical Representation for Action in Crows Obeys the Weber-Fechner Law.
Psychological science, 34(12):1322-1335.
The psychophysical laws governing the judgment of perceived numbers of objects or events, called the number sense, have been studied in detail. However, the behavioral principles of equally important numerical representations for action are largely unexplored in both humans and animals. We trained two male carrion crows (Corvus corone) to judge numerical values of instruction stimuli from one to five and to flexibly perform a matching number of pecks. Our quantitative analysis of the crows' number production performance shows the same behavioral regularities that have previously been demonstrated for the judgment of sensory numerosity, such as the numerical distance effect, the numerical magnitude effect, and the logarithmical compression of the number line. The presence of these psychophysical phenomena in crows producing number of pecks suggests a unified sensorimotor number representation system underlying the judgment of the number of external stimuli and internally generated actions.
Additional Links: PMID-37883792
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PubMed:
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@article {pmid37883792,
year = {2023},
author = {Kirschhock, ME and Nieder, A},
title = {Numerical Representation for Action in Crows Obeys the Weber-Fechner Law.},
journal = {Psychological science},
volume = {34},
number = {12},
pages = {1322-1335},
doi = {10.1177/09567976231201624},
pmid = {37883792},
issn = {1467-9280},
mesh = {Animals ; Humans ; Male ; Differential Threshold ; *Crows ; Cognition ; Judgment ; Neurons ; },
abstract = {The psychophysical laws governing the judgment of perceived numbers of objects or events, called the number sense, have been studied in detail. However, the behavioral principles of equally important numerical representations for action are largely unexplored in both humans and animals. We trained two male carrion crows (Corvus corone) to judge numerical values of instruction stimuli from one to five and to flexibly perform a matching number of pecks. Our quantitative analysis of the crows' number production performance shows the same behavioral regularities that have previously been demonstrated for the judgment of sensory numerosity, such as the numerical distance effect, the numerical magnitude effect, and the logarithmical compression of the number line. The presence of these psychophysical phenomena in crows producing number of pecks suggests a unified sensorimotor number representation system underlying the judgment of the number of external stimuli and internally generated actions.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Humans
Male
Differential Threshold
*Crows
Cognition
Judgment
Neurons
RevDate: 2023-10-31
The Role of Some Free-Ranging Animals in the Transmission of Multi-Host Species of Cryptosporidium Spp.
Iranian journal of parasitology, 18(3):313-323.
BACKGROUND: We aimed to characterize Cryptosporidium spp. in rats, cats, pigeons, and crows.
METHODS: Fifty-five animal origin Cryptosporidium spp. genome were identified, genotyped and confirmed by nested PCR and of RFLP-PCR analysis as well as sequenced based on 18s rRNA and gp60 genes in Tehran (2012-2019). Finally, the phylogenetic analysis was performed by MEGA software (version 7).
RESULTS: By the molecular method, Cryptosporidium spp. were detected in 24 (15.2%), 15 (15%), 2 (2%) and 13 (13%) cases of wild rats, cat, pigeon, and crow, respectively. Among the identified species by the RFLP pattern, most isolates were identified as C. parvum (24/157) 17.8% in rats, (15/100) 15% in cats, (13/100) 13%in crew and (2/100) 2% in pigeons; and the rest of the cases were C. muris and C. felis. The results of sequencing did not prove the existence of C. parvum, C. felis, C. muris, and rat genotype. Subtyping of C. parvum was indicated that the dominant subtype family belongs to the IId family and the subtype A20G1 was the most common subtype detected in all hosts while A19G1 was detected in one isolate of cat and pigeon.
CONCLUSION: Free-ranging animals are infected by species/subtype of Cryptosporidium, which can infect humans. This shows by itself the hygienic importance of the free-ranging animals in urban ecosystems. In the transmission of human cryptosporidiosis, the multi-host Cryptosporidium species such as C. parvum, C. felis, and C. muris can be transferred potentially from these animals to humans.
Additional Links: PMID-37886251
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Citation:
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@article {pmid37886251,
year = {2023},
author = {Mirzaghavami, M and Sadraei, J and Pirestani, M and Bahadory, S},
title = {The Role of Some Free-Ranging Animals in the Transmission of Multi-Host Species of Cryptosporidium Spp.},
journal = {Iranian journal of parasitology},
volume = {18},
number = {3},
pages = {313-323},
pmid = {37886251},
issn = {1735-7020},
abstract = {BACKGROUND: We aimed to characterize Cryptosporidium spp. in rats, cats, pigeons, and crows.
METHODS: Fifty-five animal origin Cryptosporidium spp. genome were identified, genotyped and confirmed by nested PCR and of RFLP-PCR analysis as well as sequenced based on 18s rRNA and gp60 genes in Tehran (2012-2019). Finally, the phylogenetic analysis was performed by MEGA software (version 7).
RESULTS: By the molecular method, Cryptosporidium spp. were detected in 24 (15.2%), 15 (15%), 2 (2%) and 13 (13%) cases of wild rats, cat, pigeon, and crow, respectively. Among the identified species by the RFLP pattern, most isolates were identified as C. parvum (24/157) 17.8% in rats, (15/100) 15% in cats, (13/100) 13%in crew and (2/100) 2% in pigeons; and the rest of the cases were C. muris and C. felis. The results of sequencing did not prove the existence of C. parvum, C. felis, C. muris, and rat genotype. Subtyping of C. parvum was indicated that the dominant subtype family belongs to the IId family and the subtype A20G1 was the most common subtype detected in all hosts while A19G1 was detected in one isolate of cat and pigeon.
CONCLUSION: Free-ranging animals are infected by species/subtype of Cryptosporidium, which can infect humans. This shows by itself the hygienic importance of the free-ranging animals in urban ecosystems. In the transmission of human cryptosporidiosis, the multi-host Cryptosporidium species such as C. parvum, C. felis, and C. muris can be transferred potentially from these animals to humans.},
}
RevDate: 2023-10-29
A Retrospective of Project Robo Raven: Developing New Capabilities for Enhancing the Performance of Flapping Wing Aerial Vehicles.
Biomimetics (Basel, Switzerland), 8(6):.
Flapping Wing Air Vehicles (FWAVs) have proven to be attractive alternatives to fixed wing and rotary air vehicles at low speeds because of their bio-inspired ability to hover and maneuver. However, in the past, they have not been able to reach their full potential due to limitations in wing control and payload capacity, which also has limited endurance. Many previous FWAVs used a single actuator that couples and synchronizes motions of the wings to flap both wings, resulting in only variable rate flapping control at a constant amplitude. Independent wing control is achieved using two servo actuators that enable wing motions for FWAVs by programming positions and velocities to achieve desired wing shapes and associated aerodynamic forces. However, having two actuators integrated into the flying platform significantly increases its weight and makes it more challenging to achieve flight than a single actuator. This article presents a retrospective overview of five different designs from the "Robo Raven" family based on our previously published work. The first FWAVs utilize two servo motors to achieve independent wing control. The basic platform is capable of successfully performing dives, flips, and button hook turns, which demonstrates the potential maneuverability afforded by the independently actuated and controlled wings. Subsequent designs in the Robo Raven family were able to use multifunctional wings to harvest solar energy to overcome limitations on endurance, use on-board decision-making capabilities to perform maneuvers autonomously, and use mixed-mode propulsion to increase payload capacity by exploiting the benefits of fixed and flapping wing flight. This article elucidates how each successive version of the Robo Raven platform built upon the findings from previous generations. The Robo Raven family collectively addresses requirements related to control autonomy, energy autonomy, and maneuverability. We conclude this article by identifying new opportunities for research in avian-scale flapping wing aerial vehicles.
Additional Links: PMID-37887616
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Citation:
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@article {pmid37887616,
year = {2023},
author = {Bruck, HA and Gupta, SK},
title = {A Retrospective of Project Robo Raven: Developing New Capabilities for Enhancing the Performance of Flapping Wing Aerial Vehicles.},
journal = {Biomimetics (Basel, Switzerland)},
volume = {8},
number = {6},
pages = {},
pmid = {37887616},
issn = {2313-7673},
support = {FA9550-12-1-0158 and FA9550-15-1-0350//United States Air Force Office of Scientific Research/ ; },
abstract = {Flapping Wing Air Vehicles (FWAVs) have proven to be attractive alternatives to fixed wing and rotary air vehicles at low speeds because of their bio-inspired ability to hover and maneuver. However, in the past, they have not been able to reach their full potential due to limitations in wing control and payload capacity, which also has limited endurance. Many previous FWAVs used a single actuator that couples and synchronizes motions of the wings to flap both wings, resulting in only variable rate flapping control at a constant amplitude. Independent wing control is achieved using two servo actuators that enable wing motions for FWAVs by programming positions and velocities to achieve desired wing shapes and associated aerodynamic forces. However, having two actuators integrated into the flying platform significantly increases its weight and makes it more challenging to achieve flight than a single actuator. This article presents a retrospective overview of five different designs from the "Robo Raven" family based on our previously published work. The first FWAVs utilize two servo motors to achieve independent wing control. The basic platform is capable of successfully performing dives, flips, and button hook turns, which demonstrates the potential maneuverability afforded by the independently actuated and controlled wings. Subsequent designs in the Robo Raven family were able to use multifunctional wings to harvest solar energy to overcome limitations on endurance, use on-board decision-making capabilities to perform maneuvers autonomously, and use mixed-mode propulsion to increase payload capacity by exploiting the benefits of fixed and flapping wing flight. This article elucidates how each successive version of the Robo Raven platform built upon the findings from previous generations. The Robo Raven family collectively addresses requirements related to control autonomy, energy autonomy, and maneuverability. We conclude this article by identifying new opportunities for research in avian-scale flapping wing aerial vehicles.},
}
RevDate: 2024-10-01
Study of the Interface between Wild Bird Populations and Poultry and Their Potential Role in the Spread of Avian Influenza.
Microorganisms, 11(10):.
Water birds play a crucial role in disseminating and amplifying avian influenza viruses (AIVs) in the environment. However, they may have limited interactions with domestic facilities, raising the hypothesis that other wild birds may play the bridging role in introducing AIVs into poultry. An ornithocoenosis study, based on census-transect and camera-trapping methods, was conducted in 2019 in ten poultry premises in northeast Italy to characterize the bird communities and envisage the species that might act as bridge hosts for AIVs. The data collected were explored through a series of multivariate analyses (correspondence analysis and non-metric multidimensional scaling), and biodiversity indices (observed and estimated richness, Shannon entropy and Pielou's evenness). The analyses revealed a high level of complexity in the ornithic population, with 147 censused species, and significant qualitative and quantitative differences in wild bird species composition, both in space and in time. Among these, only a few were observed in close proximity to the farm premises (i.e., Magpies, Blackbirds, Cattle Egrets, Pheasants, Eurasian Collared Doves, and Wood Pigeons), thus suggesting their potential role in spilling over AIVs to poultry; contrarily, waterfowls appeared to be scarcely inclined to close visits, especially during autumn and winter seasons. These findings stress the importance of ongoing research on the wild-domestic bird interface, advocating for a wider range of species to be considered in AIVs surveillance and prevention programs.
Additional Links: PMID-37894259
PubMed:
Citation:
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@article {pmid37894259,
year = {2023},
author = {Martelli, L and Fornasiero, D and Scarton, F and Spada, A and Scolamacchia, F and Manca, G and Mulatti, P},
title = {Study of the Interface between Wild Bird Populations and Poultry and Their Potential Role in the Spread of Avian Influenza.},
journal = {Microorganisms},
volume = {11},
number = {10},
pages = {},
pmid = {37894259},
issn = {2076-2607},
abstract = {Water birds play a crucial role in disseminating and amplifying avian influenza viruses (AIVs) in the environment. However, they may have limited interactions with domestic facilities, raising the hypothesis that other wild birds may play the bridging role in introducing AIVs into poultry. An ornithocoenosis study, based on census-transect and camera-trapping methods, was conducted in 2019 in ten poultry premises in northeast Italy to characterize the bird communities and envisage the species that might act as bridge hosts for AIVs. The data collected were explored through a series of multivariate analyses (correspondence analysis and non-metric multidimensional scaling), and biodiversity indices (observed and estimated richness, Shannon entropy and Pielou's evenness). The analyses revealed a high level of complexity in the ornithic population, with 147 censused species, and significant qualitative and quantitative differences in wild bird species composition, both in space and in time. Among these, only a few were observed in close proximity to the farm premises (i.e., Magpies, Blackbirds, Cattle Egrets, Pheasants, Eurasian Collared Doves, and Wood Pigeons), thus suggesting their potential role in spilling over AIVs to poultry; contrarily, waterfowls appeared to be scarcely inclined to close visits, especially during autumn and winter seasons. These findings stress the importance of ongoing research on the wild-domestic bird interface, advocating for a wider range of species to be considered in AIVs surveillance and prevention programs.},
}
RevDate: 2023-11-03
CmpDate: 2023-10-30
Australasian Pigeon Circoviruses Demonstrate Natural Spillover Infection.
Viruses, 15(10):.
Pigeon circovirus (PiCV) is considered to be genetically diverse, with a relatively small circular single-stranded DNA genome of 2 kb that encodes for a capsid protein (Cap) and a replication initiator protein (Rep). Australasia is known to be the origin of diverse species of the Order Columbiformes, but limited data on the PiCV genome sequence has hindered phylogeographic studies in this species. To fill this gap, this study was conducted to investigate PiCV in 118 characteristic samples from different birds across Australia using PCR and sequencing. Eighteen partial PiCV Rep sequences and one complete PiCV genome sequence were recovered from reservoir and aberrant hosts. Phylogenetic analyses revealed that PiCV circulating in Australia was scattered across three different subclades. Importantly, one subclade dominated within the PiCV sequenced from Australia and Poland, whereas other PiCV sequenced in this study were more closely related to the PiCV sequenced from China, USA and Japan. In addition, PiCV Rep sequences obtained from clinically affected plumed whistling duck, blue billed duck and Australian magpie demonstrated natural spillover of PiCV unveiled host generalist characteristics of the pigeon circovirus. These findings indicate that PiCV genomes circulating in Australia lack host adapted population structure but demonstrate natural spillover infection.
Additional Links: PMID-37896802
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Citation:
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@article {pmid37896802,
year = {2023},
author = {Nath, BK and Das, T and Peters, A and Gupta, SD and Sarker, S and Forwood, JK and Raidal, SR and Das, S},
title = {Australasian Pigeon Circoviruses Demonstrate Natural Spillover Infection.},
journal = {Viruses},
volume = {15},
number = {10},
pages = {},
pmid = {37896802},
issn = {1999-4915},
mesh = {Animals ; Columbidae ; *Circovirus/genetics ; Phylogeny ; Australia/epidemiology ; Polymerase Chain Reaction ; Genome, Viral ; *Circoviridae Infections ; *Bird Diseases ; },
abstract = {Pigeon circovirus (PiCV) is considered to be genetically diverse, with a relatively small circular single-stranded DNA genome of 2 kb that encodes for a capsid protein (Cap) and a replication initiator protein (Rep). Australasia is known to be the origin of diverse species of the Order Columbiformes, but limited data on the PiCV genome sequence has hindered phylogeographic studies in this species. To fill this gap, this study was conducted to investigate PiCV in 118 characteristic samples from different birds across Australia using PCR and sequencing. Eighteen partial PiCV Rep sequences and one complete PiCV genome sequence were recovered from reservoir and aberrant hosts. Phylogenetic analyses revealed that PiCV circulating in Australia was scattered across three different subclades. Importantly, one subclade dominated within the PiCV sequenced from Australia and Poland, whereas other PiCV sequenced in this study were more closely related to the PiCV sequenced from China, USA and Japan. In addition, PiCV Rep sequences obtained from clinically affected plumed whistling duck, blue billed duck and Australian magpie demonstrated natural spillover of PiCV unveiled host generalist characteristics of the pigeon circovirus. These findings indicate that PiCV genomes circulating in Australia lack host adapted population structure but demonstrate natural spillover infection.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Columbidae
*Circovirus/genetics
Phylogeny
Australia/epidemiology
Polymerase Chain Reaction
Genome, Viral
*Circoviridae Infections
*Bird Diseases
RevDate: 2025-09-29
CmpDate: 2023-11-01
Association neurons in the crow telencephalon link visual signs to numerical values.
Proceedings of the National Academy of Sciences of the United States of America, 120(45):e2313923120.
Many animals can associate signs with numerical values and use these signs in a goal-directed way during task performance. However, the neuronal basis of this semantic association has only rarely been investigated, and so far only in primates. How mechanisms of number associations are implemented in the distinctly evolved brains of other animal taxa such as birds is currently unknown. Here, we explored this semantic number-sign mapping by recording single-neuron activity in the crows' nidopallium caudolaterale (NCL), a brain structure critically involved in avian numerical cognition. Crows were trained to associate visual shapes with varying numbers of items in a number production task. The responses of many NCL neurons during stimulus presentation reflected the numerical values associated with visual shapes in a behaviorally relevant way. Consistent with the crow's better behavioral performance with signs, neuronal representations of numerical values extracted from shapes were more selective compared to those from dot arrays. The existence of number association neurons in crows points to a phylogenetic preadaptation of the brains of cognitively advanced vertebrates to link visual shapes with numerical meaning.
Additional Links: PMID-37903264
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Citation:
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@article {pmid37903264,
year = {2023},
author = {Kirschhock, ME and Nieder, A},
title = {Association neurons in the crow telencephalon link visual signs to numerical values.},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {120},
number = {45},
pages = {e2313923120},
pmid = {37903264},
issn = {1091-6490},
support = {NI 618/12-1//Deutsche Forschungsgemeinschaft (DFG)/ ; },
mesh = {Animals ; *Crows ; Phylogeny ; Brain/physiology ; Neurons/physiology ; Telencephalon ; },
abstract = {Many animals can associate signs with numerical values and use these signs in a goal-directed way during task performance. However, the neuronal basis of this semantic association has only rarely been investigated, and so far only in primates. How mechanisms of number associations are implemented in the distinctly evolved brains of other animal taxa such as birds is currently unknown. Here, we explored this semantic number-sign mapping by recording single-neuron activity in the crows' nidopallium caudolaterale (NCL), a brain structure critically involved in avian numerical cognition. Crows were trained to associate visual shapes with varying numbers of items in a number production task. The responses of many NCL neurons during stimulus presentation reflected the numerical values associated with visual shapes in a behaviorally relevant way. Consistent with the crow's better behavioral performance with signs, neuronal representations of numerical values extracted from shapes were more selective compared to those from dot arrays. The existence of number association neurons in crows points to a phylogenetic preadaptation of the brains of cognitively advanced vertebrates to link visual shapes with numerical meaning.},
}
MeSH Terms:
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hide MeSH Terms
Animals
*Crows
Phylogeny
Brain/physiology
Neurons/physiology
Telencephalon
RevDate: 2024-09-28
fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia.
Schizophrenia (Heidelberg, Germany), 9(1):75.
Although schizophrenia (SZ) represents a complex multiform psychiatric disorder, one of its most striking symptoms are auditory verbal hallucinations (AVH). While the neurophysiological origin of this pervasive symptom has been extensively studied, there is so far no consensus conclusion on the neural correlates of the vulnerability to hallucinate. With a network-based fMRI approach, following the hypothesis of altered hemispheric dominance (Crow, 1997), we expected that LN alterations might result in self-other distinction impairments in SZ patients, and lead to the distressing subjective experiences of hearing voices. We used the independent component analysis of resting-state fMRI data, to first analyze LN connectivity in three groups of participants: SZ patients with and without hallucinations (AVH/D+ and AVH/D-, respectively), and a matched healthy control (HC) group. Then, we assessed the fMRI fluctuations using additional analyses based on fractional Amplitude of Low Frequency-Fluctuations (fALFF), both at the network- and region of interest (ROI)-level. Specific LN nodes were recruited in the right hemisphere (insula and Broca homologous area) for AVH/D+ , but not for HC and AVH/D-, consistent with a left hemisphere deficit in AVH patients. The fALFF analysis at the ROI level showed a negative correlation between fALFF Slow-4 and P1 Delusions PANSS subscale and a positive correlation between the fALFF Slow-5 and P3 Hallucination PANSS subscale for AVH/D+ only. These effects were not a consequence of structural differences between groups, as morphometric analysis did not evidence any group differences. Given the role of language as an emerging property resulting from the integration of many high-level cognitive processes and the underlying cortical areas, our results suggest that LN features from fMRI connectivity and fluctuations can be a marker of neurophysiological features characterizing SZ patients depending on their vulnerability to hallucinate.
Additional Links: PMID-37903802
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Citation:
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@article {pmid37903802,
year = {2023},
author = {Spironelli, C and Marino, M and Mantini, D and Montalti, R and Craven, AR and Ersland, L and Angrilli, A and Hugdahl, K},
title = {fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia.},
journal = {Schizophrenia (Heidelberg, Germany)},
volume = {9},
number = {1},
pages = {75},
pmid = {37903802},
issn = {2754-6993},
abstract = {Although schizophrenia (SZ) represents a complex multiform psychiatric disorder, one of its most striking symptoms are auditory verbal hallucinations (AVH). While the neurophysiological origin of this pervasive symptom has been extensively studied, there is so far no consensus conclusion on the neural correlates of the vulnerability to hallucinate. With a network-based fMRI approach, following the hypothesis of altered hemispheric dominance (Crow, 1997), we expected that LN alterations might result in self-other distinction impairments in SZ patients, and lead to the distressing subjective experiences of hearing voices. We used the independent component analysis of resting-state fMRI data, to first analyze LN connectivity in three groups of participants: SZ patients with and without hallucinations (AVH/D+ and AVH/D-, respectively), and a matched healthy control (HC) group. Then, we assessed the fMRI fluctuations using additional analyses based on fractional Amplitude of Low Frequency-Fluctuations (fALFF), both at the network- and region of interest (ROI)-level. Specific LN nodes were recruited in the right hemisphere (insula and Broca homologous area) for AVH/D+ , but not for HC and AVH/D-, consistent with a left hemisphere deficit in AVH patients. The fALFF analysis at the ROI level showed a negative correlation between fALFF Slow-4 and P1 Delusions PANSS subscale and a positive correlation between the fALFF Slow-5 and P3 Hallucination PANSS subscale for AVH/D+ only. These effects were not a consequence of structural differences between groups, as morphometric analysis did not evidence any group differences. Given the role of language as an emerging property resulting from the integration of many high-level cognitive processes and the underlying cortical areas, our results suggest that LN features from fMRI connectivity and fluctuations can be a marker of neurophysiological features characterizing SZ patients depending on their vulnerability to hallucinate.},
}
RevDate: 2023-11-20
CmpDate: 2023-11-20
Diversifying medical humanities: The case for Jay-Z.
Cleveland Clinic journal of medicine, 89(9):501-503 pii:89/9/501.
Additional Links: PMID-37907444
Publisher:
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Citation:
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@article {pmid37907444,
year = {2022},
author = {Khorana, AA},
title = {Diversifying medical humanities: The case for Jay-Z.},
journal = {Cleveland Clinic journal of medicine},
volume = {89},
number = {9},
pages = {501-503},
doi = {10.3949/ccjm.89a.22011},
pmid = {37907444},
issn = {1939-2869},
}
RevDate: 2023-11-08
CmpDate: 2023-11-02
Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides.
Scientific reports, 13(1):18728.
Multidrug resistance has become a global health problem associated with high morbidity and mortality. Antimicrobial peptides have been acknowledged as potential leads for prospective anti-infectives. Owing to their scavenging lifestyle, Corvus splendens is thought to have developed robust immunity to pathogens found in their diet, implying that they have evolved mechanisms to resist infection. In the current study, the transcriptome of C. splendens was sequenced, and de novo assembled to identify the presence of antimicrobial peptide genes. 72.09 million high-quality clean reads were obtained which were then de novo assembled into 3,43,503 transcripts and 74,958 unigenes. About 37,559 unigenes were successfully annotated using SwissProt, Pfam, GO, and KEGG databases. A search against APD3, CAMPR3 and LAMP databases identified 63 AMP candidates belonging to more than 20 diverse families and functional classes. mRNA of AvBD-2, AvBD-13 and CATH-2 were found to be differentially expressed between the three tested crows as well as among the tissues. We also characterized Corvus Cathelicidin 2 (CATH-2) to gain knowledge of its antimicrobial mechanisms. The CD spectroscopy of synthesized mature Corvus CATH-2 peptide displayed an amphipathic α-helical structure. Though the synthetic CATH-2 caused hemolysis of human RBC, it also exhibited antimicrobial activity against E. coli, S. aureus, and B. cereus. Docking simulation results revealed that this peptide could bind to the LPS binding site of MD-2, which may prevent LPS from entering the MD-2 binding pocket, and trigger TLR4 signaling pathway. The Corvus CATH-2 characterized in this study could aid in the development of novel therapeutics.
Additional Links: PMID-37907616
PubMed:
Citation:
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@article {pmid37907616,
year = {2023},
author = {Kannoth, S and Ali, N and Prasanth, GK and Arvind, K and Mohany, M and Hembrom, PS and Sadanandan, S and Vasu, DA and Grace, T},
title = {Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {18728},
pmid = {37907616},
issn = {2045-2322},
mesh = {Animals ; Humans ; *Crows ; Antimicrobial Peptides ; Staphylococcus aureus/genetics ; Escherichia coli/genetics ; Lipopolysaccharides ; Gene Expression Profiling ; *Anti-Infective Agents/pharmacology ; Cathelicidins/chemistry ; Transcriptome ; },
abstract = {Multidrug resistance has become a global health problem associated with high morbidity and mortality. Antimicrobial peptides have been acknowledged as potential leads for prospective anti-infectives. Owing to their scavenging lifestyle, Corvus splendens is thought to have developed robust immunity to pathogens found in their diet, implying that they have evolved mechanisms to resist infection. In the current study, the transcriptome of C. splendens was sequenced, and de novo assembled to identify the presence of antimicrobial peptide genes. 72.09 million high-quality clean reads were obtained which were then de novo assembled into 3,43,503 transcripts and 74,958 unigenes. About 37,559 unigenes were successfully annotated using SwissProt, Pfam, GO, and KEGG databases. A search against APD3, CAMPR3 and LAMP databases identified 63 AMP candidates belonging to more than 20 diverse families and functional classes. mRNA of AvBD-2, AvBD-13 and CATH-2 were found to be differentially expressed between the three tested crows as well as among the tissues. We also characterized Corvus Cathelicidin 2 (CATH-2) to gain knowledge of its antimicrobial mechanisms. The CD spectroscopy of synthesized mature Corvus CATH-2 peptide displayed an amphipathic α-helical structure. Though the synthetic CATH-2 caused hemolysis of human RBC, it also exhibited antimicrobial activity against E. coli, S. aureus, and B. cereus. Docking simulation results revealed that this peptide could bind to the LPS binding site of MD-2, which may prevent LPS from entering the MD-2 binding pocket, and trigger TLR4 signaling pathway. The Corvus CATH-2 characterized in this study could aid in the development of novel therapeutics.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Humans
*Crows
Antimicrobial Peptides
Staphylococcus aureus/genetics
Escherichia coli/genetics
Lipopolysaccharides
Gene Expression Profiling
*Anti-Infective Agents/pharmacology
Cathelicidins/chemistry
Transcriptome
RevDate: 2023-11-08
CmpDate: 2023-11-06
A new Chinese crow's feet grading scale based on the DermaTOP system.
Scientific reports, 13(1):18903.
Many Chinese wrinkle studies continue to use non-Chinese scales because few Chinese-based wrinkle scales have been developed. The study aims to develop a crow's feet grading scale for Chinese individuals. We enrolled 608 healthy Chinese subjects and measured data through the DermaTOP system. We chose exploratory factor analysis (EFA) to reduce the dimensions of the data. A three-factor structure was obtained by using EFA, and it explained a cumulative total of 89.551% of the variance. A computational formula was obtained by calculating the total factor tilt scores and taking the variance contribution rate of three factors as the weight. Based on the computational formula, a grading map was designed and tested. The model validation was conducted using both subjective assessments from the expert panel and objective results from the model calculations. The results showed that our grading scale model is stable. This study developed a Chinese crow's feet (CCF) grading scale, which included a parameter, a grading map, and literal descriptions. The CCF grading scale is a validated tool for evaluating the effects of cosmetics or specific therapies. More importantly, the CCF scale was developed based on objective data, which may inspire new ideas for wrinkle grading scale development in the future.
Additional Links: PMID-37919347
PubMed:
Citation:
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@article {pmid37919347,
year = {2023},
author = {Han, Y and Li, C and Wang, R and Zhang, J and Wu, F and Zhao, J and Yan, S and Liu, Q and Pan, Y},
title = {A new Chinese crow's feet grading scale based on the DermaTOP system.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {18903},
pmid = {37919347},
issn = {2045-2322},
mesh = {Humans ; *Cosmetics ; East Asian People ; *Skin Aging ; },
abstract = {Many Chinese wrinkle studies continue to use non-Chinese scales because few Chinese-based wrinkle scales have been developed. The study aims to develop a crow's feet grading scale for Chinese individuals. We enrolled 608 healthy Chinese subjects and measured data through the DermaTOP system. We chose exploratory factor analysis (EFA) to reduce the dimensions of the data. A three-factor structure was obtained by using EFA, and it explained a cumulative total of 89.551% of the variance. A computational formula was obtained by calculating the total factor tilt scores and taking the variance contribution rate of three factors as the weight. Based on the computational formula, a grading map was designed and tested. The model validation was conducted using both subjective assessments from the expert panel and objective results from the model calculations. The results showed that our grading scale model is stable. This study developed a Chinese crow's feet (CCF) grading scale, which included a parameter, a grading map, and literal descriptions. The CCF grading scale is a validated tool for evaluating the effects of cosmetics or specific therapies. More importantly, the CCF scale was developed based on objective data, which may inspire new ideas for wrinkle grading scale development in the future.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
*Cosmetics
East Asian People
*Skin Aging
RevDate: 2023-12-16
CmpDate: 2023-12-16
[Independence of the anthropometric profile, attention and intelligence in higher education students in the field of physical activity in Chile].
Nutricion hospitalaria, 40(6):1246-1252.
Introduction: kinanthropometry is the current science that studies body parameters in relation to its functioning (such as body composition, proportionality, somatotype, etc.), with established norms, techniques and criteria. Objective: to relate anthropometric profile, attention and problem solving in higher education students in the field of physical activity in Chile. Method: quantitative-correlational approach, with non-experimental and cross-sectional design. Results: there is no significant relationship between body composition (body masses) and cognitive tests (attention and Raven). Regarding anthropometric data (body composition), no significant differences were observed between the sexes for any parameter. Conclusion: it can be deduced that the results of the cognitive factors may be associated with other variables, and not specifically with the variables that may affect anthropometric parameters. These are very interesting topics for future studies, so it is suggested to continue studying cognitive abilities with other variables.
Additional Links: PMID-37929861
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PubMed:
Citation:
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@article {pmid37929861,
year = {2023},
author = {Morales, C and Flores Ferro, E and Osorio, J and Maureira Cid, F},
title = {[Independence of the anthropometric profile, attention and intelligence in higher education students in the field of physical activity in Chile].},
journal = {Nutricion hospitalaria},
volume = {40},
number = {6},
pages = {1246-1252},
doi = {10.20960/nh.04719},
pmid = {37929861},
issn = {1699-5198},
mesh = {Humans ; Chile ; Cross-Sectional Studies ; Anthropometry ; *Body Composition ; *Exercise ; Intelligence ; Students ; Attention ; },
abstract = {Introduction: kinanthropometry is the current science that studies body parameters in relation to its functioning (such as body composition, proportionality, somatotype, etc.), with established norms, techniques and criteria. Objective: to relate anthropometric profile, attention and problem solving in higher education students in the field of physical activity in Chile. Method: quantitative-correlational approach, with non-experimental and cross-sectional design. Results: there is no significant relationship between body composition (body masses) and cognitive tests (attention and Raven). Regarding anthropometric data (body composition), no significant differences were observed between the sexes for any parameter. Conclusion: it can be deduced that the results of the cognitive factors may be associated with other variables, and not specifically with the variables that may affect anthropometric parameters. These are very interesting topics for future studies, so it is suggested to continue studying cognitive abilities with other variables.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Chile
Cross-Sectional Studies
Anthropometry
*Body Composition
*Exercise
Intelligence
Students
Attention
RevDate: 2023-11-09
CmpDate: 2023-11-08
Corvids optimize working memory by categorizing continuous stimuli.
Communications biology, 6(1):1122.
Working memory (WM) is a crucial element of the higher cognition of primates and corvid songbirds. Despite its importance, WM has a severely limited capacity and is vulnerable to noise. In primates, attractor dynamics mitigate the effect of noise by discretizing continuous information. Yet, it remains unclear whether similar dynamics are seen in avian brains. Here, we show jackdaws (Corvus monedula) have similar behavioral biases as humans; memories are less precise and more biased as memory demands increase. Model-based analysis reveal discrete attractors are evenly spread across the stimulus space. Altogether, our comparative approach suggests attractor dynamics in primates and corvids mitigate the effect of noise by systematically drifting towards specific attractors. By demonstrating this effect in an evolutionary distant species, our results strengthen attractor dynamics as general, adaptive biological principle to efficiently use WM.
Additional Links: PMID-37932494
PubMed:
Citation:
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@article {pmid37932494,
year = {2023},
author = {Apostel, A and Panichello, M and Buschman, TJ and Rose, J},
title = {Corvids optimize working memory by categorizing continuous stimuli.},
journal = {Communications biology},
volume = {6},
number = {1},
pages = {1122},
pmid = {37932494},
issn = {2399-3642},
mesh = {Animals ; Humans ; *Memory, Short-Term ; Brain ; Cognition ; *Songbirds ; Primates ; },
abstract = {Working memory (WM) is a crucial element of the higher cognition of primates and corvid songbirds. Despite its importance, WM has a severely limited capacity and is vulnerable to noise. In primates, attractor dynamics mitigate the effect of noise by discretizing continuous information. Yet, it remains unclear whether similar dynamics are seen in avian brains. Here, we show jackdaws (Corvus monedula) have similar behavioral biases as humans; memories are less precise and more biased as memory demands increase. Model-based analysis reveal discrete attractors are evenly spread across the stimulus space. Altogether, our comparative approach suggests attractor dynamics in primates and corvids mitigate the effect of noise by systematically drifting towards specific attractors. By demonstrating this effect in an evolutionary distant species, our results strengthen attractor dynamics as general, adaptive biological principle to efficiently use WM.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Humans
*Memory, Short-Term
Brain
Cognition
*Songbirds
Primates
RevDate: 2024-12-09
CmpDate: 2024-09-17
Crows make optimal choices based on relative probabilities.
Learning & behavior, 52(3):207-208.
A recent study by Johnston, Brecht, and Nieder (2023, Current Biology, 33, 3238-3243) finds that carrion crows associate varying rates of reinforcement with novel arbitrary stimuli and make optimal decisions when they must later choose between stimulus pairs. These results demonstrate that crows are capable of not only storing information about reward probabilities in their memory but also making optimal choices based on this information even a month later.
Additional Links: PMID-37945911
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Citation:
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@article {pmid37945911,
year = {2024},
author = {Bastos, APM},
title = {Crows make optimal choices based on relative probabilities.},
journal = {Learning & behavior},
volume = {52},
number = {3},
pages = {207-208},
pmid = {37945911},
issn = {1543-4508},
mesh = {*Crows ; *Choice Behavior ; Animals ; Probability ; Reward ; Reinforcement, Psychology ; },
abstract = {A recent study by Johnston, Brecht, and Nieder (2023, Current Biology, 33, 3238-3243) finds that carrion crows associate varying rates of reinforcement with novel arbitrary stimuli and make optimal decisions when they must later choose between stimulus pairs. These results demonstrate that crows are capable of not only storing information about reward probabilities in their memory but also making optimal choices based on this information even a month later.},
}
MeSH Terms:
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*Crows
*Choice Behavior
Animals
Probability
Reward
Reinforcement, Psychology
RevDate: 2024-02-10
CmpDate: 2023-11-13
Developing and Implementing a Culturally Consonant Treatment Fidelity Support Plan with the Apsáalooke Nation.
International journal of environmental research and public health, 20(21):.
Treatment fidelity remains underreported in health intervention research, particularly among Indigenous communities. One explanation for this gap is the lack of culturally consonant strategies listed in the National Institutes of Health (NIH) Behavior Change Consortium (BCC) treatment fidelity framework, the gold standard for understanding and measuring fidelity. This paper focuses on the development and implementation of a culturally consonant treatment fidelity support plan across two of the five BCC fidelity areas, provider training and treatment delivery, within a chronic illness self-management program for the Apsáalooke (Crow) Nation. Our team selected and adapted strategies from, and added strategies to, the BCC framework, that centered on relational accountability and the Apsáalooke culture. To be culturally consonant, we approached treatment fidelity as supporting Aakbaabaaniilea (Apsáalooke program facilitators) rather than monitoring them. This resulted in the development of a fifth treatment fidelity area: building and fostering relationships. We propose that fidelity to relational accountability is the foundation of successful programs in Indigenous communities. This suggests an important shift from tracking what was conducted in an intervention to prioritizing how things were conducted. We encourage others to view the BCC framework as a starting point in developing fidelity strategies that are consonant with local cultures.
Additional Links: PMID-37947547
PubMed:
Citation:
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@article {pmid37947547,
year = {2023},
author = {Keene, S and Allen, S and McCormick, AKHG and Trottier, C and Bull Shows, B and Hallett, J and Deernose, R and Held, S},
title = {Developing and Implementing a Culturally Consonant Treatment Fidelity Support Plan with the Apsáalooke Nation.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {21},
pages = {},
pmid = {37947547},
issn = {1660-4601},
support = {P20 GM103474/GM/NIGMS NIH HHS/United States ; U01 MD010619/MD/NIMHD NIH HHS/United States ; U54 GM104944/GM/NIGMS NIH HHS/United States ; },
mesh = {United States ; Humans ; Behavior Therapy ; *Self-Management ; Chronic Disease ; *Health Services, Indigenous ; National Institutes of Health (U.S.) ; },
abstract = {Treatment fidelity remains underreported in health intervention research, particularly among Indigenous communities. One explanation for this gap is the lack of culturally consonant strategies listed in the National Institutes of Health (NIH) Behavior Change Consortium (BCC) treatment fidelity framework, the gold standard for understanding and measuring fidelity. This paper focuses on the development and implementation of a culturally consonant treatment fidelity support plan across two of the five BCC fidelity areas, provider training and treatment delivery, within a chronic illness self-management program for the Apsáalooke (Crow) Nation. Our team selected and adapted strategies from, and added strategies to, the BCC framework, that centered on relational accountability and the Apsáalooke culture. To be culturally consonant, we approached treatment fidelity as supporting Aakbaabaaniilea (Apsáalooke program facilitators) rather than monitoring them. This resulted in the development of a fifth treatment fidelity area: building and fostering relationships. We propose that fidelity to relational accountability is the foundation of successful programs in Indigenous communities. This suggests an important shift from tracking what was conducted in an intervention to prioritizing how things were conducted. We encourage others to view the BCC framework as a starting point in developing fidelity strategies that are consonant with local cultures.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
United States
Humans
Behavior Therapy
*Self-Management
Chronic Disease
*Health Services, Indigenous
National Institutes of Health (U.S.)
RevDate: 2024-07-22
CmpDate: 2024-02-12
Effectiveness of intermittent iron and high-dose vitamin A supplementation on cognitive development of school children in southern Ethiopia: a randomized placebo-controlled trial.
The American journal of clinical nutrition, 119(2):470-484.
BACKGROUND: Iron is an essential mineral whose deficiency results in cognitive alteration, impaired emotional behaviors, and altered myelination and neurotransmission. In animal models, it has been shown that vitamin A (VA) could affect cognition.
OBJECTIVES: The study aimed to evaluate the effectiveness of intermittent iron and VA supplementation on cognitive development of schoolchildren, and to assess the interaction between these supplementations.
METHODS: Considering a 2 × 2 factorial design, 504 children were randomly assigned to 1 of the 4 arms: placebo VA and placebo iron supplement; high-dose vitamin VA and placebo iron supplement; iron supplement and placebo VA; and iron and high-dose vitamin VA supplements. Cognitive development was assessed using Raven's Coloured Progressive Matrices, digit span, Tower of London, and visual search tasks.
RESULTS: The mean [± standard deviation (SD)] age of the enrolled children was 9.6 (±1.6) y. One-fifth of the children had iron deficiency or anemia, whereas 2.9%, 3.9%, and 12.1% of children had low iron stores, iron deficiency anemia, and VA deficiency, respectively. Intermittent iron supplementation did not result in any significant improvement of children's cognitive development and had a negative effect on the performance index of the visual search task compared with placebo (-0.17 SD, 95% confidence interval: -0.32, -0.02). Effects were evident among children with stunting, thinness, or children coming from understimulating home environments. High-dose VA supplementation resulted in a significant improvement of digit span z-score with a mean difference of 0.30 SD (95% confidence interval: 0.14, 0.46) compared with placebo VA. VA had a more beneficial impact for girls, children infected with helminths, and those from food secure households.
CONCLUSION: In a population where the prevalence of iron deficiency is low, intermittent iron supplementation did not have any or negative effect on the child's cognitive development outcomes. Conversely, VA supplementation improved the child's working memory.
TRIAL REGISTRATION NUMBER: The study is registered at clinicaltrials.gov as NCT04137354 (https://clinicaltrials.gov/study/NCT04137354).
Additional Links: PMID-37952928
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PubMed:
Citation:
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@article {pmid37952928,
year = {2024},
author = {Gutema, BT and Levecke, B and Sorrie, MB and Megersa, ND and Zewdie, TH and Yesera, GE and De Henauw, S and Abubakar, A and Abbeddou, S},
title = {Effectiveness of intermittent iron and high-dose vitamin A supplementation on cognitive development of school children in southern Ethiopia: a randomized placebo-controlled trial.},
journal = {The American journal of clinical nutrition},
volume = {119},
number = {2},
pages = {470-484},
doi = {10.1016/j.ajcnut.2023.11.005},
pmid = {37952928},
issn = {1938-3207},
mesh = {Child ; Female ; Humans ; Cognition ; Dietary Supplements ; Ethiopia ; *Iron ; *Iron Deficiencies ; Vitamin A ; Vitamins ; Male ; },
abstract = {BACKGROUND: Iron is an essential mineral whose deficiency results in cognitive alteration, impaired emotional behaviors, and altered myelination and neurotransmission. In animal models, it has been shown that vitamin A (VA) could affect cognition.
OBJECTIVES: The study aimed to evaluate the effectiveness of intermittent iron and VA supplementation on cognitive development of schoolchildren, and to assess the interaction between these supplementations.
METHODS: Considering a 2 × 2 factorial design, 504 children were randomly assigned to 1 of the 4 arms: placebo VA and placebo iron supplement; high-dose vitamin VA and placebo iron supplement; iron supplement and placebo VA; and iron and high-dose vitamin VA supplements. Cognitive development was assessed using Raven's Coloured Progressive Matrices, digit span, Tower of London, and visual search tasks.
RESULTS: The mean [± standard deviation (SD)] age of the enrolled children was 9.6 (±1.6) y. One-fifth of the children had iron deficiency or anemia, whereas 2.9%, 3.9%, and 12.1% of children had low iron stores, iron deficiency anemia, and VA deficiency, respectively. Intermittent iron supplementation did not result in any significant improvement of children's cognitive development and had a negative effect on the performance index of the visual search task compared with placebo (-0.17 SD, 95% confidence interval: -0.32, -0.02). Effects were evident among children with stunting, thinness, or children coming from understimulating home environments. High-dose VA supplementation resulted in a significant improvement of digit span z-score with a mean difference of 0.30 SD (95% confidence interval: 0.14, 0.46) compared with placebo VA. VA had a more beneficial impact for girls, children infected with helminths, and those from food secure households.
CONCLUSION: In a population where the prevalence of iron deficiency is low, intermittent iron supplementation did not have any or negative effect on the child's cognitive development outcomes. Conversely, VA supplementation improved the child's working memory.
TRIAL REGISTRATION NUMBER: The study is registered at clinicaltrials.gov as NCT04137354 (https://clinicaltrials.gov/study/NCT04137354).},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Child
Female
Humans
Cognition
Dietary Supplements
Ethiopia
*Iron
*Iron Deficiencies
Vitamin A
Vitamins
Male
RevDate: 2023-11-17
A Novel Prognostic Model Using Chaotic CNN with Hybridized Spoofing for Enhancing Diagnostic Accuracy in Epileptic Seizure Prediction.
Diagnostics (Basel, Switzerland), 13(21):.
Epileptic seizure detection has undergone progressive advancements since its conception in the 1970s. From proof-of-concept experiments in the latter part of that decade, it has now become a vibrant area of clinical and laboratory research. In an effort to bring this technology closer to practical application in human patients, this study introduces a customized approach to selecting electroencephalogram (EEG) features and electrode positions for seizure prediction. The focus is on identifying precursors that occur within 10 min of the onset of abnormal electrical activity during a seizure. However, there are security concerns related to safeguarding patient EEG recordings against unauthorized access and network-based attacks. Therefore, there is an urgent need for an efficient prediction and classification method for encrypted EEG data. This paper presents an effective system for analyzing and recognizing encrypted EEG information using Arnold transform algorithms, chaotic mapping, and convolutional neural networks (CNNs). In this system, the EEG time series from each channel is converted into a 2D spectrogram image, which is then encrypted using chaotic algorithms. The encrypted data is subsequently processed by CNNs coupled with transfer learning (TL) frameworks. To optimize the fusion parameters of the ensemble learning classifiers, a hybridized spoofing optimization method is developed by combining the characteristics of corvid and gregarious-seeking agents. The evaluation of the model's effectiveness yielded the following results: 98.9 ± 0.3% accuracy, 98.2 ± 0.7% sensitivity, 98.6 ± 0.6% specificity, 98.6 ± 0.6% precision, and an F1 measure of 98.9 ± 0.6%. When compared with other state-of-the-art techniques applied to the same dataset, this novel strategy demonstrated one of the most effective seizure detection systems, as evidenced by these results.
Additional Links: PMID-37958278
PubMed:
Citation:
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@article {pmid37958278,
year = {2023},
author = {Palanisamy, P and Urooj, S and Arunachalam, R and Lay-Ekuakille, A},
title = {A Novel Prognostic Model Using Chaotic CNN with Hybridized Spoofing for Enhancing Diagnostic Accuracy in Epileptic Seizure Prediction.},
journal = {Diagnostics (Basel, Switzerland)},
volume = {13},
number = {21},
pages = {},
pmid = {37958278},
issn = {2075-4418},
support = {PNURSP2023R79//Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia./ ; },
abstract = {Epileptic seizure detection has undergone progressive advancements since its conception in the 1970s. From proof-of-concept experiments in the latter part of that decade, it has now become a vibrant area of clinical and laboratory research. In an effort to bring this technology closer to practical application in human patients, this study introduces a customized approach to selecting electroencephalogram (EEG) features and electrode positions for seizure prediction. The focus is on identifying precursors that occur within 10 min of the onset of abnormal electrical activity during a seizure. However, there are security concerns related to safeguarding patient EEG recordings against unauthorized access and network-based attacks. Therefore, there is an urgent need for an efficient prediction and classification method for encrypted EEG data. This paper presents an effective system for analyzing and recognizing encrypted EEG information using Arnold transform algorithms, chaotic mapping, and convolutional neural networks (CNNs). In this system, the EEG time series from each channel is converted into a 2D spectrogram image, which is then encrypted using chaotic algorithms. The encrypted data is subsequently processed by CNNs coupled with transfer learning (TL) frameworks. To optimize the fusion parameters of the ensemble learning classifiers, a hybridized spoofing optimization method is developed by combining the characteristics of corvid and gregarious-seeking agents. The evaluation of the model's effectiveness yielded the following results: 98.9 ± 0.3% accuracy, 98.2 ± 0.7% sensitivity, 98.6 ± 0.6% specificity, 98.6 ± 0.6% precision, and an F1 measure of 98.9 ± 0.6%. When compared with other state-of-the-art techniques applied to the same dataset, this novel strategy demonstrated one of the most effective seizure detection systems, as evidenced by these results.},
}
RevDate: 2024-02-09
CmpDate: 2024-02-09
Punctuated equilibrium at 50: Anything there for evolutionary anthropology? Yes; definitely.
Evolutionary anthropology, 33(1):e22009.
The theory of punctuated equilibrium (PE) was developed a little over 50 years ago to explain long-term, large-scale appearance and disappearance of species in the fossil record. A theory designed specifically for that purpose cannot be expected, out of the box, to be directly applicable to biocultural evolution, but in revised form, PE offers a promising approach to incorporating not only a wealth of recent empirical research on genetic, linguistic, and technological evolution but also large databases that document human biological and cultural diversity across time and space. Here we isolate the fundamental components of PE and propose which pieces, when reassembled or renamed, can be highly useful in evolutionary anthropology, especially as humanity faces abrupt ecological challenges on an increasingly larger scale.
Additional Links: PMID-37961949
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PubMed:
Citation:
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@article {pmid37961949,
year = {2024},
author = {O'Brien, MJ and Valverde, S and Duran-Nebreda, S and Vidiella, B and Bentley, RA},
title = {Punctuated equilibrium at 50: Anything there for evolutionary anthropology? Yes; definitely.},
journal = {Evolutionary anthropology},
volume = {33},
number = {1},
pages = {e22009},
doi = {10.1002/evan.22009},
pmid = {37961949},
issn = {1520-6505},
support = {2019 BP 00206//Beatriu de Pinós postdoctoral programme in the Office of the General Secretary of Research and Universities and the Ministry of Research and Univertisites/ ; 801370//Marie Sklodowska-Curie COFUND/ ; //2020-2021 Biodiversa and Water JPI/ ; 101003777//BiodivRestore ERA-NET Cofund/ ; //Innovation Fund Denmark (IFD)/ ; //Agence Nationale de la Recherche (ANR)/ ; //Fundação para a Ciência e a Tecnologia (FCT)/ ; //Swedish Environmental Protection Agency (SEPA)/ ; PCI2022-132936//MCIN/AEI/10.13039/501100011033/ ; //European Union NextGenerationEU/PRTR/ ; PID2020-117822GB-I00/AEI/10.13039/501100011033//Spanish Ministry of Science and Innovation through the State Research Agency (AEI)/ ; },
mesh = {Humans ; *Biological Evolution ; *Fossils ; Cultural Diversity ; Databases, Factual ; },
abstract = {The theory of punctuated equilibrium (PE) was developed a little over 50 years ago to explain long-term, large-scale appearance and disappearance of species in the fossil record. A theory designed specifically for that purpose cannot be expected, out of the box, to be directly applicable to biocultural evolution, but in revised form, PE offers a promising approach to incorporating not only a wealth of recent empirical research on genetic, linguistic, and technological evolution but also large databases that document human biological and cultural diversity across time and space. Here we isolate the fundamental components of PE and propose which pieces, when reassembled or renamed, can be highly useful in evolutionary anthropology, especially as humanity faces abrupt ecological challenges on an increasingly larger scale.},
}
MeSH Terms:
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Humans
*Biological Evolution
*Fossils
Cultural Diversity
Databases, Factual
RevDate: 2024-12-07
CmpDate: 2023-11-16
National hospital costing systems matter for universal healthcare: the India PM-JAY experience.
BMJ global health, 8(11):.
India envisions achieving universal health coverage to provide its people with access to affordable quality health services. A breakthrough effort in this direction has been the launch of the world's largest health assurance scheme Ayushman Bharat Pradhan Mantri Jan Arogya Yojana, the implementation of which resides with the National Health Authority. Appropriate provider payment systems and reimbursement rates are an important element for the success of PM-JAY, which in turn relies on robust cost evidence to support pricing decisions. Since the launch of PM-JAY, the health benefits package and provider payment rates have undergone a series of revisions. At the outset, there was a relative lack of cost data. Later revisions relied on health facility costing studies, and now there is an initiative to establish a national hospital costing system relying on provider-generated data. Lessons from PM-JAY experience show that the success of such cost systems to ensure regular and routine generation of evidence is contingent on integrating with existing billing or patient information systems or management information systems, which digitise similar information on resource consumption without any additional data entry effort. Therefore, there is a need to focus on building sustainable mechanisms for setting up systems for generating accurate cost data rather than relying on resource-intensive studies for cost data collection.
Additional Links: PMID-37963613
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Citation:
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@article {pmid37963613,
year = {2023},
author = {Prinja, S and Chugh, Y and Garg, B and Guinness, L},
title = {National hospital costing systems matter for universal healthcare: the India PM-JAY experience.},
journal = {BMJ global health},
volume = {8},
number = {11},
pages = {},
pmid = {37963613},
issn = {2059-7908},
mesh = {Humans ; *Universal Health Care ; *Health Care Costs ; Hospitals ; India ; },
abstract = {India envisions achieving universal health coverage to provide its people with access to affordable quality health services. A breakthrough effort in this direction has been the launch of the world's largest health assurance scheme Ayushman Bharat Pradhan Mantri Jan Arogya Yojana, the implementation of which resides with the National Health Authority. Appropriate provider payment systems and reimbursement rates are an important element for the success of PM-JAY, which in turn relies on robust cost evidence to support pricing decisions. Since the launch of PM-JAY, the health benefits package and provider payment rates have undergone a series of revisions. At the outset, there was a relative lack of cost data. Later revisions relied on health facility costing studies, and now there is an initiative to establish a national hospital costing system relying on provider-generated data. Lessons from PM-JAY experience show that the success of such cost systems to ensure regular and routine generation of evidence is contingent on integrating with existing billing or patient information systems or management information systems, which digitise similar information on resource consumption without any additional data entry effort. Therefore, there is a need to focus on building sustainable mechanisms for setting up systems for generating accurate cost data rather than relying on resource-intensive studies for cost data collection.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
*Universal Health Care
*Health Care Costs
Hospitals
India
RevDate: 2023-11-19
CmpDate: 2023-11-16
Neurocognitive and mental health outcomes in children with tungiasis: a cross-sectional study in rural Kenya and Uganda.
Infectious diseases of poverty, 12(1):100.
BACKGROUND: Tungiasis, a neglected tropical parasitosis, disproportionately affects children. Few empirical studies have reported neurocognitive and mental health outcomes of children with ectoparasitic skin diseases like tungiasis. Pathophysiology of tungiasis suggests it could detrimentally affect cognition and behaviour. This study pioneered the investigation of neurocognitive and mental health outcomes in children with tungiasis.
METHODS: This was a multi-site cross-sectional study including 454 quasi-randomly sampled school-children aged 8-14 from 48 randomly selected schools in two counties in Kenya and a district in Uganda. The participants were stratified into infected and uninfected based on the presence of tungiasis. The infected were further classified into mild and severe infection groups based on the intensity of the infection. Adapted, validated, and standardized measures of cognition and mental health such as Raven Matrices and Child Behaviour Checklist were used to collect data. Statistical tests including a multilevel, generalized mixed-effects linear models with family link set to identity were used to compare the scores of uninfected and infected children and to identify other potential risk factors for neurocognitive and behavioural outcomes.
RESULTS: When adjusted for covariates, mild infection was associated with lower scores in literacy [adjusted β(aβ) = - 8.9; 95% confidence interval (CI) - 17.2, - 0.6], language (aβ = - 1.7; 95% CI - 3.2, - 0.3), cognitive flexibility (aβ = - 6.1; 95% CI - 10.4, - 1.7) and working memory (aβ = - 0.3; 95% CI - 0.6, - 0.1). Severe infection was associated with lower scores in literacy (aβ = - 11.0; 95% CI - 19.3, - 2.8), response inhibition, (aβ = - 2.2; 95% CI - 4.2, - 0.2), fine motor control (aβ = - 0.7; 95% CI - 1.1, - 0.4) and numeracy (aβ = - 3; 95% CI - 5.5, - 0.4).
CONCLUSIONS: This study provides first evidence that tungiasis is associated with poor neurocognitive functioning in children. Since tungiasis is a chronic disease with frequent reinfections, such negative effects may potentially impair their development and life achievements.
Additional Links: PMID-37964353
PubMed:
Citation:
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@article {pmid37964353,
year = {2023},
author = {Otieno, B and Elson, L and Matharu, AK and Riithi, N and Chongwo, E and Katana, K and Nasambu, C and Mutebi, F and Feldmeier, H and Krücken, J and Fillinger, U and Abubakar, A},
title = {Neurocognitive and mental health outcomes in children with tungiasis: a cross-sectional study in rural Kenya and Uganda.},
journal = {Infectious diseases of poverty},
volume = {12},
number = {1},
pages = {100},
pmid = {37964353},
issn = {2049-9957},
support = {405027164//Deutsche Forschungsgemeinschaft/ ; KR 2245/7-1//Deutsche Forschungsgemeinschaft/ ; },
mesh = {Animals ; Humans ; Child ; *Tungiasis/epidemiology ; Cross-Sectional Studies ; Uganda/epidemiology ; Kenya/epidemiology ; Tunga/physiology ; Outcome Assessment, Health Care ; },
abstract = {BACKGROUND: Tungiasis, a neglected tropical parasitosis, disproportionately affects children. Few empirical studies have reported neurocognitive and mental health outcomes of children with ectoparasitic skin diseases like tungiasis. Pathophysiology of tungiasis suggests it could detrimentally affect cognition and behaviour. This study pioneered the investigation of neurocognitive and mental health outcomes in children with tungiasis.
METHODS: This was a multi-site cross-sectional study including 454 quasi-randomly sampled school-children aged 8-14 from 48 randomly selected schools in two counties in Kenya and a district in Uganda. The participants were stratified into infected and uninfected based on the presence of tungiasis. The infected were further classified into mild and severe infection groups based on the intensity of the infection. Adapted, validated, and standardized measures of cognition and mental health such as Raven Matrices and Child Behaviour Checklist were used to collect data. Statistical tests including a multilevel, generalized mixed-effects linear models with family link set to identity were used to compare the scores of uninfected and infected children and to identify other potential risk factors for neurocognitive and behavioural outcomes.
RESULTS: When adjusted for covariates, mild infection was associated with lower scores in literacy [adjusted β(aβ) = - 8.9; 95% confidence interval (CI) - 17.2, - 0.6], language (aβ = - 1.7; 95% CI - 3.2, - 0.3), cognitive flexibility (aβ = - 6.1; 95% CI - 10.4, - 1.7) and working memory (aβ = - 0.3; 95% CI - 0.6, - 0.1). Severe infection was associated with lower scores in literacy (aβ = - 11.0; 95% CI - 19.3, - 2.8), response inhibition, (aβ = - 2.2; 95% CI - 4.2, - 0.2), fine motor control (aβ = - 0.7; 95% CI - 1.1, - 0.4) and numeracy (aβ = - 3; 95% CI - 5.5, - 0.4).
CONCLUSIONS: This study provides first evidence that tungiasis is associated with poor neurocognitive functioning in children. Since tungiasis is a chronic disease with frequent reinfections, such negative effects may potentially impair their development and life achievements.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Humans
Child
*Tungiasis/epidemiology
Cross-Sectional Studies
Uganda/epidemiology
Kenya/epidemiology
Tunga/physiology
Outcome Assessment, Health Care
RevDate: 2024-02-12
Mechanism of fungal remediation of wetland water: Stropharia rugosoannulata as promising fungal species for the development of biofilters to remove clinically important pathogenic and antibiotic resistant bacteria in contaminated water.
Frontiers in microbiology, 14:1234586.
Mycoremediation uses mushroom forming fungi for remediation of sites contaminated with biotic and abiotic contaminants. The root-like hyphae of many fungi, the mycelia, have been used to remediate soil and water. In this study mushroom mycelia biofilters were evaluated for remediation efficacy of wetland water polluted with crow feces containing antibiotic resistant (AMR) bacteria. Three strains of fungi, Pleurotus ostreatus, Stropharia rugosoannulata, and Pleurotus pulmonarius, were allowed to develop dense mycelia for 3-5 weeks on wood chips within cylindrical jars. Biofilter jars were incubated with wetland water (WW) obtained from a crow roost area that was additionally spiked with AMR bacteria isolated from previous crow fecal collections. E. coli, Staphylococcus aureus, Enterococcus faecium, Campylobacter jejuni, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enteritidis were added at concentrations of 1,500-3,500 CFU/100 ml. Remediation was calculated from bacterial counts or gene copy numbers (GCN), before and after passage of water through jars. Stropharia and P. pulmonarius biofilters remediated all bacteria, but Klebsiella, in the range of 43-78%, after 1 h. Incubation of water for 24 h showed Stropharia remediation to be superior relative to other tested fungi. Percent remediation varied as follows: S. aureus-100%, E. faecium-97%, C. jejuni-59%, P. aeruginosa-54%, E. coli-65% and S. enteritidis-27%. The mechanism of remediation was tested by removing the mycelium from the biofilter column after passage of water, followed by extraction of DNA. Association of bacterial DNA with the mycelia was demonstrated by qPCR for all bacteria, except S. aureus and Salmonella. Depending on the bacteria, the GCN ranged from 3,500 to 54,000/250 mg of mycelia. Thus, some of the ways in which mycelia biofilters decrease bacteria from water are through bio-filtration and bio-absorption. Active fungal growth and close contact with bacteria appear necessary for removal. Overall these results suggest that mushroom mycelia biofilters have the potential to effectively remediate water contaminated with pathogenic and AMR bacteria.
Additional Links: PMID-37965549
PubMed:
Citation:
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@article {pmid37965549,
year = {2023},
author = {Sen, K and Llewellyn, M and Taheri, B and Turner, RJ and Berglund, T and Maloney, K},
title = {Mechanism of fungal remediation of wetland water: Stropharia rugosoannulata as promising fungal species for the development of biofilters to remove clinically important pathogenic and antibiotic resistant bacteria in contaminated water.},
journal = {Frontiers in microbiology},
volume = {14},
number = {},
pages = {1234586},
pmid = {37965549},
issn = {1664-302X},
abstract = {Mycoremediation uses mushroom forming fungi for remediation of sites contaminated with biotic and abiotic contaminants. The root-like hyphae of many fungi, the mycelia, have been used to remediate soil and water. In this study mushroom mycelia biofilters were evaluated for remediation efficacy of wetland water polluted with crow feces containing antibiotic resistant (AMR) bacteria. Three strains of fungi, Pleurotus ostreatus, Stropharia rugosoannulata, and Pleurotus pulmonarius, were allowed to develop dense mycelia for 3-5 weeks on wood chips within cylindrical jars. Biofilter jars were incubated with wetland water (WW) obtained from a crow roost area that was additionally spiked with AMR bacteria isolated from previous crow fecal collections. E. coli, Staphylococcus aureus, Enterococcus faecium, Campylobacter jejuni, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enteritidis were added at concentrations of 1,500-3,500 CFU/100 ml. Remediation was calculated from bacterial counts or gene copy numbers (GCN), before and after passage of water through jars. Stropharia and P. pulmonarius biofilters remediated all bacteria, but Klebsiella, in the range of 43-78%, after 1 h. Incubation of water for 24 h showed Stropharia remediation to be superior relative to other tested fungi. Percent remediation varied as follows: S. aureus-100%, E. faecium-97%, C. jejuni-59%, P. aeruginosa-54%, E. coli-65% and S. enteritidis-27%. The mechanism of remediation was tested by removing the mycelium from the biofilter column after passage of water, followed by extraction of DNA. Association of bacterial DNA with the mycelia was demonstrated by qPCR for all bacteria, except S. aureus and Salmonella. Depending on the bacteria, the GCN ranged from 3,500 to 54,000/250 mg of mycelia. Thus, some of the ways in which mycelia biofilters decrease bacteria from water are through bio-filtration and bio-absorption. Active fungal growth and close contact with bacteria appear necessary for removal. Overall these results suggest that mushroom mycelia biofilters have the potential to effectively remediate water contaminated with pathogenic and AMR bacteria.},
}
RevDate: 2023-12-01
Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study.
JMIR dermatology, 6:e51070.
BACKGROUND: Placental extract has been mostly used in skin care for cosmetic purposes. However, the use of various placental extracts has been limited due to the lack of established and effective application methods.
OBJECTIVE: In this study, we investigated the antiwrinkle effect of a cream formulation-LNC wrinkle eye cream (LNC-EC)-containing horse placental extract as the main ingredient.
METHODS: A total of 24 healthy women, aged 37-54 years, with wrinkle grades 1-3, were treated with LNC-EC for 2 weeks. The cream was applied on one-half of the participants' faces, and the results were compared with the untreated half of the face.
RESULTS: Visual inspection, using the wrinkle grade standard, showed that the area treated with LNC-EC had a significantly lower wrinkle grade than the untreated area when comparing before and after the application of LNC-EC. In addition, replica analysis showed a significant reduction in both the maximum wrinkle width and the number of wrinkles in the LNC-EC-treated area in comparison to the untreated area before and after the application. These results suggest that LNC-EC has an antiwrinkle effect on the corners of the eyes based on parameters like the maximum wrinkle width and the number of wrinkles.
CONCLUSIONS: LNC-EC, with horse placental extract as its main ingredient, was shown to be effective in improving wrinkles at the eye corners, presumably due to a reduction in the maximum wrinkle width and the number of wrinkles. Interpretation of the results is limited because this study was conducted only in the intervention group. A randomized controlled trial with a placebo control group is necessary to verify the antiwrinkle effects of horse placental extract.
Additional Links: PMID-37966883
PubMed:
Citation:
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@article {pmid37966883,
year = {2023},
author = {Watanabe, T and Tahara, K and Hirano, E},
title = {Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study.},
journal = {JMIR dermatology},
volume = {6},
number = {},
pages = {e51070},
pmid = {37966883},
issn = {2562-0959},
abstract = {BACKGROUND: Placental extract has been mostly used in skin care for cosmetic purposes. However, the use of various placental extracts has been limited due to the lack of established and effective application methods.
OBJECTIVE: In this study, we investigated the antiwrinkle effect of a cream formulation-LNC wrinkle eye cream (LNC-EC)-containing horse placental extract as the main ingredient.
METHODS: A total of 24 healthy women, aged 37-54 years, with wrinkle grades 1-3, were treated with LNC-EC for 2 weeks. The cream was applied on one-half of the participants' faces, and the results were compared with the untreated half of the face.
RESULTS: Visual inspection, using the wrinkle grade standard, showed that the area treated with LNC-EC had a significantly lower wrinkle grade than the untreated area when comparing before and after the application of LNC-EC. In addition, replica analysis showed a significant reduction in both the maximum wrinkle width and the number of wrinkles in the LNC-EC-treated area in comparison to the untreated area before and after the application. These results suggest that LNC-EC has an antiwrinkle effect on the corners of the eyes based on parameters like the maximum wrinkle width and the number of wrinkles.
CONCLUSIONS: LNC-EC, with horse placental extract as its main ingredient, was shown to be effective in improving wrinkles at the eye corners, presumably due to a reduction in the maximum wrinkle width and the number of wrinkles. Interpretation of the results is limited because this study was conducted only in the intervention group. A randomized controlled trial with a placebo control group is necessary to verify the antiwrinkle effects of horse placental extract.},
}
RevDate: 2024-02-12
CmpDate: 2023-11-27
The effects of creatine supplementation on cognitive performance-a randomised controlled study.
BMC medicine, 21(1):440.
BACKGROUND: Creatine is an organic compound that facilitates the recycling of energy-providing adenosine triphosphate (ATP) in muscle and brain tissue. It is a safe, well-studied supplement for strength training. Previous studies have shown that supplementation increases brain creatine levels, which might increase cognitive performance. The results of studies that have tested cognitive performance differ greatly, possibly due to different populations, supplementation regimens, and cognitive tasks. This is the largest study on the effect of creatine supplementation on cognitive performance to date.
METHODS: Our trial was preregistered, cross-over, double-blind, placebo-controlled, and randomised, with daily supplementation of 5 g for 6 weeks each. We tested participants on Raven's Advanced Progressive Matrices (RAPM) and on the Backward Digit Span (BDS). In addition, we included eight exploratory cognitive tests. About half of our 123 participants were vegetarians and half were omnivores.
RESULTS: Bayesian evidence supported a small beneficial effect of creatine. The creatine effect bordered significance for BDS (p = 0.064, η[2]P = 0.029) but not RAPM (p = 0.327, η[2]P = 0.008). There was no indication that creatine improved the performance of our exploratory cognitive tasks. Side effects were reported significantly more often for creatine than for placebo supplementation (p = 0.002, RR = 4.25). Vegetarians did not benefit more from creatine than omnivores.
CONCLUSIONS: Our study, in combination with the literature, implies that creatine might have a small beneficial effect. Larger studies are needed to confirm or rule out this effect. Given the safety and broad availability of creatine, this is well worth investigating; a small effect could have large benefits when scaled over time and over many people.
TRIAL REGISTRATION: The trial was prospectively registered (drks.de identifier: DRKS00017250, https://osf.io/xpwkc/).
Additional Links: PMID-37968687
PubMed:
Citation:
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@article {pmid37968687,
year = {2023},
author = {Sandkühler, JF and Kersting, X and Faust, A and Königs, EK and Altman, G and Ettinger, U and Lux, S and Philipsen, A and Müller, H and Brauner, J},
title = {The effects of creatine supplementation on cognitive performance-a randomised controlled study.},
journal = {BMC medicine},
volume = {21},
number = {1},
pages = {440},
pmid = {37968687},
issn = {1741-7015},
mesh = {Humans ; *Creatine/adverse effects ; Bayes Theorem ; *Dietary Supplements ; Brain ; Double-Blind Method ; Cognition ; },
abstract = {BACKGROUND: Creatine is an organic compound that facilitates the recycling of energy-providing adenosine triphosphate (ATP) in muscle and brain tissue. It is a safe, well-studied supplement for strength training. Previous studies have shown that supplementation increases brain creatine levels, which might increase cognitive performance. The results of studies that have tested cognitive performance differ greatly, possibly due to different populations, supplementation regimens, and cognitive tasks. This is the largest study on the effect of creatine supplementation on cognitive performance to date.
METHODS: Our trial was preregistered, cross-over, double-blind, placebo-controlled, and randomised, with daily supplementation of 5 g for 6 weeks each. We tested participants on Raven's Advanced Progressive Matrices (RAPM) and on the Backward Digit Span (BDS). In addition, we included eight exploratory cognitive tests. About half of our 123 participants were vegetarians and half were omnivores.
RESULTS: Bayesian evidence supported a small beneficial effect of creatine. The creatine effect bordered significance for BDS (p = 0.064, η[2]P = 0.029) but not RAPM (p = 0.327, η[2]P = 0.008). There was no indication that creatine improved the performance of our exploratory cognitive tasks. Side effects were reported significantly more often for creatine than for placebo supplementation (p = 0.002, RR = 4.25). Vegetarians did not benefit more from creatine than omnivores.
CONCLUSIONS: Our study, in combination with the literature, implies that creatine might have a small beneficial effect. Larger studies are needed to confirm or rule out this effect. Given the safety and broad availability of creatine, this is well worth investigating; a small effect could have large benefits when scaled over time and over many people.
TRIAL REGISTRATION: The trial was prospectively registered (drks.de identifier: DRKS00017250, https://osf.io/xpwkc/).},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
*Creatine/adverse effects
Bayes Theorem
*Dietary Supplements
Brain
Double-Blind Method
Cognition
RevDate: 2026-06-23
CmpDate: 2024-05-06
Correspondence to: Henry O'Brien, Jay Paniker and Liam Brown: Is a smartphone application as accurate as a traditional goniometer for assessing finger joint angles in Dupuytren's disease? Hand Surg Rehabil 2023 Sep 29.
Hand surgery & rehabilitation, 43(2):101619.
Additional Links: PMID-37979839
Publisher:
PubMed:
Citation:
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@article {pmid37979839,
year = {2024},
author = {Broekstra, DC and Werker, PMN},
title = {Correspondence to: Henry O'Brien, Jay Paniker and Liam Brown: Is a smartphone application as accurate as a traditional goniometer for assessing finger joint angles in Dupuytren's disease? Hand Surg Rehabil 2023 Sep 29.},
journal = {Hand surgery & rehabilitation},
volume = {43},
number = {2},
pages = {101619},
doi = {10.1016/j.hansur.2023.11.004},
pmid = {37979839},
issn = {2468-1210},
mesh = {Humans ; *Smartphone ; *Dupuytren Contracture/physiopathology ; *Mobile Applications ; *Finger Joint/physiopathology ; *Arthrometry, Articular/instrumentation ; },
}
MeSH Terms:
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hide MeSH Terms
Humans
*Smartphone
*Dupuytren Contracture/physiopathology
*Mobile Applications
*Finger Joint/physiopathology
*Arthrometry, Articular/instrumentation
RevDate: 2025-09-23
CmpDate: 2024-04-04
Implantable Hearing Devices in Ontario: A Population-Based Study of Access to Care and Access to Devices.
Audiology & neuro-otology, 29(2):136-145.
INTRODUCTION: The prevalence of hearing loss in Canada is high, with many patients requiring implantable hearing devices (IHDs) as treatment for their disease severity. Despite this need, many eligible patients do not pursue these interventions. The objective of this study was to examine rates of IHD based on geographic location to understand locoregional variation in access to care.
STUDY DESIGN: This was a retrospective population-based cohort study.
SETTING: All hospitals in the Canadian province of Ontario.
METHODS: Of all patients with IHD between April 1, 1992, and March 31, 2021, cochlear implants (CIs) (4,720) and bone-anchored hearing aids (BAHA) (1,125) cohorts were constructed. Place of residence was categorized based on Local Health Integrated Network (LHIN). Summary statistics for place of surgical institution based on LHIN at first surgery, name of institution of first surgery and "as the crow flies" distance (in km) between place of residence and surgical institution were calculated. Rate of implantations was calculated for LHIN regions based on number of surgeries per 1,000,000 persons/years.
RESULTS: Toronto Central, Central, Central East, and Champlain regions had >10% of patients undergoing BAHA and CI. 1,019 (90.6%) and 4,232 (89.7%) of patients receiving BAHA and CI, respectively, resided in urban/suburban regions and 94 patients (8.4%) and 436 (9.2%) resided in rural regions. The median distance between residential location and the institution was 46.4 km (interquartile range [IQR], 18.9-103.6) and 44.7 km (IQR, 15.7-96.9) for BAHA and CI, respectively. From 1992 to 2021, the number of CI and BAHA performed across Ontario increased by 17 folds and 6 folds, respectively.
CONCLUSION: This large comprehensive population study provides longitudinal insight into the access to care of IHD based on geographic factors. Our findings of the present population-based study indicate an overall increase in access to devices with disproportionate access to care based on geographic locations. Further work is needed to characterize barriers to IHD access to align with demands.
Additional Links: PMID-37984348
Publisher:
PubMed:
Citation:
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@article {pmid37984348,
year = {2024},
author = {Kirubalingam, K and Nguyen, P and Kang, A and Beyea, JA},
title = {Implantable Hearing Devices in Ontario: A Population-Based Study of Access to Care and Access to Devices.},
journal = {Audiology & neuro-otology},
volume = {29},
number = {2},
pages = {136-145},
doi = {10.1159/000534384},
pmid = {37984348},
issn = {1421-9700},
mesh = {Humans ; Retrospective Studies ; Ontario/epidemiology ; Cohort Studies ; *Hearing Aids ; *Cochlear Implants ; Hearing ; Health Services Accessibility ; Bone Conduction ; },
abstract = {INTRODUCTION: The prevalence of hearing loss in Canada is high, with many patients requiring implantable hearing devices (IHDs) as treatment for their disease severity. Despite this need, many eligible patients do not pursue these interventions. The objective of this study was to examine rates of IHD based on geographic location to understand locoregional variation in access to care.
STUDY DESIGN: This was a retrospective population-based cohort study.
SETTING: All hospitals in the Canadian province of Ontario.
METHODS: Of all patients with IHD between April 1, 1992, and March 31, 2021, cochlear implants (CIs) (4,720) and bone-anchored hearing aids (BAHA) (1,125) cohorts were constructed. Place of residence was categorized based on Local Health Integrated Network (LHIN). Summary statistics for place of surgical institution based on LHIN at first surgery, name of institution of first surgery and "as the crow flies" distance (in km) between place of residence and surgical institution were calculated. Rate of implantations was calculated for LHIN regions based on number of surgeries per 1,000,000 persons/years.
RESULTS: Toronto Central, Central, Central East, and Champlain regions had >10% of patients undergoing BAHA and CI. 1,019 (90.6%) and 4,232 (89.7%) of patients receiving BAHA and CI, respectively, resided in urban/suburban regions and 94 patients (8.4%) and 436 (9.2%) resided in rural regions. The median distance between residential location and the institution was 46.4 km (interquartile range [IQR], 18.9-103.6) and 44.7 km (IQR, 15.7-96.9) for BAHA and CI, respectively. From 1992 to 2021, the number of CI and BAHA performed across Ontario increased by 17 folds and 6 folds, respectively.
CONCLUSION: This large comprehensive population study provides longitudinal insight into the access to care of IHD based on geographic factors. Our findings of the present population-based study indicate an overall increase in access to devices with disproportionate access to care based on geographic locations. Further work is needed to characterize barriers to IHD access to align with demands.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
Retrospective Studies
Ontario/epidemiology
Cohort Studies
*Hearing Aids
*Cochlear Implants
Hearing
Health Services Accessibility
Bone Conduction
RevDate: 2024-02-07
CmpDate: 2024-01-11
Innovative problem solving by wild falcons.
Current biology : CB, 34(1):190-195.e3.
Innovation (i.e., a new solution to a familiar problem, or applying an existing behavior to a novel problem[1][,][2]) plays a fundamental role in species' ecology and evolution. It can be a useful measure for cross-group comparisons of behavioral and cognitive flexibility and a proxy for general intelligence.[3][,][4][,][5] Among birds, experimental studies of innovation (and cognition more generally) are largely from captive corvids and parrots,[6][,][7][,][8][,][9][,][10][,][11][,][12] though we lack serious models for avian technical intelligence outside these taxa. Striated caracaras (Phalcoboenus australis) are Falconiformes, sister clade to parrots and passerines,[13][,][14][,][15] and those endemic to the Falkland Islands (Malvinas) show curiosity and neophilia similar to notoriously neophilic kea parrots[16][,][17] and face similar socio-ecological pressures to corvids and parrots.[18][,][19] We tested wild striated caracaras as a new avian model for technical cognition and innovation using a field-applicable 8-task comparative paradigm (adapted from Rössler et al.[20] and Auersperg et al.[21]). The setup allowed us to assess behavior, rate, and flexibility of problem solving over repeated exposure in a natural setting. Like other generalist species with low neophobia,[21][,][22] we predicted caracaras to demonstrate a haptic approach to solving tasks, flexibly switching to new, unsolved problems and improving their performance over time. Striated caracaras performed comparably to tool-using parrots,[20] nearly reaching ceiling levels of innovation in few trials, repeatedly and flexibly solving tasks, and rapidly learning. We attribute our findings to the birds' ecology, including geographic restriction, resource unpredictability, and opportunistic generalism,[23][,][24][,][25] and encourage future work investigating their cognitive abilities in the wild. VIDEO ABSTRACT.
Additional Links: PMID-37989310
Publisher:
PubMed:
Citation:
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@article {pmid37989310,
year = {2024},
author = {Harrington, KJ and Folkertsma, R and Auersperg, AMI and Biondi, L and Lambert, ML},
title = {Innovative problem solving by wild falcons.},
journal = {Current biology : CB},
volume = {34},
number = {1},
pages = {190-195.e3},
doi = {10.1016/j.cub.2023.10.061},
pmid = {37989310},
issn = {1879-0445},
mesh = {Animals ; Problem Solving ; Cognition ; Learning ; *Parrots ; *Falconiformes ; },
abstract = {Innovation (i.e., a new solution to a familiar problem, or applying an existing behavior to a novel problem[1][,][2]) plays a fundamental role in species' ecology and evolution. It can be a useful measure for cross-group comparisons of behavioral and cognitive flexibility and a proxy for general intelligence.[3][,][4][,][5] Among birds, experimental studies of innovation (and cognition more generally) are largely from captive corvids and parrots,[6][,][7][,][8][,][9][,][10][,][11][,][12] though we lack serious models for avian technical intelligence outside these taxa. Striated caracaras (Phalcoboenus australis) are Falconiformes, sister clade to parrots and passerines,[13][,][14][,][15] and those endemic to the Falkland Islands (Malvinas) show curiosity and neophilia similar to notoriously neophilic kea parrots[16][,][17] and face similar socio-ecological pressures to corvids and parrots.[18][,][19] We tested wild striated caracaras as a new avian model for technical cognition and innovation using a field-applicable 8-task comparative paradigm (adapted from Rössler et al.[20] and Auersperg et al.[21]). The setup allowed us to assess behavior, rate, and flexibility of problem solving over repeated exposure in a natural setting. Like other generalist species with low neophobia,[21][,][22] we predicted caracaras to demonstrate a haptic approach to solving tasks, flexibly switching to new, unsolved problems and improving their performance over time. Striated caracaras performed comparably to tool-using parrots,[20] nearly reaching ceiling levels of innovation in few trials, repeatedly and flexibly solving tasks, and rapidly learning. We attribute our findings to the birds' ecology, including geographic restriction, resource unpredictability, and opportunistic generalism,[23][,][24][,][25] and encourage future work investigating their cognitive abilities in the wild. VIDEO ABSTRACT.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Problem Solving
Cognition
Learning
*Parrots
*Falconiformes
RevDate: 2025-12-02
CmpDate: 2023-11-24
Draft genomes of novel avian Chlamydia abortus strains from Australian Torresian crows (Corvus orru) shed light on possible reservoir hosts and evolutionary pathways.
Microbial genomics, 9(11):.
Chlamydia abortus, an obligate intracellular bacterium, is a major causative agent of reproductive loss in ruminants, with zoonotic potential. Though this pathogen is primarily known to infect livestock, recent studies have detected and isolated genetically distinct avian strains of C. abortus from wild birds globally. Before this study, only five avian C. abortus genomes were publicly available. Therefore, we performed culture-independent probe-based whole-genome sequencing on clinical swabs positive for avian C. abortus obtained from Australian Torresian crows (Corvus orru) in 2019 and 2020. We successfully obtained draft genomes for three avian C. abortus strains (C1, C2 and C3), each comprising draft chromosomes with lengths of 1 115 667, 1 120 231 and 1 082 115 bp, and associated 7 553 bp plasmids, with a genome completeness exceeding 92 %. Molecular characterization revealed that these three strains comprise a novel sequence type (ST333), whilst phylogenetic analyses placed all three strains in a cluster with other avian C. abortus genomes. Interestingly, these three strains share a distant genomic relation (2693 single nucleotide variants) with the reference strain 15-58d/44 (ST152), isolated from a Eurasian magpie (Pica pica) in Poland, highlighting the need for more publicly available genomes. Broad comparative analyses with other avian C. abortus genomes revealed that the three draft genomes contain conserved Chlamydia genomic features, including genes coding for type III secretion system and polymorphic membrane proteins, and potential virulence factors such as the large chlamydial cytotoxin, warranting further studies. This research provides the first avian C. abortus draft genomes from Australian birds, highlighting Torresian crows as novel reservoir hosts for these potential pathogens, and demonstrates a practical methodology for sequencing novel Chlamydia genomes without relying on traditional cell culture.
Additional Links: PMID-37991482
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@article {pmid37991482,
year = {2023},
author = {Kasimov, V and White, RT and Jelocnik, M},
title = {Draft genomes of novel avian Chlamydia abortus strains from Australian Torresian crows (Corvus orru) shed light on possible reservoir hosts and evolutionary pathways.},
journal = {Microbial genomics},
volume = {9},
number = {11},
pages = {},
pmid = {37991482},
issn = {2057-5858},
mesh = {Animals ; Australia ; Birds ; *Chlamydia/genetics ; *Crows ; Phylogeny ; *Genome, Bacterial ; },
abstract = {Chlamydia abortus, an obligate intracellular bacterium, is a major causative agent of reproductive loss in ruminants, with zoonotic potential. Though this pathogen is primarily known to infect livestock, recent studies have detected and isolated genetically distinct avian strains of C. abortus from wild birds globally. Before this study, only five avian C. abortus genomes were publicly available. Therefore, we performed culture-independent probe-based whole-genome sequencing on clinical swabs positive for avian C. abortus obtained from Australian Torresian crows (Corvus orru) in 2019 and 2020. We successfully obtained draft genomes for three avian C. abortus strains (C1, C2 and C3), each comprising draft chromosomes with lengths of 1 115 667, 1 120 231 and 1 082 115 bp, and associated 7 553 bp plasmids, with a genome completeness exceeding 92 %. Molecular characterization revealed that these three strains comprise a novel sequence type (ST333), whilst phylogenetic analyses placed all three strains in a cluster with other avian C. abortus genomes. Interestingly, these three strains share a distant genomic relation (2693 single nucleotide variants) with the reference strain 15-58d/44 (ST152), isolated from a Eurasian magpie (Pica pica) in Poland, highlighting the need for more publicly available genomes. Broad comparative analyses with other avian C. abortus genomes revealed that the three draft genomes contain conserved Chlamydia genomic features, including genes coding for type III secretion system and polymorphic membrane proteins, and potential virulence factors such as the large chlamydial cytotoxin, warranting further studies. This research provides the first avian C. abortus draft genomes from Australian birds, highlighting Torresian crows as novel reservoir hosts for these potential pathogens, and demonstrates a practical methodology for sequencing novel Chlamydia genomes without relying on traditional cell culture.},
}
MeSH Terms:
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Animals
Australia
Birds
*Chlamydia/genetics
*Crows
Phylogeny
*Genome, Bacterial
RevDate: 2023-11-27
CmpDate: 2023-11-27
SOCIAL COGNITION AND OXIDATIVE STRESS IN SCHIZOPHRENIA PATIENTS AND FIRST-DEGREE RELATIVES OF PATIENTS.
Psychiatria Danubina, 35(4):523-534.
BACKGROUND: Misattribution of motivational salience to non-salient (neutral) stimuli could be viewed as a hallmark of psychosis in schizophrenia. Studies have recently revealed increased subjective experience of emotional arousal (EA) to neutral social stimuli in paranoid schizophrenia psychosis, suggesting a misattribution of emotional salience to them. We examined this phenomenon directly by quantifying the level of EA subjectively attributed to low-arousal, neutral-valenced faces.
SUBJECTS AND METHODS: Patients with remitted schizophrenia (PG) (n=26), first-degree relatives of schizophrenic patients (RG) (n=25), and healthy controls (HCG) (n=36) were compared in terms of oxidative stress parameters -serum Superoxide Dismutase, Catalase, Glutathione Peroxidase (GPx), Nitrite, Nitrate, Malondialdehyde, and Total Glutathione levels-, social cognition measured by the Reading the Mind in the Eyes Test and working memory measured by the N-back Task. Groups were compared, assuming that HCG had a genetically lower risk of schizophrenia compared to PG and RG.
RESULTS: HCG performed significantly better than PG and RG, who were genetically at high risk, in terms of social cognition (respectively p=0.000, p=0.014), working memory (respectively p=0.001, p=0.003), and had statistically lower Glutathione Peroxidase (GPX) level than the PG and RG (both p:0.000). After controlling for the effect of the general intellectual abilities measured by the Raven Standard Progressive Matrices Test and working memory the differences between groups on the Eyes Test disappeared (p=0.057). However, this value tended to be significant.
CONCLUSION: It was concluded that social cognition and working memory and GPx level may be used as endophenotypes and social cognition, working memory, and general intellectual skills are different but strongly related constructs. Endophenotypes guide treatment targets even after the disease has developed. The results of our study showed that in addition to psychopharmacological treatments, interventions to reduce oxidative stress and approaches to improve cognitive skills will have a positive impact on the disease's progression.
Additional Links: PMID-37992097
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@article {pmid37992097,
year = {2023},
author = {Çilem Kızılpınar, S and Çiğdem Aydemır, M and Doğan, Ö and Bahar Atak-Akkus, F and Baran, Z},
title = {SOCIAL COGNITION AND OXIDATIVE STRESS IN SCHIZOPHRENIA PATIENTS AND FIRST-DEGREE RELATIVES OF PATIENTS.},
journal = {Psychiatria Danubina},
volume = {35},
number = {4},
pages = {523-534},
doi = {10.24869/psyd.2023.523},
pmid = {37992097},
issn = {0353-5053},
mesh = {Humans ; *Social Cognition ; *Psychotic Disorders ; Cognition ; Schizophrenia, Paranoid ; Oxidative Stress ; Glutathione Peroxidase ; Neuropsychological Tests ; },
abstract = {BACKGROUND: Misattribution of motivational salience to non-salient (neutral) stimuli could be viewed as a hallmark of psychosis in schizophrenia. Studies have recently revealed increased subjective experience of emotional arousal (EA) to neutral social stimuli in paranoid schizophrenia psychosis, suggesting a misattribution of emotional salience to them. We examined this phenomenon directly by quantifying the level of EA subjectively attributed to low-arousal, neutral-valenced faces.
SUBJECTS AND METHODS: Patients with remitted schizophrenia (PG) (n=26), first-degree relatives of schizophrenic patients (RG) (n=25), and healthy controls (HCG) (n=36) were compared in terms of oxidative stress parameters -serum Superoxide Dismutase, Catalase, Glutathione Peroxidase (GPx), Nitrite, Nitrate, Malondialdehyde, and Total Glutathione levels-, social cognition measured by the Reading the Mind in the Eyes Test and working memory measured by the N-back Task. Groups were compared, assuming that HCG had a genetically lower risk of schizophrenia compared to PG and RG.
RESULTS: HCG performed significantly better than PG and RG, who were genetically at high risk, in terms of social cognition (respectively p=0.000, p=0.014), working memory (respectively p=0.001, p=0.003), and had statistically lower Glutathione Peroxidase (GPX) level than the PG and RG (both p:0.000). After controlling for the effect of the general intellectual abilities measured by the Raven Standard Progressive Matrices Test and working memory the differences between groups on the Eyes Test disappeared (p=0.057). However, this value tended to be significant.
CONCLUSION: It was concluded that social cognition and working memory and GPx level may be used as endophenotypes and social cognition, working memory, and general intellectual skills are different but strongly related constructs. Endophenotypes guide treatment targets even after the disease has developed. The results of our study showed that in addition to psychopharmacological treatments, interventions to reduce oxidative stress and approaches to improve cognitive skills will have a positive impact on the disease's progression.},
}
MeSH Terms:
show MeSH Terms
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Humans
*Social Cognition
*Psychotic Disorders
Cognition
Schizophrenia, Paranoid
Oxidative Stress
Glutathione Peroxidase
Neuropsychological Tests
RevDate: 2023-11-27
Indication of West Nile Virus (WNV) Lineage 2 Overwintering among Wild Birds in the Regions of Peloponnese and Western Greece.
Veterinary sciences, 10(11):.
West Nile virus (WNV), a zoonotic mosquito-borne virus, has recently caused human outbreaks in Europe, including Greece. Its transmission cycle in nature includes wild birds as amplifying hosts and ornithophilic mosquito vectors. The aim of this study was to assess WNV circulation among wild birds from two regions of Greece, Peloponnese and Western Greece, during 2022. To this end, a total of 511 birds belonging to 37 different species were sampled and molecularly screened. WNV RNA was detected from February to November in a total of 71 wild birds of nine species originating from both investigated regions. The first eight positive samples were sequenced on a part of NS3 and, according to the phylogenetic analysis, they belonged to evolutionary lineage 2 and presented similarity to previous outbreak-causing Greek strains (Argolis 2017, Macedonia 2010 and 2012). It was more likely to identify a PCR positive bird as the population density and the distance from water sources decreased. The present report provides evidence of WNV occurrence in both Peloponnese and Western Greece during 2022 and underlines its possible overwintering, highlighting the need for avian species surveillance to be conducted annually and throughout the year. Magpies are proposed as sentinels for WNV monitoring.
Additional Links: PMID-37999484
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Citation:
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@article {pmid37999484,
year = {2023},
author = {Athanasakopoulou, Z and Sofia, M and Skampardonis, V and Giannakopoulos, A and Birtsas, P and Tsolakos, K and Spyrou, V and Chatzopoulos, DC and Satra, M and Diamantopoulos, V and Mpellou, S and Galamatis, D and G Papatsiros, V and Billinis, C},
title = {Indication of West Nile Virus (WNV) Lineage 2 Overwintering among Wild Birds in the Regions of Peloponnese and Western Greece.},
journal = {Veterinary sciences},
volume = {10},
number = {11},
pages = {},
pmid = {37999484},
issn = {2306-7381},
support = {"Integrated Program for Mosquito Control, Creation of a Control Structure and Development of a West Nile Virus Surveillance and Vigilance Mechanism in the Peloponnese Region" and "Epidemiological surveillance of West Nile Virus in wild birds and equines i//the Prefecture of Peloponnese (Peloponnisos SA) and the Joint Venture 2 INSEKO EU - Eleftheriou Bioapplications and Co. LTD./ ; },
abstract = {West Nile virus (WNV), a zoonotic mosquito-borne virus, has recently caused human outbreaks in Europe, including Greece. Its transmission cycle in nature includes wild birds as amplifying hosts and ornithophilic mosquito vectors. The aim of this study was to assess WNV circulation among wild birds from two regions of Greece, Peloponnese and Western Greece, during 2022. To this end, a total of 511 birds belonging to 37 different species were sampled and molecularly screened. WNV RNA was detected from February to November in a total of 71 wild birds of nine species originating from both investigated regions. The first eight positive samples were sequenced on a part of NS3 and, according to the phylogenetic analysis, they belonged to evolutionary lineage 2 and presented similarity to previous outbreak-causing Greek strains (Argolis 2017, Macedonia 2010 and 2012). It was more likely to identify a PCR positive bird as the population density and the distance from water sources decreased. The present report provides evidence of WNV occurrence in both Peloponnese and Western Greece during 2022 and underlines its possible overwintering, highlighting the need for avian species surveillance to be conducted annually and throughout the year. Magpies are proposed as sentinels for WNV monitoring.},
}
RevDate: 2024-11-18
CmpDate: 2023-11-27
Evaluating long-read de novo assembly tools for eukaryotic genomes: insights and considerations.
GigaScience, 12:.
BACKGROUND: Assembly algorithm choice should be a deliberate, well-justified decision when researchers create genome assemblies for eukaryotic organisms from third-generation sequencing technologies. While third-generation sequencing by Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio) has overcome the disadvantages of short read lengths specific to next-generation sequencing (NGS), third-generation sequencers are known to produce more error-prone reads, thereby generating a new set of challenges for assembly algorithms and pipelines. However, the introduction of HiFi reads, which offer substantially reduced error rates, has provided a promising solution for more accurate assembly outcomes. Since the introduction of third-generation sequencing technologies, many tools have been developed that aim to take advantage of the longer reads, and researchers need to choose the correct assembler for their projects.
RESULTS: We benchmarked state-of-the-art long-read de novo assemblers to help readers make a balanced choice for the assembly of eukaryotes. To this end, we used 12 real and 64 simulated datasets from different eukaryotic genomes, with different read length distributions, imitating PacBio continuous long-read (CLR), PacBio high-fidelity (HiFi), and ONT sequencing to evaluate the assemblers. We include 5 commonly used long-read assemblers in our benchmark: Canu, Flye, Miniasm, Raven, and wtdbg2 for ONT and PacBio CLR reads. For PacBio HiFi reads , we include 5 state-of-the-art HiFi assemblers: HiCanu, Flye, Hifiasm, LJA, and MBG. Evaluation categories address the following metrics: reference-based metrics, assembly statistics, misassembly count, BUSCO completeness, runtime, and RAM usage. Additionally, we investigated the effect of increased read length on the quality of the assemblies and report that read length can, but does not always, positively impact assembly quality.
CONCLUSIONS: Our benchmark concludes that there is no assembler that performs the best in all the evaluation categories. However, our results show that overall Flye is the best-performing assembler for PacBio CLR and ONT reads, both on real and simulated data. Meanwhile, best-performing PacBio HiFi assemblers are Hifiasm and LJA. Next, the benchmarking using longer reads shows that the increased read length improves assembly quality, but the extent to which that can be achieved depends on the size and complexity of the reference genome.
Additional Links: PMID-38000912
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Citation:
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@article {pmid38000912,
year = {2022},
author = {Cosma, BM and Shirali Hossein Zade, R and Jordan, EN and van Lent, P and Peng, C and Pillay, S and Abeel, T},
title = {Evaluating long-read de novo assembly tools for eukaryotic genomes: insights and considerations.},
journal = {GigaScience},
volume = {12},
number = {},
pages = {},
pmid = {38000912},
issn = {2047-217X},
mesh = {Sequence Analysis, DNA/methods ; *Genome ; Algorithms ; High-Throughput Nucleotide Sequencing/methods ; *Nanopores ; },
abstract = {BACKGROUND: Assembly algorithm choice should be a deliberate, well-justified decision when researchers create genome assemblies for eukaryotic organisms from third-generation sequencing technologies. While third-generation sequencing by Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio) has overcome the disadvantages of short read lengths specific to next-generation sequencing (NGS), third-generation sequencers are known to produce more error-prone reads, thereby generating a new set of challenges for assembly algorithms and pipelines. However, the introduction of HiFi reads, which offer substantially reduced error rates, has provided a promising solution for more accurate assembly outcomes. Since the introduction of third-generation sequencing technologies, many tools have been developed that aim to take advantage of the longer reads, and researchers need to choose the correct assembler for their projects.
RESULTS: We benchmarked state-of-the-art long-read de novo assemblers to help readers make a balanced choice for the assembly of eukaryotes. To this end, we used 12 real and 64 simulated datasets from different eukaryotic genomes, with different read length distributions, imitating PacBio continuous long-read (CLR), PacBio high-fidelity (HiFi), and ONT sequencing to evaluate the assemblers. We include 5 commonly used long-read assemblers in our benchmark: Canu, Flye, Miniasm, Raven, and wtdbg2 for ONT and PacBio CLR reads. For PacBio HiFi reads , we include 5 state-of-the-art HiFi assemblers: HiCanu, Flye, Hifiasm, LJA, and MBG. Evaluation categories address the following metrics: reference-based metrics, assembly statistics, misassembly count, BUSCO completeness, runtime, and RAM usage. Additionally, we investigated the effect of increased read length on the quality of the assemblies and report that read length can, but does not always, positively impact assembly quality.
CONCLUSIONS: Our benchmark concludes that there is no assembler that performs the best in all the evaluation categories. However, our results show that overall Flye is the best-performing assembler for PacBio CLR and ONT reads, both on real and simulated data. Meanwhile, best-performing PacBio HiFi assemblers are Hifiasm and LJA. Next, the benchmarking using longer reads shows that the increased read length improves assembly quality, but the extent to which that can be achieved depends on the size and complexity of the reference genome.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Sequence Analysis, DNA/methods
*Genome
Algorithms
High-Throughput Nucleotide Sequencing/methods
*Nanopores
RevDate: 2023-11-27
High Variability Periods in the EEG Distinguish Cognitive Brain States.
Brain sciences, 13(11):.
OBJECTIVE: To describe a novel measure of EEG signal variability that distinguishes cognitive brain states.
METHOD: We describe a novel characterization of amplitude variability in the EEG signal termed "High Variability Periods" or "HVPs", defined as segments when the standard deviation of a moving window is continuously higher than the quartile cutoff. We characterize the parameter space of the metric in terms of window size, overlap, and threshold to suggest ideal parameter choice and compare its performance as a discriminator of brain state to alternate single channel measures of variability such as entropy, complexity, harmonic regression fit, and spectral measures.
RESULTS: We show that the average HVP duration provides a substantially distinct view of the signal relative to alternate metrics of variability and, when used in combination with these metrics, significantly enhances the ability to predict whether an individual has their eyes open or closed and is performing a working memory and Raven's pattern completion task. In addition, HVPs disappear under anesthesia and do not reappear in early periods of recovery.
CONCLUSIONS: HVP metrics enhance the discrimination of various brain states and are fast to estimate.
SIGNIFICANCE: HVP metrics can provide an additional view of signal variability that has potential clinical application in the rapid discrimination of brain states.
Additional Links: PMID-38002488
PubMed:
Citation:
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@article {pmid38002488,
year = {2023},
author = {Parameshwaran, D and Thiagarajan, TC},
title = {High Variability Periods in the EEG Distinguish Cognitive Brain States.},
journal = {Brain sciences},
volume = {13},
number = {11},
pages = {},
pmid = {38002488},
issn = {2076-3425},
abstract = {OBJECTIVE: To describe a novel measure of EEG signal variability that distinguishes cognitive brain states.
METHOD: We describe a novel characterization of amplitude variability in the EEG signal termed "High Variability Periods" or "HVPs", defined as segments when the standard deviation of a moving window is continuously higher than the quartile cutoff. We characterize the parameter space of the metric in terms of window size, overlap, and threshold to suggest ideal parameter choice and compare its performance as a discriminator of brain state to alternate single channel measures of variability such as entropy, complexity, harmonic regression fit, and spectral measures.
RESULTS: We show that the average HVP duration provides a substantially distinct view of the signal relative to alternate metrics of variability and, when used in combination with these metrics, significantly enhances the ability to predict whether an individual has their eyes open or closed and is performing a working memory and Raven's pattern completion task. In addition, HVPs disappear under anesthesia and do not reappear in early periods of recovery.
CONCLUSIONS: HVP metrics enhance the discrimination of various brain states and are fast to estimate.
SIGNIFICANCE: HVP metrics can provide an additional view of signal variability that has potential clinical application in the rapid discrimination of brain states.},
}
RevDate: 2023-12-20
CmpDate: 2023-11-30
The foraging ecology of yellow-billed and red- billed choughs changed between two climatically different years.
Scientific reports, 13(1):20908.
Climate change is affecting the alpine ecosystem at an unprecedented rate, with marked changes in spring phenology and the elevation distribution of birds. Changes in the European Alps are happening rapidly, and it is possible behaviours stand to change from one year to the next. The year 2022 was characterised by climatic extremes: Italy experienced its hottest year ever, and it was the driest since 1800. Here, we assessed whether the foraging ecology of two coexisting upland bird species, the yellow-billed and the red-billed chough, changed from 2021 to 2022. We assessed foraging stay times, flock size, propensity to mixed flocking, foraging home ranges and altitudinal distribution. Stay times of both species when foraging in monospecific flocks significantly shortened in 2022, especially in the case of the red-billed chough. The two corvids are known to influence each other when foraging together. In 2021, as expected, the stay times of the red-billed chough decreased when in the presence of the congener, but this did not occur in 2022. Instead, the yellow-billed chough increased its altitudinal foraging distribution in 2022. The results are in line with the hypothesis that large climate variations may disrupt the foraging ecology of mountain birds. However, as it is not possible to draw solid conclusions from just two years of observations, further field research will have to be planned in the future.
Additional Links: PMID-38016972
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@article {pmid38016972,
year = {2023},
author = {Rolando, A and Basso, C and Brunelli, N and Bocca, M and Laini, A},
title = {The foraging ecology of yellow-billed and red- billed choughs changed between two climatically different years.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {20908},
pmid = {38016972},
issn = {2045-2322},
mesh = {Animals ; *Ecosystem ; *Passeriformes ; Ecology ; Homing Behavior ; Italy ; },
abstract = {Climate change is affecting the alpine ecosystem at an unprecedented rate, with marked changes in spring phenology and the elevation distribution of birds. Changes in the European Alps are happening rapidly, and it is possible behaviours stand to change from one year to the next. The year 2022 was characterised by climatic extremes: Italy experienced its hottest year ever, and it was the driest since 1800. Here, we assessed whether the foraging ecology of two coexisting upland bird species, the yellow-billed and the red-billed chough, changed from 2021 to 2022. We assessed foraging stay times, flock size, propensity to mixed flocking, foraging home ranges and altitudinal distribution. Stay times of both species when foraging in monospecific flocks significantly shortened in 2022, especially in the case of the red-billed chough. The two corvids are known to influence each other when foraging together. In 2021, as expected, the stay times of the red-billed chough decreased when in the presence of the congener, but this did not occur in 2022. Instead, the yellow-billed chough increased its altitudinal foraging distribution in 2022. The results are in line with the hypothesis that large climate variations may disrupt the foraging ecology of mountain birds. However, as it is not possible to draw solid conclusions from just two years of observations, further field research will have to be planned in the future.},
}
MeSH Terms:
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Animals
*Ecosystem
*Passeriformes
Ecology
Homing Behavior
Italy
RevDate: 2023-12-01
Determinants for the presence of avian influenza virus in live bird markets in Bangladesh: Towards an easy fix of a looming one health issue.
One health (Amsterdam, Netherlands), 17:100643.
Highly pathogenic avian influenza virus subtype H5N1 endangers poultry, wildlife, and human health and is enzootic in large parts of Asia, with live bird markets (LBMs) as putative hotspots for their maintenance, amplification, and spread. To mitigate the extent of these and other avian influenza viruses (AIV) of concern, we aimed to increase our quantitative understanding of the factors determining the presence of avian influenza virus in LBM stalls. Between 2016 and 2017, we collected fecal or offal samples from 1008 stalls in 113 LBMs across the Dhaka and Rajshahi districts in Bangladesh. For each stall, samples were pooled and tested for the AIV matrix gene, followed by H5 and H9 subtyping using rRT-PCR. We detected Influenza A viral RNA in 49% of the stalls. Of the AIV positive samples, 52% and 24% were determined to be H5 and H9 viruses, respectively, which are both subtypes of considerable health concern. We used generalized linear mixed effect modelling to study AIV presence in individual stalls within LBMs as a function of 13 out of the 20 risk factors identified by FAO. We found that small and feasible improvements in cleaning and disinfection frequency, installing running water in stalls, and not mixing different breeds of chicken in the same cages had large impacts on the presence of AIV in stalls (Odds ratios 0.03-0.05). Next, cleaning vehicles used in poultry transport, not selling waterfowl with chickens in the same stall, buying stock directly from commercial farms, separating sick birds from healthy ones, and avoiding access by wild birds like house crows, also had major effects on lowering the risk of stalls having AIV (Odds ratios 0.16-0.33). These findings can be directly used in developing practical and affordable measures to reduce the prevalence of AIV in LBMs. Also, in settings with limited resources like Bangladesh, such mitigation may significantly contribute to reducing AIV circulation amongst poultry and spillover to wildlife and humans.
Additional Links: PMID-38024264
PubMed:
Citation:
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@article {pmid38024264,
year = {2023},
author = {Islam, A and Rahman, MZ and Hassan, MM and Epstein, JH and Klaassen, M},
title = {Determinants for the presence of avian influenza virus in live bird markets in Bangladesh: Towards an easy fix of a looming one health issue.},
journal = {One health (Amsterdam, Netherlands)},
volume = {17},
number = {},
pages = {100643},
pmid = {38024264},
issn = {2352-7714},
abstract = {Highly pathogenic avian influenza virus subtype H5N1 endangers poultry, wildlife, and human health and is enzootic in large parts of Asia, with live bird markets (LBMs) as putative hotspots for their maintenance, amplification, and spread. To mitigate the extent of these and other avian influenza viruses (AIV) of concern, we aimed to increase our quantitative understanding of the factors determining the presence of avian influenza virus in LBM stalls. Between 2016 and 2017, we collected fecal or offal samples from 1008 stalls in 113 LBMs across the Dhaka and Rajshahi districts in Bangladesh. For each stall, samples were pooled and tested for the AIV matrix gene, followed by H5 and H9 subtyping using rRT-PCR. We detected Influenza A viral RNA in 49% of the stalls. Of the AIV positive samples, 52% and 24% were determined to be H5 and H9 viruses, respectively, which are both subtypes of considerable health concern. We used generalized linear mixed effect modelling to study AIV presence in individual stalls within LBMs as a function of 13 out of the 20 risk factors identified by FAO. We found that small and feasible improvements in cleaning and disinfection frequency, installing running water in stalls, and not mixing different breeds of chicken in the same cages had large impacts on the presence of AIV in stalls (Odds ratios 0.03-0.05). Next, cleaning vehicles used in poultry transport, not selling waterfowl with chickens in the same stall, buying stock directly from commercial farms, separating sick birds from healthy ones, and avoiding access by wild birds like house crows, also had major effects on lowering the risk of stalls having AIV (Odds ratios 0.16-0.33). These findings can be directly used in developing practical and affordable measures to reduce the prevalence of AIV in LBMs. Also, in settings with limited resources like Bangladesh, such mitigation may significantly contribute to reducing AIV circulation amongst poultry and spillover to wildlife and humans.},
}
RevDate: 2023-12-01
A network analysis involving mental difficulties, cognition, physical fitness, 24-hour movement components, fatness, and sociodemographic factors in children.
Journal of exercise science and fitness, 21(4):416-423.
BACKGROUND: Evidence supports the beneficial linear influence of diverse lifestyle behaviors on brain health since childhood; however, multiple behaviors -and not only one-simultaneously affect such outcomes. Therefore, the aim was to explore the multivariate relationship through a network analysis among mental difficulty and cognitive function with physical fitness (PF), 24-h movement components, fatness, and sociodemographic factors in children.
METHODS: Cross-sectional study involved 226 children (52.2 % boys) aged between six and 11 years. Mental difficulties were evaluated through the Strengths and Difficulties Questionnaire and cognitive function by the Raven's Colored Progressive Matrices Test. The body mass index and PF were assessed according to the procedures suggested by the Proesp-Br, while moderate-to vigorous-intensity physical activity (MVPA) using accelerometry. The socioeconomic level, sleep, and screen time were evaluated by questionnaires. A network analysis was carried out to evaluate the associations among variables and establish centrality measures.
RESULTS: Age and PF moderated the negative relationship between cognitive function and MVPA. Furthermore, the direct and inverse relationship between cognitive function and mental difficulties appears to be affected by the 24-h movement components. Finally, age, PF, and screen time are the nodes with higher values of expected influence, indicating more sensitivity to interventions for decreasing mental difficulty and improving cognitive function.
CONCLUSION: Mental health and cognitive function were moderated by the multivariate interaction among age, PF, and the three 24-h movement components. Nonetheless, centrality measures from the network analysis suggest that PF, MVPA, and screen time are crucial nodes in order to implement future interventions.
Additional Links: PMID-38028983
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@article {pmid38028983,
year = {2023},
author = {Felin Fochesatto, C and Cristi-Montero, C and Ribeiro Bandeira, PF and Brand, C and Dias, AF and Bandeira, DR and Mota, J and Araujo Gaya, AC and Reis Gaya, A},
title = {A network analysis involving mental difficulties, cognition, physical fitness, 24-hour movement components, fatness, and sociodemographic factors in children.},
journal = {Journal of exercise science and fitness},
volume = {21},
number = {4},
pages = {416-423},
pmid = {38028983},
issn = {1728-869X},
abstract = {BACKGROUND: Evidence supports the beneficial linear influence of diverse lifestyle behaviors on brain health since childhood; however, multiple behaviors -and not only one-simultaneously affect such outcomes. Therefore, the aim was to explore the multivariate relationship through a network analysis among mental difficulty and cognitive function with physical fitness (PF), 24-h movement components, fatness, and sociodemographic factors in children.
METHODS: Cross-sectional study involved 226 children (52.2 % boys) aged between six and 11 years. Mental difficulties were evaluated through the Strengths and Difficulties Questionnaire and cognitive function by the Raven's Colored Progressive Matrices Test. The body mass index and PF were assessed according to the procedures suggested by the Proesp-Br, while moderate-to vigorous-intensity physical activity (MVPA) using accelerometry. The socioeconomic level, sleep, and screen time were evaluated by questionnaires. A network analysis was carried out to evaluate the associations among variables and establish centrality measures.
RESULTS: Age and PF moderated the negative relationship between cognitive function and MVPA. Furthermore, the direct and inverse relationship between cognitive function and mental difficulties appears to be affected by the 24-h movement components. Finally, age, PF, and screen time are the nodes with higher values of expected influence, indicating more sensitivity to interventions for decreasing mental difficulty and improving cognitive function.
CONCLUSION: Mental health and cognitive function were moderated by the multivariate interaction among age, PF, and the three 24-h movement components. Nonetheless, centrality measures from the network analysis suggest that PF, MVPA, and screen time are crucial nodes in order to implement future interventions.},
}
RevDate: 2024-10-14
Intersectionality and Social Security Age-18 Redetermination: Reducing the Stress and Trauma of Transition for Black Transition-Age Youth with Disabilities.
Child & adolescent social work journal : C & A, 40(4):513-523.
Greater attention is being paid to the transition to adulthood for youth with disabilities. We are also at a period of reckoning with the vestiges of slavery, Jim Crow, and a lack of constitutional protections for Black-identifying persons. The contemporary impact of inequitable access to opportunities, services, and supports that would improve the quality of life of racialized Black individuals has added consequences for Black youth with disabilities. A sub-population of youth with disabilities receives monthly support in the form of Supplemental Security Income (SSI), with a disproportionate number of Black-identifying youth qualifying for SSI. Such youth are impacted by the intersectionality of racism, disability, and poverty. The outcome of an SSI age-18 redetermination can be precarious and occurs in the backdrop of these intersectional forces, impacting the life course of racialized Black youth and their families on a scale that is concerning. The authors describe the time frames of pre age-18 redetermination, age-18 redetermination and post age-18 redetermination in the contexts of intersectionality and transition, and articulate what type of services and supports can reduce the experience of chronic stress in the lives of racialized Black youth facing an SSI age-18 redetermination, and thereby improve the outcomes of these youth as they transition to adulthood.
Additional Links: PMID-38031577
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@article {pmid38031577,
year = {2023},
author = {Davis, A and Gourdine, R},
title = {Intersectionality and Social Security Age-18 Redetermination: Reducing the Stress and Trauma of Transition for Black Transition-Age Youth with Disabilities.},
journal = {Child & adolescent social work journal : C & A},
volume = {40},
number = {4},
pages = {513-523},
pmid = {38031577},
issn = {0738-0151},
support = {R61 HD104570/HD/NICHD NIH HHS/United States ; T32 HD094687/HD/NICHD NIH HHS/United States ; },
abstract = {Greater attention is being paid to the transition to adulthood for youth with disabilities. We are also at a period of reckoning with the vestiges of slavery, Jim Crow, and a lack of constitutional protections for Black-identifying persons. The contemporary impact of inequitable access to opportunities, services, and supports that would improve the quality of life of racialized Black individuals has added consequences for Black youth with disabilities. A sub-population of youth with disabilities receives monthly support in the form of Supplemental Security Income (SSI), with a disproportionate number of Black-identifying youth qualifying for SSI. Such youth are impacted by the intersectionality of racism, disability, and poverty. The outcome of an SSI age-18 redetermination can be precarious and occurs in the backdrop of these intersectional forces, impacting the life course of racialized Black youth and their families on a scale that is concerning. The authors describe the time frames of pre age-18 redetermination, age-18 redetermination and post age-18 redetermination in the contexts of intersectionality and transition, and articulate what type of services and supports can reduce the experience of chronic stress in the lives of racialized Black youth facing an SSI age-18 redetermination, and thereby improve the outcomes of these youth as they transition to adulthood.},
}
RevDate: 2023-12-02
Safety and tolerability of onabotulinumtoxinA in the treatment of upper facial lines from global registration studies in 5298 participants: A meta-analysis.
JAAD international, 14:4-18.
BACKGROUND: Since its discovery as a facial aesthetic treatment >30 years ago, onabotulinumtoxinA has received worldwide approval for dynamic upper facial line treatment.
OBJECTIVE: Meta-analysis examining the safety of onabotulinumtoxinA for treatment of glabellar lines (GL), crow's feet lines (CFL), and forehead lines (FHL).
METHODS: Participants (N = 5298) with moderate to severe GL, CFL, or FHL at maximum contraction received onabotulinumtoxinA or placebo in 1 of 18 registration studies (14 double-blind, placebo-controlled [DBPC]; 1 double-blind; 3 open-label). Adverse events (AEs) were analyzed by descriptive statistics and fixed-effects meta-analysis.
RESULTS: In the overall double-blind placebo-controlled (DBPC) population, AEs were reported in 1443 (42.1%) and 486 (35.8%) participants in the onabotulinumtoxinA (n = 3431) and placebo (n = 1359) groups, respectively. Serious AEs were reported in 54 (1.6%) and 17 (1.3%) participants; 1 (spontaneous abortion) was considered possibly treatment related by the investigator. Using fixed-effects statistical meta-analysis, AEs of interest that were found to be statistically higher for onabotulinumtoxinA than placebo in the DBPC population were eyelid ptosis, eyelid sensory disorder, skin tightness, brow ptosis, eyelid edema, and facial pain (P ≤ .05).
LIMITATIONS: Retrospective, ad hoc analysis.
CONCLUSION: This meta-analysis confirms the onabotulinumtoxinA safety profile for GL, CFL, and FHL treatment, with no new onabotulinumtoxinA-associated AEs.
Additional Links: PMID-38035126
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Citation:
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@article {pmid38035126,
year = {2024},
author = {Brin, MF and De Boulle, K and Liew, S and Carruthers, A and Carruthers, J and Rivkin, A and Wu, Y and Kawashima, M and Yushmanova, I and Boodhoo, TI and Lee, E},
title = {Safety and tolerability of onabotulinumtoxinA in the treatment of upper facial lines from global registration studies in 5298 participants: A meta-analysis.},
journal = {JAAD international},
volume = {14},
number = {},
pages = {4-18},
pmid = {38035126},
issn = {2666-3287},
abstract = {BACKGROUND: Since its discovery as a facial aesthetic treatment >30 years ago, onabotulinumtoxinA has received worldwide approval for dynamic upper facial line treatment.
OBJECTIVE: Meta-analysis examining the safety of onabotulinumtoxinA for treatment of glabellar lines (GL), crow's feet lines (CFL), and forehead lines (FHL).
METHODS: Participants (N = 5298) with moderate to severe GL, CFL, or FHL at maximum contraction received onabotulinumtoxinA or placebo in 1 of 18 registration studies (14 double-blind, placebo-controlled [DBPC]; 1 double-blind; 3 open-label). Adverse events (AEs) were analyzed by descriptive statistics and fixed-effects meta-analysis.
RESULTS: In the overall double-blind placebo-controlled (DBPC) population, AEs were reported in 1443 (42.1%) and 486 (35.8%) participants in the onabotulinumtoxinA (n = 3431) and placebo (n = 1359) groups, respectively. Serious AEs were reported in 54 (1.6%) and 17 (1.3%) participants; 1 (spontaneous abortion) was considered possibly treatment related by the investigator. Using fixed-effects statistical meta-analysis, AEs of interest that were found to be statistically higher for onabotulinumtoxinA than placebo in the DBPC population were eyelid ptosis, eyelid sensory disorder, skin tightness, brow ptosis, eyelid edema, and facial pain (P ≤ .05).
LIMITATIONS: Retrospective, ad hoc analysis.
CONCLUSION: This meta-analysis confirms the onabotulinumtoxinA safety profile for GL, CFL, and FHL treatment, with no new onabotulinumtoxinA-associated AEs.},
}
RevDate: 2023-12-02
Fully reconfigurable MEMS-based second-order coupled-resonator optical waveguide (CROW) with ultra-low tuning energy.
Optics express, 31(24):40166-40178.
Integrated microring resonators are well suited for wavelength-filtering applications in optical signal processing, and cascaded microring resonators allow flexible filter design in coupled-resonator optical waveguide (CROW) configurations. However, the implementation of high-order cascaded microring resonators with high extinction ratios (ERs) remains challenging owing to stringent fabrication requirements and the need for precise resonator tunability. We present a fully integrated on-chip second-order CROW filter using silicon photonic microelectromechanical systems (MEMS) to adjust tunable directional couplers and a phase shifter using nanoscale mechanical out-of-plane waveguide displacement. The filter can be fully reconfigured with regard to both the ER and center wavelength. We experimentally demonstrated an ER exceeding 25 dB and continuous wavelength tuning across the full free spectral range of 0.123 nm for single microring resonator, and showed reconfigurability in second-order CROW by tuning the ER and resonant wavelength. The tuning energy for an individual silicon photonic MEMS phase shifter or tunable coupler is less than 22 pJ with sub-microwatt static power consumption, which is far better than conventional integrated phase shifters based on other physical modulation mechanisms.
Additional Links: PMID-38041323
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PubMed:
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@article {pmid38041323,
year = {2023},
author = {Lim, MG and Park, YJ and Choi, DJ and Kim, DU and Hong, MS and Her, MJ and Takabayashi, AY and Jeong, Y and Park, J and Han, S and Quack, N and Bae, Y and Yu, K and Han, S},
title = {Fully reconfigurable MEMS-based second-order coupled-resonator optical waveguide (CROW) with ultra-low tuning energy.},
journal = {Optics express},
volume = {31},
number = {24},
pages = {40166-40178},
doi = {10.1364/OE.505295},
pmid = {38041323},
issn = {1094-4087},
abstract = {Integrated microring resonators are well suited for wavelength-filtering applications in optical signal processing, and cascaded microring resonators allow flexible filter design in coupled-resonator optical waveguide (CROW) configurations. However, the implementation of high-order cascaded microring resonators with high extinction ratios (ERs) remains challenging owing to stringent fabrication requirements and the need for precise resonator tunability. We present a fully integrated on-chip second-order CROW filter using silicon photonic microelectromechanical systems (MEMS) to adjust tunable directional couplers and a phase shifter using nanoscale mechanical out-of-plane waveguide displacement. The filter can be fully reconfigured with regard to both the ER and center wavelength. We experimentally demonstrated an ER exceeding 25 dB and continuous wavelength tuning across the full free spectral range of 0.123 nm for single microring resonator, and showed reconfigurability in second-order CROW by tuning the ER and resonant wavelength. The tuning energy for an individual silicon photonic MEMS phase shifter or tunable coupler is less than 22 pJ with sub-microwatt static power consumption, which is far better than conventional integrated phase shifters based on other physical modulation mechanisms.},
}
RevDate: 2023-12-05
Verbal-analytical rather than visuo-spatial Raven's puzzle solving favors Raven's-like puzzle generation.
Frontiers in psychology, 14:1205056.
Raven's advanced progressive matrices (APM) comprise two types of representational codes, namely visuo-spatial and verbal-analytical, that are used to solve APM puzzles. Studies using analytical, behavioral, and imaging methods have supported the multidimensional perspectives of APM puzzles. The visuo-spatial code is expected to recruit operations more responsive to the visual perception tasks. In contrast, the verbal-analytical code is expected to use operations more responsive to the logical reasoning task and may entail different cognitive strategies. Acknowledging different representational codes used in APM puzzle-solving is critical for a better understanding of APM's performance and their relationship with other tasks, especially creative reasoning. We used the eye-tracking method to investigate the role of two representational codes, visuo-spatial and verbal-analytical, in strategies involved in solving APM puzzles and in generating an APM-like puzzle by using a creative-reasoning task (CRT). Participants took longer time to complete the verbal-analytical than visuo-spatial puzzles. In addition, visuo-analytical than visual-spatial puzzles showed higher progressive and regressive saccade counts, suggesting the use of more response elimination than constructive matching strategies employed while solving verbal-analytical than visuo-spatial puzzles. We observed higher CRT scores when it followed verbal-analytical (Mdn = 84) than visuo-spatial (Mdn = 73) APM puzzles, suggesting puzzle-solving specific strategies affect puzzle-creating task performance. The advantage of verbal-analytical over visuo-spatial puzzle-solving has been discussed in light of shared cognitive processing between APM puzzle-solving and APM-like puzzle-creating task performance.
Additional Links: PMID-38046123
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@article {pmid38046123,
year = {2023},
author = {Srivastava, P and Jaarsveld, S and Sangani, K},
title = {Verbal-analytical rather than visuo-spatial Raven's puzzle solving favors Raven's-like puzzle generation.},
journal = {Frontiers in psychology},
volume = {14},
number = {},
pages = {1205056},
pmid = {38046123},
issn = {1664-1078},
abstract = {Raven's advanced progressive matrices (APM) comprise two types of representational codes, namely visuo-spatial and verbal-analytical, that are used to solve APM puzzles. Studies using analytical, behavioral, and imaging methods have supported the multidimensional perspectives of APM puzzles. The visuo-spatial code is expected to recruit operations more responsive to the visual perception tasks. In contrast, the verbal-analytical code is expected to use operations more responsive to the logical reasoning task and may entail different cognitive strategies. Acknowledging different representational codes used in APM puzzle-solving is critical for a better understanding of APM's performance and their relationship with other tasks, especially creative reasoning. We used the eye-tracking method to investigate the role of two representational codes, visuo-spatial and verbal-analytical, in strategies involved in solving APM puzzles and in generating an APM-like puzzle by using a creative-reasoning task (CRT). Participants took longer time to complete the verbal-analytical than visuo-spatial puzzles. In addition, visuo-analytical than visual-spatial puzzles showed higher progressive and regressive saccade counts, suggesting the use of more response elimination than constructive matching strategies employed while solving verbal-analytical than visuo-spatial puzzles. We observed higher CRT scores when it followed verbal-analytical (Mdn = 84) than visuo-spatial (Mdn = 73) APM puzzles, suggesting puzzle-solving specific strategies affect puzzle-creating task performance. The advantage of verbal-analytical over visuo-spatial puzzle-solving has been discussed in light of shared cognitive processing between APM puzzle-solving and APM-like puzzle-creating task performance.},
}
RevDate: 2023-12-06
The Brain Networks Basis for Deductive and Inductive Reasoning: A Functional Magnetic Resonance Imaging Study.
Basic and clinical neuroscience, 14(4):529-542.
INTRODUCTION: Frontoparietal (FPN) and cingulo-opercular network (CON) control cognitive functions needed in deductive and inductive reasoning via different functional frameworks. The FPN is a fast intuitive system while the CON is slow and analytical. The default-interventionist model presents a serial view of the interaction between intuitive and analytic cognitive systems. This study aims to examine the activity pattern of the FPN and CON from the perspective of the default-interventionist model via reasoning.
METHODS: We employed functional magnetic resonance imaging (fMRI) to investigate cingulo-opercular and frontoparietal network activities in 24 healthy university students during Raven and Wason reasoning tasks. Due to the different operation times of the CON and FPN, the reaction time was assessed as a behavioral factor.
RESULTS: During Raven's advanced progressive matrices (RAPM) test, both the CON and FPN were activated. Also, with the increase in the difficulty level of the Raven test, a linear increase in response time was observed. In contrast, during the Wason's selection task (WST) test, only the activity of FPN was observed.
CONCLUSION: The results of the study support the hypothesis that the default-interventionist model of dual-process theory provides an accurate explanation of the cognitive mechanisms involved in reasoning. Thus, the response method (intuitive/analytical) determines which cognitive skills and brain regions are involved in responding.
HIGHLIGHTS: The cingulo-opercular and fronto-parietal networks (FPNs) control cognitive functions and processes.The frontoparietal network is a fast intuitive system that utilizes short-time attention which is compatible with type 1 processing. In contrast, the cingulo-opercular network (CON) is an analytical time-consuming system that utilizes attention and working memory for a longer time, compatible with type 2 processing.The default-interventionist model of a dual-process theory states that our behaviors are controlled by type 1 processing unless we are confronted with novel and complex problems in which we have no prior experiences.
PLAIN LANGUAGE SUMMARY: The present study examined the activity of two task-based brain networks through performing diffrent type of reasoning tasks. Fronto-parietal and Cingulo-opercular are the two task-based brain networks that are responsible for cognitive control. These two brain networks direct the way to use cognitive skills and executive functions which are necessary to perform cognitive tasks especially higher-order ones as reasoning tasks. Since the two types of inductive and deductive reasoning tasks requier two different bottom-up and top-down cognitive control respectively, different cognitive skills would be needed which affect the activity of fronto-parietal and cingulo-opercular brain networks. Our results showed that through inductive reasoning task which examined by RAVEN, both of the fronto-parietal and cingulo-opercular brain networks were activated but deductive reasoning task which examined by Wason Selection Card test, just the fronto-parietal brain network was activated. It seems that in the case of deductive reasoninf task, there is a higher probability of errors which lead to giving less correct responses. Based on our results, subjects paid not enough attention to details, so had failure to update informations that leaded to responding with errors. Inactivity of cingulo-opercular network through dedeuctive reasoning task clearly showed that the bottom-up cognitive control did not happen successfully. As a result of that, information processing did not proceed properly.
Additional Links: PMID-38050565
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@article {pmid38050565,
year = {2023},
author = {Seyyed Hashemi, SF and Tehrani-Doost, M and Khosrowabadi, R},
title = {The Brain Networks Basis for Deductive and Inductive Reasoning: A Functional Magnetic Resonance Imaging Study.},
journal = {Basic and clinical neuroscience},
volume = {14},
number = {4},
pages = {529-542},
pmid = {38050565},
issn = {2008-126X},
abstract = {INTRODUCTION: Frontoparietal (FPN) and cingulo-opercular network (CON) control cognitive functions needed in deductive and inductive reasoning via different functional frameworks. The FPN is a fast intuitive system while the CON is slow and analytical. The default-interventionist model presents a serial view of the interaction between intuitive and analytic cognitive systems. This study aims to examine the activity pattern of the FPN and CON from the perspective of the default-interventionist model via reasoning.
METHODS: We employed functional magnetic resonance imaging (fMRI) to investigate cingulo-opercular and frontoparietal network activities in 24 healthy university students during Raven and Wason reasoning tasks. Due to the different operation times of the CON and FPN, the reaction time was assessed as a behavioral factor.
RESULTS: During Raven's advanced progressive matrices (RAPM) test, both the CON and FPN were activated. Also, with the increase in the difficulty level of the Raven test, a linear increase in response time was observed. In contrast, during the Wason's selection task (WST) test, only the activity of FPN was observed.
CONCLUSION: The results of the study support the hypothesis that the default-interventionist model of dual-process theory provides an accurate explanation of the cognitive mechanisms involved in reasoning. Thus, the response method (intuitive/analytical) determines which cognitive skills and brain regions are involved in responding.
HIGHLIGHTS: The cingulo-opercular and fronto-parietal networks (FPNs) control cognitive functions and processes.The frontoparietal network is a fast intuitive system that utilizes short-time attention which is compatible with type 1 processing. In contrast, the cingulo-opercular network (CON) is an analytical time-consuming system that utilizes attention and working memory for a longer time, compatible with type 2 processing.The default-interventionist model of a dual-process theory states that our behaviors are controlled by type 1 processing unless we are confronted with novel and complex problems in which we have no prior experiences.
PLAIN LANGUAGE SUMMARY: The present study examined the activity of two task-based brain networks through performing diffrent type of reasoning tasks. Fronto-parietal and Cingulo-opercular are the two task-based brain networks that are responsible for cognitive control. These two brain networks direct the way to use cognitive skills and executive functions which are necessary to perform cognitive tasks especially higher-order ones as reasoning tasks. Since the two types of inductive and deductive reasoning tasks requier two different bottom-up and top-down cognitive control respectively, different cognitive skills would be needed which affect the activity of fronto-parietal and cingulo-opercular brain networks. Our results showed that through inductive reasoning task which examined by RAVEN, both of the fronto-parietal and cingulo-opercular brain networks were activated but deductive reasoning task which examined by Wason Selection Card test, just the fronto-parietal brain network was activated. It seems that in the case of deductive reasoninf task, there is a higher probability of errors which lead to giving less correct responses. Based on our results, subjects paid not enough attention to details, so had failure to update informations that leaded to responding with errors. Inactivity of cingulo-opercular network through dedeuctive reasoning task clearly showed that the bottom-up cognitive control did not happen successfully. As a result of that, information processing did not proceed properly.},
}
RevDate: 2025-12-23
CmpDate: 2023-12-11
Social influences on delayed gratification in New Caledonian crows and Eurasian jays.
PloS one, 18(12):e0289197.
Self-control underlies goal-directed behaviour in humans and other animals. Delayed gratification - a measure of self-control - requires the ability to tolerate delays and/or invest more effort to obtain a reward of higher value over one of lower value, such as food or mates. Social context, in particular, the presence of competitors, may influence delayed gratification. We adapted the 'rotating-tray' paradigm, where subjects need to forgo an immediate, lower-quality (i.e. less preferred) reward for a delayed, higher-quality (i.e. more preferred) one, to test social influences on delayed gratification in two corvid species: New Caledonian crows and Eurasian jays. We compared choices for immediate vs. delayed rewards while alone, in the presence of a competitive conspecific and in the presence of a non-competitive conspecific. We predicted that, given the increased risk of losing a reward with a competitor present, both species would similarly, flexibly alter their choices in the presence of a conspecific compared to when alone. We found that species differed: jays were more likely to select the immediate, less preferred reward than the crows. We also found that jays were more likely to select the immediate, less preferred reward when a competitor or non-competitor was present than when alone, or when a competitor was present compared to a non-competitor, while the crows selected the delayed, highly preferred reward irrespective of social presence. We discuss our findings in relation to species differences in socio-ecological factors related to adult sociality and food-caching (storing). New Caledonian crows are more socially tolerant and moderate cachers, while Eurasian jays are highly territorial and intense cachers that may have evolved under the social context of cache pilfering and cache protection strategies. Therefore, flexibility (or inflexibility) in delay of gratification under different social contexts may relate to the species' social tolerance and related risk of competition.
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@article {pmid38055711,
year = {2023},
author = {Miller, R and Davies, JR and Schiestl, M and Garcia-Pelegrin, E and Gray, RD and Taylor, AH and Clayton, NS},
title = {Social influences on delayed gratification in New Caledonian crows and Eurasian jays.},
journal = {PloS one},
volume = {18},
number = {12},
pages = {e0289197},
pmid = {38055711},
issn = {1932-6203},
support = {/ERC_/European Research Council/International ; },
mesh = {Animals ; Adult ; Humans ; *Crows ; *Delay Discounting ; Feeding Behavior ; *Songbirds ; *Passeriformes ; Reward ; },
abstract = {Self-control underlies goal-directed behaviour in humans and other animals. Delayed gratification - a measure of self-control - requires the ability to tolerate delays and/or invest more effort to obtain a reward of higher value over one of lower value, such as food or mates. Social context, in particular, the presence of competitors, may influence delayed gratification. We adapted the 'rotating-tray' paradigm, where subjects need to forgo an immediate, lower-quality (i.e. less preferred) reward for a delayed, higher-quality (i.e. more preferred) one, to test social influences on delayed gratification in two corvid species: New Caledonian crows and Eurasian jays. We compared choices for immediate vs. delayed rewards while alone, in the presence of a competitive conspecific and in the presence of a non-competitive conspecific. We predicted that, given the increased risk of losing a reward with a competitor present, both species would similarly, flexibly alter their choices in the presence of a conspecific compared to when alone. We found that species differed: jays were more likely to select the immediate, less preferred reward than the crows. We also found that jays were more likely to select the immediate, less preferred reward when a competitor or non-competitor was present than when alone, or when a competitor was present compared to a non-competitor, while the crows selected the delayed, highly preferred reward irrespective of social presence. We discuss our findings in relation to species differences in socio-ecological factors related to adult sociality and food-caching (storing). New Caledonian crows are more socially tolerant and moderate cachers, while Eurasian jays are highly territorial and intense cachers that may have evolved under the social context of cache pilfering and cache protection strategies. Therefore, flexibility (or inflexibility) in delay of gratification under different social contexts may relate to the species' social tolerance and related risk of competition.},
}
MeSH Terms:
show MeSH Terms
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Animals
Adult
Humans
*Crows
*Delay Discounting
Feeding Behavior
*Songbirds
*Passeriformes
Reward
RevDate: 2025-09-25
CmpDate: 2024-02-23
Development of reasoning performance in Raven's matrices is grounded in the development of effective strategy use.
Journal of experimental psychology. General, 153(3):689-705.
Performance in reasoning tasks such as Raven's matrices experiences a dramatic increase over cognitive development, but the mechanisms responsible for this increase are unknown. Many cognitive processes are involved in a matrix task and could potentially change with age; strategy use appears to be a good candidate, as it typically improves over development and has a large impact on reasoning performance in adults. The present study tested the role of effective strategy use in Raven's standard progressive matrices in groups of 6-, 8-, 10-, 12-, 14-, 16-, and 18-year-olds (total N = 474). Strategy use was assessed with behavioral measures of gaze patterns in Raven's matrices. We also measured working memory capacity (WMC), a good predictor of strategy use in adults, using a battery of complex spans. The results showed that the effective strategy of constructive matching substantially increased with age, along with performance. Strategy use mediated over half the effect of age on reasoning performance. Older participants were also better at adapting strategy use to difficulty of the problems. Effective strategy use was beneficial to the same extent for participants of all ages. Age-related improvements in strategy use occurred in tandem with improvements in WMC, but did not appear to be primarily driven by them. Overall, our results indicate that strategy use is a critical underpinning of reasoning performance in children as well as in adults, and that theories of cognitive development of reasoning have to consider the central role of strategy use. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Additional Links: PMID-38059964
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@article {pmid38059964,
year = {2024},
author = {Gonthier, C and Harma, K and Gavornikova-Baligand, Z},
title = {Development of reasoning performance in Raven's matrices is grounded in the development of effective strategy use.},
journal = {Journal of experimental psychology. General},
volume = {153},
number = {3},
pages = {689-705},
doi = {10.1037/xge0001518},
pmid = {38059964},
issn = {1939-2222},
support = {//City of Rennes/ ; },
mesh = {Adult ; Child ; Humans ; *Problem Solving ; *Cognition ; Intelligence Tests ; Memory, Short-Term ; Neuropsychological Tests ; },
abstract = {Performance in reasoning tasks such as Raven's matrices experiences a dramatic increase over cognitive development, but the mechanisms responsible for this increase are unknown. Many cognitive processes are involved in a matrix task and could potentially change with age; strategy use appears to be a good candidate, as it typically improves over development and has a large impact on reasoning performance in adults. The present study tested the role of effective strategy use in Raven's standard progressive matrices in groups of 6-, 8-, 10-, 12-, 14-, 16-, and 18-year-olds (total N = 474). Strategy use was assessed with behavioral measures of gaze patterns in Raven's matrices. We also measured working memory capacity (WMC), a good predictor of strategy use in adults, using a battery of complex spans. The results showed that the effective strategy of constructive matching substantially increased with age, along with performance. Strategy use mediated over half the effect of age on reasoning performance. Older participants were also better at adapting strategy use to difficulty of the problems. Effective strategy use was beneficial to the same extent for participants of all ages. Age-related improvements in strategy use occurred in tandem with improvements in WMC, but did not appear to be primarily driven by them. Overall, our results indicate that strategy use is a critical underpinning of reasoning performance in children as well as in adults, and that theories of cognitive development of reasoning have to consider the central role of strategy use. (PsycInfo Database Record (c) 2024 APA, all rights reserved).},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Adult
Child
Humans
*Problem Solving
*Cognition
Intelligence Tests
Memory, Short-Term
Neuropsychological Tests
RevDate: 2023-12-22
CmpDate: 2023-12-16
Long-term memory of experienced jays facilitates problem-solving by naïve group members in the wild.
Scientific reports, 13(1):21593.
Long-term memory affects animal fitness, especially in social species. In these species, the memory of group members facilitates the acquisition of novel foraging skills through social learning when naïve individuals observe and imitate the successful foraging behavior. Long-term memory and social learning also provide the framework for cultural behavior, a trait found in humans but very few other animal species. In birds, little is known about the duration of long-term memories for complex foraging skills, or the impact of long-term memory on group members. We tested whether wild jays remembered a complex foraging task more than 3 years after their initial experience and quantified the effect of this memory on naïve jay behavior. Experienced jays remembered how to solve the task and their behavior had significant positive effects on interactions by naïve group members at the task. This suggests that natural selection may favor long-term memory of solutions to foraging problems to facilitate the persistence of foraging skills that are specifically useful in the local environment in social birds with long lifespans and overlapping generations.
Additional Links: PMID-38062030
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@article {pmid38062030,
year = {2023},
author = {Jo, H and McCune, KB and Jablonski, PG and Lee, SI},
title = {Long-term memory of experienced jays facilitates problem-solving by naïve group members in the wild.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {21593},
pmid = {38062030},
issn = {2045-2322},
mesh = {Humans ; Animals ; *Songbirds ; Problem Solving ; Memory, Long-Term ; Mental Recall ; },
abstract = {Long-term memory affects animal fitness, especially in social species. In these species, the memory of group members facilitates the acquisition of novel foraging skills through social learning when naïve individuals observe and imitate the successful foraging behavior. Long-term memory and social learning also provide the framework for cultural behavior, a trait found in humans but very few other animal species. In birds, little is known about the duration of long-term memories for complex foraging skills, or the impact of long-term memory on group members. We tested whether wild jays remembered a complex foraging task more than 3 years after their initial experience and quantified the effect of this memory on naïve jay behavior. Experienced jays remembered how to solve the task and their behavior had significant positive effects on interactions by naïve group members at the task. This suggests that natural selection may favor long-term memory of solutions to foraging problems to facilitate the persistence of foraging skills that are specifically useful in the local environment in social birds with long lifespans and overlapping generations.},
}
MeSH Terms:
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Humans
Animals
*Songbirds
Problem Solving
Memory, Long-Term
Mental Recall
RevDate: 2024-09-17
CmpDate: 2024-02-26
Entopallium Lost GFAP Immunoreactivity during Avian Evolution: Is GFAP a "Condition Sine Qua Non"?.
Brain, behavior and evolution, 98(6):302-313.
INTRODUCTION: The present study demonstrates that in the same brain area the astroglia can express GFAP (the main cytoskeletal protein of astroglia) in some species but not in the others of the same vertebrate class. It contrasts the former opinions that the distribution of GFAP found in a species is characteristic of the entire class. The present study investigated birds in different phylogenetic positions: duck (Cairina moschata domestica), chicken (Gallus gallus domesticus), and quails (Coturnix japonica and Excalfactoria chinensis) of Galloanserae; pigeon (Columba livia domestica) of a group of Neoaves, in comparison with representatives of other Neoaves lineages, which emerged more recently in evolution: finches (Taeniopygia guttata and Erythrura gouldiae), magpie (Pica pica), and parrots (Melopsittacus undulatus and Nymphicus hollandicus).
METHODS: Following a perfusion with 4% buffered paraformaldehyde, immunoperoxidase reactions were performed with two types of anti-GFAP: monoclonal and polyclonal, on floating sections.
RESULTS: The entopallium (formerly "ectostriatum," a telencephalic area in birds) was GFAP-immunopositive in pigeon and in the representatives of Galloanserae but not in songbirds and parrots, which emerged more recently in evolution. The lack of GFAP expression of a brain area, however, does not mean the lack of astroglia. Lesions induced GFAP expression in the territory of GFAP-immunonegative entopallia. It proved that the GFAP immunonegativity is not due to the lack of capability, but rather the suppression of GFAP production of the astrocytes in this territory. In the other areas investigated besides the entopallium (optic tectum and cerebellum), no considerable interspecific differences of GFAP immunopositivity were found. It proved that the immunonegativity of entopallium is due to neither the general lack of GFAP expression nor the incapability of our reagents to detect GFAP in these species.
CONCLUSION: The data are congruent with our proposal that a lack of GFAP expression has evolved in different brain areas in vertebrate evolution, typically in lineages that emerged more recently. Comparative studies on GFAP-immunopositive and GFAP-immunonegative entopallia may promote understanding the role of GFAP in neural networks.
Additional Links: PMID-38071961
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Citation:
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@article {pmid38071961,
year = {2023},
author = {Kálmán, M and Sebők, OM},
title = {Entopallium Lost GFAP Immunoreactivity during Avian Evolution: Is GFAP a "Condition Sine Qua Non"?.},
journal = {Brain, behavior and evolution},
volume = {98},
number = {6},
pages = {302-313},
pmid = {38071961},
issn = {1421-9743},
mesh = {Animals ; *Columbidae ; Coturnix ; Phylogeny ; Pica ; Chickens ; *Songbirds ; },
abstract = {INTRODUCTION: The present study demonstrates that in the same brain area the astroglia can express GFAP (the main cytoskeletal protein of astroglia) in some species but not in the others of the same vertebrate class. It contrasts the former opinions that the distribution of GFAP found in a species is characteristic of the entire class. The present study investigated birds in different phylogenetic positions: duck (Cairina moschata domestica), chicken (Gallus gallus domesticus), and quails (Coturnix japonica and Excalfactoria chinensis) of Galloanserae; pigeon (Columba livia domestica) of a group of Neoaves, in comparison with representatives of other Neoaves lineages, which emerged more recently in evolution: finches (Taeniopygia guttata and Erythrura gouldiae), magpie (Pica pica), and parrots (Melopsittacus undulatus and Nymphicus hollandicus).
METHODS: Following a perfusion with 4% buffered paraformaldehyde, immunoperoxidase reactions were performed with two types of anti-GFAP: monoclonal and polyclonal, on floating sections.
RESULTS: The entopallium (formerly "ectostriatum," a telencephalic area in birds) was GFAP-immunopositive in pigeon and in the representatives of Galloanserae but not in songbirds and parrots, which emerged more recently in evolution. The lack of GFAP expression of a brain area, however, does not mean the lack of astroglia. Lesions induced GFAP expression in the territory of GFAP-immunonegative entopallia. It proved that the GFAP immunonegativity is not due to the lack of capability, but rather the suppression of GFAP production of the astrocytes in this territory. In the other areas investigated besides the entopallium (optic tectum and cerebellum), no considerable interspecific differences of GFAP immunopositivity were found. It proved that the immunonegativity of entopallium is due to neither the general lack of GFAP expression nor the incapability of our reagents to detect GFAP in these species.
CONCLUSION: The data are congruent with our proposal that a lack of GFAP expression has evolved in different brain areas in vertebrate evolution, typically in lineages that emerged more recently. Comparative studies on GFAP-immunopositive and GFAP-immunonegative entopallia may promote understanding the role of GFAP in neural networks.},
}
MeSH Terms:
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Animals
*Columbidae
Coturnix
Phylogeny
Pica
Chickens
*Songbirds
RevDate: 2025-03-02
CmpDate: 2024-02-15
A profile of spatial abilities in people with Down syndrome.
Journal of intellectual disability research : JIDR, 68(3):223-236.
BACKGROUND: Spatial abilities are fundamental cognitive abilities, have direct applications in daily life, serve as a cognitive foundation for many other complex skills and are used in many specialty jobs. The current study aimed to systematically and comprehensively evaluate the spatial abilities of individuals with Down syndrome (DS) relative to mental ability-matched typically developing (TD) children based on Newcombe and Shipley's double-dimension theoretical framework for classifying spatial abilities.
METHODS: Forty adolescents and young adults with DS and 40 TD children completed a nonverbal intelligence test (Raven's), two measures of static-extrinsic skills (water-level task and cart task), two measures of static-intrinsic skills (figure ground and form completion), two measures of dynamic-extrinsic skills (three mountains task and dog task) and two measures of dynamic-intrinsic spatial skills (mental rotation task and block design task).
RESULTS: Participants with DS showed reduced performance on two dynamic-intrinsic tasks and one static-extrinsic task (i.e. cart task) relative to TD children. Performances were similar in two dynamic-extrinsic tasks and two static-intrinsic tasks. Analyses of composite accuracy for each spatial category further confirmed deficits in dynamic-intrinsic and static-extrinsic categories for people with DS relative to TD children.
CONCLUSIONS: Our results showed an uneven profile of spatial abilities in people with DS relative to ability-matched TD children with particular weaknesses in comprehending and manipulating dynamic-intrinsic and static-extrinsic spatial relations. Furthermore, our research has important clinical implications for more targeted interventions to improve spatial abilities in people with DS.
Additional Links: PMID-38072820
PubMed:
Citation:
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@article {pmid38072820,
year = {2024},
author = {Bracken, A and Hauss, J and Grinshpun, S and Lasc, D and Hershkovich, A and Yang, Y},
title = {A profile of spatial abilities in people with Down syndrome.},
journal = {Journal of intellectual disability research : JIDR},
volume = {68},
number = {3},
pages = {223-236},
pmid = {38072820},
issn = {1365-2788},
support = {SC2 HD103587/HD/NICHD NIH HHS/United States ; SC2HD103587/NH/NIH HHS/United States ; },
mesh = {Adolescent ; Child ; Humans ; Young Adult ; Aptitude ; Cognition ; *Down Syndrome/psychology ; *Spatial Navigation ; },
abstract = {BACKGROUND: Spatial abilities are fundamental cognitive abilities, have direct applications in daily life, serve as a cognitive foundation for many other complex skills and are used in many specialty jobs. The current study aimed to systematically and comprehensively evaluate the spatial abilities of individuals with Down syndrome (DS) relative to mental ability-matched typically developing (TD) children based on Newcombe and Shipley's double-dimension theoretical framework for classifying spatial abilities.
METHODS: Forty adolescents and young adults with DS and 40 TD children completed a nonverbal intelligence test (Raven's), two measures of static-extrinsic skills (water-level task and cart task), two measures of static-intrinsic skills (figure ground and form completion), two measures of dynamic-extrinsic skills (three mountains task and dog task) and two measures of dynamic-intrinsic spatial skills (mental rotation task and block design task).
RESULTS: Participants with DS showed reduced performance on two dynamic-intrinsic tasks and one static-extrinsic task (i.e. cart task) relative to TD children. Performances were similar in two dynamic-extrinsic tasks and two static-intrinsic tasks. Analyses of composite accuracy for each spatial category further confirmed deficits in dynamic-intrinsic and static-extrinsic categories for people with DS relative to TD children.
CONCLUSIONS: Our results showed an uneven profile of spatial abilities in people with DS relative to ability-matched TD children with particular weaknesses in comprehending and manipulating dynamic-intrinsic and static-extrinsic spatial relations. Furthermore, our research has important clinical implications for more targeted interventions to improve spatial abilities in people with DS.},
}
MeSH Terms:
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Adolescent
Child
Humans
Young Adult
Aptitude
Cognition
*Down Syndrome/psychology
*Spatial Navigation
RevDate: 2024-03-27
CmpDate: 2024-01-11
Fitness benefits of alternated chick provisioning in cooperatively breeding carrion crows.
The Journal of animal ecology, 93(1):95-108.
In most bird species, parents raise offspring cooperatively. In some cases, this cooperation extends to helpers-at-the-nest who assist the breeders with a range of tasks. While cooperative food provisioning might merely arise incidentally, as a result of the efforts of carers that act independently from each other, recent studies suggest that birds may coordinate by taking turns in visiting the nest. However, evidence that such coordination emerges because individuals actively respond to each other's behaviour is controversial, and the potential benefits of carers' alternation remain unknown. We addressed this knowledge gap by analysing a multiyear dataset for cooperatively breeding carrion crows Corvus corone, comprising 8693 nest visits across 50 groups. Our results reveal that turn-taking does occur in this species and that all group members, regardless of their sex and social role (breeder/helper), tend to alternate at the nest with other carers rather than to make repeat visits. Importantly, we found that the body mass of nestlings increased significantly with the degree of carers' alternation, possibly because well-coordinated groups provided food at more regular intervals. Using earlier monitoring data, the observed increase in body mass is predicted to substantially boost postfledging survival rates. Our analyses demonstrate that alternation in nestling provisioning has measurable fitness benefits in this study system. This raises the possibility that cooperatively breeding carrion crows, as well as other bird species with similarly coordinated brood provisioning, exhibit specialized behavioural strategies that enable effective alternation.
Additional Links: PMID-38078562
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PubMed:
Citation:
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@article {pmid38078562,
year = {2024},
author = {Trapote, E and Moreno-González, V and Canestrari, D and Rutz, C and Baglione, V},
title = {Fitness benefits of alternated chick provisioning in cooperatively breeding carrion crows.},
journal = {The Journal of animal ecology},
volume = {93},
number = {1},
pages = {95-108},
doi = {10.1111/1365-2656.14033},
pmid = {38078562},
issn = {1365-2656},
support = {CGL2016-77636-P//Spanish Ministerio de Economía y Competitividad/ ; //SEO-Birdlife Research to ET/ ; BB/S018484/1//Biotechnology and Biological Sciences Research Council (BBSRC)/ ; },
mesh = {Humans ; Animals ; *Crows ; Cooperative Behavior ; *Songbirds ; Breeding ; Nesting Behavior ; },
abstract = {In most bird species, parents raise offspring cooperatively. In some cases, this cooperation extends to helpers-at-the-nest who assist the breeders with a range of tasks. While cooperative food provisioning might merely arise incidentally, as a result of the efforts of carers that act independently from each other, recent studies suggest that birds may coordinate by taking turns in visiting the nest. However, evidence that such coordination emerges because individuals actively respond to each other's behaviour is controversial, and the potential benefits of carers' alternation remain unknown. We addressed this knowledge gap by analysing a multiyear dataset for cooperatively breeding carrion crows Corvus corone, comprising 8693 nest visits across 50 groups. Our results reveal that turn-taking does occur in this species and that all group members, regardless of their sex and social role (breeder/helper), tend to alternate at the nest with other carers rather than to make repeat visits. Importantly, we found that the body mass of nestlings increased significantly with the degree of carers' alternation, possibly because well-coordinated groups provided food at more regular intervals. Using earlier monitoring data, the observed increase in body mass is predicted to substantially boost postfledging survival rates. Our analyses demonstrate that alternation in nestling provisioning has measurable fitness benefits in this study system. This raises the possibility that cooperatively breeding carrion crows, as well as other bird species with similarly coordinated brood provisioning, exhibit specialized behavioural strategies that enable effective alternation.},
}
MeSH Terms:
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Humans
Animals
*Crows
Cooperative Behavior
*Songbirds
Breeding
Nesting Behavior
RevDate: 2024-06-13
CmpDate: 2024-03-13
Maxine Deborrah Hyde: First Female Graduate of Case Western Reserve University's Neurologic Surgery Residency Program and Second Black Female Neurosurgeon in the United States.
World neurosurgery, 183:63-69.
BACKGROUND: The historical diversity gap in the neurosurgical workforce persists to this day. Women, despite constituting over half of the yearly total of medical school graduates, comprise only 6% of certified practicing neurosurgeons in the United States. Furthermore, Black Americans make up under 4% of U.S. neurosurgeons, despite making up around 14% of the national population. The purpose of this account is to highlight the life and career of Dr. Maxine Deborrah Hyde and illustrate the importance and necessity of diversity and inclusivity in advancing the field of neurosurgery. Through this paper, we aspire to encourage the development of new diversity initiatives.
METHODS: Original scientific and bibliographic materials of Hyde were examined, and an extensive analysis of her life was compiled.
RESULTS: Despite growing up during the era of Jim Crow, Dr. Hyde persevered and became the valedictorian of Oak Park High School. As a first-generation college student at Tougaloo College, she later earned her MS from Cleveland State University. Dr. Hyde graduated with honors from Case Western Reserve University School of Medicine in 1977. Thereafter, she became the first female and first Black graduate of Case Western's neurosurgery residency and the second Black woman to receive certification from the American Board of Neurological Surgery. Later in life, Dr. Hyde established the Beacon of Hope Scholarship Foundation to assist disadvantaged students in overcoming educational barriers.
CONCLUSIONS: Dr. Hyde was a trailblazer who overcame systematic barriers and paved the way for future generations of aspiring neurosurgeons.
Additional Links: PMID-38081583
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PubMed:
Citation:
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@article {pmid38081583,
year = {2024},
author = {Anand, S and Reddy, RV and Omoba, OE and Detchou, D and Barrie, U and Aoun, SG},
title = {Maxine Deborrah Hyde: First Female Graduate of Case Western Reserve University's Neurologic Surgery Residency Program and Second Black Female Neurosurgeon in the United States.},
journal = {World neurosurgery},
volume = {183},
number = {},
pages = {63-69},
doi = {10.1016/j.wneu.2023.12.021},
pmid = {38081583},
issn = {1878-8769},
mesh = {Humans ; Female ; United States ; Neurosurgeons ; *Internship and Residency ; Universities ; Neurosurgical Procedures ; *Neurosurgery/education ; },
abstract = {BACKGROUND: The historical diversity gap in the neurosurgical workforce persists to this day. Women, despite constituting over half of the yearly total of medical school graduates, comprise only 6% of certified practicing neurosurgeons in the United States. Furthermore, Black Americans make up under 4% of U.S. neurosurgeons, despite making up around 14% of the national population. The purpose of this account is to highlight the life and career of Dr. Maxine Deborrah Hyde and illustrate the importance and necessity of diversity and inclusivity in advancing the field of neurosurgery. Through this paper, we aspire to encourage the development of new diversity initiatives.
METHODS: Original scientific and bibliographic materials of Hyde were examined, and an extensive analysis of her life was compiled.
RESULTS: Despite growing up during the era of Jim Crow, Dr. Hyde persevered and became the valedictorian of Oak Park High School. As a first-generation college student at Tougaloo College, she later earned her MS from Cleveland State University. Dr. Hyde graduated with honors from Case Western Reserve University School of Medicine in 1977. Thereafter, she became the first female and first Black graduate of Case Western's neurosurgery residency and the second Black woman to receive certification from the American Board of Neurological Surgery. Later in life, Dr. Hyde established the Beacon of Hope Scholarship Foundation to assist disadvantaged students in overcoming educational barriers.
CONCLUSIONS: Dr. Hyde was a trailblazer who overcame systematic barriers and paved the way for future generations of aspiring neurosurgeons.},
}
MeSH Terms:
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Humans
Female
United States
Neurosurgeons
*Internship and Residency
Universities
Neurosurgical Procedures
*Neurosurgery/education
RevDate: 2023-12-28
CmpDate: 2023-12-20
Applications of the new Aeva-HE™ imaging system: Its link with the visual evaluation of facial wrinkles and its potential in screening tensile products.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 29(12):e13512.
OBJECTIVES: To evaluate, in vivo, a recently developed imaging system (Aeva-HE™), based on fringe projection methodology: (i) its correlation with expert's assessments and real age of 85 French Caucasian women and (ii) its potential, as a screening tool, in rapidly selecting prototypes of tensile cosmetic products.
MATERIALS AND METHODS: First, the bare faces of 85 differently aged French/Caucasian women were photographed under standard conditions and further analyzed by the Aeva-HE™ device. An expert aesthetician graded the severity of wrinkling on a fixed scale, helped by the use of a dedicated Skin Aging Atlas. A panel of 15 judges performed the same task on full-face standard photographs. The Aeva-HE™ software yielded various wrinkle's parameters (density, volume, mean depth, etc.) on different facial locations, according to age-groups. Second, seven women, balanced in age and wrinkling severity, were recruited in a separate study. These women applied at Day 1 a prototype of the tensile product and at Day 2, they applied another prototype of the tensile product. The whole faces (before and after products application) of the seven studied women were captured and analyzed by the Aeva-HE™ system.
RESULTS: The density of wrinkles was significantly highly correlated with the aesthetician scores and, unsurprisingly, with age. Some parameters (volume, depths) of different wrinkles (glabellar, crow's feet, cheeks) were quantified, showing different absolute values and of statistically different progressions with age. The amplitudes of the rapid effects brought by the two prototypes of tensile products were clearly differentiated.
CONCLUSION: The recently developed device Aeva-HE™ is an efficient system for rapidly establishing a faithful and precise status of facial wrinkles, in vivo and seems like a precious tool in the rapid screening of tensile products, possibly performed on a rather limited number of subjects.
Additional Links: PMID-38081798
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@article {pmid38081798,
year = {2023},
author = {Shaiek, A and Monot, M and Rubert, V and Cornillon, C and Vicic, M and Decocq, G and Flament, F},
title = {Applications of the new Aeva-HE™ imaging system: Its link with the visual evaluation of facial wrinkles and its potential in screening tensile products.},
journal = {Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)},
volume = {29},
number = {12},
pages = {e13512},
pmid = {38081798},
issn = {1600-0846},
mesh = {Female ; Humans ; Cheek ; *Cosmetics ; Face/diagnostic imaging ; *Skin Aging ; White People ; },
abstract = {OBJECTIVES: To evaluate, in vivo, a recently developed imaging system (Aeva-HE™), based on fringe projection methodology: (i) its correlation with expert's assessments and real age of 85 French Caucasian women and (ii) its potential, as a screening tool, in rapidly selecting prototypes of tensile cosmetic products.
MATERIALS AND METHODS: First, the bare faces of 85 differently aged French/Caucasian women were photographed under standard conditions and further analyzed by the Aeva-HE™ device. An expert aesthetician graded the severity of wrinkling on a fixed scale, helped by the use of a dedicated Skin Aging Atlas. A panel of 15 judges performed the same task on full-face standard photographs. The Aeva-HE™ software yielded various wrinkle's parameters (density, volume, mean depth, etc.) on different facial locations, according to age-groups. Second, seven women, balanced in age and wrinkling severity, were recruited in a separate study. These women applied at Day 1 a prototype of the tensile product and at Day 2, they applied another prototype of the tensile product. The whole faces (before and after products application) of the seven studied women were captured and analyzed by the Aeva-HE™ system.
RESULTS: The density of wrinkles was significantly highly correlated with the aesthetician scores and, unsurprisingly, with age. Some parameters (volume, depths) of different wrinkles (glabellar, crow's feet, cheeks) were quantified, showing different absolute values and of statistically different progressions with age. The amplitudes of the rapid effects brought by the two prototypes of tensile products were clearly differentiated.
CONCLUSION: The recently developed device Aeva-HE™ is an efficient system for rapidly establishing a faithful and precise status of facial wrinkles, in vivo and seems like a precious tool in the rapid screening of tensile products, possibly performed on a rather limited number of subjects.},
}
MeSH Terms:
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hide MeSH Terms
Female
Humans
Cheek
*Cosmetics
Face/diagnostic imaging
*Skin Aging
White People
RevDate: 2024-03-07
CmpDate: 2024-03-07
The taphonomic impact of scavenger guilds in peri-urban and rural regions of central and southern Alberta. Part I - Identification of forensically relevant vertebrate scavengers.
Journal of forensic sciences, 69(2):415-429.
As a body decomposes in an outdoor environment, numerous taphonomic agents can act on the process of human decomposition. It is important to understand the impact of these agents as they can vary the rate of soft and hard tissue loss which may alter postmortem interval estimations. One taphonomic factor which has not been extensively investigated in many regions of the world, including Canada, are vertebrate scavengers. The current study aimed to identify scavenger guilds in the peri-urban and rural regions of two major cities in Alberta (Calgary and Edmonton) where human remains are frequently located. Vertebrate scavenger activity was recorded continuously using cellular and noncellular trail cameras. Images were analyzed to determine how the scavenging profiles (i.e., scavenger species, arrival time, and feeding behavior) impacted the loss of soft and hard tissue. We identified a range of mammalian and avian scavengers and found that coyote and black-billed magpie were the predominant scavengers recorded at the Edmonton peri-urban and rural sites, and the Calgary peri-urban sites. In contrast, when a site was within bear territory such as the Calgary rural sites, black and grizzly bears were the predominant scavengers. At all sites, the large mammalian scavengers were responsible for most soft tissue loss and subsequent hard tissue dispersal. None of the scavengers demonstrated a clear preference for open versus closed sites. This taphonomic information is important to consider when searching for human remains at these locations or in other North American regions with comparable scavenger guilds.
Additional Links: PMID-38084754
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PubMed:
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@article {pmid38084754,
year = {2024},
author = {Forbes, SL and Kjorlien, Y and Watson, CJ},
title = {The taphonomic impact of scavenger guilds in peri-urban and rural regions of central and southern Alberta. Part I - Identification of forensically relevant vertebrate scavengers.},
journal = {Journal of forensic sciences},
volume = {69},
number = {2},
pages = {415-429},
doi = {10.1111/1556-4029.15443},
pmid = {38084754},
issn = {1556-4029},
support = {RGPIN/6098/2019]//Natural Sciences and Engineering Research Council of Canada/ ; C150-2017-12//The Canada 150 Research Chair in Forensic Thanatology/ ; },
mesh = {Animals ; Humans ; Alberta ; *Body Remains ; Vertebrates ; Feeding Behavior ; Birds ; Fishes ; *Ursidae ; },
abstract = {As a body decomposes in an outdoor environment, numerous taphonomic agents can act on the process of human decomposition. It is important to understand the impact of these agents as they can vary the rate of soft and hard tissue loss which may alter postmortem interval estimations. One taphonomic factor which has not been extensively investigated in many regions of the world, including Canada, are vertebrate scavengers. The current study aimed to identify scavenger guilds in the peri-urban and rural regions of two major cities in Alberta (Calgary and Edmonton) where human remains are frequently located. Vertebrate scavenger activity was recorded continuously using cellular and noncellular trail cameras. Images were analyzed to determine how the scavenging profiles (i.e., scavenger species, arrival time, and feeding behavior) impacted the loss of soft and hard tissue. We identified a range of mammalian and avian scavengers and found that coyote and black-billed magpie were the predominant scavengers recorded at the Edmonton peri-urban and rural sites, and the Calgary peri-urban sites. In contrast, when a site was within bear territory such as the Calgary rural sites, black and grizzly bears were the predominant scavengers. At all sites, the large mammalian scavengers were responsible for most soft tissue loss and subsequent hard tissue dispersal. None of the scavengers demonstrated a clear preference for open versus closed sites. This taphonomic information is important to consider when searching for human remains at these locations or in other North American regions with comparable scavenger guilds.},
}
MeSH Terms:
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hide MeSH Terms
Animals
Humans
Alberta
*Body Remains
Vertebrates
Feeding Behavior
Birds
Fishes
*Ursidae
RevDate: 2024-11-02
CmpDate: 2024-03-08
Why birds are smart.
Trends in cognitive sciences, 28(3):197-209.
Many cognitive neuroscientists believe that both a large brain and an isocortex are crucial for complex cognition. Yet corvids and parrots possess non-cortical brains of just 1-25 g, and these birds exhibit cognitive abilities comparable with those of great apes such as chimpanzees, which have brains of about 400 g. This opinion explores how this cognitive equivalence is possible. We propose four features that may be required for complex cognition: a large number of associative pallial neurons, a prefrontal cortex (PFC)-like area, a dense dopaminergic innervation of association areas, and dynamic neurophysiological fundaments for working memory. These four neural features have convergently evolved and may therefore represent 'hard to replace' mechanisms enabling complex cognition.
Additional Links: PMID-38097447
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Citation:
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@article {pmid38097447,
year = {2024},
author = {Güntürkün, O and Pusch, R and Rose, J},
title = {Why birds are smart.},
journal = {Trends in cognitive sciences},
volume = {28},
number = {3},
pages = {197-209},
pmid = {38097447},
issn = {1879-307X},
support = {101021354//AVIAN MIND/ ; 316803389//Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)/ ; },
mesh = {Animals ; *Birds/physiology ; *Cognition/physiology ; Neocortex ; Prefrontal Cortex ; },
abstract = {Many cognitive neuroscientists believe that both a large brain and an isocortex are crucial for complex cognition. Yet corvids and parrots possess non-cortical brains of just 1-25 g, and these birds exhibit cognitive abilities comparable with those of great apes such as chimpanzees, which have brains of about 400 g. This opinion explores how this cognitive equivalence is possible. We propose four features that may be required for complex cognition: a large number of associative pallial neurons, a prefrontal cortex (PFC)-like area, a dense dopaminergic innervation of association areas, and dynamic neurophysiological fundaments for working memory. These four neural features have convergently evolved and may therefore represent 'hard to replace' mechanisms enabling complex cognition.},
}
MeSH Terms:
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Animals
*Birds/physiology
*Cognition/physiology
Neocortex
Prefrontal Cortex
RevDate: 2026-01-04
CmpDate: 2025-12-02
An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution.
bioRxiv : the preprint server for biology.
IMPORTANCE: DNA methylation (DNAm) provides a plausible mechanism by which adverse exposures become embodied and contribute to health inequities, due to its role in genome regulation and responsiveness to social and biophysical exposures tied to societal context. However, scant epigenome-wide association studies (EWAS) have included structural and lifecourse measures of exposure, especially in relation to structural discrimination.
OBJECTIVE: Our study tests the hypothesis that DNAm is a mechanism by which racial discrimination, economic adversity, and air pollution become biologically embodied.
DESIGN: A series of cross-sectional EWAS, conducted in My Body My Story (MBMS, biological specimens collected 2008-2010, DNAm assayed in 2021); and the Multi Ethnic Study of Atherosclerosis (MESA; biological specimens collected 2010-2012, DNAm assayed in 2012-2013); using new georeferenced social exposure data for both studies (generated in 2022).
SETTING: MBMS was recruited from four community health centers in Boston; MESA was recruited from four field sites in: Baltimore, MD; Forsyth County, NC; New York City, NY; and St. Paul, MN.
PARTICIPANTS: Two population-based samples of US-born Black non-Hispanic (Black NH), white non-Hispanic (white NH), and Hispanic individuals (MBMS; n=224 Black NH and 69 white NH) and (MESA; n=229 Black NH, n=555 white NH and n=191 Hispanic).
EXPOSURES: Eight social exposures encompassing racial discrimination, economic adversity, and air pollution.
MAIN OUTCOME: Genome-wide changes in DNAm, as measured using the Illumina EPIC BeadChip (MBMS; using frozen blood spots) and Illumina 450k BeadChip (MESA; using purified monocytes). Our hypothesis was formulated after data collection.
RESULTS: We observed the strongest associations with traffic-related air pollution (measured via black carbon and nitrogen oxides exposure), with evidence from both studies suggesting that air pollution exposure may induce epigenetic changes related to inflammatory processes. We also found suggestive associations of DNAm variation with measures of structural racial discrimination (e.g., for Black NH participants, born in a Jim Crow state; adult exposure to racialized economic residential segregation) situated in genes with plausible links to effects on health.
CONCLUSIONS AND RELEVANCE: Overall, this work suggests that DNAm is a biological mechanism through which structural racism and air pollution become embodied and may lead to health inequities.
Additional Links: PMID-38105971
PubMed:
Citation:
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@article {pmid38105971,
year = {2023},
author = {Watkins, SH and Testa, C and Simpkin, AJ and Smith, GD and Coull, B and De Vivo, I and Tilling, K and Waterman, PD and Chen, JT and Diez-Roux, AV and Krieger, N and Suderman, M and Relton, C},
title = {An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution.},
journal = {bioRxiv : the preprint server for biology},
volume = {},
number = {},
pages = {},
pmid = {38105971},
issn = {2692-8205},
support = {R01 AG027122/AG/NIA NIH HHS/United States ; R01 HL135009/HL/NHLBI NIH HHS/United States ; P30 DK063491/DK/NIDDK NIH HHS/United States ; UL1 TR000040/TR/NCATS NIH HHS/United States ; N01 HC095166/HL/NHLBI NIH HHS/United States ; N01 HC095160/HL/NHLBI NIH HHS/United States ; 75N92020D00002/HL/NHLBI NIH HHS/United States ; HHSN268201500003C/HL/NHLBI NIH HHS/United States ; N01 HC095161/HL/NHLBI NIH HHS/United States ; 75N92020D00005/HL/NHLBI NIH HHS/United States ; N01 HC095168/HL/NHLBI NIH HHS/United States ; T32 AI007358/AI/NIAID NIH HHS/United States ; UL1 TR001079/TR/NCATS NIH HHS/United States ; N01 HC095169/HL/NHLBI NIH HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 DK101921/DK/NIDDK NIH HHS/United States ; 75N92020D00001/HL/NHLBI NIH HHS/United States ; R01 HL101250/HL/NHLBI NIH HHS/United States ; R01 MD014304/MD/NIMHD NIH HHS/United States ; N01 HC095167/HL/NHLBI NIH HHS/United States ; N01 HC095159/HL/NHLBI NIH HHS/United States ; 75N92020D00003/HL/NHLBI NIH HHS/United States ; UL1 TR001420/TR/NCATS NIH HHS/United States ; 75N92020D00004/HL/NHLBI NIH HHS/United States ; N01 HC095163/HL/NHLBI NIH HHS/United States ; 75N92020D00007/HL/NHLBI NIH HHS/United States ; HHSN268201500003I/HL/NHLBI NIH HHS/United States ; RF1 AG054474/AG/NIA NIH HHS/United States ; R01 HL126477/HL/NHLBI NIH HHS/United States ; N01 HC095162/HL/NHLBI NIH HHS/United States ; 75N92020D00006/HL/NHLBI NIH HHS/United States ; UL1 TR001881/TR/NCATS NIH HHS/United States ; N01 HC095165/HL/NHLBI NIH HHS/United States ; N01 HC095164/HL/NHLBI NIH HHS/United States ; },
abstract = {IMPORTANCE: DNA methylation (DNAm) provides a plausible mechanism by which adverse exposures become embodied and contribute to health inequities, due to its role in genome regulation and responsiveness to social and biophysical exposures tied to societal context. However, scant epigenome-wide association studies (EWAS) have included structural and lifecourse measures of exposure, especially in relation to structural discrimination.
OBJECTIVE: Our study tests the hypothesis that DNAm is a mechanism by which racial discrimination, economic adversity, and air pollution become biologically embodied.
DESIGN: A series of cross-sectional EWAS, conducted in My Body My Story (MBMS, biological specimens collected 2008-2010, DNAm assayed in 2021); and the Multi Ethnic Study of Atherosclerosis (MESA; biological specimens collected 2010-2012, DNAm assayed in 2012-2013); using new georeferenced social exposure data for both studies (generated in 2022).
SETTING: MBMS was recruited from four community health centers in Boston; MESA was recruited from four field sites in: Baltimore, MD; Forsyth County, NC; New York City, NY; and St. Paul, MN.
PARTICIPANTS: Two population-based samples of US-born Black non-Hispanic (Black NH), white non-Hispanic (white NH), and Hispanic individuals (MBMS; n=224 Black NH and 69 white NH) and (MESA; n=229 Black NH, n=555 white NH and n=191 Hispanic).
EXPOSURES: Eight social exposures encompassing racial discrimination, economic adversity, and air pollution.
MAIN OUTCOME: Genome-wide changes in DNAm, as measured using the Illumina EPIC BeadChip (MBMS; using frozen blood spots) and Illumina 450k BeadChip (MESA; using purified monocytes). Our hypothesis was formulated after data collection.
RESULTS: We observed the strongest associations with traffic-related air pollution (measured via black carbon and nitrogen oxides exposure), with evidence from both studies suggesting that air pollution exposure may induce epigenetic changes related to inflammatory processes. We also found suggestive associations of DNAm variation with measures of structural racial discrimination (e.g., for Black NH participants, born in a Jim Crow state; adult exposure to racialized economic residential segregation) situated in genes with plausible links to effects on health.
CONCLUSIONS AND RELEVANCE: Overall, this work suggests that DNAm is a biological mechanism through which structural racism and air pollution become embodied and may lead to health inequities.},
}
RevDate: 2023-12-19
Exploring Emotion Recognition Patterns Among Iranian People Using CANTAB as an Approved Neuro-Psychological Assessment.
Basic and clinical neuroscience, 14(2):289-295.
INTRODUCTION: Emotion recognition is the main component of social cognition and has various patterns in different cultures and nationalities. The present study aimed to investigate emotion recognition patterns among Iranians using the Cambridge neuro-psychological test automated battery (CANTAB) as a valid neuropsychological test.
METHODS: In this descriptive-analytical study, 117 males and females (Mean±SD of age 32.1±6.4) were initially assessed by computerized intelligence and progressive matrices of RAVEN-2. Furthermore, the excitement recognition subtest taken from the Cambridge neuro-psychological test automated battery (CANTAB) was performed. The correct response of participants to each of the six basic emotions as well as the recognition time was used for analysis.
RESULTS: The maximum correct response rate was 75.83% related to happy emotion. The correct responses for sadness, surprise, disgust, anger, and fear were 70%, 68.48%, 47.84%, 42.54%, and 38.26%, respectively. Moreover, the shortest recognition time was related to disgust at 322 ms, while sadness with a mean response time of 1800 ms and fear response time at 1529 ms indicated the longest recognition time. In addition, participants recognized happiness with a mean response time of 1264 ms better than other emotions; however, post-hoc t-test analyses showed that only the correct responses for sadness and surprised emotions did not differ significantly, (t(112)=-0.59, P=0.55, d=0.05). These results suggested that different emotions have various correct responses. However, sadness and surprise did not differ.
CONCLUSION: The findings of this study could be beneficial for evaluating cognitive elements, as well as cognitive abilities and inabilities among the Iranian population. Moreover, the findings could be used for investigating social cognition in this population.
HIGHLIGHTS: Emotion recognition patterns among Iranians were investigated using a valid neuropsychological test.Iranians showed higher accuracy in recognizing happiness and lower accuracy in recognizing fear.Disgust was recognized with the shortest response time, while sadness and fear had the longest recognition time.The findings highlight cultural differences in emotion recognition and can aid in evaluating cognitive abilities and social cognition in the Iranian population.The study emphasizes the importance of considering cultural factors in assessing and understanding emotion recognition.
PLAIN LANGUAGE SUMMARY: Understanding how people recognize emotions is crucial for effective communication and building social connections. However, the ability to recognize emotions can vary across cultures. This study aimed to investigate how Iranians recognize emotions using a reliable test. The researchers assessed 117 Iranian adults, both males and females, using a computer-based test. Participants were asked to identify six basic emotions (happiness, sadness, anger, disgust, fear, and surprise) displayed on a screen. The researchers measured the participants' accuracy in identifying each emotion and the time it took them to recognize it. The findings revealed that Iranians were most accurate in recognizing happiness and least accurate in recognizing fear. They were better at identifying positive emotions like happiness and surprise compared to negative emotions like disgust and anger. Participants took the least time to recognize disgust and the longest time to recognize sadness and fear. These results show that Iranians have specific patterns in recognizing emotions, which can be influenced by cultural factors. Understanding these patterns is important for assessing cognitive abilities and social cognition in the Iranian population. Moreover, these findings have broader implications. They highlight the need to consider cultural differences in emotion recognition, as it can impact communication and social interactions. The study's outcomes can be valuable for various applications. For instance, they can aid in developing tests to assess emotion recognition difficulties in individuals with conditions such as autism or schizophrenia. Furthermore, these findings can be useful for professionals, such as employees in customer service or mental health providers, who need to accurately interpret others' emotions. By shedding light on cultural variations in emotion recognition, this research contributes to our understanding of human emotions and their role in interpersonal relationships.
Additional Links: PMID-38107531
PubMed:
Citation:
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@article {pmid38107531,
year = {2023},
author = {Lohrasbi, S and Moradi, AR and Sadeghi, M},
title = {Exploring Emotion Recognition Patterns Among Iranian People Using CANTAB as an Approved Neuro-Psychological Assessment.},
journal = {Basic and clinical neuroscience},
volume = {14},
number = {2},
pages = {289-295},
pmid = {38107531},
issn = {2008-126X},
abstract = {INTRODUCTION: Emotion recognition is the main component of social cognition and has various patterns in different cultures and nationalities. The present study aimed to investigate emotion recognition patterns among Iranians using the Cambridge neuro-psychological test automated battery (CANTAB) as a valid neuropsychological test.
METHODS: In this descriptive-analytical study, 117 males and females (Mean±SD of age 32.1±6.4) were initially assessed by computerized intelligence and progressive matrices of RAVEN-2. Furthermore, the excitement recognition subtest taken from the Cambridge neuro-psychological test automated battery (CANTAB) was performed. The correct response of participants to each of the six basic emotions as well as the recognition time was used for analysis.
RESULTS: The maximum correct response rate was 75.83% related to happy emotion. The correct responses for sadness, surprise, disgust, anger, and fear were 70%, 68.48%, 47.84%, 42.54%, and 38.26%, respectively. Moreover, the shortest recognition time was related to disgust at 322 ms, while sadness with a mean response time of 1800 ms and fear response time at 1529 ms indicated the longest recognition time. In addition, participants recognized happiness with a mean response time of 1264 ms better than other emotions; however, post-hoc t-test analyses showed that only the correct responses for sadness and surprised emotions did not differ significantly, (t(112)=-0.59, P=0.55, d=0.05). These results suggested that different emotions have various correct responses. However, sadness and surprise did not differ.
CONCLUSION: The findings of this study could be beneficial for evaluating cognitive elements, as well as cognitive abilities and inabilities among the Iranian population. Moreover, the findings could be used for investigating social cognition in this population.
HIGHLIGHTS: Emotion recognition patterns among Iranians were investigated using a valid neuropsychological test.Iranians showed higher accuracy in recognizing happiness and lower accuracy in recognizing fear.Disgust was recognized with the shortest response time, while sadness and fear had the longest recognition time.The findings highlight cultural differences in emotion recognition and can aid in evaluating cognitive abilities and social cognition in the Iranian population.The study emphasizes the importance of considering cultural factors in assessing and understanding emotion recognition.
PLAIN LANGUAGE SUMMARY: Understanding how people recognize emotions is crucial for effective communication and building social connections. However, the ability to recognize emotions can vary across cultures. This study aimed to investigate how Iranians recognize emotions using a reliable test. The researchers assessed 117 Iranian adults, both males and females, using a computer-based test. Participants were asked to identify six basic emotions (happiness, sadness, anger, disgust, fear, and surprise) displayed on a screen. The researchers measured the participants' accuracy in identifying each emotion and the time it took them to recognize it. The findings revealed that Iranians were most accurate in recognizing happiness and least accurate in recognizing fear. They were better at identifying positive emotions like happiness and surprise compared to negative emotions like disgust and anger. Participants took the least time to recognize disgust and the longest time to recognize sadness and fear. These results show that Iranians have specific patterns in recognizing emotions, which can be influenced by cultural factors. Understanding these patterns is important for assessing cognitive abilities and social cognition in the Iranian population. Moreover, these findings have broader implications. They highlight the need to consider cultural differences in emotion recognition, as it can impact communication and social interactions. The study's outcomes can be valuable for various applications. For instance, they can aid in developing tests to assess emotion recognition difficulties in individuals with conditions such as autism or schizophrenia. Furthermore, these findings can be useful for professionals, such as employees in customer service or mental health providers, who need to accurately interpret others' emotions. By shedding light on cultural variations in emotion recognition, this research contributes to our understanding of human emotions and their role in interpersonal relationships.},
}
RevDate: 2025-09-15
CmpDate: 2024-02-21
Urban Magpies Frequently Feed on Coyote Scats and May Spread an Emerging Zoonotic Tapeworm.
EcoHealth, 20(4):441-452.
Allocoprophagy, in which animals feed on the feces of other individuals or species, has been little studied in vertebrates, despite its relevance to parasite transmission. These relationships may be especially important in cities, where animal density, disease incidence, and spatial overlap of humans and wildlife increase. Our goal was to document the incidence and predictors of coprophagy by black-billed magpies (Pica hudsonia) at coyote (Canis latrans) scats in Edmonton, Canada. We detected scats by following coyote trails and recorded whether coprophagy had occurred. We used multiple logistic regression to determine the top contextual and environmental predictors of coprophagy. Of 668 coyote scats, 37.3% had apparently been fed on. Coprophagy was more likely in winter and when scats were not fresh and did not contain vegetation or garbage. Environmental predictors of coprophagy included proximity to other coyote scats and playgrounds, distance from water and maintained trails, abundant natural land cover, and proximity to encampments of people experiencing homelessness. Our results reveal that magpies frequently access coyote scat and often do so near human-use areas. In Edmonton, where > 50% of coyotes are infected with a zoonotic tapeworm, coprophagy likely causes magpies to transport parasites with implications for zoonotic disease risk.
Additional Links: PMID-38109036
PubMed:
Citation:
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@article {pmid38109036,
year = {2023},
author = {Raymond, S and St Clair, CC},
title = {Urban Magpies Frequently Feed on Coyote Scats and May Spread an Emerging Zoonotic Tapeworm.},
journal = {EcoHealth},
volume = {20},
number = {4},
pages = {441-452},
pmid = {38109036},
issn = {1612-9210},
support = {Canada Graduate Scholarship--Master's//Natural Sciences and Engineering Research Council of Canada/ ; Discovery Grant (RGPIN-2017-05915)//Natural Sciences and Engineering Research Council of Canada/ ; Faculty of Science Research Fellowship//University of Alberta/ ; Walter H. Johns Graduate Fellowship//University of Alberta/ ; },
mesh = {Animals ; Humans ; *Coyotes/parasitology ; Animals, Wild/parasitology ; Zoonoses/epidemiology ; Cities ; *Cestoda ; *Parasites ; },
abstract = {Allocoprophagy, in which animals feed on the feces of other individuals or species, has been little studied in vertebrates, despite its relevance to parasite transmission. These relationships may be especially important in cities, where animal density, disease incidence, and spatial overlap of humans and wildlife increase. Our goal was to document the incidence and predictors of coprophagy by black-billed magpies (Pica hudsonia) at coyote (Canis latrans) scats in Edmonton, Canada. We detected scats by following coyote trails and recorded whether coprophagy had occurred. We used multiple logistic regression to determine the top contextual and environmental predictors of coprophagy. Of 668 coyote scats, 37.3% had apparently been fed on. Coprophagy was more likely in winter and when scats were not fresh and did not contain vegetation or garbage. Environmental predictors of coprophagy included proximity to other coyote scats and playgrounds, distance from water and maintained trails, abundant natural land cover, and proximity to encampments of people experiencing homelessness. Our results reveal that magpies frequently access coyote scat and often do so near human-use areas. In Edmonton, where > 50% of coyotes are infected with a zoonotic tapeworm, coprophagy likely causes magpies to transport parasites with implications for zoonotic disease risk.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Humans
*Coyotes/parasitology
Animals, Wild/parasitology
Zoonoses/epidemiology
Cities
*Cestoda
*Parasites
RevDate: 2024-04-05
CmpDate: 2024-04-05
Chemosensory detection of glucosinolates as token stimuli for specialist insects on brassicaceous plants: discovery and impact.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 210(2):243-248.
In this paper, we take a historical perspective by going back to Verschaffelt's landmark study published in 1910, in which he found that glucosinolates were used as token stimuli by larvae of Pieris butterflies, specialist feeders on plants in the family Brassicaceae. This classic discovery provided key evidence for Fraenkel (Science 129:1466-1470, 1959) to elaborate on the function of secondary plant substances and for Ehrlich and Raven (Evolution 18:586-608, 1964) to put forward the hypothesis of insect-plant coevolution. The discovery by Schoonhoven (Kon Nederl Akad Wetensch Amsterdam Proc Ser C70:556-568, 1967) of taste neurons highly sensitive to glucosinolates in Pieris brassicae was an important milestone in elucidating the chemosensory basis of host-plant specialization. The molecular basis of glucosinolate sensitivity was elucidated recently (Yang et al., PLoS Genet 17, 2021) paving the way to unravel the evolution of gustatory receptors tuned to glucosinolates that are crucial for host-plant selection of Pieris butterflies. We propose a hypothetical model for the evolution of labeled-line neurons tuned to token stimuli.
Additional Links: PMID-38114856
PubMed:
Citation:
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@article {pmid38114856,
year = {2024},
author = {Wang, CZ and van Loon, JJA},
title = {Chemosensory detection of glucosinolates as token stimuli for specialist insects on brassicaceous plants: discovery and impact.},
journal = {Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology},
volume = {210},
number = {2},
pages = {243-248},
pmid = {38114856},
issn = {1432-1351},
support = {32130090//the National Natural Science Foundation of China/ ; },
mesh = {Animals ; *Butterflies/physiology ; Glucosinolates ; Insecta ; Larva ; },
abstract = {In this paper, we take a historical perspective by going back to Verschaffelt's landmark study published in 1910, in which he found that glucosinolates were used as token stimuli by larvae of Pieris butterflies, specialist feeders on plants in the family Brassicaceae. This classic discovery provided key evidence for Fraenkel (Science 129:1466-1470, 1959) to elaborate on the function of secondary plant substances and for Ehrlich and Raven (Evolution 18:586-608, 1964) to put forward the hypothesis of insect-plant coevolution. The discovery by Schoonhoven (Kon Nederl Akad Wetensch Amsterdam Proc Ser C70:556-568, 1967) of taste neurons highly sensitive to glucosinolates in Pieris brassicae was an important milestone in elucidating the chemosensory basis of host-plant specialization. The molecular basis of glucosinolate sensitivity was elucidated recently (Yang et al., PLoS Genet 17, 2021) paving the way to unravel the evolution of gustatory receptors tuned to glucosinolates that are crucial for host-plant selection of Pieris butterflies. We propose a hypothetical model for the evolution of labeled-line neurons tuned to token stimuli.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
*Butterflies/physiology
Glucosinolates
Insecta
Larva
RevDate: 2025-05-30
CmpDate: 2024-02-19
Developmental Delay and Behavior Challenges in an Internationally Adopted Child.
Journal of developmental and behavioral pediatrics : JDBP, 45(1):e88-e91.
Jay is a 6-year-old boy who was referred to a multidisciplinary developmental clinic for evaluation because of speech/language delays and challenging behaviors. He attends kindergarten with an Individualized Education Program (IEP) supporting developmental challenges with speech/language, motor, and academic skills.Jay was reportedly born full-term after an uneventful pregnancy and lived with his biological family for several months before transitioning to institutional care. Shortly before his first birthday, he transitioned to the first of 3 foster homes. It is suspected that Jay experienced malnourishment, neglect, lack of appropriate supervision, and inappropriate levels of responsibility (e.g., providing care to an infant when he was a toddler) as well as limited language input while in foster care. Ages at which he attained developmental milestones are unknown, but he has displayed delays across all developmental domains, including speech/language development in his primary language, which is not English.Jay's adoptive parents report that he is learning English vocabulary well but has been noted to have occasional word-finding difficulties and errors in verb conjugation, pronoun use, and syntax in English. Behavioral concerns include impulsivity, hyperactivity, and aggression exacerbated by new or loud environments and transitions. Socially, he seems to be typically engaged with peers but lacks understanding of personal space/boundaries. His adoptive parents have also noted that he is very sensitive to the emotions of others around him, more irritable in the morning, fascinated by "scary" things, and seems to fear abandonment. During the initial months in his adoptive home, he had frequent night awakenings, fear of the dark, and aggression at bedtime, but all these concerns have improved with time.Neuropsychological testing was completed as part of the multidisciplinary developmental evaluation, and Jay demonstrated low-average cognitive abilities, delayed preacademic skills in all language-based areas, and receptive and expressive language delays. He was socially engaged during the evaluation. Ultimately, he was diagnosed with mixed receptive-expressive language disorder, attention-deficit/hyperactivity disorder, combined presentation, and unspecified trauma/stress-related disorder.Given what is known about Jay's early history, what factors would you consider in addressing his parents' concerns regarding his speech/language development and behavior challenges?
Additional Links: PMID-38117679
Publisher:
PubMed:
Citation:
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@article {pmid38117679,
year = {2024},
author = {Lipton, LR and Prock, L and Camarata, S and Fogler, J and Nyp, SS},
title = {Developmental Delay and Behavior Challenges in an Internationally Adopted Child.},
journal = {Journal of developmental and behavioral pediatrics : JDBP},
volume = {45},
number = {1},
pages = {e88-e91},
doi = {10.1097/DBP.0000000000001235},
pmid = {38117679},
issn = {1536-7312},
mesh = {Male ; Humans ; Child ; *Child, Adopted ; Social Behavior ; Aggression ; *Attention Deficit Disorder with Hyperactivity/diagnosis ; *Language Development Disorders/diagnosis ; },
abstract = {Jay is a 6-year-old boy who was referred to a multidisciplinary developmental clinic for evaluation because of speech/language delays and challenging behaviors. He attends kindergarten with an Individualized Education Program (IEP) supporting developmental challenges with speech/language, motor, and academic skills.Jay was reportedly born full-term after an uneventful pregnancy and lived with his biological family for several months before transitioning to institutional care. Shortly before his first birthday, he transitioned to the first of 3 foster homes. It is suspected that Jay experienced malnourishment, neglect, lack of appropriate supervision, and inappropriate levels of responsibility (e.g., providing care to an infant when he was a toddler) as well as limited language input while in foster care. Ages at which he attained developmental milestones are unknown, but he has displayed delays across all developmental domains, including speech/language development in his primary language, which is not English.Jay's adoptive parents report that he is learning English vocabulary well but has been noted to have occasional word-finding difficulties and errors in verb conjugation, pronoun use, and syntax in English. Behavioral concerns include impulsivity, hyperactivity, and aggression exacerbated by new or loud environments and transitions. Socially, he seems to be typically engaged with peers but lacks understanding of personal space/boundaries. His adoptive parents have also noted that he is very sensitive to the emotions of others around him, more irritable in the morning, fascinated by "scary" things, and seems to fear abandonment. During the initial months in his adoptive home, he had frequent night awakenings, fear of the dark, and aggression at bedtime, but all these concerns have improved with time.Neuropsychological testing was completed as part of the multidisciplinary developmental evaluation, and Jay demonstrated low-average cognitive abilities, delayed preacademic skills in all language-based areas, and receptive and expressive language delays. He was socially engaged during the evaluation. Ultimately, he was diagnosed with mixed receptive-expressive language disorder, attention-deficit/hyperactivity disorder, combined presentation, and unspecified trauma/stress-related disorder.Given what is known about Jay's early history, what factors would you consider in addressing his parents' concerns regarding his speech/language development and behavior challenges?},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Male
Humans
Child
*Child, Adopted
Social Behavior
Aggression
*Attention Deficit Disorder with Hyperactivity/diagnosis
*Language Development Disorders/diagnosis
RevDate: 2024-02-06
CmpDate: 2024-01-26
Hexachlorobenzene and omega-3 fatty acid intake from traditional foods in the northern Yukon: A risk and benefit analysis.
The Science of the total environment, 914:169205.
A human biomonitoring study was conducted in the community of Old Crow, Yukon, in 2019, finding that levels of hexachlorobenzene (HCB) in plasma were elevated in the community relative to the general Canadian population. The aim of this study was to estimate dietary intake of both hexachlorobenzene, and the nutrient omega-3 fatty acids from locally harvested traditional foods in Old Crow, with the aim of identifying possible regional sources of exposure. A stochastic model was constructed to estimate intake of both hexachlorobenzene and the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Average predicted hexachlorobenzene exposure levels from traditional food consumption in Old Crow were below the tolerable daily intake of 1600-1700 ng/kg body weight/day in both average (18 ng/kg body weight/day) and short-term maximum (27 ng/kg body weight/day) exposure models. The primary contributors to average hexachlorobenzene intake were caribou fat, bone marrow, ribs, and kidneys, and Chinook salmon muscle. Average estimated dietary EPA + DHA intake levels from traditional foods were below the recommendation of 2.1 to 3.2 g of EPA + DHA per week in the average (1.6 g/week) exposure model, but above this recommendation in the short-term maximum model (3.3 g/week). The primary contributors to average EPA + DHA intake were the meat of Chinook, coho, and, chum salmon muscle, and whitefish muscle and eggs. The results of this study support the message that traditional foods continue to be an important source of nutrients and other health benefits and that the health benefits of traditional foods generally outweigh contaminant risks.
Additional Links: PMID-38145675
Publisher:
PubMed:
Citation:
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@article {pmid38145675,
year = {2024},
author = {Drysdale, M and Gamberg, M and Brammer, J and Majowicz, SE and Packull-McCormick, S and Skinner, K and Laird, BD},
title = {Hexachlorobenzene and omega-3 fatty acid intake from traditional foods in the northern Yukon: A risk and benefit analysis.},
journal = {The Science of the total environment},
volume = {914},
number = {},
pages = {169205},
doi = {10.1016/j.scitotenv.2023.169205},
pmid = {38145675},
issn = {1879-1026},
mesh = {Humans ; *Hexachlorobenzene/analysis ; Yukon Territory ; Canada ; *Fatty Acids, Omega-3 ; Docosahexaenoic Acids ; Eicosapentaenoic Acid ; Body Weight ; },
abstract = {A human biomonitoring study was conducted in the community of Old Crow, Yukon, in 2019, finding that levels of hexachlorobenzene (HCB) in plasma were elevated in the community relative to the general Canadian population. The aim of this study was to estimate dietary intake of both hexachlorobenzene, and the nutrient omega-3 fatty acids from locally harvested traditional foods in Old Crow, with the aim of identifying possible regional sources of exposure. A stochastic model was constructed to estimate intake of both hexachlorobenzene and the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Average predicted hexachlorobenzene exposure levels from traditional food consumption in Old Crow were below the tolerable daily intake of 1600-1700 ng/kg body weight/day in both average (18 ng/kg body weight/day) and short-term maximum (27 ng/kg body weight/day) exposure models. The primary contributors to average hexachlorobenzene intake were caribou fat, bone marrow, ribs, and kidneys, and Chinook salmon muscle. Average estimated dietary EPA + DHA intake levels from traditional foods were below the recommendation of 2.1 to 3.2 g of EPA + DHA per week in the average (1.6 g/week) exposure model, but above this recommendation in the short-term maximum model (3.3 g/week). The primary contributors to average EPA + DHA intake were the meat of Chinook, coho, and, chum salmon muscle, and whitefish muscle and eggs. The results of this study support the message that traditional foods continue to be an important source of nutrients and other health benefits and that the health benefits of traditional foods generally outweigh contaminant risks.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Humans
*Hexachlorobenzene/analysis
Yukon Territory
Canada
*Fatty Acids, Omega-3
Docosahexaenoic Acids
Eicosapentaenoic Acid
Body Weight
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Robbins holds BS, MS, and PhD degrees in the life sciences. He served as a tenured faculty member in the Zoology and Biological Science departments at Michigan State University. He is currently exploring the intersection between genomics, microbial ecology, and biodiversity — an area that promises to transform our understanding of the biosphere.
Educator
Robbins has extensive experience in college-level education: At MSU he taught introductory biology, genetics, and population genetics. At JHU, he was an instructor for a special course on biological database design. At FHCRC, he team-taught a graduate-level course on the history of genetics. At Bellevue College he taught medical informatics.
Administrator
Robbins has been involved in science administration at both the federal and the institutional levels. At NSF he was a program officer for database activities in the life sciences, at DOE he was a program officer for information infrastructure in the human genome project. At the Fred Hutchinson Cancer Research Center, he served as a vice president for fifteen years.
Technologist
Robbins has been involved with information technology since writing his first Fortran program as a college student. At NSF he was the first program officer for database activities in the life sciences. At JHU he held an appointment in the CS department and served as director of the informatics core for the Genome Data Base. At the FHCRC he was VP for Information Technology.
Publisher
While still at Michigan State, Robbins started his first publishing venture, founding a small company that addressed the short-run publishing needs of instructors in very large undergraduate classes. For more than 20 years, Robbins has been operating The Electronic Scholarly Publishing Project, a web site dedicated to the digital publishing of critical works in science, especially classical genetics.
Speaker
Robbins is well-known for his speaking abilities and is often called upon to provide keynote or plenary addresses at international meetings. For example, in July, 2012, he gave a well-received keynote address at the Global Biodiversity Informatics Congress, sponsored by GBIF and held in Copenhagen. The slides from that talk can be seen HERE.
Facilitator
Robbins is a skilled meeting facilitator. He prefers a participatory approach, with part of the meeting involving dynamic breakout groups, created by the participants in real time: (1) individuals propose breakout groups; (2) everyone signs up for one (or more) groups; (3) the groups with the most interested parties then meet, with reports from each group presented and discussed in a subsequent plenary session.
Designer
Robbins has been engaged with photography and design since the 1960s, when he worked for a professional photography laboratory. He now prefers digital photography and tools for their precision and reproducibility. He designed his first web site more than 20 years ago and he personally designed and implemented this web site. He engages in graphic design as a hobby.
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Big Data & Informatics
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